CN1067243C - Xinmailong extract and Xinmailong medical preparation for curing angiocardiopath - Google Patents
Xinmailong extract and Xinmailong medical preparation for curing angiocardiopath Download PDFInfo
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- CN1067243C CN1067243C CN94118839A CN94118839A CN1067243C CN 1067243 C CN1067243 C CN 1067243C CN 94118839 A CN94118839 A CN 94118839A CN 94118839 A CN94118839 A CN 94118839A CN 1067243 C CN1067243 C CN 1067243C
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- xinmailong
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a medicinal material and a medicinal preparation with insect extract as a main component, particularly to medicinal medicine extracted from cockroaches for treating cardiovascular diseases. The Xinmailong extract of the present invention is composed of 10% to 50% of compound nucleus glycoside and 40% to 80% of sticking propylhomoserin. 3% to 30% of Xinmailong extract and medicinal assistant material as the rest are used by the Xinmainlong medicinal preparation of the present invention to prepare a medicinal preparation acceptable in medicine. The medicine of the present invention is mainly used for treating cardiovascular diseases. As an acute toxicity test and a long-term toxicity test prove, the medicine has the advantages of nonpoisonous side effect, heart stimulation, pressure boosting, microcirculation improvement, breathing excitation, coronary blood flow increasing, renal blood flow increasing and urination promoting act.
Description
The present invention relates to a kind of is the medicinal raw material and the pharmaceutical formulation of main component by the insecticide extract, especially from Blatta seu periplaneta, extract to the medicable medicine of cardiovascular diseases.
Chinese patent CN87100537 discloses " a kind of preparation method for the treatment of the medicine of traumatic surface ", its step is that (a) is dry with the cockroach insect soma, coarse pulverization, (b) with the above-mentioned polypide of alcohol solution dipping, extract effective medicinal components wherein, then filtering residue is separated with filtrate, and filtering residue extracted repeatedly, (c) filtrate is carried out concentrating under reduced pressure, reclaim ethanol, obtain thick thing, (d) in thick thing, add distilled water, filter then, discard upper strata grease and lower floor's residue, concentrating under reduced pressure filtrate obtains water solublity extractum, (e) by above-mentioned water solublity extractum (being converted into dry weight) 0.4-1% (percentage by weight), antiseptic 2-5% (percentage by weight), dispersant 10-12% (percentage by weight), the ratio of distilled water surplus is mixed with medicament.Drug prepared is a kind of external used medicine for the treatment of traumatic surface.
Purpose of the present invention aim to provide a kind of by above-mentioned Blatta seu periplaneta extract make and purified processing after extractum be the pharmaceutical formulation of the treatment cardiovascular disease of effective ingredient.
The pharmaceutical formulation of treatment cardiovascular disease of the present invention is made pharmaceutically acceptable pharmaceutical preparation by the Blatta seu periplaneta extractum of 3-30% and the pharmaceutic adjuvant of surplus.
Blatta seu periplaneta extractum of the present invention is made up of compound nucleoside 10-50% and sticking propylhomoserin 40-80%, also can contain free amino acid 0.5-3%, neutral sugar 2-5%, sticking sugared 5-15%.
Sticking propylhomoserin of the present invention is the mixture that the sugar derivatives in the Blatta seu periplaneta polypide combines the resulting chemical compound of different aminoacids, its mean molecule quantity is 258, slant acidity, under long wave ultraviolet light, do not see blue-fluorescence, the TLC collection of illustrative plates is a band continuously, do not see the point-like separation, 110 ℃ of strong acid hydrolyzate are aminoacid and derivant.
Compound nucleoside itself in the extractum of the present invention has heart tonifying and boosting, but this effect is very weak, this is well known, but in the present invention, owing to also contain sticking propylhomoserin, sticking propylhomoserin itself is heart tonifying and boosting not, but in the presence of sticking propylhomoserin, the heart tonifying of compound nucleoside and boosting have obtained strengthening significantly, make it have therapeutical effect well to cardiovascular disease.This effect is referred to as " permission effect " on the physiology, be commonly referred to as " sensitization " or " booster action " on the pharmacology.
Medicine of the present invention is mainly used in the treatment of cardiovascular disease, prove through acute toxicity test and long term toxicity test, this medicine has no side effect, and have heart tonifying, boost, microcirculation improvement, excitedly breathe, increase coronary flow, renal blood flow and diuresis.This product directly acts on cardiac muscle, can strengthen its contractile function, and during intravenous injection, its heart tonifying efficiency ratio poison K is about 30%, and quiet notes back 3-5 second is a produce effects, acts on and holding time more than one hour.When strengthening myocardial contraction, cardiac output also increases, and Peripheral resistance, myocardial oxygen consumption and heart rate are not had obvious influence.This product can make animal than large artery trunks generation blockage effect in various degree, and the intensity of its vasoconstrictive effect is about 1/3 of norepinephrine.So have moderate boosting, the characteristics of its boosting are lasting for relaxing, and to the hypotension animal model, its boosting can be kept more than 1 hour.Studied of the variation of this medicine with " C; labelling biological microsphere tracer method " to each organic blood flow volume of hemorrhagic shock domestic cat, confirm that this medicine can significantly increase the blood flow of vitals such as the hemorrhagic shock animal heart, brain, lung, kidney, significant to the clinical rescue shock patient.In the microcirculatory research of rat mesentery, further confirmed the effect of its microcirculation improvement.To flow velocity, fluidised form, external caliber, blood capillary quantity etc. all have improvement simultaneously.During heavy dose of quiet the injecting of this pharmaceutical preparation, the respiratory frequency when the rabbit morphine is suppressed increases more than three times.Because this medicine can strengthen myocardial contraction, increase coronary flow, renal blood flow and diuresis, and heart failure is had obvious therapeutic action.
Embodiment:
After getting the dried polypide 90-95% of Blatta seu periplaneta ethanol extraction, remove degrease, get water solublity extractum, the effective ingredient activated carbon adsorption gets extractum, through removing impurity such as pigment and allergic component, makes purification extractum again.
Get above-mentioned extractum 5g, Polyethylene Glycol-40020ml, NaCl0.9g adds the injection water to 100ml, makes the injection of treatment cardiovascular disease.
When producing injection, the content of extractum generally can be the 3-10% of total amount.
Claims (1)
- A kind of pharmaceutical formulation for the treatment of cardiovascular disease, it is characterized in that making pharmaceutically acceptable pharmaceutical preparation by the pharmaceutic adjuvant of 3-30% Blatta seu periplaneta extractum and surplus, described Blatta seu periplaneta extractum is that the Blatta seu periplaneta polypide is behind the 90-95% ethanol extraction, remove degrease, the effective ingredient activated carbon adsorption, through removing the extractum of pigment and allergic component, described pharmaceutic adjuvant is Polyethylene Glycol, sodium chloride and water for injection again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94118839A CN1067243C (en) | 1994-12-09 | 1994-12-09 | Xinmailong extract and Xinmailong medical preparation for curing angiocardiopath |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94118839A CN1067243C (en) | 1994-12-09 | 1994-12-09 | Xinmailong extract and Xinmailong medical preparation for curing angiocardiopath |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1124141A CN1124141A (en) | 1996-06-12 |
| CN1067243C true CN1067243C (en) | 2001-06-20 |
Family
ID=5039043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94118839A Expired - Lifetime CN1067243C (en) | 1994-12-09 | 1994-12-09 | Xinmailong extract and Xinmailong medical preparation for curing angiocardiopath |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1067243C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156875B (en) * | 2007-04-25 | 2011-10-05 | 深圳信立泰药业股份有限公司 | Cockroach extractive for treating cardiovascular disease, preparation method and its composition |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100361649C (en) * | 2003-05-22 | 2008-01-16 | 福州金象中药制药有限公司 | Prepn process of alive adult roach extract |
| WO2006056097A1 (en) * | 2004-11-23 | 2006-06-01 | Weichang You | A pharmaceutical composition for treating senile dementia |
| CN102319268B (en) * | 2011-08-12 | 2013-01-23 | 云南省腾冲制药厂 | Preparation method of injection used for treating chronic congestive cardiac failure |
| CN109125355B (en) * | 2018-08-03 | 2022-07-08 | 昆明医科大学第一附属医院 | Psychopharmacology application of Xinmailong for anti-platelet and anti-thrombus |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87100537A (en) * | 1987-01-27 | 1988-08-31 | 大理医学院 | A kind of preparation method for the treatment of the traumatic surface medicine |
-
1994
- 1994-12-09 CN CN94118839A patent/CN1067243C/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87100537A (en) * | 1987-01-27 | 1988-08-31 | 大理医学院 | A kind of preparation method for the treatment of the traumatic surface medicine |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156875B (en) * | 2007-04-25 | 2011-10-05 | 深圳信立泰药业股份有限公司 | Cockroach extractive for treating cardiovascular disease, preparation method and its composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1124141A (en) | 1996-06-12 |
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Address after: Shimonoseki South Road, Shimonoseki City, Yunnan, Dali Patentee after: Dali University Address before: Shimonoseki South Road, Shimonoseki City, Yunnan, Dali Patentee before: Dali Medical College |
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Effective date of registration: 20081107 Address after: Guanghua Road Tengyue town of Tengchong County Yunnan province No. 61 West Street Patentee after: YUNNAN TENGCHONG PHARMACEUTICAL FACTORY Address before: Shimonoseki South Road, Shimonoseki City, Yunnan, Dali Patentee before: Dali University |
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Owner name: YUNNAN TENGYAO PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: YUNNAN TENGCHONG PHARMACEUTICAL FACTORY |
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Address after: 679100 Tengchong County of Yunnan Province town of Tengyue Tiancheng Park District No. 139 Wing Fung community Patentee after: YUNNAN TENG YAO PHARMACEUTICAL CO.,LTD. Address before: Guanghua Road 679100 Tengchong County, Yunnan Province town of Tengyue Street No. 61 Patentee before: Yunnan Tengchong Pharmaceutical Factory |
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Expiration termination date: 20141209 Granted publication date: 20010620 |