CN1066953C - Drug for curing 'subdermal implantation', 'drug abortion' postoperative endometrorrhagia and its preparing method - Google Patents
Drug for curing 'subdermal implantation', 'drug abortion' postoperative endometrorrhagia and its preparing method Download PDFInfo
- Publication number
- CN1066953C CN1066953C CN98106552A CN98106552A CN1066953C CN 1066953 C CN1066953 C CN 1066953C CN 98106552 A CN98106552 A CN 98106552A CN 98106552 A CN98106552 A CN 98106552A CN 1066953 C CN1066953 C CN 1066953C
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- CN
- China
- Prior art keywords
- radix
- medicine
- endometrorrhagia
- postoperative
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 28
- 206010000210 abortion Diseases 0.000 title claims abstract description 9
- 231100000176 abortion Toxicity 0.000 title claims abstract description 9
- 238000002513 implantation Methods 0.000 title claims abstract description 9
- 230000002980 postoperative effect Effects 0.000 title claims abstract description 9
- 229940079593 drug Drugs 0.000 title claims description 11
- 238000000034 method Methods 0.000 title abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 18
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 10
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000005325 percolation Methods 0.000 claims description 6
- 230000001476 alcoholic effect Effects 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 239000003610 charcoal Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 241001465754 Metazoa Species 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 241000213006 Angelica dahurica Species 0.000 abstract 2
- 241000514824 Cyathula officinalis Species 0.000 abstract 2
- 239000002075 main ingredient Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 206010027514 Metrorrhagia Diseases 0.000 description 3
- 230000002254 contraceptive effect Effects 0.000 description 3
- 239000003433 contraceptive agent Substances 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- 241000241550 Cyathula Species 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 241000545442 Radix Species 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229950006142 carbazochrome salicylate Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 229960003248 mifepristone Drugs 0.000 description 1
- VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- CELKBRMLNUNCIP-HTFHIHPASA-M sodium;2-hydroxybenzoate;[(e)-(3-hydroxy-1-methyl-6-oxo-2,3-dihydroindol-5-ylidene)amino]urea Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O.NC(=O)N\N=C/1C(=O)C=C2N(C)CC(O)C2=C\1 CELKBRMLNUNCIP-HTFHIHPASA-M 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a medicine for curing sub-dermal implantation, medical abortion and postoperative endometrorrhagia and a preparing method. The medicine is made by the preparation of the main ingredients of cyathula officinalis, notoginseng, dahurian angelica roots, and charred radix rubiae. The preparing method is that the extracting liquid of the cyathula officinalis and the dahurian angelica roots is made into paste powder by pressure reduction, concentration and spraying dryness, and the notoginseng is ground into fine powder to be mixed with the charred radix rubiae and the paste powder to be made into a certain medicament form. The medicine of the present invention is mainly used for the sub-dermal implantation, the medical abortion and the postoperative endometrorrhagia of birth control. After animal experiments and clinical trials, the treating effect is obvious, no side effect exists, and the contraception effect is not influenced.
Description
The present invention relates to a kind of medicine for the treatment of subdermal implantation, drug induced abortion postoperative endometrorrhagia, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
" subdermal implantation " agent belongs to simple progestogen contraceptive, is reversible long-acting contraceptive, and accepting heeling-in person generally has the women of 60-70% menostaxis to occur the first half after acceptance, frequent hemorrhage and intermenstrual bleeding or bleed.Domestic 3 year stage summed up report and accounts for 12.8-37.7%, the main cause that the metrorrhagia person of being to use stops because of what problem of menstruation stopped.Still there is not effective medicine at present both at home and abroad.Each clinical center hemorrhage symptomatic treatment, peaceful as vitamin K, carbazochrome salicylate, GONGXUENING, woman's blood, external bleeding problems ethinylestradiol, ibuprofen treatment once to causing behind the subdermal implantation, these medicines can play temporary transient hemostatic effect, but curative effect is all undesirable.
The objective of the invention is a kind of promotion endometrium growth of working out at the problem of above-mentioned existence, reduce metrorrhagia, be applicable to the novel drugs of treatment women's long-acting contraception (subdermal implants, mifepristone drug induced abortion) postoperative endometrorrhagia, belong to pure Chinese medicinal preparation.
The present invention seeks to realize like this:
Composition and compatibility:
Radix Cyathulae 60-78% Radix Notoginseng 8-15% charred RADIX RUBIAE 5-15% Radix Angelicae Dahuricae 5-15%
Preparation method:
A, be that 60～70% Radix Cyathulae, 5～15% Radix Angelicae Dahuricae coarse powder and equivalent ethanol mix are moistening with weight proportion, place after 4 hours in the percolator that it is evenly packed into and add alcoholic solution, soaked 24 hours, carry out percolation, after percolation stops, collect the merging percolate, reclaim ethanol, and medicinal liquid is concentrated into relative density is 1.1, makes extract powder with spray drying, standby;
B, be that 5～15% Radix Rubiae is fried into charcoal with medicine roasting machine with weight proportion, weight proportion is that 8～15% Radix Notoginseng is ground into fine powder 100 orders, and extract powder is mixed with Radix Rubiae powdered carbon, Radix Notoginseng fine powder, and dosage form is made in check;
The relevant technologies parameter:
1, the technical parameter in the spray-drying process is:
Feed liquor speed: 9000 ml/min
Centrifugal turntable speed: 14000 rev/mins
Intake air temperature: 100 ℃
2, alcoholic solution is that concentration is the ethanol organic solvent of 78-90%.
The present invention is by animal experiment and clinic trial, and is evident in efficacy and have no side effect, and do not influence contraceptive effect, can be used as the conventional supporting medicine of subdermal implants, to drug induced abortion, placement of intrauterine devices postoperative endometrorrhagia, curative effect preferably arranged also simultaneously.
Embodiment:
To make 1000 capsules is example:
1, gets 60 kilograms of Radix Cyathulaes, 8.5 kilograms of the Radixs Angelicae Dahuricae, be ground into coarse powder with pulverizer.Got 68.5 kilograms of concentration and be 85% alcoholic solution moistening 4 hours, and moved into percolator, press the percolation routine, soak after 24 hours, carry out percolation with the flow velocity of 3 milliliters of/kilogram branches, to percolate colourless till.Collect the merging percolate, suck in the energy-conservation concentrator of triple effect, reclaim ethanol, and medicinal liquid is concentrated into relative density 1.1, with spray dryer feed liquor speed: 9000 ml/min, 14000 rev/mins of centrifugal turntable speed, 100 ℃ of intake air temperatures, it is standby to make extract powder.
2, get 8.5 kilograms of charred RADIX RUBIAEs, it is standby that 8.5 kilograms of Radix Notoginseng are ground into 100 purpose fine powders with pulverizer.
3, extract powder and charred RADIX RUBIAE, Radix Notoginseng fine powder are inserted in the mixer, abundant mixing, the container of packing into gives airtight standby.Get mixed powder with the integrated zero capsule of the automatic filling machine of capsule, every is equivalent to crude drug 0.8 gram.
Claims (5)
1, a kind of medicine for the treatment of subdermal implantation, drug induced abortion postoperative endometrorrhagia is characterized in that it is the medicament of being made by the following weight proportion raw material: Radix Cyathulae 60-70%, Radix Notoginseng 8-15%, charred RADIX RUBIAE 5-15%, Radix Angelicae Dahuricae 5-15%.
2, medicine according to claim 1 is characterized in that described medicament is capsule or electuary.
3, a kind of preparation method for the treatment of the medicine of subdermal implantation, drug induced abortion postoperative endometrorrhagia is characterized in that:
A, be that 60～70% Radix Cyathulae, 5～15% Radix Angelicae Dahuricae coarse powder and equivalent ethanol mix are moistening with weight proportion, place after 4 hours in the percolator that it is evenly packed into and add alcoholic solution, soaked 24 hours, carry out percolation, after percolation stops, collect the merging percolate, reclaim ethanol, and medicinal liquid is concentrated into relative density is 1.1, makes extract powder with spray drying, standby;
B, be that 5～15% Radix Rubiae is fried into charcoal with medicine roasting machine with weight proportion, weight proportion is after 8～15% Radix Notoginseng is ground into fine powder 100 orders, extract powder to be mixed with Radix Rubiae powdered carbon, Radix Notoginseng fine powder again, and dosage form is made in check.
4, preparation method according to claim 3 is characterized in that described alcoholic solution is that concentration is the ethanol organic solvent of 70-90%.
5, preparation method according to claim 3 is characterized in that the technical parameter in the concentrated spray dry run is: feed liquor speed 9000 ml/min, 14000 rev/mins of centrifugal turntable speed, 100 ℃ of intake air temperatures.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98106552A CN1066953C (en) | 1998-03-10 | 1998-03-10 | Drug for curing 'subdermal implantation', 'drug abortion' postoperative endometrorrhagia and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98106552A CN1066953C (en) | 1998-03-10 | 1998-03-10 | Drug for curing 'subdermal implantation', 'drug abortion' postoperative endometrorrhagia and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1228314A CN1228314A (en) | 1999-09-15 |
| CN1066953C true CN1066953C (en) | 2001-06-13 |
Family
ID=5218995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98106552A Expired - Lifetime CN1066953C (en) | 1998-03-10 | 1998-03-10 | Drug for curing 'subdermal implantation', 'drug abortion' postoperative endometrorrhagia and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1066953C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152290B (en) * | 2007-09-26 | 2010-06-23 | 吴金林 | Externally used powder preparation stypticum |
-
1998
- 1998-03-10 CN CN98106552A patent/CN1066953C/en not_active Expired - Lifetime
Non-Patent Citations (3)
| Title |
|---|
| 中医药研究，1991,(3) 1991.1.1 白吉祥，化瘀止血煎治疗功能性子宫出血 * |
| 时珍国药研究，1994,5(4) 1994.1.1 吴玉茹，张国瑞，目止血调经汤治疗功能性子宫出血132例体会 * |
| 时珍国药研究，1994,5(4) 1994.1.1 吴玉茹，张国瑞，目止血调经汤治疗功能性子宫出血132例体会;中医药研究，1991,(3) 1991.1.1 白吉祥，化瘀止血煎治疗功能性子宫出血 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1228314A (en) | 1999-09-15 |
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Owner name: ZHONG PING Free format text: FORMER OWNER: ZHENG FUTUAN Effective date: 20060407 |
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Owner name: GANSU XINLAN MEDICINE CO.,LTD. Free format text: FORMER OWNER: ZHONG PING Effective date: 20080523 |
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Effective date of registration: 20080523 Address after: Gansu province Lanzhou city road salt ditch Ping No. 21 Patentee after: Gansu Xinlanyao Pharmaceuticals Co., Ltd. Address before: Gansu Province Chengguan District of Lanzhou City, No. 21 Ping Patentee before: Zhong Ping |
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Owner name: GANSU LANYAO PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: GANSU XINLANYAO PHARMACEUTICAL CO., LTD. |
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Address after: 730070, Gansu, Anning District, Lanzhou 5 Avenue No. Patentee after: Gansu Lanyao Pharmaceutical Co., Ltd. Address before: 730046 Gansu province Lanzhou city road salt ditch Ping No. 21 Patentee before: Gansu Xinlanyao Pharmaceuticals Co., Ltd. |
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Denomination of invention: Drug for curing 'subdermal implantation', 'drug abortion' postoperative endometrorrhagia and its preparing method Effective date of registration: 20150618 Granted publication date: 20010613 Pledgee: China Cinda Asset Management Corp Gansu branch Pledgor: Gansu Lanyao Pharmaceutical Co., Ltd. Registration number: 2015620000008 |
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Date of cancellation: 20160712 Granted publication date: 20010613 Pledgee: China Cinda Asset Management Corp Gansu branch Pledgor: Gansu Lanyao Pharmaceutical Co., Ltd. Registration number: 2015620000008 |
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Denomination of invention: Drug for curing 'subdermal implantation', 'drug abortion' postoperative endometrorrhagia and its preparing method Effective date of registration: 20160719 Granted publication date: 20010613 Pledgee: China Cinda Asset Management Corp Gansu branch Pledgor: Gansu Lanyao Pharmaceutical Co., Ltd. Registration number: 2016620000014 |
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