CN109212759A - 一种vr眼镜 - Google Patents
一种vr眼镜 Download PDFInfo
- Publication number
- CN109212759A CN109212759A CN201811174412.1A CN201811174412A CN109212759A CN 109212759 A CN109212759 A CN 109212759A CN 201811174412 A CN201811174412 A CN 201811174412A CN 109212759 A CN109212759 A CN 109212759A
- Authority
- CN
- China
- Prior art keywords
- glasses
- antimicrobial peptide
- pro
- antimicrobial
- bacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000011521 glass Substances 0.000 title claims abstract description 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 11
- 229920001184 polypeptide Polymers 0.000 claims abstract description 9
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims description 5
- 230000000844 anti-bacterial effect Effects 0.000 claims description 4
- 108700042778 Antimicrobial Peptides Proteins 0.000 abstract description 27
- 102000044503 Antimicrobial Peptides Human genes 0.000 abstract description 27
- 239000003910 polypeptide antibiotic agent Substances 0.000 abstract description 27
- 239000010408 film Substances 0.000 abstract description 12
- 241000894006 Bacteria Species 0.000 abstract description 11
- 239000007921 spray Substances 0.000 abstract description 7
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 239000004909 Moisturizer Substances 0.000 abstract description 3
- 230000001333 moisturizer Effects 0.000 abstract description 3
- 230000003385 bacteriostatic effect Effects 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 244000052769 pathogen Species 0.000 abstract description 2
- 230000001717 pathogenic effect Effects 0.000 abstract description 2
- 230000035699 permeability Effects 0.000 abstract description 2
- 230000001681 protective effect Effects 0.000 abstract description 2
- 239000010409 thin film Substances 0.000 abstract description 2
- 241000269335 Ambystoma laterale x Ambystoma jeffersonianum Species 0.000 description 8
- 239000000243 solution Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000002949 hemolytic effect Effects 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 3
- 241000588653 Neisseria Species 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 241000194017 Streptococcus Species 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000008588 hemolysis Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 241000191940 Staphylococcus Species 0.000 description 2
- 101000802478 Sylvirana guentheri Brevinin-2GHa Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 208000030533 eye disease Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- WFJIVOKAWHGMBH-UHFFFAOYSA-N 4-hexylbenzene-1,3-diol Chemical compound CCCCCCC1=CC=C(O)C=C1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 description 1
- GGZZISOUXJHYOY-UHFFFAOYSA-N 8-amino-4-hydroxynaphthalene-2-sulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=C2C(N)=CC=CC2=C1O GGZZISOUXJHYOY-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- OKIKVSXTXVVFDV-MMWGEVLESA-N Ala-Ile-Pro Chemical compound CC[C@H](C)[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](C)N OKIKVSXTXVVFDV-MMWGEVLESA-N 0.000 description 1
- VJVQKGYHIZPSNS-FXQIFTODSA-N Ala-Ser-Arg Chemical compound C[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCCN=C(N)N VJVQKGYHIZPSNS-FXQIFTODSA-N 0.000 description 1
- YYAVDNKUWLAFCV-ACZMJKKPSA-N Ala-Ser-Gln Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O YYAVDNKUWLAFCV-ACZMJKKPSA-N 0.000 description 1
- ZVWXMTTZJKBJCI-BHDSKKPTSA-N Ala-Trp-Ala Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](N)C)C(=O)N[C@@H](C)C(O)=O)=CNC2=C1 ZVWXMTTZJKBJCI-BHDSKKPTSA-N 0.000 description 1
- REWSWYIDQIELBE-FXQIFTODSA-N Ala-Val-Ser Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(O)=O REWSWYIDQIELBE-FXQIFTODSA-N 0.000 description 1
- QIWYWCYNUMJBTC-CIUDSAMLSA-N Arg-Cys-Gln Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(O)=O QIWYWCYNUMJBTC-CIUDSAMLSA-N 0.000 description 1
- YKBHOXLMMPZPHQ-GMOBBJLQSA-N Arg-Ile-Asp Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(O)=O YKBHOXLMMPZPHQ-GMOBBJLQSA-N 0.000 description 1
- LXMKTIZAGIBQRX-HRCADAONSA-N Arg-Phe-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCN=C(N)N)N)C(=O)O LXMKTIZAGIBQRX-HRCADAONSA-N 0.000 description 1
- BXLDDWZOTGGNOJ-SZMVWBNQSA-N Arg-Trp-Met Chemical compound CSCC[C@@H](C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CCCN=C(N)N)N BXLDDWZOTGGNOJ-SZMVWBNQSA-N 0.000 description 1
- ZKDGORKGHPCZOV-DCAQKATOSA-N Asn-His-Arg Chemical compound C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC(=O)N)N ZKDGORKGHPCZOV-DCAQKATOSA-N 0.000 description 1
- UYXXMIZGHYKYAT-NHCYSSNCSA-N Asn-His-Val Chemical compound CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CC(=O)N)N UYXXMIZGHYKYAT-NHCYSSNCSA-N 0.000 description 1
- UBPMOJLRVMGTOQ-GARJFASQSA-N Asp-His-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CC(=O)O)N)C(=O)O UBPMOJLRVMGTOQ-GARJFASQSA-N 0.000 description 1
- HRVQDZOWMLFAOD-BIIVOSGPSA-N Asp-Ser-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)N)C(=O)O HRVQDZOWMLFAOD-BIIVOSGPSA-N 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- PRXCTTWKGJAPMT-ZLUOBGJFSA-N Cys-Ala-Ser Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(O)=O PRXCTTWKGJAPMT-ZLUOBGJFSA-N 0.000 description 1
- GEEXORWTBTUOHC-FXQIFTODSA-N Cys-Arg-Ser Chemical compound C(C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CS)N)CN=C(N)N GEEXORWTBTUOHC-FXQIFTODSA-N 0.000 description 1
- PRHGYQOSEHLDRW-VGDYDELISA-N Cys-Ile-His Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@H](CS)N PRHGYQOSEHLDRW-VGDYDELISA-N 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- XJKAKYXMFHUIHT-AUTRQRHGSA-N Gln-Glu-Val Chemical compound CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)N XJKAKYXMFHUIHT-AUTRQRHGSA-N 0.000 description 1
- GFLNKSQHOBOMNM-AVGNSLFASA-N Gln-His-His Chemical compound C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CC2=CN=CN2)C(=O)O)NC(=O)[C@H](CCC(=O)N)N GFLNKSQHOBOMNM-AVGNSLFASA-N 0.000 description 1
- GQZDDFRXSDGUNG-YVNDNENWSA-N Gln-Ile-Gln Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(O)=O GQZDDFRXSDGUNG-YVNDNENWSA-N 0.000 description 1
- YJCZUTXLPXBNIO-BHYGNILZSA-N Gln-Trp-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CCC(=O)N)N)C(=O)O YJCZUTXLPXBNIO-BHYGNILZSA-N 0.000 description 1
- UMZHHILWZBFPGL-LOKLDPHHSA-N Glu-Thr-Pro Chemical compound C[C@H]([C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CCC(=O)O)N)O UMZHHILWZBFPGL-LOKLDPHHSA-N 0.000 description 1
- YFGONBOFGGWKKY-VHSXEESVSA-N Gly-His-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)CN)C(=O)O YFGONBOFGGWKKY-VHSXEESVSA-N 0.000 description 1
- MWWOPNQSBXEUHO-ULQDDVLXSA-N His-Arg-Tyr Chemical compound C([C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)C1=CN=CN1 MWWOPNQSBXEUHO-ULQDDVLXSA-N 0.000 description 1
- FIMNVXRZGUAGBI-AVGNSLFASA-N His-Glu-Leu Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O FIMNVXRZGUAGBI-AVGNSLFASA-N 0.000 description 1
- CNHSMSFYVARZLI-YJRXYDGGSA-N His-His-Thr Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O CNHSMSFYVARZLI-YJRXYDGGSA-N 0.000 description 1
- VFBZWZXKCVBTJR-SRVKXCTJSA-N His-Leu-Asp Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)NC(=O)[C@H](CC1=CN=CN1)N VFBZWZXKCVBTJR-SRVKXCTJSA-N 0.000 description 1
- YKLOMBNBQUTJDT-HVTMNAMFSA-N Ile-His-Glu Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCC(=O)O)C(=O)O)N YKLOMBNBQUTJDT-HVTMNAMFSA-N 0.000 description 1
- UASTVUQJMLZWGG-PEXQALLHSA-N Ile-His-Gly Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)NCC(=O)O)N UASTVUQJMLZWGG-PEXQALLHSA-N 0.000 description 1
- CAHCWMVNBZJVAW-NAKRPEOUSA-N Ile-Pro-Ser Chemical compound CC[C@H](C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)O)N CAHCWMVNBZJVAW-NAKRPEOUSA-N 0.000 description 1
- RQZFWBLDTBDEOF-RNJOBUHISA-N Ile-Val-Pro Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)O)N RQZFWBLDTBDEOF-RNJOBUHISA-N 0.000 description 1
- 241000446313 Lamella Species 0.000 description 1
- MMEDVBWCMGRKKC-GARJFASQSA-N Leu-Asp-Pro Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@@H]1C(=O)O)N MMEDVBWCMGRKKC-GARJFASQSA-N 0.000 description 1
- GAHJXEMYXKLZRQ-AJNGGQMLSA-N Lys-Lys-Ile Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O GAHJXEMYXKLZRQ-AJNGGQMLSA-N 0.000 description 1
- AFLBTVGQCQLOFJ-AVGNSLFASA-N Lys-Pro-Arg Chemical compound NCCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O AFLBTVGQCQLOFJ-AVGNSLFASA-N 0.000 description 1
- GAELMDJMQDUDLJ-BQBZGAKWSA-N Met-Ala-Gly Chemical compound CSCC[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O GAELMDJMQDUDLJ-BQBZGAKWSA-N 0.000 description 1
- DRINJBAHUGXNFC-DCAQKATOSA-N Met-Asp-His Chemical compound [H]N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O DRINJBAHUGXNFC-DCAQKATOSA-N 0.000 description 1
- TWTNGJMBFRTKEX-FXQIFTODSA-N Met-Cys-Cys Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(O)=O TWTNGJMBFRTKEX-FXQIFTODSA-N 0.000 description 1
- DYTWOWJWJCBFLE-IHRRRGAJSA-N Met-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCSC)CC1=CNC=N1 DYTWOWJWJCBFLE-IHRRRGAJSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- AJHCSUXXECOXOY-UHFFFAOYSA-N N-glycyl-L-tryptophan Natural products C1=CC=C2C(CC(NC(=O)CN)C(O)=O)=CNC2=C1 AJHCSUXXECOXOY-UHFFFAOYSA-N 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- QXNSKJLSLYCTMT-FXQIFTODSA-N Pro-Cys-Asp Chemical compound C1C[C@H](NC1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)O QXNSKJLSLYCTMT-FXQIFTODSA-N 0.000 description 1
- QNZLIVROMORQFH-BQBZGAKWSA-N Pro-Gly-Cys Chemical compound C1C[C@H](NC1)C(=O)NCC(=O)N[C@@H](CS)C(=O)O QNZLIVROMORQFH-BQBZGAKWSA-N 0.000 description 1
- NAIPAPCKKRCMBL-JYJNAYRXSA-N Pro-Pro-Phe Chemical compound C([C@@H](C(=O)O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1NCCC1)C1=CC=CC=C1 NAIPAPCKKRCMBL-JYJNAYRXSA-N 0.000 description 1
- GZNYIXWOIUFLGO-ZJDVBMNYSA-N Pro-Thr-Thr Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O GZNYIXWOIUFLGO-ZJDVBMNYSA-N 0.000 description 1
- 241000169446 Promethis Species 0.000 description 1
- BRKHVZNDAOMAHX-BIIVOSGPSA-N Ser-Ala-Pro Chemical compound C[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CO)N BRKHVZNDAOMAHX-BIIVOSGPSA-N 0.000 description 1
- DGPGKMKUNGKHPK-QEJZJMRPSA-N Ser-Gln-Trp Chemical compound C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)N DGPGKMKUNGKHPK-QEJZJMRPSA-N 0.000 description 1
- FLONGDPORFIVQW-XGEHTFHBSA-N Ser-Pro-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO FLONGDPORFIVQW-XGEHTFHBSA-N 0.000 description 1
- BMKNXTJLHFIAAH-CIUDSAMLSA-N Ser-Ser-Leu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O BMKNXTJLHFIAAH-CIUDSAMLSA-N 0.000 description 1
- VAIWUNAAPZZGRI-IHPCNDPISA-N Ser-Trp-Phe Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CO)N VAIWUNAAPZZGRI-IHPCNDPISA-N 0.000 description 1
- 101000802471 Sylvirana guentheri Brevinin-2GHb Proteins 0.000 description 1
- 101000802470 Sylvirana guentheri Brevinin-2GHc Proteins 0.000 description 1
- 101000906575 Sylvirana guentheri Guentherin Proteins 0.000 description 1
- 101000851879 Sylvirana guentheri Temporin-GH Proteins 0.000 description 1
- FLPZMPOZGYPBEN-PPCPHDFISA-N Thr-Leu-Ile Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O FLPZMPOZGYPBEN-PPCPHDFISA-N 0.000 description 1
- UGFSAPWZBROURT-IXOXFDKPSA-N Thr-Phe-Cys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CS)C(=O)O)N)O UGFSAPWZBROURT-IXOXFDKPSA-N 0.000 description 1
- BDENGIGFTNYZSJ-RCWTZXSCSA-N Thr-Pro-Met Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(O)=O BDENGIGFTNYZSJ-RCWTZXSCSA-N 0.000 description 1
- NMCBVGFGWSIGSB-NUTKFTJISA-N Trp-Ala-Leu Chemical compound C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)N NMCBVGFGWSIGSB-NUTKFTJISA-N 0.000 description 1
- HYNAKPYFEYJMAS-XIRDDKMYSA-N Trp-Arg-Glu Chemical compound [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(O)=O HYNAKPYFEYJMAS-XIRDDKMYSA-N 0.000 description 1
- RNFZZCMCRDFNAE-WFBYXXMGSA-N Trp-Asn-Ala Chemical compound [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(O)=O RNFZZCMCRDFNAE-WFBYXXMGSA-N 0.000 description 1
- HNIWONZFMIPCCT-SIXJUCDHSA-N Trp-His-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)N HNIWONZFMIPCCT-SIXJUCDHSA-N 0.000 description 1
- RERRMBXDSFMBQE-ZFWWWQNUSA-N Trp-Met-Gly Chemical compound CSCC[C@@H](C(=O)NCC(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)N RERRMBXDSFMBQE-ZFWWWQNUSA-N 0.000 description 1
- LWHUUHCERHMOAB-WDSOQIARSA-N Trp-Pro-His Chemical compound N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O LWHUUHCERHMOAB-WDSOQIARSA-N 0.000 description 1
- PALLCTDPFINNMM-JQHSSLGASA-N Trp-Val-Pro Chemical compound CC(C)[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)N PALLCTDPFINNMM-JQHSSLGASA-N 0.000 description 1
- RCLOWEZASFJFEX-KKUMJFAQSA-N Tyr-Asp-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 RCLOWEZASFJFEX-KKUMJFAQSA-N 0.000 description 1
- KRXFXDCNKLANCP-CXTHYWKRSA-N Tyr-Tyr-Ile Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 KRXFXDCNKLANCP-CXTHYWKRSA-N 0.000 description 1
- WANVRBAZGSICCP-SRVKXCTJSA-N Val-Pro-Met Chemical compound CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(O)=O WANVRBAZGSICCP-SRVKXCTJSA-N 0.000 description 1
- QTPQHINADBYBNA-DCAQKATOSA-N Val-Ser-Lys Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCCCN QTPQHINADBYBNA-DCAQKATOSA-N 0.000 description 1
- YLBNZCJFSVJDRJ-KJEVXHAQSA-N Val-Thr-Tyr Chemical compound CC(C)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O YLBNZCJFSVJDRJ-KJEVXHAQSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 108010078114 alanyl-tryptophyl-alanine Proteins 0.000 description 1
- 108010050025 alpha-glutamyltryptophan Proteins 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 108010013835 arginine glutamate Proteins 0.000 description 1
- 108010077245 asparaginyl-proline Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 108010069495 cysteinyltyrosine Proteins 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000012407 engineering method Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 108010028295 histidylhistidine Proteins 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 108010073101 phenylalanylleucine Proteins 0.000 description 1
- 108010070643 prolylglutamic acid Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- HODRFAVLXIFVTR-RKDXNWHRSA-N tevenel Chemical compound NS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl)C=C1 HODRFAVLXIFVTR-RKDXNWHRSA-N 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 108010051110 tyrosyl-lysine Proteins 0.000 description 1
- 108010027345 wheylin-1 peptide Proteins 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/01—Head-up displays
- G02B27/017—Head mounted
- G02B27/0176—Head mounted characterised by mechanical features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/01—Head-up displays
- G02B27/017—Head mounted
- G02B2027/0178—Eyeglass type
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
Abstract
本发明涉及一种VR眼镜，包含用于佩带的眼罩壳；所述的眼罩壳为人体面部曲面结构，表面涂覆有抗微生物多肽，能够用于杀死眼部和脸部常见致病菌。抗微生物肽喷雾于VR眼镜后几分钟内即形成一层薄膜，对眼镜不仅起到直接的保护作用，迅速杀死细菌，防止眼镜细菌的感染，而且该膜对皮肤具有良好的亲和性和透气性；该喷雾成膜剂含有保湿剂成分，可吸收水分，起到较好的保湿作用。另外抗微生物肽抑菌活性高，成本低廉，能够大规模的推广使用，具有极大的应用前景和重要的社会价值价值。
Description
技术领域
本发明涉及视觉器械领域，特别涉及一种VR眼镜。
背景技术
VR眼镜即VR头显，虚拟现实头戴式显示设备。VR头显是利用头戴式显示设备将人的对外界的视觉、听觉封闭，引导用户产生一种身在虚拟环境中的感觉。其显示原理是左右眼屏幕分别显示左右眼的图像，人眼获取这种带有差异的信息后在脑海中产生立体感。
近几年随着智能佩带设备的快速发展，VR虚拟现实技术获得了重大的技术突破，各种VR虚拟现实设备快速的推向了市场，获得了巨大的成功，但是随之而来的设备安全卫生问题成为困扰厂家的一大技术难题。由于VR眼镜一般在影院或者使用频繁的场所由不固定的不同人群每天来佩戴，导致VR眼镜上面残留了大量的致病菌，特别是一些眼病或者脸部皮肤病患者使用后，可能会给后续的使用者带来交叉感染的风险，因此设备卫生安全也成为了VR虚拟现实技术发展的一大瓶颈。
抗微生物肽(AMP)是相对新近发现的一组具有新作用模式的抗微生物剂。AMP广泛分布于动物、植物和微生物并且属于最古老的宿主防御因子。绝大多数的该种肽在天然情况下是阳离子的和两亲性的；该特性允许与带负电荷的细菌或真菌的膜相互作用。该种肽大小范围从6-7个氨基酸至60个氨基酸。迄今为止已经分离出500种以上不同的AMP。基于结构或M酸组成可以将它们分为几类。最简单的结构是小的螺旋肽。其它AMP折叠形成片层结构，而另外的再次形成刚性的二硫桥连接的三级结构。
AMP通常是杀微生物的并且作用极其快。通常，微生物在几分钟之内被杀死。它们通过干扰靶生物的膜功能而起作用。已经显示存在几种不同的作用机制，但是对于大多数AMP，总体结果是细胞膜破裂和细胞裂解。
但是目前存在的AMP也有技术上的障碍，即并不能够特异性的针对脸部和皮肤病菌，这在现有技术中并没有相应的研究，因此，开发一种效果较好的AMP，具有极强的应用前景。
发明内容
本发明的其中一个技术方案提供一种具有杀灭眼病病菌和脸部病菌的抗微生物肽，所述肽的序列为：
AMP-1：MCCPTTHHTNHVMAGWQIQRWMHT(SEQ ID NO：1)；
AMP-2：PGCYYIDHPPPFLDPFSSLTFCQEVNV(SEQ ID NO：2)；
AMP-3：NHRSPTWPHYDLASQLPCDRCQWRENP(SEQ ID NO：3)；
AMP-4：AVSAIPWNAAWATPMHVTYKPRGHPE(SEQ ID NO：4)；
AMP-5：IHEWHIWMGIPSWVPWQWPQHHHELVPM(SEQ ID NO：5)；
AMP-6：IHGRRFPMDHRIDHRYVSKTLISAPL(SEQ ID NO：6)；
AMP-7：ASRETPDSPCRSKKIMTSMRYRAWP(SEQ ID NO：7)；
AMP-8：WALMHKSQWSWFIVPHCIHHLDCASIP(SEQ ID NO：8)。
其中本发明所述的抗微生物肽针对的病原菌为铜绿假单孢菌、表皮葡萄球菌、金黄色葡萄球菌、淋球菌、溶血性链球菌和痤疮杆菌。
本发明另外提供一种VR眼镜设备，包含用于佩带的眼罩壳；所述的眼罩壳为人体面部曲面结构，其特征在于：表面涂覆有抗微生物多肽，所述的抗微生物多肽的序列如SEQID NO：1-8任一所示。
上述抗微生物肽可通过人工合成，即多肽固相合成的方法或基因工程方法获得。
所述涂覆通过喷雾实现，所述喷雾是通过喷雾成膜剂喷覆到VR眼镜表面实现的。
成膜剂的组分为：抗微生物肽100ppm，聚乙烯醇2wt％，聚乙烯吡咯烷酮5wt％，和甘油10wt％，水余量；所述及的抗微生物肽选自SEQ ID NO：1-8任一所示。
本发明的抗微生物肽喷雾成膜剂的制备方法，包括如下步骤：
(1)将水溶性成膜高分子材料溶解于热水中；
(2)加入保湿剂和已配置好的抗菌肽水溶液，混合均匀，灌装于喷雾器内。
本发明的有益效果在于：
本发明提供的抗微生物肽喷雾成膜剂喷于VR眼镜后几分钟内即形成一层薄膜，对眼镜不仅起到直接的保护作用，迅速杀死细菌，防止眼镜细菌的感染，而且该膜对皮肤具有良好的亲和性和透气性；该喷雾成膜剂含有保湿剂成分，可吸收水分，起到较好的保湿作用。另外抗微生物肽抑菌活性高，成本低廉，能够大规模的推广使用，具有极大的应用前景和重要的社会价值价值。
具体实施方式
实施例抗微生物肽的制备及活性验证
根据申请人前期筛选得到的抗微生物肽SEQ ID NO：1-8分别委托上海生工利用固相合成法合成，并将C末端酰胺化，合成后经HPLC纯化，纯度达到99.0％。
抗菌性检测：
将多肽用蒸馏水溶解成浓度为100ppm，采用琼脂糖扩散法进行抗菌活性检测。琼脂糖扩散法中使用的菌株为铜绿假单孢菌、表皮葡萄球菌、金黄色葡萄球菌、淋球菌、溶血性链球菌和痤疮杆菌的组合。菌株复苏后，接种于培养基后活化培养菌株得到培养液之后分别取50微升菌液涂布于固体培养基。静置带菌液吸收后，分别加入100ppm的多肽溶液10微升。37℃培养1小时后，观察抑菌圈的有无和大小。结果见表1。
表1多肽抗菌活性分析结果
从表1可以看出，AMP-1～8均具有较好的抗菌特性。
抗微生物肽的溶血性检测
利用羊血红细胞检测抗微生物肽的溶血作用；将浓度为100ppm的抗微生物肽AMP-1～810微升滴加在血平皿表面，以蒸馏水做对照。置于37℃24小时以上，然后观察溶血圈的有无。结果所有受测抗微生物肽均没有出现溶血圈。初步结果表明，所述抗微生物肽不存在溶血毒性。
多肽修饰的VR眼镜的制备
将聚乙烯醇2wt％，聚乙烯吡咯烷酮5wt％先溶解，而后将抗微生物肽100ppm，和甘油10wt％混匀，水余量，所述及的抗微生物肽选自SEQ ID NO：1-8任一所示。混合均匀，灌装于喷雾器内。
取VR眼镜设备，将眼罩壳面喷涂覆上述制备的喷雾剂，即可在表面形成肽膜。以没有涂覆肽膜的VR眼镜为对照，分别将眼镜置于体验厅，每日平均使用量在200人左右，分别刮取1*1cm表面积进行菌落分析，通过分析发现，表面涂覆肽膜的VR眼镜表面基本无致病菌，而未涂覆菌膜的眼镜表面存在着众多的致病菌，分别为铜绿假单孢菌、金黄色葡萄球菌、淋球菌、溶血性链球菌和痤疮杆菌，菌落个数达到了2.0*103左右。从以上结果可以看出，本发明的VR眼镜具有较好的杀菌效果。
以上为本发明的具体实施例，其作用在于对本发明的内容做进一步详细的说明，使阅读者更易理解，但不构成对本发明所要求的保护。
序列表
<110> 李忠波
<120> 一种VR眼镜
<160> 8
<170> SIPOSequenceListing 1.0
<210> 1
<211> 24
<212> PRT
<213> 人工序列(2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 1
Met Cys Cys Pro Thr Thr His His Thr Asn His Val Met Ala Gly Trp
1 5 10 15
Gln Ile Gln Arg Trp Met His Thr
20
<210> 2
<211> 27
<212> PRT
<213> 人工序列(2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 2
Pro Gly Cys Tyr Tyr Ile Asp His Pro Pro Pro Phe Leu Asp Pro Phe
1 5 10 15
Ser Ser Leu Thr Phe Cys Gln Glu Val Asn Val
20 25
<210> 3
<211> 27
<212> PRT
<213> 人工序列(2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 3
Asn His Arg Ser Pro Thr Trp Pro His Tyr Asp Leu Ala Ser Gln Leu
1 5 10 15
Pro Cys Asp Arg Cys Gln Trp Arg Glu Asn Pro
20 25
<210> 4
<211> 26
<212> PRT
<213> 人工序列(2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 4
Ala Val Ser Ala Ile Pro Trp Asn Ala Ala Trp Ala Thr Pro Met His
1 5 10 15
Val Thr Tyr Lys Pro Arg Gly His Pro Glu
20 25
<210> 5
<211> 28
<212> PRT
<213> 人工序列(2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 5
Ile His Glu Trp His Ile Trp Met Gly Ile Pro Ser Trp Val Pro Trp
1 5 10 15
Gln Trp Pro Gln His His His Glu Leu Val Pro Met
20 25
<210> 6
<211> 26
<212> PRT
<213> 人工序列(2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 6
Ile His Gly Arg Arg Phe Pro Met Asp His Arg Ile Asp His Arg Tyr
1 5 10 15
Val Ser Lys Thr Leu Ile Ser Ala Pro Leu
20 25
<210> 7
<211> 25
<212> PRT
<213> 人工序列(2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 7
Ala Ser Arg Glu Thr Pro Asp Ser Pro Cys Arg Ser Lys Lys Ile Met
1 5 10 15
Thr Ser Met Arg Tyr Arg Ala Trp Pro
20 25
<210> 8
<211> 27
<212> PRT
<213> 人工序列(2 Ambystoma laterale x Ambystoma jeffersonianum)
<400> 8
Trp Ala Leu Met His Lys Ser Gln Trp Ser Trp Phe Ile Val Pro His
1 5 10 15
Cys Ile His His Leu Asp Cys Ala Ser Ile Pro
20 25
Claims (4)
1.一种VR眼镜，其特征在于：包含用于佩带的眼罩壳；所述的眼罩壳为人体面部曲面结构。
2.如权利要求1所述的VR眼镜，其特征在于：所述的眼罩壳表面涂覆有SEQ ID NO：2所示抗微生物多肽。
3.SEQ ID NO：2所示抗微生物多肽在制备抗菌VR眼镜中的应用。
4.一种多肽，其序列为SEQ ID NO：2所示。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811174412.1A CN109212759A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710074834.0A CN106707517B (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174412.1A CN109212759A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710074834.0A Division CN106707517B (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109212759A true CN109212759A (zh) | 2019-01-15 |
Family
ID=58909212
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811174372.0A Withdrawn CN109116568A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174920.XA Withdrawn CN109143586A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174379.2A Withdrawn CN109164580A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174460.0A Withdrawn CN109164581A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174918.2A Withdrawn CN109239923A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201710074834.0A Active CN106707517B (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174412.1A Withdrawn CN109212759A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174398.5A Withdrawn CN109212758A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811174372.0A Withdrawn CN109116568A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174920.XA Withdrawn CN109143586A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174379.2A Withdrawn CN109164580A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174460.0A Withdrawn CN109164581A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201811174918.2A Withdrawn CN109239923A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
| CN201710074834.0A Active CN106707517B (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811174398.5A Withdrawn CN109212758A (zh) | 2017-02-12 | 2017-02-12 | 一种vr眼镜 |
Country Status (1)
| Country | Link |
|---|---|
| CN (8) | CN109116568A (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109343655B (zh) * | 2018-09-04 | 2021-09-10 | 杭州翔毅科技有限公司 | 一种提高可穿戴式智能设备舒适性的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101111256B (zh) * | 2004-12-15 | 2012-04-25 | 科罗拉多大学 | 抗菌肽及其使用方法 |
| CN105622741A (zh) * | 2014-10-28 | 2016-06-01 | 无锡灵锡医疗器械科技有限公司 | 隐形眼镜表面抗菌涂层用组合物的制备方法及使用方法 |
| CN205620613U (zh) * | 2016-05-13 | 2016-10-05 | 王金龙 | 一种佩戴舒适的vr眼镜 |
| CN205720895U (zh) * | 2016-06-15 | 2016-11-23 | 深圳市鼎烨源信息科技有限公司 | 一种vr眼镜设备 |
-
2017
- 2017-02-12 CN CN201811174372.0A patent/CN109116568A/zh not_active Withdrawn
- 2017-02-12 CN CN201811174920.XA patent/CN109143586A/zh not_active Withdrawn
- 2017-02-12 CN CN201811174379.2A patent/CN109164580A/zh not_active Withdrawn
- 2017-02-12 CN CN201811174460.0A patent/CN109164581A/zh not_active Withdrawn
- 2017-02-12 CN CN201811174918.2A patent/CN109239923A/zh not_active Withdrawn
- 2017-02-12 CN CN201710074834.0A patent/CN106707517B/zh active Active
- 2017-02-12 CN CN201811174412.1A patent/CN109212759A/zh not_active Withdrawn
- 2017-02-12 CN CN201811174398.5A patent/CN109212758A/zh not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN109164580A (zh) | 2019-01-08 |
| CN109212758A (zh) | 2019-01-15 |
| CN106707517A (zh) | 2017-05-24 |
| CN109116568A (zh) | 2019-01-01 |
| CN106707517B (zh) | 2019-12-03 |
| CN109164581A (zh) | 2019-01-08 |
| CN109143586A (zh) | 2019-01-04 |
| CN109239923A (zh) | 2019-01-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6908568B2 (ja) | 病原性バイオフィルムと関連した状態を治療するための物質および方法 | |
| CN104884074B (zh) | 源自亚麻蛋白质水解的亚麻提取物作为活性抗微生物剂的用途 | |
| KR20180056226A (ko) | 전복에서 유래한 항균 펩타이드 유사체 및 이를 포함하는 항균용 약학 조성물 | |
| CN106344956A (zh) | 一种壳聚糖抑菌促愈合凝胶及其制备方法 | |
| US20230391839A1 (en) | Bioactive peptides derived from snakes | |
| CN106589088B (zh) | 一种具有抗菌抗炎活性的多肽及其应用 | |
| CN113908074A (zh) | 用于诱导抗微生物肽生成的烟酰胺 | |
| US20120269739A1 (en) | Composition, use, and preservation method | |
| CN111518163B (zh) | 一类脂肽化合物在抗新型冠状病毒中的应用 | |
| EP3120850B1 (en) | Niacinamide for inducing generation of antimicrobial peptides | |
| CN106707517B (zh) | 一种vr眼镜 | |
| CN102333546B (zh) | 用于在跨角蛋白的局部药物递送中使用表面活性蛋白的组合物、用途和方法 | |
| CN106074211A (zh) | 一种皮肤抑菌液 | |
| CN106597681A (zh) | 一种3d眼镜 | |
| CN105622741A (zh) | 隐形眼镜表面抗菌涂层用组合物的制备方法及使用方法 | |
| CN115558031B (zh) | 一种融合肽及其具有抑菌功效的胶原蛋白复合物和应用 | |
| CN110099674A (zh) | 具有高含量的泉水和/或矿泉水的组合物 | |
| KR102120981B1 (ko) | 겐티스산 유도체, 이의 제조방법 및 이를 포함하는 피부외용제 조성물 | |
| KR100593706B1 (ko) | 실리콘 가교 폴리머 조합을 이용한 방부제 무첨가 w/s형함수 화장료 조성물 및 그의 제조 방법 | |
| CN108350030A (zh) | 皮肤可渗透肽及其使用方法 | |
| JP2002308749A (ja) | 外用剤組成物 | |
| CN102940876B (zh) | 多肽gh27在制备预防及治疗山羊腹泻药物中的应用 | |
| CN114667130A (zh) | 杂化无机-有机复合物及其用于维持皮肤和/或化妆品和/或皮肤药物组合物的微生物平衡的用途 | |
| EP3370690A1 (en) | Mucin topical deodorants and antiperspirants | |
| CN102935223A (zh) | 多肽gc25在制备治疗抗感染药物中的应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190115 |
|
| WW01 | Invention patent application withdrawn after publication |