CN106693295B

CN106693295B - Swallowing training pen with segmented administration

Info

Publication number: CN106693295B
Application number: CN201710195913.7A
Authority: CN
Inventors: 陈巧鸽
Original assignee: Jinhua central hospital
Current assignee: Jinhua central hospital
Priority date: 2017-03-29
Filing date: 2017-03-29
Publication date: 2023-07-28
Anticipated expiration: 2037-03-29
Also published as: CN106693295A

Abstract

The invention provides a swallowing training pen with segmented administration and application thereof in treating radioactive oral mucositis. The training pen comprises a pen holder with a medicine core arranged inside, and a core storage cavity in the pen holder can at least hold two medicine cores which are arranged in sequence inside. The rear end of the pen holder is provided with a pushing part which sequentially pushes the medicines on the medicine core to a medicine outlet of the training pen. The front end of the pen holder is provided with a clamping part to keep the medicine from being separated from the pen holder in the process of being taken by a patient. The medicine on the training pen can be withdrawn from the oral cavity in time, and the requirement of the radioactive oral mucositis patient on the repeated administration can be met. The swallowing training pen integrates a plurality of swallowing training tools, so that the swallowing training is more convenient.

Description

Swallowing training pen with segmented administration

Technical Field

The invention relates to a drug delivery device, in particular to a swallowing training pen for segmented drug delivery and application thereof in treating radioactive oral mucositis.

Background

The radioactive oral mucosa reaction is easy to cause swallowing disorder, and the biggest danger of swallowing disorder is aspiration. It is reported in the literature that foods with different properties are mixed together, so that higher chewing capacity is required, and a food mass with strong cohesive force is not easy to form, and part of foods easily fall into the pharynx and the airway in swallowing. Thus, patients with less than ideal swallowing should avoid intermixing of differently shaped solid foods. Such as liquid and solid mixed foods. The proper adjustment of food characteristics of patients with dysphagia after nasopharyngeal carcinoma radiotherapy can effectively reduce the occurrence of aspiration, and is an economical, practical and safe method. Most dysphagia patients are easy to inhale by mistake, and the thickener is added into the thin liquid to increase the viscosity, so that the aspiration can be reduced. In the prior art, the medicine for treating the radioactive oral mucositis is made into ice cubes, but the water sample medicine after being iced easily enters the pharynx to cause the patient to be choked due to aspiration, and unsafe factors exist.

Besides radiotherapy of nasopharyngeal carcinoma, diseases such as brain stem lesion, brain trauma, tongue cancer and the like often cause swallowing dysfunction such as insufficient tongue muscle strength, uncoordinated tongue movements and the like during swallowing. Clinically serious oral tracheal sensation, namely movement dysfunction often causes lip closure disorder, opening disorder and movement disorder of the tongue in all directions, swallowing initiation delay occurs, liquid flows into the pharynx and other abnormal manifestations before swallowing action, aspiration before swallowing is easily caused, repeated pulmonary infection, malnutrition, dehydration, resistance reduction and other problems are caused, and serious patients can also cause death.

The technology of training the sense of the mouth and the movement is one of the current clinical methods for improving the swallowing dysfunction, and the method can be applied to the treatment of the sense and the muscle function of the mouth and the face and is helpful for improving the sense of the mouth organ, namely the movement function. Therefore, the oral cavity feeling and motor training is very important, the technology comprises tongue pressure anti-resistance feedback training, K point stimulation and vibration stimulation of a vibration rod on the oral cavity of a patient, and the method is simple and practical and can help the patient recover the oral cavity feeling.

Tongue pressure training and lip training are often performed using tongue depressors. For example, the tongue depressor is placed in the middle of the tongue of the patient, and the patient is prescribed to lift the tongue forcefully up against the hard palate. During lip training, patients are instructed to clamp the tongue depressor by lips, adhere for 5 seconds, relax and repeat for a plurality of times.

The K point is located at the height of the post-molar triangle, and by stimulating this point, the patient's mouth opening and swallowing initiation can be induced. In the treatment of dysphagia, stimulating the K-site can help the patient to open, creating good conditions for oral and facial training and oral care. There are several ways to stimulate the K-site, one is to stimulate the K-site with a finger. Secondly, for patients with serious opening difficulty, the small island spoon (K spoon) can be used for directly stimulating the K point.

The patient has dyskinesia of the mouth and face, and can use the vibrating rod to perform sensory vibration stimulation of the oral cavity so as to promote the recovery of the oral cavity. When the vibration rod is used, the head of the vibration rod is placed at the part needing to be stimulated in the oral cavity, the power supply is started to vibrate, and the part needing to be stimulated can be vibrated by the head of the vibration rod in a sliding mode until the stimulated organ generates action or feel.

Whether the tongue pressing plate, the K spoon or the vibrating rod are independent auxiliary devices, a patient needs to prepare a plurality of tools when doing the oral cavity sensory and motor training. Because such patients are accompanied by ulcers and pain due to the oral mucositis, patients are often given drugs with anesthetic action orally prior to training to relieve the pain experienced by the patient during training. At present, the drug with anesthetic effect is usually administered in the form of ice cubes, but the water-like drug after being frozen easily enters the pharynx to cause aspiration and choking to patients. Therefore, the preparation of the instrument before the training of the oral exercise and the observation of adverse reactions such as the use of the instrument and the aspiration of a patient in the training process are complicated. Therefore, how to improve the efficiency of the existing oral sensory and motor training is a problem which needs to be solved by the swallowing rehabilitation training discipline.

Disclosure of Invention

The invention aims to provide a swallowing training pen with segmented drug delivery, which comprises a pen holder with drug cores arranged inside, wherein a core storage cavity in the pen holder can accommodate at least two drug cores which are sequentially arranged inside the pen holder, a pushing part is arranged at the rear end of the pen holder, drugs on the drug cores are sequentially pushed to a drug outlet, and a clamping part is arranged at the front end of the pen holder so as to prevent the drugs from being separated from the pen holder in the process of being taken by a patient.

Further, the pushing part is a piston type pushing structure or a spring structure.

Further, the clamping part is selected from a blocking piece, a clamping piece with clamping feet, or a lug on the medicine holder and a lug bayonet on the pen holder.

Furthermore, the medicine support is of a hollow structure.

Furthermore, the front part of the medicine support is provided with a functional rod, the functional rod is flat, and the front end of the functional rod is provided with a bulge.

Further, a vibrator is arranged on the outer wall of the pen holder.

Further, the pen cap comprises a pen cap, the front section of the pen cap is connected with a long rod which can be folded on the pen cap, and the pen cap is connected with the long rod through a rotating shaft.

Further, the front end of the long rod is provided with a bulge.

Further, the medicine is a compound licorice preparation, and is prepared by mixing and proportioning a plurality of medicines, wherein the medicines comprise 175-350ml of licorice liquid, 2.5-7.5g of bikino, 40-120 ten thousand units of gentamicin, 0.05-0.15g of lidocaine, and a proper amount of auxiliary materials and solid agents for nourishing yin, moistening dryness and promoting fluid production.

The invention also provides the clinical application of the segmented administration swallowing training pen in treating radioactive oral mucositis.

The training pen provided by the invention can meet the requirement of the radioactive oral mucositis patient on the repeated administration, and can integrate a plurality of swallowing training tools, so that the swallowing training is more convenient.

Drawings

Fig. 1 is a schematic diagram showing the internal structure of a first type of sectional administration swallowing training pen.

Fig. 2 is a schematic structural view of a first-section drug delivery swallowing training pen with a separated pen point sleeve and a pen holder.

Fig. 3 is a schematic external view of a second type of segmented dosing swallowing training pen.

FIG. 4 is a schematic cross-sectional view taken along the direction A-A of FIG. 3.

Fig. 5 is an exploded view of a second type of swallowing training pen.

Fig. 6 is a schematic external view of a third type of segmentally administered swallowing training pen.

FIG. 7 is a schematic cross-sectional view taken along the direction B-B in FIG. 6.

Fig. 8 is a schematic view of the clamping state of the clamping member.

Fig. 9 is a schematic view of the released state of the clip.

The drug core of fig. 10 is shown detached from the released clip.

Fig. 11 is a schematic diagram showing the internal structure of a fourth type of a swallowing training pen for segmented administration.

Fig. 12 is a schematic view of a hollow drug holder structure.

Fig. 13 is a schematic side view of a hollow drug tray.

Fig. 14 is a schematic view of a hollow tray with medicine mounted.

Fig. 15 is a schematic diagram of a swallowing training ratio of a vibrator mounted on a pen holder.

Fig. 16 is a schematic view of a pen cap with a wand.

Detailed Description

The sectional administration swallowing training pen shown in fig. 1 to 11 comprises a pen holder 1 with a medicine core therein, wherein a core storage cavity 11 in the pen holder can accommodate at least two medicine cores 2 which are sequentially arranged therein, and medicines on the medicine cores extend out from a medicine outlet 12. The rear end of the pen holder is provided with a pushing part for pushing the medicines on the medicine core to the medicine outlet in sequence. The front end of the pen holder is provided with a clamping part to keep the medicine from being separated from the pen holder in the process of being taken by a patient.

The swallowing training pen as shown in fig. 1 to 2 comprises a pen holder 1 with a core storage cavity 11, and a medicine core 2 comprises a medicine support 21 and a medicine 22 connected to the medicine support. The pushing part is of a piston type pushing structure and comprises a push rod 31 and a piston 32, and the piston 32 is tightly matched with the inner wall of the pen holder and is abutted against the medicine holder. The front end of the pen holder is provided with a pen head sleeve 4 which is sleeved on the pen holder in a threaded or fastening mode. The pen cap is provided with a medicine outlet 12, and a blocking piece 41 at the opening is a clamping part. When the medicine extends out of the outlet 12, the protruding part 211 on the medicine holder is blocked by the blocking part of the pen point sleeve, so that the whole medicine core is prevented from leaving the pen rod when a patient takes the medicine. After the medicine is taken, the pen point cap is unscrewed to take out the used medicine core, and then the pen point is sleeved on the pen holder. When the drug on the second drug core is to be used, the push rod is pushed, and then the piston pushes the unused drug core to move forward until the drug extends out of the drug outlet.

The swallowing training pen as shown in fig. 3 to 5 comprises a pen holder 1 with a core storage cavity 11, and a medicine core 2 comprises a medicine support 21 and a medicine 22 connected to the medicine support. The front end of the pen holder is provided with a pen head sleeve 4 which is sleeved on the pen holder in a threaded or fastening mode. The pen cap is provided with a medicine outlet, a blocking piece 41 at the opening is a clamping part, and the blocking piece plays a role of blocking the convex part 211 on the medicine holder. The rear end of the pen holder is provided with a pen cap 13. After the medicine is taken, the pen point cap is unscrewed to take out the used medicine core, and then the pen point is sleeved on the pen holder. When a new medicine core is to be used, the pen cap 13 is opened, a new medicine core is filled from the rear end of the pen holder, then the pen cap is covered, and the pen cap is matched with the newly filled medicine core to push the original medicine core to move forwards until the medicine extends out of the medicine outlet. The push section in this embodiment includes a cap and a post-loaded drug core.

The swallowing training pen as shown in fig. 6 to 10 comprises a pen shaft 1 with a core storage cavity, and a medicine core comprises a medicine support 21 and a medicine 22 connected to the medicine support. The pushing part is a spring assembly and comprises a spring 33, two ends of the spring are respectively connected with a pushing piece 34 and a spring fixing piece 35, and the pushing piece 34 is in contact with the medicine holder. When the spring is in a compressed state and the medicine core which is used up is taken out, the residual medicine core in the pen holder is pushed to move forward by the elasticity of the spring until the medicine stretches out of the medicine outlet. The clamping part is a clamping piece 5, and the clamping piece comprises a clamping foot 51. As shown in fig. 8, the legs tightly hold the core; as shown in fig. 9, the legs are broken to both sides, thereby releasing the core; as shown in fig. 10, the spent core is removed and the latter core follows up to the drug outlet; the old drug core is discarded and the new drug core is again clamped at the drug outlet.

The swallowing training pen shown in fig. 11 comprises a pen holder 1 with a core storage cavity 11, and a medicine core 2 comprises a medicine support 21 and a medicine 22 connected to the medicine support. The pushing part is a spring assembly and comprises a spring 33, two ends of the spring are respectively connected with a pushing piece 34 and a spring fixing piece 35, and the pushing piece 34 is in contact with the medicine holder. When the spring is in a compressed state and the medicine core which is used up is taken out, the residual medicine core in the pen holder is pushed to move forward by the elasticity of the spring until the medicine stretches out of the medicine outlet. The clamping part comprises an elastic lug 6 on the outer wall of the medicine holder and a lug bayonet 7 on the penholder. And a limiting groove 14 for the elastic lug to move is also arranged on the inner wall of the pen holder, and extends to the lug bayonet. The elastic protruding blocks of the medicine cores are inserted into the limit grooves 14, and the medicine cores are sequentially filled into the medicine storage cavities along the limit grooves. When the lug 6 of the medicine core moves to the bayonet 7, the compressed lug is inserted into the bayonet after being reset, so that the medicine core at the forefront end is clamped. When the medicine is used, a force is applied to the lug in the bayonet to enable the lug to be compressed again so as to be separated from the bayonet, the medicine core which is not clamped can be taken out from the pen holder, the latter medicine core is pressed by the spring, the lug moves to the bayonet, and the new medicine core is clamped.

The drug support on the drug core can be solid structure as shown in figure 1 or hollow structure as shown in figure 6 or 12. When the medicine cores are sequentially placed in the pen holder, medicines on the later medicine core can enter the medicine holder cavity 212 of the former medicine core, and the combination mode can save the discharge space of the medicine cores in the pen holder and reduce the length of the pen holder.

As shown in fig. 12 to 14, a functional lever 213 is installed at the front of the medicine tray. The function lever is flat and has a protrusion 214 at the front end, which is exposed when the medicine adhered to the function lever is taken, and which can be used to stimulate the K point of the teeth. Or a flat functional rod is used as a tongue depressor.

In the solution shown in fig. 15, a vibrator 16 is mounted on the outer wall of the barrel 1. The vibrator is started, and the pen holder vibrates accordingly.

The swallowing training pen further comprises a pen cap 15. As shown in fig. 16, the front section of the pen cap is connected with a long rod 151 which can be folded on the pen cap, the pen cap is connected with the long rod through a rotating shaft 152, and the front end of the long rod is provided with a protrusion 214. The projections may be used to stimulate the K-point of the teeth. Or the long rod can also be used as a tongue depressor.

The medicine on the swallowing training pen is a compound licorice preparation, and is prepared by mixing and proportioning a plurality of medicines, wherein the medicines comprise 175-350ml of licorice liquid, 2.5-7.5g of bikino, 40-120 ten thousand units of gentamicin, 0.05-0.15g of lidocaine, and a proper amount of auxiliary materials and solid agents for nourishing yin, moistening dryness and promoting fluid.

In a specific embodiment, the medicine comprises 250ml of liquorice liquid, 5g of bivalve, 80 ten thousand units of gentamicin, 0.1g of lidocaine, and proper amount of auxiliary materials and solid agents for nourishing yin, moistening dryness and promoting fluid production.

The following functions of the main components and auxiliary materials in the compound licorice preparation are as follows:

licorice root: the modern medical research proves that the licorice contains various active ingredients, has various effects of resisting virus, resisting ulcer, relieving pain, regulating immunity, endocrine and the like, and the licorice extract can effectively inhibit staphylococcus aureus, bacillus subtilis, clostridium, pseudomonas aerogenes and the like.

Bikini: has deep hydration, and is effective in keeping moisture and supplementing water; can increase blood flow speed, improve microcirculation, help discharge exudates, and relieve inflammation; improving tissue hypoxia and relieving pain; it also can reduce 1L-6 generation, has positive significance for inhibiting muscle fibrosis caused by radiotherapy, and has effects of moistening, preventing fibrosis, relieving pain, promoting exudate removal, and relieving inflammation.

Lidocaine: the amide-type local anesthetic has the characteristics of quick acting, wide dispersion, strong penetrability and the like, and can paralyze mucous membrane peripheral sensation during chemical treatment to cause analgesic effect, and the cryotherapy can reduce the reduction of local blood flow of the oral cavity, limit the diffusion of inflammation, inhibit the movement of the oral mucous membrane and reduce the sensitivity of nerve peripheral.

Auxiliary materials for nourishing yin, moistening dryness and promoting fluid production: the food which is added with proper amount of foods for nourishing yin, moistening dryness and promoting the production of body fluid, such as sugarcane juice, pear juice, water chestnut juice, watermelon juice, lotus root juice, strawberry juice, orange juice and the like, has the effects of nourishing yin, moistening dryness and promoting the production of body fluid, reduces dry mouth, increases salivary secretion and promotes recovery of gustatory dysfunction.

And (3) a solid agent: the solid agent is pectin, and further comprises color enhancer caramel, and sweetener such as corn syrup, mel, white sugar or xylitol.

The compound licorice preparation as a medicine can be prepared according to one of the following methods.

The preparation method 1 specifically comprises the following steps:

(1) 10-30g of raw licorice is selected, 250-750ml of water is added for soaking for 30min, then the mixture is decocted with small fire for 10min, filtered, deslagged and naturally cooled to be about 125-375ml for standby. Taking 125-375ml of licorice liquid, adding 2.5-7.5g of bivalve, 40-120 ten thousand units of gentamicin, 0.05-0.15g of lidocaine, 10-30g of sugarcane juice, 20-60g of pectin, 5-15g of caramel and 10-30g of corn syrup to form a mixture;

(2) Pouring the mixture obtained in the step (1) into a lollipop die, pressing into an elliptic sugar structure with the thickness of 0.5cm and the width of 2cm, and performing condensation drying on a stick;

(3) And after the condensation and drying are finished, preparing the compound liquorice lollipop for treating the radioactive oral mucositis.

The preparation method 2 specifically comprises the following steps:

(1) 10-30g of raw licorice is selected, 250-750ml of water is added for soaking for 30min, then the mixture is decocted with small fire for 10min, filtered, deslagged and naturally cooled to be about 125-375ml for standby. Taking 125-375ml of licorice liquid, adding 2.5-7.5g of bivalve, 40-120 ten thousand units of gentamicin, 0.05-0.15g of lidocaine, 10-30g of chufa juice, 20-60g of pectin, 5-15g of caramel and 10-30g of xylitol to form a mixture;

The preparation method adopts a low sugar formula, and is suitable for diabetics.

The preparation method 3 comprises the following specific steps:

(1) Selecting 10g of raw licorice, soaking in 250ml of water for 30min, decocting with slow fire for 10min, filtering to remove residues, and naturally cooling to obtain 125ml for later use. Taking 125ml of licorice liquid, adding 2.5g of bivalve, 40 ten thousand units of gentamicin, 0.05g of lidocaine, 10g of sugarcane juice, 20g of pectin, 5g of caramel and 10g of corn syrup to form a mixture;

Preparation method 4 specifically comprises the following steps:

(1) 30g of raw licorice is selected, 750ml of water is added for soaking for 30min, then the mixture is decocted for 10min with small fire, filtered, deslagged and naturally cooled to be about 375ml for standby. Taking 375ml of licorice liquid, adding 7.5g of bivalve, 120 ten thousand units of gentamicin, 0.15g of lidocaine, 30g of sugarcane juice, 60g of pectin, 15g of caramel and 30g of corn syrup to form a mixture;

The preparation method 5 specifically comprises the following steps:

(1) Selecting 20g of raw licorice, soaking in 500ml of water for 30min, decocting with slow fire for 10min, filtering to remove residues, and naturally cooling to obtain about 250ml for later use. Taking 250ml of licorice liquid, adding 5g of bivalve, 80 ten thousand units of gentamicin, 0.1g of lidocaine, 20g of sugarcane juice, 40g of pectin, 10g of caramel and 20g of corn syrup to form a mixture;

The segmented administration swallowing training pen is clinically applied to treatment of radioactive oral mucositis. According to the illness state of the patient, a proper compound licorice preparation is prepared, and the compound licorice preparation is adhered to a multifunctional rod of a medicine support to prepare a medicine core. The medicine cores are sequentially filled into the core storage cavity of the swallowing training pen one by one, the medicine of the forefront medicine core extends out of the medicine outlet, and then the pen cap is covered for standby. The drug cores placed in the pen holder can use drugs with different formulas or dosages, for example, the corresponding drug cores are sequentially arranged in the pen holder according to the type and the time of each administration of a patient. The medicine is put in advance, so that the occurrence of forgetting to take the medicine can be avoided.

When a patient needs to do swallowing training or diet, the pen cap is removed, so that the patient holds the pen holder to suck medicines at the front end of the pen holder. The preparation in the medicine is slowly melted in the mouth of the patient, is not easy to choke the patient, and the components in the medicine can play a role in anesthetizing the oral cavity and reducing pain. If only a small amount of medicines are taken to play the effect of oral anesthesia, the swallowing training pen is taken out, and the pen cap is covered to isolate the rest medicines which are not taken out from the outside. If the oral rehabilitation training is needed at this time, the long rod 151 on the pen cap is opened, the long rod is extended into the oral cavity, the K point is stimulated through the bulge 214 on the long rod, and the opening and swallowing starting of the patient are induced. Or the long rod is directly used as a tongue depressor.

After the medicine at the forefront is taken, the multifunctional rod on the medicine support is exposed, and K-point stimulation can be finished or tongue depressor can be used for tongue depressor training by utilizing the multifunctional rod. The pen holder can be used as a handheld part, and medical staff can hold the pen holder by hand to help a patient complete swallowing training.

Therefore, the medicine on the segmented administration swallowing training pen can be withdrawn from the oral cavity in time, and the requirement of the radioactive oral mucositis patient on the split administration can be met. The swallowing training pen integrates a plurality of swallowing training tools, so that the swallowing training is more convenient.

Claims

1. The utility model provides a deglutition training pen of segmentation dosing, includes the pen-holder of inside dress flux core, its characterized in that: the medicine core storing cavity in the pen holder can contain at least two medicine cores which are sequentially arranged in the medicine core storing cavity, the pushing part is arranged at the rear end of the pen holder, medicines on the medicine cores are sequentially pushed to the medicine outlet, the clamping part is arranged at the front end of the pen holder, so that the medicines are not separated from the pen holder in the process of being taken by a patient, the medicine cores comprise medicine holders and medicines connected to the medicine holders, the functional rods are arranged at the front parts of the medicine holders, and the functional rods are flat and are provided with bulges at the front ends.

2. The swallowing training pen according to claim 1, wherein the pushing part is a piston type pushing structure or a spring structure.

3. The swallowing exercise pen according to claim 1, wherein the gripping portion is selected from the group consisting of a blocking member, a clip member with a clip leg, or a bump on a drug holder and a bump bayonet on a pen shaft.

4. The swallowing exercise pen according to claim 1, wherein the drug holder is a hollow structure.

5. The swallowing training pen according to claim 1, wherein a vibrator is mounted on the outer wall of the pen shaft.

6. The swallowing training pen according to claim 1, wherein the pen holder further comprises a pen cap, the front section of the pen cap is connected with a long rod which can be folded on the pen cap, and the pen cap is connected with the long rod through a rotating shaft.

7. The swallowing exercise pen according to claim 6, wherein the front end of the wand is provided with a protrusion.

8. The swallowing training pen according to claim 1, wherein the medicine is a compound licorice preparation, and the medicine comprises 175-350ml licorice liquid, 2.5-7.5g bikini, 40-120 ten thousand gentamicin, 0.05-0.15g lidocaine, and proper amount of auxiliary materials and solid agents for nourishing yin, moistening dryness and promoting fluid production.