JP2017002015A - Supplement and production method thereof - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide supplements consisting of a naturally-occurring cod liver oil abundantly containing vitamin A and omega 3 fatty acid which tend to be deficient in diet, a tuna fish oil, a linseed oil, a lamprey oil, and an anti-oxidant; and to provide production methods thereof.SOLUTION: The invention is commercialized by combining 25-45% of a cod liver oil abundantly containing vitamin A and omega 3 fatty acid, 15-35% of a tuna fish oil, 10-25% of a linseed oil, 5-15% of a lamprey oil, and a mixed tocopherol as an anti-oxidant, into 500 ppm or more, and stirring and molding.SELECTED DRAWING: None

Description

The present invention relates to a supplement as a dietary supplement that can be taken by humans and animals other than humans, and a method for producing the same. Specifically, the main ingredient is natural cod liver oil, which is rich in vitamin A, omega-3 fatty acid and oleic acid, which are often deficient in dietary habits, tuna fish oil, flaxseed oil, Yatsume coconut oil and antioxidants. It is a supplement made of a composition that takes into account and its manufacturing method.

Vitamin A is a fat-soluble vitamin that is taken from animal foods such as liver in its own form, or taken in the form of β-carotene in greenish yellow vegetables and then converted into vitamin A in the body. .
The recommended daily intake is 0.3 μg for adults as 1 International Unit (IU).
Male: 2660-3000 IU
Female: 2160-2330 IU.
(2015 Japanese Ministry of Health, Labor and Welfare)

Vitamin A deficiency can be caused by insufficient intake, fat malabsorption, liver disease. Deficiency impairs immunity, weakens mucous membranes, tends to catch a cold, and is susceptible to infection. or,
Causes skin rashes and typical eye effects (eg, xerophthalmia, night blindness). This is particularly a serious problem in developing countries. In addition, when vitamin A is deficient, the horny layer is thickened on dry skin and pore keratinization occurs. In addition, the resistance of the skin is weakened and bacterial infection is likely to occur.

Vitamin A-derived retinal is a component of a photosensitive substance (rhodopsin) that is present in the retina of the eye, and retinoic acid is a signaling substance that binds to receptors in the nucleus in the same way as steroid hormones, and acts in various tissues. Plays a variety of roles.

Vitamin A has an effect on the eyes and mucous membranes, the possibility of reducing cancer risk has been shown by epidemiological studies, and evidence that it is useful for the prevention of human cataract is suggested.
In addition, it is involved in maintaining the health of skin and mucous membranes, promoting growth, spermatogenesis, maintaining healthy immune function, and maintaining iron metabolism by using stored iron.

Omega 3 fatty acids are unsaturated fatty acids that have recently been confirmed to have a wide range of health effects such as prevention of lifestyle-related diseases and brain activation. Today, especially cardiovascular disease, immune disorders, inflammation, kidney disorders,
Advantageous effects have been published and acknowledged in the control of atopy, allergies, diabetes, and cancer.

Omega 3 fatty acids that are considered to be strongly related to these effects are “DHA (docosahexaenoic acid)”, “EPA (eicosapentaenoic acid)”, and “ALA (α-linolenic acid)”.
Speaking of “fat” is a bad image, but fat plays an important role as a source of energy, a source of sex hormones and cell membranes.

60% of a person's brain is occupied by fat. Since 1996, there has been an announcement of research related to the development of cranial nerves, optic nerves and brain development and fatty acids, and in particular, fatty acids are effective in visual acuity and memory, have excellent functions such as improving head and smoothing blood. The omega-3 fatty acid that it has attracted attention.

DHA accumulates in the central nervous system throughout fetal development, childhood, and childhood, and as a result is abundant in the brain and retina. In addition, as society ages and Alzheimer's dementia and depression, which are one type of neurodegenerative disease, DHA is considered suitable for the prevention or treatment of the disease.
DHA is a component of phospholipids in the brain and retina that is indispensable for maintaining the growth and function of the brain and nerve tissue. By ingesting appropriate amounts, the brain is activated and information transmission is smooth. It is considered to be related to visual function, cognitive development, language, or communication ability.

  In addition, EPA and DHA reduce the lipid concentration in the blood to make it smooth and improve the flow, lower cholesterol and neutral fat, and increase HDL (good) cholesterol concentration. Helps prevent arteriosclerosis, cerebral infarction, arrhythmia, myocardial infarction and hypertension, fatty liver, dyslipidemia, age-related macular degeneration, and maintain healthy cell membrane flexibility. Its effects, such as alleviation of allergic symptoms such as atopic dermatitis, have been announced and attracting attention.

If deficiency occurs, there is a risk of developing metabolic disorders, dermatitis, and growth disorders in children.
In recent years, there are reports showing effectiveness against diabetes, breast cancer, colon cancer, liver cancer, and age-related macular degeneration.
The recommended daily intake of EPA + DHA is about 1000 mg.

  The visual substances rhodopsin and photopsin necessary for seeing things in the retina of the eye are composed of protein and vitamin A in rod and cone cells in the retina. In DHA, vitamin A plays an important role when vitamin A enters cells, and helps maintain normal vision. Therefore, the presence of DHA is important in order for vitamin A to function sufficiently to maintain healthy vision, and it is considered that not only vitamin A but also deficiency of DHA affects vision.

  In nature, these “good fatty acids”, omega-3 fatty acids, are present in marine organisms such as several types of fish and algae. In particular, it is abundant in fat fish oil such as salmon, salmon, persimmon, herring, fresh tuna, cod liver oil, and eight-thick salmon oil. For plant, flaxseed oil, egoma oil, shiso oil, sesame oil, walnut oil Many are included.

  Nutritionally essential omega-3 fatty acids are ALA, EPA and DHA. In animals, including humans, EPA and DHA can be produced using ALA as a raw material, but the conversion rate is reported to be about 10 to 15%. ALA helps maintain healthy cell membrane flexibility in the body, similar to EPA and DHA.

Recommended daily intake of omega-3 fatty acids for adults: males: 2.0-2.4 g
Female: 1.6-2.0g
(Japanese dietary intake standards 2015 Ministry of Health, Labor and Welfare).

Oleic acid is a monounsaturated fatty acid found mainly in olive oil and is thought to maintain normal blood cholesterol levels, prevent hypertension and reduce the risk of vascular disease.
Since monounsaturated fatty acids are ingested from foods and are also synthesized in vivo from saturated fatty acids by enzymes, no reference amount has been set.

  Cod liver oil is extracted from the whole cod liver or internal organs. It contains a large amount of vitamin A and is rich in EPA, DHA and oleic acid.

  Tuna fish oil is obtained from the tuna head, contains a large amount of DHA, and also contains EPA and oleic acid.

Flaxseed oil is obtained by squeezing plant flax seeds, rich in polyunsaturated fatty acids, mostly composed of α-linolenic acid (ALA), linoleic acid, oleic acid, higher than other vegetable oils Has a concentration of ALA. 50-62% is included. There are research reports that lowering cholesterol levels by taking 5g daily.
It is effective for chronic constipation, irritable bowel syndrome, enteritis, diverticulitis, and is generally said to be good for allergies, osteoporosis, diabetes, cardiovascular disease and cancer.

Yatsume camellia oil is particularly known to contain a large amount of vitamin A, and also contains a large amount of omega-3 fatty acids such as EPA and DHA, which are useful for adult diseases, and oleic acid.
It is recognized to have the effects of preventing vision loss, strengthening mucous membranes, strengthening immunity, and preventing bacterial and viral infections.

  Since the omega-3 fatty acid in the composition according to the present patent is easily oxidized and is harmful when oxidized, mixed tocopherol (trade name: RIKEN E Oil 700) is used as an antioxidant.

Therefore, as a result of repeated research and trials and experiments, the applicants have made tuna liver oil, which is a natural ingredient rich in vitamin A and omega-3 fatty acids, which are often lacking in daily life, as a main ingredient. Acquired knowledge that can provide a product with a composition that includes fish oil, linseed oil, Yatsume koji oil, and antioxidants in an efficient, safe and inexpensive manner, and commercialized a novel supplement that has never existed before. .
In addition, we have developed a new product that can be used as a pet food based on the knowledge that it can be consumed safely by animals other than humans.

The present invention is a composition comprising the above-mentioned composition, ie, cod liver oil rich in naturally-derived vitamin A and omega-3 fatty acids, and adding tuna fish oil, linseed oil, yatsume koji oil and an antioxidant. A supplement as a product was commercialized.
Cod liver oil squeezed from the whole liver or internal organs of cod rich in vitamin A and omega-3 fatty acids, tuna fish oil obtained from tuna head, flaxseed oil obtained by squeezing plant flax seeds, and eight A supplement formed by encapsulating a composition composed of oil squeezed from eyelids and mixed tocopherol as an antioxidant with gelatin and glycerin was formed as a capsule.

Furthermore, it can be supplied as a dietary supplement for pet food that can be safely ingested without harm to non-human animals such as dogs and cats.
In terms of safety, this product is not only for humans, but also residual agricultural chemicals for pets (glyphosate, chlorpyrifosmethyl, pyrimifosmethyl, malathion, metadophos), organochlorine compounds (BHC, DDT, aldrin diltrin, endrin, The raw materials of the composition were carefully selected so as to meet all safety standards of Peptachlor / Peptachlor Epoxide) and Heavy Metals (Cadmium, Lead, Arsenic).

The recommended daily intake of vitamin A for dogs and cats is
For 5Kg dogs, the daily diet is 120g of general dry food. Young dog: 600 IU Adult dog: 600 IU
For a 4Kg cat, the daily diet is 80g of general dry food. Young cat: 720IU Adult cat: 400IU
(From Pet Food Fair Trade Council “General Nutrition Diet Nutrition Standards”)
Since cats lack the enzyme that breaks down the precursor β-carotene into vitamin A, the necessary vitamin A must be included in pet food.

The recommended daily intake of total omega-3 fatty acids for dogs and cats is
For 5Kg dogs, the daily diet is 250mg with a typical dry food of 120g.
For a 4Kg cat, the daily diet is 200mg with a typical dry food of 80g.
(Clinical Nutrition of Small Animals 4th edition, supervised by Shigekazu Motoyoshi, Gakumado Tokyo)

As a manufacturing method of this product, at room temperature, cod liver oil 25% -45% and tuna fish oil 15%-
35%, linseed oil 10% to 25%, and Yatsume koji oil 5% to 15% are mixed and stirred in order, and mixed tocopherol is added as an antioxidant to make it 500 ppm or more, followed by stirring and molding to produce a product.

  The present invention seeks all the raw materials of composition from natural raw materials, and performs the extraction work of cod liver oil and yatsume koji oil, tuna fish oil, linseed oil, antioxidants at the company's own factory in Japan, and further into the container The filling work is done.

  The content of each component in each raw material was measured, or the composition raw material with a component standard as a product was set based on the standard value. From the content of each ingredient in each raw material obtained in this way, the content of each ingredient in the product when mixed can strictly adhere to safety for humans, dogs and cats, and there is no worry of overdose As a result of considering the upper limit intake so that each component is contained in a well-balanced manner and exhibiting their respective effects sufficiently, the blending ratio is 25% to 45% cod liver oil and tuna fish oil It was determined to be 15% to 35%, linseed oil 10% to 25%, and Yatsume camellia oil 5% to 15%. With this formulation, the respective contents were vitamin A 800 IU-1500 IU / ml, DHA 100-135 mg / ml, EPA 50-65 mg / ml, α-linolenic acid 60-90 mg / ml, and oleic acid 120-180 mg / ml.

In the present invention comprising the above-mentioned compositions, vitamin A and omega-3 fatty acids ALA, DHA, and EPA contained in each naturally derived composition, which is a nutrient that tends to be deficient in daily life, can be ingested without side effects, and its action The effect is synergistic and can be applied to various diseases associated with lifestyle and aging.
For example, it can be expected to maintain the function of the eye and improve / prevent diseases, and can be used to control cardiovascular diseases, immune disorders, inflammation, kidney disorders, allergies, diabetes, and cancer, which have been attracting attention recently. Alzheimer-type dementia and depression, one of the neurodegenerative diseases, lower cholesterol and neutral fat, prevent arteriosclerosis, cerebral infarction, myocardial infarction and hypertension and fatty liver, dyslipidemia, It is expected to have effective effects such as prevention of age-related macular degeneration, allergy symptoms such as hay fever and atopic dermatitis.

  Furthermore, since it can be used as a pet food that can be safely ingested by animals other than human beings, the useful effect of the pet food as a dietary supplement is great.

The composition of the present invention comprises tuna fish oil rich in DHA in naturally occurring cod liver oil rich in vitamin A and omega-3 fatty acid EPA and mostly alpha-linolenic acid (ALA).
And flaxseed oil having a higher ALA concentration (containing 50% to 65%) than other plants (yield: 50% to 65%) and stirring with mixed tocopherol as an antioxidant .

Cod liver oil is extracted from the whole liver or internal organs of walleye pollock caught in the Sea of Okhotsk and the Pacific Ocean.
Examining the difference in nutritional value and yield, we obtain oil with higher nutritional value and superior quality.

The Yatsume Pass grows while migrating around the ocean and goes up the river during the spawning season. Yatsume Koji Oil is obtained by capturing Yatsume Koji, which has risen up the river for egg laying, and thawing and squeezing raw or frozen ones.
Since it has become rare in recent years, we have obtained various information from inside and outside the country, carefully selected high-quality Yatsume-don and obtained its oil.

The method for producing cod liver oil and yatsume koji oil is as follows.
Raw material thawing ⇒ Raw material crushing ⇒ Hydro-pressure separation ⇒ Heavy and light liquid separation by high-speed centrifugation ⇒
Alkaline refining ⇒ Degumming treatment ⇒ Wintering ⇒ Product filling ⇒ Nitrogen filling ⇒ Product

In each process, trial and error are repeated with the goal of keeping the yield of oil high, keeping the content of active ingredient (vitamin A) high, and keeping the quality as oil (oxidation, peroxide value) in good condition, The current manufacturing method has been reached.

(Other raw materials used)
Tuna fish oil: DHA-35 (Summit Oil Co., Ltd.)
Linseed oil: Linseed oil (Summit Oil Co., Ltd.)
Mixed tocopherol: RIKEN OIL 700 (RIKEN VITAMIN Co., Ltd.)
As the antioxidant, mixed tocopherol having strong antioxidant power is used.

The amount of mixed tocopherol added is suitably 150 to 300 ppm, and it is effective to increase the amount added for the purpose of long-term storage. In this product, confirm the change in quality (peroxide value) under each storage condition (open, unopened, normal temperature, refrigerated), and add 500 tons of mixed tocopherol (total tocopherol content in the product is 595 mg / g or more) Therefore, it was set as 0.1% as a product.

In order to prevent oxidation, the liquid in which each composition is mixed and stirred is filled in a container that is immediately light-shielded and non-gas permeable, further filled with nitrogen, and then stoppered to produce a product.

Capsules encapsulated in gelatin and glycerin with a mixture of cod liver oil, tuna fish oil, flaxseed oil, linseed oil, mixed tocopherol as an antioxidant and agitated and mixed with vitamin A and omega-3 fatty acids As a product. 300mg capsules Adult: 4-6 capsules per day

Furthermore, it was dripped on the food for animals other than dogs or cats, and animals, and the knowledge of the use as a dietary supplement was obtained, and the use as a dietary supplement of pet food was also enabled.

Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to the following examples.

(Example 1)
The present invention is a composition comprising the above-mentioned composition, ie, cod liver oil rich in naturally-derived vitamin A and omega-3 fatty acids, and adding tuna fish oil, linseed oil, yatsume koji oil and an antioxidant. A supplement as a product was commercialized.
Cod liver oil squeezed from the whole liver or internal organs of cod rich in vitamin A and omega-3 fatty acids, tuna fish oil obtained from tuna head, flaxseed oil obtained by squeezing plant flax seeds, and eight A supplement formed by encapsulating a composition composed of oil squeezed from eyelids and mixed tocopherol as an antioxidant with gelatin and glycerin was formed as a capsule.

(Example 2)
Furthermore, it can be supplied as a dietary supplement for pet food that can be safely ingested without harm to non-human animals such as dogs and cats.
In other words, this product is not only safe for humans, but also as residual agricultural chemicals for pets (glyphosate, chlorpyrifosmethyl, pyrimifosmethyl, malathion, metadophos), and as an organochlorine compound (BHC, DDT, aldrin dilt) Phosphorus, endrin, peptachlor / peptachlor epoxide), and heavy metals (cadmium, lead, arsenic) and carefully selected ingredients to provide as a liquid supplement (dietary supplement) for dogs and cats It was possible.

Daily standard amount of pet food, which is a staple food (1 ml / day with a body weight of 5 kg or less,
5-10 kg, 2 ml a day, 10 kg or more, 2-4 ml a day). For homemade foods, give an appropriate amount according to the recipe. For dogs and cats,
It has a high palatability and can be ingested deliciously.
In particular, vitamin A contained in pet food is easily degraded and reduced during processing and storage. Therefore, adding this product to pet food is extremely useful.

Claims (4)

A supplement consisting of a composition containing cod liver oil rich in vitamin A, omega-3 fatty acid and oleic acid, and tuna fish oil, linseed oil, yatsume koji oil and antioxidants. Gelatin and glycerin are supplements made of a composition that is made from cod liver oil rich in vitamin A, omega-3 fatty acid, and oleic acid, with tuna fish oil, linseed oil, yatsume koji oil and antioxidants added. The supplement according to claim 1, which is encapsulated and formed as a capsule. The pet supplement according to any one of claims 1 and 2, wherein the supplement is for dogs, cats and animals other than humans. Cod liver oil 25% to 45%, tuna fish oil 15% to 35% and flaxseed oil 10% at room temperature
A method for producing a supplement comprising 25% and 8% to 15% yatsume koji oil mixed in order and stirred by adding 0.1% of mixed tocopherol as an antioxidant.