CN106692201A - Composition for preventing and treating radiation-induced oral mucositis and application of composition - Google Patents
Composition for preventing and treating radiation-induced oral mucositis and application of composition Download PDFInfo
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- CN106692201A CN106692201A CN201611264404.7A CN201611264404A CN106692201A CN 106692201 A CN106692201 A CN 106692201A CN 201611264404 A CN201611264404 A CN 201611264404A CN 106692201 A CN106692201 A CN 106692201A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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Abstract
The invention belongs to the field of medical treatment and particularly relates to composition for preventing and treating radiation-induced oral mucositis and an application of the composition. The composition contains mytilus edulis linnaeus soft tissue extract and fungal polysaccharide. The composition for preventing and treating radiation-induced oral mucositis can block radiation injury caused by extrinsic factors, has ultrastrong radiation-proof effect, promotes tissue regeneration and repair of oral mucosa while preventing oral mucositis, shortens wound healing time and has functions of diminishing inflammation and relieving pain. The composition is mild and non-irritating, has no toxic or side effects and avoids usage dependency.
Description
Technical field
The invention belongs to field of medicaments, more particularly to a kind of composition for preventing and treating radioactivity portacaval mucositis and its should
With.
Background technology
In medical domain, extensively, especially clinic has carried out radiotherapy to tumor patient for radiodiagnosis and treatment use
Conventional means as oncotherapy, each of which increases hospitalized patients and the probability of radioactive exposure.Be chronically at directly or
Connect under the conditions of ionization radiation irradiation, radiation can seriously damage whole body body function, cause immunity of organism, defence reparation function serious
Decline, patients with radioactive mucositis of oral cavity is one of common severe complication in head and neck neoplasm radiation therapy process, is initially mouth
Transmucosal is red and swollen, capillary reactivity expansion, contrafluxion, erythema, erosion, ulcer, pseudomembrane covering, severe patient then occurs
Merge the extensive atrophy of mucous membrane and local infection.Often feel oral mucosa discomfort, dry, halitosis, or even continue pain unbearably.Put
Ray makes the capilary in radiation open country that swelling to occur in addition to coup injury mucous membrane of mouth, and tube wall thickening, tube chamber narrows or closes
, there is damaged part blood supply insufficiency in plug, and oral mucositis occur.
It is clinically many for patients with radioactive mucositis of oral cavity to treat and alleviate using topical anti-inflammatory, sterilized and anodyne, but
It is that reparation of the simple anti-inflammation to mucous membrane does not have a positive effect, and radiates and cause the immunity of organisms to reduce, Chang Yinhe
And other infect and aggravate symptom, wound healing is influenceed.So, the research and development for radiating protective agents are asking for current urgent need to resolve
Topic.
Mussel (Mytilusedulis Linnaeus) is a kind of sea mollusk, belongs to bivalve shellfish, is commonly called as " blue or green
Mouthful " and " mussel ", each coastwise contries of throughout world.Mussel species are various, and only coastal area of china just has kind more than 30, and economic worth is higher
Have kind more than 10, wherein Mytilus galloprovincialis, Perna viridis and Trachyostracous mussel is main breed variety.Enriched Mussel containing protein, fat,
The nutrients such as carbohydrate, calcium, phosphorus, iron, riboflavin, niacin, and with medical value very high.
Fungi polysaccharide is that the class isolated from fungus sporophore, mycelium, zymotic fluid can control cell division point
Change, adjust the active polysaccharide of cell growth and aging, typically all by monose more than ten molecules by glycosidic bond connection
Into macromolecule polymer.Between fungi polysaccharide molecule monomer, combined with β (1-6) glycosidic bond with β (1-3) in large quantities, formed chain
Shape molecule, with spiral helicine spatial configuration.Scientific experiment shows that fungi polysaccharide has very strong antitumor activity, thin to cancer
Born of the same parents have a very strong restraint, and in immunological regulation, lowering blood pressure and blood fat, antithrombotic, and the aspect such as promoting digestion and protecting liver plays important work
With.Fungi polysaccharide has been widely used in the clinical treatment of the diseases such as immunodefiiciency disease, autoimmune disease and tumour, because
And it is referred to as a kind of important biological response modifiers.
The content of the invention
For the defect for overcoming above-mentioned prior art to exist, the present invention proposes a kind of group for preventing and treating radioactivity portacaval mucositis
Compound and its application, the composition can block radiation injury caused by extrinsic factor, with superpower radiation resistance, in advance
Promote oral cavity mucous membrane tissue regeneration while anti-oral mucositis and repair, shorten wound healing time, anti-inflammatory analgetic.Described group
Compound is gentle, non-stimulated, have no toxic side effect, without using dependence.
To achieve the above object, one aspect of the present invention is related to a kind of composition for preventing and treating radioactivity portacaval mucositis,
Characterized in that, the composition includes mussel soft tissue extract and fungi polysaccharide.
One or more implementation methods of the invention, the fungi polysaccharide in the composition is lentinan, acupuncture needle
Mushroom polysaccharide, GL-B, Cordyceps sinensis polysaccharide, pachymaran, grifola polysaccharide, Blackfungus polyhexose, mix one or more of tremella polysaccharides
Close.
One or more implementation methods of the invention, the composition for preventing and treating radioactivity portacaval mucositis is by gross weight
Gauge, including：0.1-15 parts and fungi polysaccharide 0.1-20 parts of mussel soft tissue extract.
One or more implementation methods of the invention, the composition for preventing and treating radioactivity portacaval mucositis is by gross weight
Gauge, 0.1-15 parts, fungi polysaccharide 0.1-20 parts of mussel soft tissue extract.By gross weight meter, mussel soft tissue extract is
Such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5
Part, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts,
14.5 parts, 15 parts etc., fungi polysaccharide is such as 0.1 part, 0.2 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5
Part, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts,
12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, 15.5 parts, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts,
18.5 parts, 19 parts, 19.5 parts, 20 parts etc..
One or more aspects of the invention, in the composition for preventing and treating radioactivity portacaval mucositis：Mussel is soft
Tissue extract and fungi polysaccharide are dry powder.
One or more aspects of the invention, in the composition for preventing and treating radioactivity portacaval mucositis：Mussel is soft
Tissue extract and fungi polysaccharide are liquid.
One or more aspects of the invention, the composition for preventing and treating radioactivity portacaval mucositis can be further
Auxiliary material is added, the auxiliary material can be antioxidant, bacteriostatic agent, essence or host material etc..For example, described prevent and treat radioactivity mouthful
The scorching composition of transmucosal can further add honey, propolis, menthol, peppermint oil, menthol etc..
One or more aspects of the invention, the final ph of the composition for preventing and treating radioactivity portacaval mucositis
Can be 3.8-5.8, for example, 3.8-5.5, such as be 4.0-5.6.
One or more aspects of the invention, the mussel soft tissue extract is all in addition to shell with mussel
Component is raw material, and the supernatant for being extracted by acidic aqueous solution and being obtained, wherein protein content are 0.2-15.0mg/ml, pH
Value 1.0-6.0.Especially, can be with byssus as raw material.
One or more aspects of the invention, the mussel can include Mytilus galloprovincialis, Perna viridis and Trachyostracous mussel
In one kind, two or three.
One or more implementation methods of the invention, the acidic aqueous solution can include：Acetic acid-acetate buffer
Liquid, acetic acid, citric acid, perchloric acid etc., but not limited to this.
One or more implementation methods of the invention, the protein content of the mussel soft tissue extract can be
Such as 0.2mg/ml, 0.3mg/ml, 0.4mg/ml, 0.5mg/ml, 0.6mg/ml, 0.7mg/ml, 0.8mg/ml, 0.9mg/ml,
1.0mg/ml、1.5mg/ml、2.0mg/ml、2.5mg/ml、3.0mg/ml、3.5mg/ml、4.0mg/ml、4.5mg/ml、
5.0mg/ml、5.5mg/ml、6.0mg/ml、6.5mg/ml、7.0mg/ml、7.5mg/ml、8.0mg/ml、8.5mg/ml、
9.0mg/ml、9.5mg/ml、10.0mg/ml、10.5mg/ml、11.0mg/ml、11.5mg/ml、12.0mg/ml、12.5mg/
Ml, 13.0mg/ml, 13.5mg/ml, 14.0mg/ml, 14.5mg/ml and 15.0mg/ml etc., but not limited to this.
One or more aspects of the invention, the fungi polysaccharide can be conventional purchase from the market.
One or more aspects of the invention, the composition for preventing and treating radioactivity portacaval mucositis can block outer
Radiation injury caused by the factor of source, with superpower radiation resistance, mucous membrane of mouth group is promoted while prevention oral mucositis
Knit regeneration and repair, shorten wound healing time, anti-inflammatory analgetic.
Additionally, the present invention also proposes to prevent and treat the medicine of radioactivity portacaval mucositis, containing mussel soft tissue extract and very
Granulose, optionally, can also commonly use or acceptable auxiliary material containing other field of medicaments.
One or more aspects of the invention, the composition for preventing and treating radioactivity portacaval mucositis can be prepared into
Mouthwash, effervescent tablet for rinsing mouth, spray, speed collapse the forms such as decontamination piece.
Additionally, the invention allows for the above-mentioned composition for preventing and treating radioactivity portacaval mucositis prevent and treat radioactivity oral cavity glue
Application in film inflammation.
One or more aspects of the invention, the composition for preventing and treating radioactivity portacaval mucositis can block outer
Radiation injury caused by the factor of source, with superpower radiation resistance, mucous membrane of mouth group is promoted while prevention oral mucositis
Knit regeneration and repair, shorten wound healing time, anti-inflammatory analgetic.
One or more aspects of the invention, composition of the invention, institute are given to subject in need
Stating composition includes mussel soft tissue extract and fungi polysaccharide.
In one aspect of the invention, a kind of composition for preventing and treating radioactivity portacaval mucositis and its application, including：
0.1-15 parts of mussel soft tissue extract,
Fungi polysaccharide 0.1-20 parts, and
Honey 1-20 parts.
In one aspect of the invention, a kind of composition for preventing and treating radioactivity portacaval mucositis and its application, including：
0.1-15 parts of mussel soft tissue extract,
Fungi polysaccharide 0.1-20 parts, and
Refrigerant alcohol 0.1-2 parts.
In one aspect of the invention, a kind of composition for preventing and treating radioactivity portacaval mucositis and its application, including：
0.1-15 parts of mussel soft tissue extract,
Fungi polysaccharide 0.1-20 parts, and
Menthol 0.1-2 parts.
Additionally, the present invention also proposes a kind of medicine for preventing and treating radioactivity portacaval mucositis and its application, containing soft group of mussel
Extract and fungi polysaccharide are knitted, optionally, can also pharmaceutically be commonly used or acceptable carrier containing other.
One or more aspects of the invention, the carrier can include any and all of solvent, salt, dispersion
Medium, coating material, surfactant, antioxidant, preservative (such as antiseptic, antifungal agent), isotonic agent, absorption delay
Agent, drug stabilizing agent, adhesive, excipient, disintegrant, lubricant, sweetener, flavouring, dyestuff etc. and they in it is a kind of, many
The combination of kind or whole, this is well-known to those skilled in the art (for example, see Remington's Pharmaceutical
Sciences,18th Ed.Mack Printing Company,1990,pp.1289-1329).Except with active component not phase
Outside the carrier of appearance, it is contemplated that any conventional carrier used in treatment use or pharmaceutical composition.
Additionally, the present invention also proposes a kind of medicine for preventing and treating radioactivity portacaval mucositis answering in portacaval mucositis are prevented and treated
With.Using the composition for preventing and treating radioactivity portacaval mucositis comprising mussel soft tissue extract and fungi polysaccharide, can block
Radiation injury caused by extrinsic factor, with superpower radiation resistance, mucous membrane of mouth is promoted while prevention oral mucositis
Regeneration and reparation, shorten wound healing time, anti-inflammatory analgetic.
The composition for preventing and treating radioactivity portacaval mucositis of the present invention is gentle, non-stimulated, have no toxic side effect, without using
Dependence.
Following examples are illustrated as a example by preventing and treating the composition of radioactivity portacaval mucositis, but not limited to this, above-mentioned
The various radioprotectants comprising mussel soft tissue extract and fungi polysaccharide proposed by the present invention are applied to the present invention.
Specific embodiment
Embodiment 1：A kind of preparation method of mussel soft tissue extract.
Take mussel to shell, collect soft tissue 300g, be divided into three parts, every part adds the following table acidity of 100ml contents 0.3% molten
Liquid, centrifugation obtains supernatant as mussel soft tissue extract after homogenate 10min.
Protein content and pH value in supernatant are determined, determining the protein quantity uses Coomassie Brilliant Blue.
Table 1
| Example | Acid solution | Protein content | PH value |
| 1 | Citric acid | 2.6mg/ml | 4.5 |
| 2 | Acetic acid | 3.5mg/ml | 3.2 |
| 3 | Perchloric acid | 3.0mg/ml | 1.0 |
Embodiment 2：A kind of composition for preventing and treating radioactivity portacaval mucositis
The composition for preventing and treating radioactivity portacaval mucositis including mussel soft tissue extract and fungi polysaccharide is by with the following group
Divide and constitute：Mussel soft tissue extract dry powder 15mg, fungi polysaccharide dry powder 20mg, molasses element 1mg, menthol 0.05mg are above-mentioned
Material adds purified water to be made mouthwash after fully dissolving.
Collecting 20 need carries out the patient of neck surface radiotherapy, is randomly divided into test group and control group, and test group is before radiotherapy
The mouthwash of the preventing and treating portacaval mucositis that 30min is prepared using embodiment 2 is gargled, and control group carries out blank.Radiotherapy
Each subject is observed after end and the situation of oral mucositis occurs.
Radioactive ray portacaval mucositis are evaluated according to WHO mucosa reactions：I degree-reactionless or mucous hyperemia；II degree-spot glues
Film is scorching；III degree-sheet catarrh accounts for launched field area 50% or has the obvious pain to need drug therapy；IV- sheet catarrh accounts for launched field
Area more than 50% then needs to stop radiotherapy or direct oral cavity does not give nutrition fluid infusion.
Radiotherapy is observed after terminating, and 4 (40%) patients with radioactive mucositis of oral cavity patients occurs in test group, and its degree is divided into：I degree
2 (20%), II degree 2 (20%).There are 8 (80%) patients with radioactive mucositis of oral cavity patients in control group, and its degree is divided into：II
4 (40%) of degree, III degree 3 (30%), IV degree 1 (10%).
Can be seen that protection of the present invention to radioactivity portacaval mucositis has significant curative effect from observation result.
Embodiment 3：A kind of composition for preventing and treating radioactivity portacaval mucositis
The composition for preventing and treating radioactivity portacaval mucositis including mussel soft tissue extract and fungi polysaccharide is by with the following group
Divide and constitute：Mussel soft tissue extract dry powder 13.5mg, fungi polysaccharide dry powder 16mg, peppermint oil 0.01mg, above-mentioned substance is added
Physiological saline is made spray after fully dissolving.
Embodiment 4：A kind of composition for preventing and treating radioactivity portacaval mucositis
The composition for preventing and treating radioactivity portacaval mucositis including mussel soft tissue extract and fungi polysaccharide is by with the following group
Divide and constitute：Mussel soft tissue extract dry powder 14.5mg, fungi polysaccharide dry powder 18mg, add edible solid organic acid disintegrant
Effervescent tablet for rinsing mouth is obtained with compressing tablet after adhesive mixing.
Embodiment 5：A kind of composition for preventing and treating radioactivity portacaval mucositis
The combination for preventing and treating radioactivity portacaval mucositis including mussel soft tissue extract, trypsase and fungi polysaccharide
Thing is made up of following components：Mussel soft tissue extract dry powder 14mg, fungi polysaccharide dry powder 16.5mg, above-mentioned substance adds solvable
Property the stirred sieve series grain of starch, PVP K30, place into and mix in microcrystalline cellulose, compressing tablet must be used to prevent and treat portacaval mucositis
Speed collapse decontamination piece.
Certainly, the present invention can also have other various embodiments, ripe in the case of without departing substantially from spirit of the invention and its essence
Knowing those skilled in the art can make various corresponding changes and deformation, but these corresponding changes and deformation according to the present invention
The protection domain of the claims in the present invention should all be belonged to.
Claims (10)
1. a kind of composition for preventing and treating radioactivity portacaval mucositis, comprising mussel soft tissue extract and fungi polysaccharide.
2. the composition for preventing and treating radioactivity portacaval mucositis according to any preceding claims, it is characterised in that described
Fungi polysaccharide be lentinan, flammulina velutipes, GL-B, Cordyceps sinensis polysaccharide, pachymaran, grifola polysaccharide, Blackfungus polyhexose,
One or more mixing of tremella polysaccharides.
3. the composition for preventing and treating radioactivity portacaval mucositis according to any preceding claims, it is characterised in that described
Composition presses gross weight meter, and 0.1-15 parts of mussel soft tissue extract, such as, by gross weight meter, is made a gift of by fungi polysaccharide 0.1-20 parts
Shellfish soft tissue extract is such as 0.1 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6
Part, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13
Part, 13.5 parts, 14 parts, 14.5 parts, 15 parts, fungi polysaccharide is such as 0.1 part, 0.2 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts,
3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5
Part, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, 15.5 parts, 16 parts, 16.5 parts, 17
Part, 17.5 parts, 18 parts, 18.5 parts, 19 parts, 19.5 parts, 20 parts.
4. the composition for preventing and treating radioactivity portacaval mucositis according to any preceding claims, it is characterised in that described
Composition further includes auxiliary material, such as antioxidant, bacteriostatic agent, essence or host material；Or the radioactivity mouthful of preventing and treating
The scorching composition of transmucosal further includes pharmaceutically acceptable carrier, solvent such as, salt, decentralized medium, coating material,
Surfactant, antioxidant, preservative (such as antiseptic, antifungal agent), isotonic agent, absorption delaying agent, drug stabilizing agent,
Adhesive, excipient, disintegrant, lubricant, sweetener, flavouring, dyestuff, freshener and they in it is a kind of, various or whole
Combination.
5. the composition for preventing and treating radioactivity portacaval mucositis according to any preceding claims, it is characterised in that described
Mussel soft tissue extract and fungi polysaccharide are dry powder or liquid in composition.
6. the composition for preventing and treating radioactivity portacaval mucositis according to any preceding claims, it is characterised in that described
Composition final ph soluble in water is 3.8-5.8.
7. the composition for preventing and treating radioactivity portacaval mucositis according to any preceding claims, it is characterised in that described
Mussel soft tissue extract is the component raw material with mussel in addition to shell, is extracted by acidic aqueous solution, and supernatant is taken after centrifugation
Obtain, wherein protein content 0.2-15.0mg/ml, pH value 1.0-6.0.
8. the composition for preventing and treating radioactivity portacaval mucositis according to claim 7, wherein the acidic aqueous solution includes：
Acetic acid-sodium acetate buffer solution, acetic acid, citric acid, perchloric acid, or wherein described mussel soft tissue extract protein content
For example, 0.2mg/ml, 0.3mg/ml, 0.4mg/ml, 0.5mg/ml, 0.6mg/ml, 0.7mg/ml, 0.8mg/ml, 0.9mg/
ml、1.0mg/ml、1.5mg/ml、2.0mg/ml、2.5mg/ml、3.0mg/ml、3.5mg/ml、4.0mg/ml、4.5mg/ml、
5.0mg/ml、5.5mg/ml、6.0mg/ml、6.5mg/ml、7.0mg/ml、7.5mg/ml、8.0mg/ml、8.5mg/ml、
9.0mg/ml、9.5mg/ml、10.0mg/ml、10.5mg/ml、11.0mg/ml、11.5mg/ml、12.0mg/ml、12.5mg/
Ml, 13.0mg/ml, 13.5mg/ml, 14.0mg/ml, 14.5mg/ml and 15.0mg/ml.
9. the composition for preventing and treating radioactivity portacaval mucositis according to claim 7, wherein the mussel include Mytilus galloprovincialis,
One kind in Perna viridis, Trachyostracous mussel, two or three.
10. the composition for preventing and treating radioactivity portacaval mucositis according to any preceding claims, it is characterised in that described
Composition is mouthwash, effervescent tablet, spray, the fast form for collapsing gargle tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611264404.7A CN106692201A (en) | 2016-12-30 | 2016-12-30 | Composition for preventing and treating radiation-induced oral mucositis and application of composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611264404.7A CN106692201A (en) | 2016-12-30 | 2016-12-30 | Composition for preventing and treating radiation-induced oral mucositis and application of composition |
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| Publication Number | Publication Date |
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| CN106692201A true CN106692201A (en) | 2017-05-24 |
Family
ID=58906385
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611264404.7A Withdrawn CN106692201A (en) | 2016-12-30 | 2016-12-30 | Composition for preventing and treating radiation-induced oral mucositis and application of composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116444351A (en) * | 2022-11-18 | 2023-07-18 | 中国人民解放军军事科学院军事医学研究院 | Natural small molecular compound with small intestine protecting effect in nuclear radiation injury |
-
2016
- 2016-12-30 CN CN201611264404.7A patent/CN106692201A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116444351A (en) * | 2022-11-18 | 2023-07-18 | 中国人民解放军军事科学院军事医学研究院 | Natural small molecular compound with small intestine protecting effect in nuclear radiation injury |
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Application publication date: 20170524 |