CN106692217A - Pharmaceutical composition for treating rhinitis - Google Patents
Pharmaceutical composition for treating rhinitis Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating rhinitis and a preparation method thereof. The pharmaceutical composition is prepared from phytolaccagenin B, herb of neolepisorus ovatus and herb of plagiogyria distinctissima which are used as raw medicine materials according to a ratio. The pharmaceutical composition can be prepared into various preparations according to a conventional preparation preparing process and can achieve a curative effect of treating rhinitis.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of treat pharmaceutical composition of rhinitis and preparation method thereof.
Background technology
Rhinitis chronic is the chronic inflammation disease of bronchia mucosal and submucosa, with runny nose as primary symptom of having a stuffy nose.Chronic nose
Inflammation is the chronic inflammation disease of schneiderian membrance and submucosa.More by acute rhinitis recurrent exerbation or do not recover for a long time, or by neighbouring
Organ inflammation the reason such as is involved and is caused.It is divided into：1. simple rhinitis（In alternately, intermittent nasal obstruction, schneiderian membrance chronic congestion swells
Swollen, nasal meatus has sticky discharge）；2. hypertrophic rhinitis（Had a stuffy nose in continuation, concha mucous membrane is plump, rough, such as mulberry fruit
Shape）.Treatment, using based on hormone, operative treatment being used concha fertilizer thick one more in nasal cavity.Rhinitis chronic belongs to motherland's medical science " nose
Stop up " category.Motherland's medical science
Think that chronic rhinitis is generally the positive deficiency of vital energy, evil clear caused, its interpretation of the cause, onset and process of an illness is relevant with lung, the dirty functional disturbance of spleen two and qi depression to blood stasis.Cause
Nose for lung key, lung and then nose key tonneau, if insufficiency of lung-QI, defensive Qi instability, exopathogen is easily violated lung and is defended, lung qi lose clearly respectful function,
So that evil stagnant nose key nasal obstruction is obstructed；And deficiency-weakness of spleen-QI, transporting is not good for, and loses the duty of ascending the clear and descending the turbid, and wet turbid delay nose key stops up resistance arteries and veins
Network, QI-blood circulation is not smooth also to cause nasal obstruction obstructed.Therefore exopathogen internal injury can cause asthenia of pulmonosplenic qi, evil stagnant nose key, evil poison is stayed for a long time, blood stasis nose
Key, qi depression to blood stasis, so that schneiderian membrance and concha swelling, have a stuffy nose obstructed, severe one concha is in mulberry fruit shape.The suitable QI invigorating of tcm treatment method is lived
Blood, stagnation resolvation is sensible, dispelling wind and eliminating dampness.
Esculentoside B（Phytolaccasaponin B）：CAS 66656-92-6, molecular formula C48H76O21, molecular weight
989.10.【Bioactivity】Anti-inflammatory, anti rheumatism action.【Ingredient origin】Phytolacca acinosa Phytolacca esculenta [Syn.
Phytolacca acinosa]。
Ovate neolepisorus herb：It is Polypodiaceae shield Cyclosorus plant ovum leaf shield fern Neolepisorus ovatus (Bedd.) Ching
The herb of [Pleopeltis ovata Bedd.].Whole year can harvest, and after excavation, clean, and dry.【Nature and flavor】It is bitter；It is cool.【Return
Through】The heart；Lung；Bladder warp.【Indication】Clearing heat and promoting diuresis；Hemostasis；Removing toxic substances.Main heat gonorrhea；Difficult urination；Hematuria；Tuberculosis is spat blood；Tell
Blood；Traumatism and bleeding；Carbuncle swells；Scald.【Former phytomorph】Plant 15-45cm high.Rhizome grows wild, close by ovum shape lanceolar
Scale, length is tapering, and there is thin tooth at edge.Ye Yuansheng；Petiole 10-20cm long, by scale；Blade ground paper matter, ovum shape lanceolar to ovum
Shape Long Circle or nearly triangle, 7-12cm wide, tapering, base portion is wider, circular to circle wedge shape, how many downward in petiole, full edge or
How much bottom divides；Lateral vein is obvious.Sporangiorus is big, circular, and irregular 1 to several rows are lined up in lateral vein both sides, there is shield when young
Shape paraphysis is covered.Record in dictionary of medicinal plant.
Plagiogyria distinctissima ching：It is Plagiogyriaceae knurl foot Cyclosorus plant Plagiogyria distinctissima ching Plagiogyria rankanensis
Hayata[P.distinctissima Ching;P.adnata Bedd.] herb or rhizome.Summer, autumn harvesting, clean, and shine
It is dry.【Nature and flavor】It is pungent；It is cool.【Return through】Enter bladder, lung, the warp of liver three.【Indication】Deliver heat-clearing；Dispelling wind and arresting itching；Promoting eruption.Main flow row
Sexuality emits；Measles；Pruitus；Metrorrhagia；Sprain.【Former phytomorph】Plant 30-45cm high.Has the rhizome of upright or oblique ascension.
Leafage gives birth to, two types；Nutrition petiole 14-18cm long, base portion prismatic has 1-2 to pneumatophore, is slightly in upwards prismatic or semicircle
Shape；Blade long-narrow triangular mesh or ovum shape lanceolar, 17-25cm long, base portion 8-11cm wide, a pinnation；Accessory pinna papery,
15-20 pairs, alternate, 4-6cm long, 8-13mm wide, top and bottom are green, and acumen is micro-bend in falciform lanceolar, base portion upwards
Asymmetric, upside is prolonged along rachis, and downside is circular, edge nearly full edge or with teeth；Vein pinniform, lateral vein is single or two forked.Spore
Cotyledon petioles 30-40cm long；Time pinniform of blade, 14-22cm long, 4-6cm wide；Accessory pinna 15-25 pairs, it is in linear extremely to shrink,
5-7cm long, 2-3mm wide；The usual y-bend of lateral vein, extends at limb 1/2.Sporangium is born in scun top, and accessory pinna is covered with when ripe
Below.Record in dictionary of medicinal plant.
1 bulk drug chemical constitution：
Esculentoside B（Phytolaccasaponin B）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided it is a kind of it is effective treatment rhinitis pharmaceutical composition and its
Preparation method.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition of the treatment rhinitis be：
Esculentoside B7-10 weight portion ovate neolepisorus herb 3084-3100 weight portion Plagiogyria distinctissima ching 2100-2200 weight portions.
The pharmaceutical composition for the treatment of rhinitis is preferably used in, is made up of the bulk drug of following weight portion：
The weight portion of 3090 weight portion Plagiogyria distinctissima ching of esculentoside B8 weight portions ovate neolepisorus herb 2150.
A kind of pharmaceutical composition for treating rhinitis, it is characterised in that pharmaceutical composition can be using the conventional method of galenic pharmacy
Prepare piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for treating rhinitis, it is characterised in that the treatment that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Rhinitis medicine.
A kind of preparation method of the pharmaceutical composition for treating rhinitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Esculentoside B7-10 weight portion ovate neolepisorus herb 3084-3100 weight portion sickleleaf knurl foots
Fern 2100-2200 weight portions；
Preparation method：
（1）Esculentoside B, ovate neolepisorus herb, Plagiogyria distinctissima ching are taken by bulk drug proportioning, is mixed, with the ethanol of weight percent concentration 29%
As solvent, taken in 24.5 DEG C of temperature extractions, extraction time is 23 times, and each extraction time is 19 hours, and each solvent load is
50 times of bulk drug gross weight, filtration obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.01,
Filtration, liquid is first washed with water, then washed with the ethanol solution of weight percent concentration 18% by HPD450 large pore resin absorption columns
De- HPD450 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 18%, reclaim ethanol, and concentrate drying is obtained final product
Extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 69% as solvent, heating and refluxing extraction 28 times is carried every time
The time is taken for 0.2 hour, each solvent load is 23 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.02 is concentrated into, filtered, liquid is first washed with water, then use weight by HP10 large pore resin absorption columns
The ethanol solution of percent concentration 86% elutes HP10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 86%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for treating rhinitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：The weight of 3090 weight portion Plagiogyria distinctissima ching of esculentoside B8 weight portions ovate neolepisorus herb 2150
Amount part；
Preparation method：
（1）Esculentoside B, ovate neolepisorus herb, Plagiogyria distinctissima ching are taken by bulk drug proportioning, is mixed, with the ethanol of weight percent concentration 29%
As solvent, taken in 24.5 DEG C of temperature extractions, extraction time is 23 times, and each extraction time is 19 hours, and each solvent load is
50 times of bulk drug gross weight, filtration obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.01,
Filtration, liquid is first washed with water, then washed with the ethanol solution of weight percent concentration 18% by HPD450 large pore resin absorption columns
De- HPD450 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 18%, reclaim ethanol, and concentrate drying is obtained final product
Extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 69% as solvent, heating and refluxing extraction 28 times is carried every time
The time is taken for 0.2 hour, each solvent load is 23 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.02 is concentrated into, filtered, liquid is first washed with water, then use weight by HP10 large pore resin absorption columns
The ethanol solution of percent concentration 86% elutes HP10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 86%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for treating rhinitis, it is characterised in that pharmaceutical composition can use galenic pharmacy
Conventional method prepare piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for treating rhinitis, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine
Composition treatment rhinitis medicine.
Medicine composite for curing rhinitis is evident in efficacy.
Specific embodiment
Embodiment 1：Treat pharmaceutical composition of rhinitis and preparation method thereof
Treat rhinitis pharmaceutical composition bulk drug composition and weight portion be：Esculentoside B8g ovate neolepisorus herb 3090g sickleleaves
Knurl foot fern 2150g；
Preparation method：
（1）Esculentoside B, ovate neolepisorus herb, Plagiogyria distinctissima ching are taken by bulk drug proportioning, is mixed, with the ethanol of weight percent concentration 29%
As solvent, taken in 24.5 DEG C of temperature extractions, extraction time is 23 times, and each extraction time is 19 hours, and each solvent load is
50 times of bulk drug gross weight, filtration obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.01,
Filtration, liquid is first washed with water, then washed with the ethanol solution of weight percent concentration 18% by HPD450 large pore resin absorption columns
De- HPD450 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 18%, reclaim ethanol, and concentrate drying is obtained final product
Extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 69% as solvent, heating and refluxing extraction 28 times is carried every time
The time is taken for 0.2 hour, each solvent load is 23 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.02 is concentrated into, filtered, liquid is first washed with water, then use weight by HP10 large pore resin absorption columns
The ethanol solution of percent concentration 86% elutes HP10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 86%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Treat pharmaceutical composition of rhinitis and preparation method thereof
Treat rhinitis pharmaceutical composition bulk drug composition and weight portion be：Esculentoside B7g ovate neolepisorus herb 3100g sickleleaves
Knurl foot fern 2100g；
Preparation method：
（1）Esculentoside B, ovate neolepisorus herb, Plagiogyria distinctissima ching are taken by bulk drug proportioning, is mixed, with the ethanol of weight percent concentration 29%
As solvent, taken in 24.5 DEG C of temperature extractions, extraction time is 23 times, and each extraction time is 19 hours, and each solvent load is
50 times of bulk drug gross weight, filtration obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.01,
Filtration, liquid is first washed with water, then washed with the ethanol solution of weight percent concentration 18% by HPD450 large pore resin absorption columns
De- HPD450 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 18%, reclaim ethanol, and concentrate drying is obtained final product
Extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 69% as solvent, heating and refluxing extraction 28 times is carried every time
The time is taken for 0.2 hour, each solvent load is 23 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.02 is concentrated into, filtered, liquid is first washed with water, then use weight by HP10 large pore resin absorption columns
The ethanol solution of percent concentration 86% elutes HP10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 86%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Treat pharmaceutical composition of rhinitis and preparation method thereof
Treat rhinitis pharmaceutical composition bulk drug composition and weight portion be：Esculentoside B10g ovate neolepisorus herb 3084g sickles
Leaf nodule foot fern 2200g；
Preparation method：
（1）Esculentoside B, ovate neolepisorus herb, Plagiogyria distinctissima ching are taken by bulk drug proportioning, is mixed, with the ethanol of weight percent concentration 29%
As solvent, taken in 24.5 DEG C of temperature extractions, extraction time is 23 times, and each extraction time is 19 hours, and each solvent load is
50 times of bulk drug gross weight, filtration obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.01,
Filtration, liquid is first washed with water, then washed with the ethanol solution of weight percent concentration 18% by HPD450 large pore resin absorption columns
De- HPD450 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 18%, reclaim ethanol, and concentrate drying is obtained final product
Extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 69% as solvent, heating and refluxing extraction 28 times is carried every time
The time is taken for 0.2 hour, each solvent load is 23 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.02 is concentrated into, filtered, liquid is first washed with water, then use weight by HP10 large pore resin absorption columns
The ethanol solution of percent concentration 86% elutes HP10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 86%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 248g of Example 1, adds starch 275, mixes, and granulation is dried, plus microcrystalline cellulose 102g, stearic
Sour magnesium 6g, mixes, and is pressed into 1800, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 260g of Example 2, adds starch 400g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, and encapsulated 2500, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 257g water-baths and boil molten, add the pharmaceutical composition 13g of embodiment 3, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is 4 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.4cm away from liquid level, and drop speed is optimum condition with every point 52 drop, and the cold of dripping pill surface is blotted with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Experimental example 1：Treat the experimental study of rhinitis
1 clinical data
Patient meets《ENT ＆ HN Surgery Dept.》（The national higher medical education teaching materials of Tian Yongquan the 7th edition）In chronic nose
Scorching diagnostic criteria.38 are out-patient, man 19, female 19；Age is minimum 16 years old, maximum 56 years old；It is 2 that the course of disease is most short
It is individual month, most long more than 6 years.It is mainly shown as nasal obstruction（It is alternately or lasting）, runny nose（Clear or turbid tears）, it is often accompanied by alliteration headache, smells
Feel that difference and tinnitus, ear are closed.Training is checked：Simple rhinitis sees schneiderian membrance and concha hyperemia swelling, and nasal meatus has sticky discharge；Fertilizer
Thickness rhinitis is shown in that concha Mucosal mast color is dim, rough, such as mulberry fruit shape.Wherein simple rhinitis 22, hypertrophic rhinitis
16.
2 treatment methods
The side based on pharmaceutical composition.Prescription is constituted：Pharmaceutical composition（The pharmaceutical composition of embodiment 1）5g.Added and subtracted with disease：Nose
The yellow sticky person of tears, plus cape jasmine, the root of large-flowered skullcap, dandelion etc. are with clearing heat and detoxicating；The viscous tears person of stream, plus Poria cocos, coix seed, myrobalan etc. are dehumidifying
Dispel tears；Distending pain in the head person, plus the root of Dahurain angelica, Jehol Ligusticum Rhizome, play both sides of the street etc. to dredge meridian and relieving pain；The dark red person of schneiderian membrance swelling, color, plus the root of kudzu vine, the root bark of tree peony,
Red sage root etc. is with regulating qi to disperse stagnation；There is a mulberry fruit shape concha person, plus peach kernel, safflower, Rhizoma Sparganii etc. are with promoting blood circulation.Daily 1 dose, decocting 300
ML, morning and evening sub-service, 7 doses is 1 course for the treatment of.Gynecologic menstrual withdraws 1 course for the treatment of, and advises patient's moderate exercise, it is to avoid nose is by various
Stimulate.
3 criterions of therapeutical effect
Clinical cure：The symptoms such as nasal obstruction, runny nose, distending pain in the head disappear, and smell recovers normal, training inspection：Schneiderian membrance hyperemia swelling
Substantially mitigate, in, concha nasalis inferior is without obvious congested, enlargement；Effectively：The symptoms such as nasal obstruction, runny nose, distending pain in the head substantially mitigate, training inspection
Look into：Schneiderian membrance hyperemia swelling mitigates, in, concha nasalis inferior is congested, enlargement substantially mitigates；It is invalid：Symptom and sign is unchanged before and after treatment.
Medication most short 21d, 58d most long, average out to 30d.
4 treatment results
Using we treatment patient 38, cure 15, take a turn for the better 19, invalid 4, total effective rate is 89.47%.
5 model cases
Lee so-and-so, man, 27 years old, civil servant.The first visit of 2011 Nian9Yue Lai institutes.Main suit is to have a stuffy nose more than 5 years repeatedly, the white tears of wake.5 years
To cause nasal obstruction because suffering from cold etc., in alternately, stream glues tears in vain, and alliteration, nasal sound weight is then weighed to the cold, once takes Western medicine, Chinese patent drug certainly
（Medicine name is unknown）Remission afterwards, but when it is light when weight, recurrent exerbation.Nearly January comes, and because suffering from cold, above-mentioned symptom is aggravated.Receive difference,
Sleep can, big loose stool.It is previously weak.Have a medical check-up：Whole body ordinary circumstance can, lusterless complexion, body is slightly thin, and pink tongue, tongue are white, weak pulse.
Training is checked：Schneiderian membrance chronic congestion swelling, in, lower first swelling substantially, color is dark red, slightly plump, and nasal meatus has more white sticky
Secretion.Tcm diagnosis：Chronic rhinitis, card category qi deficiency to blood stasis.Suitable qi and activate blood circulation is controlled, stagnation resolvation is sensible and removes tears.Doctor trained in Western medicine is diagnosed：Chronic nose
It is scorching.Prescription：Pharmaceutical composition（The pharmaceutical composition of embodiment 1）5g, 7 doses, daily 1 dose, decocting 300mL, morning and evening sub-service.Two
Examine, Huan Zheshu：Nasal obstruction is light on daytime, and night, substantially runny nose amount was significantly reduced, and alliteration, nasal sound mitigate, and was defecated formed.Training is examined
Look into：Schneiderian membrance swelling mitigate, in, lower first diminish, a small amount of sticky discharge of nasal meatus.Top takes 7 doses again.Three examine, and patient states and takes
After medicine, nasal obstruction daytime is without night occasionally has, not runny nose, and without alliteration and nasal sound, stool is adjusted.Training is checked：Nasal cavity is without exception.
Claims (8)
1. a kind of pharmaceutical composition for treating rhinitis, it is characterised in that be made the composition and weight of the bulk drug of the pharmaceutical composition
Part it is：
Esculentoside B7-10 weight portion ovate neolepisorus herb 3084-3100 weight portion Plagiogyria distinctissima ching 2100-2200 weight portions.
2. a kind of pharmaceutical composition for treating rhinitis according to claim 1, it is characterised in that be made the pharmaceutical composition
The composition and weight portion of bulk drug be：
The weight portion of 3090 weight portion Plagiogyria distinctissima ching of esculentoside B8 weight portions ovate neolepisorus herb 2150.
3. a kind of pharmaceutical composition for treating rhinitis according to claim 1, it is characterised in that pharmaceutical composition can be used
The conventional method of galenic pharmacy prepares piece agent or capsule or dripping pill.
4. a kind of pharmaceutical composition for treating rhinitis according to claim 1, it is characterised in that pharmaceutical composition and chemical drugs
Or the treatment rhinitis medicine of Chinese medicine composition.
5. a kind of preparation method of the pharmaceutical composition for treating rhinitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Esculentoside B7-10 weight portion ovate neolepisorus herb 3084-3100 weight portion sickleleaf knurl foots
Fern 2100-2200 weight portions；
Preparation method：
（1）Esculentoside B, ovate neolepisorus herb, Plagiogyria distinctissima ching are taken by bulk drug proportioning, is mixed, with the ethanol of weight percent concentration 29%
As solvent, taken in 24.5 DEG C of temperature extractions, extraction time is 23 times, and each extraction time is 19 hours, and each solvent load is
50 times of bulk drug gross weight, filtration obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.01,
Filtration, liquid is first washed with water, then washed with the ethanol solution of weight percent concentration 18% by HPD450 large pore resin absorption columns
De- HPD450 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 18%, reclaim ethanol, and concentrate drying is obtained final product
Extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 69% as solvent, heating and refluxing extraction 28 times is carried every time
The time is taken for 0.2 hour, each solvent load is 23 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.02 is concentrated into, filtered, liquid is first washed with water, then use weight by HP10 large pore resin absorption columns
The ethanol solution of percent concentration 86% elutes HP10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 86%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for treating rhinitis according to claim 5, it is characterised in that by following step
It is rapid to prepare：
The composition and weight portion of bulk drug be：The weight of 3090 weight portion Plagiogyria distinctissima ching of esculentoside B8 weight portions ovate neolepisorus herb 2150
Amount part；
Preparation method：
（1）Esculentoside B, ovate neolepisorus herb, Plagiogyria distinctissima ching are taken by bulk drug proportioning, is mixed, with the ethanol of weight percent concentration 29%
As solvent, taken in 24.5 DEG C of temperature extractions, extraction time is 23 times, and each extraction time is 19 hours, and each solvent load is
50 times of bulk drug gross weight, filtration obtains dregs of a decoction A and extract solution A, and extract solution A reclaims ethanol, is concentrated into relative density 1.01,
Filtration, liquid is first washed with water, then washed with the ethanol solution of weight percent concentration 18% by HPD450 large pore resin absorption columns
De- HPD450 large pore resin absorption columns, collect the ethanol eluate of weight percent concentration 18%, reclaim ethanol, and concentrate drying is obtained final product
Extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 69% as solvent, heating and refluxing extraction 28 times is carried every time
The time is taken for 0.2 hour, each solvent load is 23 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.02 is concentrated into, filtered, liquid is first washed with water, then use weight by HP10 large pore resin absorption columns
The ethanol solution of percent concentration 86% elutes HP10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 86%,
Ethanol is reclaimed, concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for treating rhinitis according to claim 5, it is characterised in that drug regimen
Thing can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for treating rhinitis according to claim 5, it is characterised in that drug regimen
Thing and chemical drugs or Chinese medicine composition treatment rhinitis medicine.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133135.0A CN106692217A (en) | 2016-12-10 | 2016-12-10 | Pharmaceutical composition for treating rhinitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611133135.0A CN106692217A (en) | 2016-12-10 | 2016-12-10 | Pharmaceutical composition for treating rhinitis |
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| Publication Number | Publication Date |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611133135.0A Withdrawn CN106692217A (en) | 2016-12-10 | 2016-12-10 | Pharmaceutical composition for treating rhinitis |
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| Country | Link |
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| CN (1) | CN106692217A (en) |
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2016
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Application publication date: 20170524 |