CN106707517B - 一种vr眼镜 - Google Patents
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Abstract
本发明涉及一种VR眼镜，包含用于佩带的眼罩壳；所述的眼罩壳为人体面部曲面结构，表面涂覆有抗微生物多肽，能够用于杀死眼部和脸部常见致病菌。抗微生物肽喷雾于VR眼镜后几分钟内即形成一层薄膜，对眼镜不仅起到直接的保护作用，迅速杀死细菌，防止眼镜细菌的感染，而且该膜对皮肤具有良好的亲和性和透气性；该喷雾成膜剂含有保湿剂成分，可吸收水分，起到较好的保湿作用。另外抗微生物肽抑菌活性高，成本低廉，能够大规模的推广使用，具有极大的应用前景和重要的社会价值价值。
Description
技术领域
本发明涉及视觉器械领域，特别涉及一种VR眼镜。
背景技术
VR眼镜即VR头显，虚拟现实头戴式显示设备。VR头显是利用头戴式显示设备将人的对外界的视觉、听觉封闭，引导用户产生一种身在虚拟环境中的感觉。其显示原理是左右眼屏幕分别显示左右眼的图像，人眼获取这种带有差异的信息后在脑海中产生立体感。
近几年随着智能佩带设备的快速发展，VR虚拟现实技术获得了重大的技术突破，各种VR虚拟现实设备快速的推向了市场，获得了巨大的成功，但是随之而来的设备安全卫生问题成为困扰厂家的一大技术难题。由于VR眼镜一般在影院或者使用频繁的场所由不固定的不同人群每天来佩戴，导致VR眼镜上面残留了大量的致病菌，特别是一些眼病或者脸部皮肤病患者使用后，可能会给后续的使用者带来交叉感染的风险，因此设备卫生安全也成为了VR虚拟现实技术发展的一大瓶颈。
抗微生物肽(AMP)是相对新近发现的一组具有新作用模式的抗微生物剂。AMP广泛分布于动物、植物和微生物并且属于最古老的宿主防御因子。绝大多数的该种肽在天然情况下是阳离子的和两亲性的；该特性允许与带负电荷的细菌或真菌的膜相互作用。该种肽大小范围从6-7个氨基酸至60个氨基酸。迄今为止已经分离出500种以上不同的AMP。基于结构或M酸组成可以将它们分为几类。最简单的结构是小的螺旋肽。其它AMP折叠形成片层结构，而另外的再次形成刚性的二硫桥连接的三级结构。
AMP通常是杀微生物的并且作用极其快。通常，微生物在几分钟之内被杀死。它们通过干扰靶生物的膜功能而起作用。已经显示存在几种不同的作用机制，但是对于大多数AMP，总体结果是细胞膜破裂和细胞裂解。
但是目前存在的AMP也有技术上的障碍，即并不能够特异性的针对脸部和皮肤病菌，这在现有技术中并没有相应的研究，因此，开发一种效果较好的AMP，具有极强的应用前景。
发明内容
本发明的其中一个技术方案提供一种具有杀灭眼病病菌和脸部病菌的抗微生物肽，所述肽的序列为：
AMP-1：MCCPTTHHTNHVMAGWQIQRWMHT(SEQ ID NO：1)；
AMP-2：PGCYYIDHPPPFLDPFSSLTFCQEVNV(SEQ ID NO：2)；
AMP-3：NHRSPTWPHYDLASQLPCDRCQWRENP(SEQ ID NO：3)；
AMP-4：AVSAIPWNAAWATPMHVTYKPRGHPE(SEQ ID NO：4)；
AMP-5：IHEWHIWMGIPSWVPWQWPQHHHELVPM(SEQ ID NO：5)；
AMP-6：IHGRRFPMDHRIDHRYVSKTLISAPL(SEQ ID NO：6)；
AMP-7：ASRETPDSPCRSKKIMTSMRYRAWP(SEQ ID NO：7)；
AMP-8：WALMHKSQWSWFIVPHCIHHLDCASIP(SEQ ID NO：8)。
其中本发明所述的抗微生物肽针对的病原菌为铜绿假单孢菌、表皮葡萄球菌、金黄色葡萄球菌、淋球菌、溶血性链球菌和痤疮杆菌。
本发明另外提供一种VR眼镜设备，包含用于佩带的眼罩壳；所述的眼罩壳为人体面部曲面结构，其特征在于：表面涂覆有抗微生物多肽，所述的抗微生物多肽的序列如SEQID NO：1-8任一所示。
上述抗微生物肽可通过人工合成，即多肽固相合成的方法或基因工程方法获得。
所述涂覆通过喷雾实现，所述喷雾是通过喷雾成膜剂喷覆到VR眼镜表面实现的。
成膜剂的组分为：抗微生物肽100ppm，聚乙烯醇2wt％，聚乙烯吡咯烷酮5wt％，和甘油10wt％，水余量；所述及的抗微生物肽选自SEQ ID NO：1-8任一所示。
本发明的抗微生物肽喷雾成膜剂的制备方法，包括如下步骤：
(1)将水溶性成膜高分子材料溶解于热水中；
(2)加入保湿剂和已配置好的抗菌肽水溶液，混合均匀，灌装于喷雾器内。
本发明的有益效果在于：
本发明提供的抗微生物肽喷雾成膜剂喷于VR眼镜后几分钟内即形成一层薄膜，对眼镜不仅起到直接的保护作用，迅速杀死细菌，防止眼镜细菌的感染，而且该膜对皮肤具有良好的亲和性和透气性；该喷雾成膜剂含有保湿剂成分，可吸收水分，起到较好的保湿作用。另外抗微生物肽抑菌活性高，成本低廉，能够大规模的推广使用，具有极大的应用前景和重要的社会价值价值。
具体实施方式
实施例抗微生物肽的制备及活性验证
根据申请人前期筛选得到的抗微生物肽SEQ ID NO：1-8分别委托上海生工利用固相合成法合成，并将C末端酰胺化，合成后经HPLC纯化，纯度达到99.0％。
抗菌性检测：
将多肽用蒸馏水溶解成浓度为100ppm，采用琼脂糖扩散法进行抗菌活性检测。琼脂糖扩散法中使用的菌株为铜绿假单孢菌、表皮葡萄球菌、金黄色葡萄球菌、淋球菌、溶血性链球菌和痤疮杆菌的组合。菌株复苏后，接种于培养基后活化培养菌株得到培养液之后分别取50微升菌液涂布于固体培养基。静置带菌液吸收后，分别加入100ppm的多肽溶液10微升。37℃培养1小时后，观察抑菌圈的有无和大小。结果见表1。
表1多肽抗菌活性分析结果
从表1可以看出，AMP-1～8均具有较好的抗菌特性。
抗微生物肽的溶血性检测
利用羊血红细胞检测抗微生物肽的溶血作用；将浓度为100ppm的抗微生物肽AMP-1～8 10微升滴加在血平皿表面，以蒸馏水做对照。置于37℃24小时以上，然后观察溶血圈的有无。结果所有受测抗微生物肽均没有出现溶血圈。初步结果表明，所述抗微生物肽不存在溶血毒性。
多肽修饰的VR眼镜的制备
将聚乙烯醇2wt％，聚乙烯吡咯烷酮5wt％先溶解，而后将抗微生物肽100ppm，和甘油10wt％混匀，水余量，所述及的抗微生物肽选自SEQ ID NO：1-8任一所示。混合均匀，灌装于喷雾器内。
取VR眼镜设备，将眼罩壳面喷涂覆上述制备的喷雾剂，即可在表面形成肽膜。以没有涂覆肽膜的VR眼镜为对照，分别将眼镜置于体验厅，每日平均使用量在200人左右，分别刮取1*1cm表面积进行菌落分析，通过分析发现，表面涂覆肽膜的VR眼镜表面基本无致病菌，而未涂覆菌膜的眼镜表面存在着众多的致病菌，分别为铜绿假单孢菌、金黄色葡萄球菌、淋球菌、溶血性链球菌和痤疮杆菌，菌落个数达到了2.0*103左右。从以上结果可以看出，本发明的VR眼镜具有较好的杀菌效果。
以上为本发明的具体实施例，其作用在于对本发明的内容做进一步详细的说明，使阅读者更易理解，但不构成对本发明所要求的保护。
序列表
〈110〉李忠波
〈120〉一种VR眼镜
〈210〉1
〈211〉24
〈212〉PRT
〈400〉AMP-1
MCCPTTHHTNHVMAGWQIQRWMHT；
〈210〉2
〈211〉27
〈212〉PRT
〈400〉AMP-2
PGCYYIDHPPPFLDPFSSLTFCQEVNV；
〈210〉3
〈211〉27
〈212〉PRT
〈400〉AMP-3
NHRSPTWPHYDLASQLPCDRCQWRENP；
〈210〉4
〈211〉26
〈212〉PRT
〈400〉AMP-4
AVSAIPWNAAWATPMHVTYKPRGHPE；
〈210〉5
〈211〉28
〈212〉PRT
〈400〉AMP-5
IHEWHIWMGIPSWVPWQWPQHHHELVPM；
〈210〉6
〈211〉26
〈212〉PRT
〈400〉AMP-6
IHGRRFPMDHRIDHRYVSKTLISAPL；
〈210〉7
〈211〉25
〈212〉PRT
〈400〉AMP-7
ASRETPDSPCRSKKIMTSMRYRAWP；
〈210〉8
〈211〉27
〈212〉PRT
〈400〉AMP-8
WALMHKSQWSWFIVPHCIHHLDCASIP
Claims (3)
1.一种VR眼镜，其特征在于：包含用于佩带的眼罩壳；所述的眼罩壳为人体面部曲面结构，所述的眼罩壳表面涂覆有SEQ ID NO：1所示抗微生物多肽。
2.SEQ ID NO：1所示抗微生物多肽在制备抗菌VR眼镜中的应用。
3.一种多肽，其序列为SEQ ID NO：1所示。
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710074834.0A CN106707517B (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174398.5A CN109212758A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174379.2A CN109164580A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174920.XA CN109143586A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174372.0A CN109116568A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174918.2A CN109239923A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174412.1A CN109212759A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
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| CN109343655B (zh) * | 2018-09-04 | 2021-09-10 | 杭州翔毅科技有限公司 | 一种提高可穿戴式智能设备舒适性的方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006065977A2 (en) * | 2004-12-15 | 2006-06-22 | The Regents Of The University Of Colorado | Antimicrobial peptides and methods of use |
| CN105622741A (zh) * | 2014-10-28 | 2016-06-01 | 无锡灵锡医疗器械科技有限公司 | 隐形眼镜表面抗菌涂层用组合物的制备方法及使用方法 |
| CN205620613U (zh) * | 2016-05-13 | 2016-10-05 | 王金龙 | 一种佩戴舒适的vr眼镜 |
| CN205720895U (zh) * | 2016-06-15 | 2016-11-23 | 深圳市鼎烨源信息科技有限公司 | 一种vr眼镜设备 |
-
2017
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- 2017-02-12 CN CN201811174398.5A patent/CN109212758A/zh not_active Withdrawn
- 2017-02-12 CN CN201811174412.1A patent/CN109212759A/zh not_active Withdrawn
- 2017-02-12 CN CN201811174379.2A patent/CN109164580A/zh not_active Withdrawn
- 2017-02-12 CN CN201710074834.0A patent/CN106707517B/zh active Active
- 2017-02-12 CN CN201811174920.XA patent/CN109143586A/zh not_active Withdrawn
- 2017-02-12 CN CN201811174918.2A patent/CN109239923A/zh not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006065977A2 (en) * | 2004-12-15 | 2006-06-22 | The Regents Of The University Of Colorado | Antimicrobial peptides and methods of use |
| CN105622741A (zh) * | 2014-10-28 | 2016-06-01 | 无锡灵锡医疗器械科技有限公司 | 隐形眼镜表面抗菌涂层用组合物的制备方法及使用方法 |
| CN205620613U (zh) * | 2016-05-13 | 2016-10-05 | 王金龙 | 一种佩戴舒适的vr眼镜 |
| CN205720895U (zh) * | 2016-06-15 | 2016-11-23 | 深圳市鼎烨源信息科技有限公司 | 一种vr眼镜设备 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109143586A (zh) | 2019-01-04 |
| CN106707517A (zh) | 2017-05-24 |
| CN109116568A (zh) | 2019-01-01 |
| CN109212759A (zh) | 2019-01-15 |
| CN109164580A (zh) | 2019-01-08 |
| CN109212758A (zh) | 2019-01-15 |
| CN109164581A (zh) | 2019-01-08 |
| CN109239923A (zh) | 2019-01-18 |
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