CN106691390A - Photoacoustic probe and photoacoustic imaging system - Google Patents
Photoacoustic probe and photoacoustic imaging system Download PDFInfo
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- CN106691390A CN106691390A CN201710046338.4A CN201710046338A CN106691390A CN 106691390 A CN106691390 A CN 106691390A CN 201710046338 A CN201710046338 A CN 201710046338A CN 106691390 A CN106691390 A CN 106691390A
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- fibre bundle
- ultrasonic probe
- probe
- laser
- reflection unit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
Abstract
The invention discloses a photoacoustic probe. The photoacoustic probe comprises an ultrasonic probe; an optical fiber bundle comprising a first optical fiber bundle and a second optical fiber bundle, wherein two optical fiber bundles are respectively positioned at two relative outer sides of the ultrasonic probe; a reflecting device positioned at the extension line of the tail end of the first optical fiber bundle and the tail end of the second optical fiber bundle, wherein the reflecting device is slantwise installed, and the distance from one end of the central shaft of the reflecting device adjacent to the optical fiber bundle to the central shaft of the ultrasonic probe is greater than the distance from one end of the central shaft of the reflecting device away from the optical fiber bundle to the central shaft of the ultrasonic probe, the reflecting device is used for reflecting the laser emitted by the first optical fiber bundle and the second optical fiber bundle to a sample, and the reflecting device is used for enabling the overlapping area of the illuminated area on the sample surface by the laser emitted by the first optical fiber bundle and the second optical fiber bundle and the detection area of the ultrasonic probe to be greater than 30% of the detection area. The invention further discloses a photoacoustic imaging system. The photoacoustic probe has the advantage of better imaging effect.
Description
Technical field
The present invention relates to imaging field, more particularly to a kind of smooth sonic probe and photoacoustic imaging system.
Background technology
Photoacoustic imaging is the new imaging means for having optical imagery hypersensitivity and ultrasonic imaging depth advantage concurrently.With optics
Imaging is different, and what photoacoustic imaging was detected is that the ultrasonic wave that optoacoustic effect is produced, i.e. pulse laser beam irradiate target area and inhaled
Receive, this will cause target area transient temperature rise, the ultrasonic wave of thermal-elastic expansion is then produced, then by gathering ultrasonic wave
Signal reconstruction image reflects the optical absorption characteristic of material.Optical technology is imaged on the aspects such as resolution ratio tool to have great advantage.Together
When ultrasonic wave biological tissue propagation attenuation be much smaller than optical signal, with deeper imaging depth；Therefore photoacoustic imaging is simultaneously
There is optical resolution and acoustics imaging depth.Additionally, photoacoustic imaging also have without ionising radiation, can real time scan etc.
The advantage that other Molecular imaging techniques do not possess；Photoacoustic imaging technology has been demonstrated that the oophoroma for being applied to per rectum is detected.Light
It is directly related with content of hemoglobin in the absorption of near infrared region, and cancer cell can trigger the fast-growth of complicated blood vessel, this
So that photoacoustic imaging turns into the tumor vascular excellent tool of detection.There is research to attempt the warp in existing supersonic imaging apparatus in recent years
Directly it is optically coupled on the basis of rectum array enddoscopic ultrasound probes, the advantage is that can make full use of original ultrasound to visit
The handiness of head, the photoacoustic image for obtaining can also be matched with ultrasonoscopy automatic reclosing, realize the purpose of multi-modality imaging.But
The Major Difficulties of this design are, how that light is simply high in the case where original ultrasonic probe size is not dramatically increased
Target tissue site is delivered to effect, and makes the search coverage coincidence of light irradiation area and ultrasonic probe organizationally, obtained
High-quality photoacoustic image.
In current optoacoustic endoscopy imaging system, its laser irradiating part point is mainly with the Coupling Design of ultrasonic probe 110：
Be coupled into four optical fiber 120 from the pulsed light of laser emitting, as shown in figure 1, light sonic probe include ultrasonic probe 110,
Optical fiber 120 and aluminium foil 130, the optical fiber 120 are bound to the surrounding of ultrasonic probe 110 respectively, by the outer surface of ultrasonic probe 110
Aluminium foil 130 and the aluminium foil 130 of light sonic probe inner surface carry out diffusing reflection, make laser divergent irradiation to the surface of sample 140, and
Converged in the underface certain depth of ultrasonic probe 110.Because the laser in optical fiber 120 out only reflexes to ultrasound by aluminium foil 130
Probe lower section, laser is radiated at the diverging of sample surface time not exclusively, and its irradiation area is overlap with ultrasonic probe search coverage
Area is less than the 10% of search coverage area, so as to be difficult to inspire sufficiently strong photoacoustic signal, so as to cause imaging effect not
It is preferable.
The content of the invention
Embodiment of the present invention technical problem to be solved is, there is provided a kind of smooth sonic probe and photoacoustic imaging system, into
As effect is more satisfactory.
In order to solve the above-mentioned technical problem, the embodiment of first aspect present invention one provides a kind of smooth sonic probe, including：
Ultrasonic probe, it is used to detect the photoacoustic signal that sample sends；
Fibre bundle, it includes the first fibre bundle and the second fibre bundle, and two fibre bundles are respectively positioned at the phase of ultrasonic probe
To two outsides, the first fibre bundle and the second fibre bundle are used to transmit laser；
Reflection unit, it is located on the extended line of the first fibre bundle end and the second fibre bundle end, the reflection unit
Be obliquely installed, and the reflection unit central shaft near one end of fibre bundle apart from ultrasonic probe central shaft distance more than anti-
The central shaft of injection device away from fibre bundle one end apart from ultrasonic probe central shaft distance, the reflection unit is used for first
Fibre bundle and the laser reflection of the second fibre bundle outgoing are on sample, and the reflection unit is used to make first laser beam and second
The laser of laser beam exits is more than detecting area in the irradiation area of sample surface with the overlapping area of the search coverage of ultrasonic probe
The 30% of domain area.
In an embodiment of the present invention, the thickness of first fibre bundle and the second fibre bundle near reflection unit one end is small
In the thickness away from reflection unit one end.
In an embodiment of the present invention, first fibre bundle and the second fibre bundle are flat near reflection unit one end
Shape.
In an embodiment of the present invention, first fibre bundle and the distance range of ultrasonic probe end are 5-15mm；Institute
It is 5-15mm that the second fibre bundle is stated with the distance range of ultrasonic probe end.
In an embodiment of the present invention, the ultrasonic probe is U-shaped, and first fibre bundle and second fibre bundle divide
Not Wei Yu U-shaped ultrasonic probe flat area.
In an embodiment of the present invention, also including holder, first fibre bundle, the second fibre bundle and the reflection dress
Put and be arranged on ultrasonic probe by holder.
In an embodiment of the present invention, gap is provided between the ultrasonic probe outer surface and coating unit inner surface, institute
State fibre bundle and the reflection unit is located in the gap, male part is filled with the gap.
In an embodiment of the present invention, the angle of inclination of the reflection unit is 60 ° -80 °.
In an embodiment of the present invention, the reflection unit includes the first level crossing and the second level crossing, and described first is flat
Face mirror is located on the extended line of the first fibre bundle end, and second level crossing is located on the extended line of the second fibre bundle end.
The embodiment of second aspect present invention one provides a kind of photoacoustic imaging system, including generating device of laser, light path system
System, light sonic probe and imaging device, wherein,
The generating device of laser is used to send laser；
The light path system gives light sonic probe for transmitting the laser that the generating device of laser sends；
The smooth sonic probe is above-mentioned light sonic probe, the fibre bundle receiving light path system transfers in the smooth sonic probe
Laser, the ultrasonic probe is used to receive the ultrasonic wave that sample sends；
Imaging device, its signal for being used to receive ultrasonic probe transmission.
Implement the embodiment of the present invention, have the advantages that：
Because the present embodiment has reflection unit, and reflection unit is located at the first fibre bundle end and the second fibre bundle end
Extended line on, namely there is a certain distance in reflection unit and the first fibre bundle end and the second fibre bundle end so that, from
The laser of the first fibre bundle end and the second fibre bundle outgoing reflexes to ultrasonic probe after space development by reflection unit respectively
Lower section, it is oblique to be mapped to sample surface, and different depth inspires photoacoustic signal in sample, produced photoacoustic signal is ultrasonic
Probe is received, and laser is more than search coverage area with ultrasonic probe search coverage overlapping area in the irradiation area of sample surface
30%, the overlapping area than prior art is more, so that imaging effect is more satisfactory；And, the present embodiment realizes not notable
Increase the size of ultrasonic probe, the position irradiated the need for laser to be simply and efficiently delivered to sample.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
The accompanying drawing to be used needed for having technology description is briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, can be with
Other accompanying drawings are obtained according to these accompanying drawings.
Fig. 1 is the schematic diagram of prior art light sonic probe of the present invention；
Fig. 2 is the schematic diagram of one embodiment of the invention light sonic probe；
Shown by reference numeral：
10- ultrasonic probes；The fibre bundles of 21- first；The fibre bundles of 22- second；30- holders；The level crossings of 41- first；42-
Two level crossings；50- coating units；60- gaps.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation is described, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.It is based on
Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of creative work is not made
Embodiment, belongs to the scope of protection of the invention.
The embodiment of the invention provides a kind of smooth sonic probe, refer to Fig. 2, the smooth sonic probe include ultrasonic probe 10,
Fibre bundle, reflection unit and coating unit 50.
The ultrasonic wave that the ultrasonic probe 10 is emitted for inspecting samples, and ultrasonic signal is converted into electric signal
It is transmitted, particularly, when laser is irradiated to sample areas, such as when being irradiated to surface of living body tissue, illuminated sample
One's respective area transient temperature rise, the sample in the subsequent region produces the photoacoustic signal of thermal-elastic expansion, and the photoacoustic signal is ultrasound
Ripple, ultrasonic wave is emitted can be gathered by ultrasonic probe 10.In the present embodiment, the ultrasonic probe 10 is per rectum battle array
Column enddoscopic ultrasound probes 10, in other embodiments of the invention, the ultrasonic probe can also be other species.
The fibre bundle includes the first fibre bundle 21 and the second fibre bundle 22, the fibre bundle of first fibre bundle 21 and second
22 all include many with optical fiber, and the number range of optical fiber is 60-80 in first fibre bundle 21, for example, 60,65,
70,75, the numbers such as 80, in second fibre bundle 22 number range of optical fiber be 60-80, for example, 60,
65,70,75, the numbers such as 80.Two fibre bundles are respectively positioned at the opposite sides of ultrasonic probe 10, such as the first light
Fine beam 21 is located at the left side of ultrasonic probe 10, and the second fibre bundle 22 is located at the right side of ultrasonic probe 10, or conversely, or first
Fibre bundle 21 is located at the front side of ultrasonic probe 10, and the second fibre bundle 22 is located at the rear side of ultrasonic probe 10, or conversely.Described
One fibre bundle 21 and the second fibre bundle 22 are used to transmit laser.
The reflection unit is located on the extended line of the end of the first fibre bundle 21 and the end of the second fibre bundle 22, namely described
Reflection unit is located on the path of the laser that the first fibre bundle 21 spreads out of, and the reflection unit also is located at the second fibre bundle 22 and spreads out of
Laser path on, the reflection unit is obliquely installed, and the reflection unit central shaft near one end of fibre bundle away from
With a distance from the central shaft of ultrasonic probe 10 more than reflection unit central shaft away from fibre bundle one end in ultrasonic probe 10
The distance of heart axle, namely the central shaft of reflection unit slopes inwardly from top to bottom, and herein, the central shaft of reflection unit is vertical for it
Axle, namely reflection unit is inclined to the direction of ultrasonic probe 10 successively from top to bottom, and the reflection unit is used to change the first optical fiber
The direction of the laser of the outgoing of 21 and second fibre bundle of beam 22, the laser of the first fibre bundle 21 and the outgoing of the second fibre bundle 22 is anti-
On directive sample, and the reflection unit is used to make first laser beam and the laser of second laser beam outgoing in the photograph of sample surface
Penetrate region and ultrasonic probe 10 search coverage overlapping area more than the 30% of search coverage area, for example, 30%, 40%,
50%th, 60%, 70%, 80%, 90%, 95%, 100% etc., when for 100% when, the irradiation area and the search coverage
It is completely overlapped.
Because the present embodiment has reflection unit, and reflection unit is located at the end of the first fibre bundle 21 and the second fibre bundle 22
On the extended line of end, namely reflection unit and the end of the first fibre bundle 21 and the end of the second fibre bundle 22 exist it is certain away from
From, so that, the laser from the end of the first fibre bundle 21 and the outgoing of the second fibre bundle 22 is respectively after space development by reflection unit
The lower section of ultrasonic probe 10 is reflexed to, it is oblique to be mapped to sample surface, and different depth inspires photoacoustic signal in sample, it is produced
Photoacoustic signal received by ultrasonic probe 10, make laser Chong Die with the search coverage of ultrasonic probe 10 in the irradiation area of sample surface
, more than the 30% of search coverage area, the overlapping area than prior art is more, so that imaging effect is more satisfactory for area；And,
The present embodiment realizes the size for not dramatically increasing ultrasonic probe 10, is irradiated the need for laser to be simply and efficiently delivered to sample
Position.
In the present embodiment, the head end of the fibre bundle 22 of first fibre bundle 21 and second be it is circular or square, it is described
In first fibre bundle 21 number range of optical fiber be 60-80, for example, 60,65,70,72,74,75,
76,78, the numbers such as 80, the number range of optical fiber is also 60-80, for example, 60 in second fibre bundle 22
Root, 65,70,72,74,75,76,78, the numbers such as 80.Because the ending volume of ultrasonic probe 10 compares
Greatly, namely ultrasonic probe 10 near sample one end volume ratio it is larger, in order to reduce the size of light sonic probe, first fibre bundle
21 and second fibre bundle 22 near one end of reflection unit thickness less than away from reflection unit one end thickness, such that it is able to subtract
The thickness of small whole optoacoustic probe end, can reduce size.In the present embodiment, the optical fiber of first fibre bundle 21 and second
Beam 22 is flat near one end of reflection unit, so that can both reduce the thickness of the end of whole light sonic probe, and
Can increase by the first fibre bundle 21 and the second fibre bundle 22 is irradiated to the irradiation area area of sample surface so that, behind lead to again
The angle of inclination of reflection unit is overregulated, makes first laser beam and the laser of second laser beam outgoing in the irradiated region of sample surface
The overlapping area of the search coverage of domain and ultrasonic probe 10 is more than search coverage area 50%, such as 50%, 60%, 70%,
80%th, 900%, 100% etc., can most preferably reach 100%, namely the irradiation area is completely overlapped with the search coverage.
In the present embodiment, the fibre bundle 22 of first fibre bundle 21 and second is close to the outer surface of the ultrasonic probe 10
Set, the distance range of first fibre bundle 21 and the end of ultrasonic probe 10 is 5-15mm, for example, 5mm, 7mm, 9mm,
10mm, 12mm, 15mm etc.；Second fibre bundle 22 is also 5-15mm with the distance range of the end of ultrasonic probe 10, for example,
5mm, 7mm, 9mm, 10mm, 12mm, 15mm etc., so as to facilitate setting and the regulation irradiation area size of reflection unit.
In the present embodiment, the ultrasonic probe 10 is U-shaped, namely ultrasonic probe 10 is cutd open down along the paper direction of vertical view 2
Go as U-shaped, on the ultrasonic probe direction shown in Fig. 2, because ultrasonic probe 10 is U-shaped, thus the left side of ultrasonic probe 10 and
The right side is all flat area, and first fibre bundle 21 and second fibre bundle 22 are respectively positioned at the flat of U-shaped ultrasonic probe
Region, for example, first fibre bundle 21 is located at the flat area in the left side of U-shaped ultrasonic probe 10, second fibre bundle 22
In the flat area on the right side of U-shaped ultrasonic probe 10, so as to facilitate the stable holding of the first fibre bundle 21 and the second fibre bundle 22
On ultrasonic probe 10.
In the present embodiment, the reflection unit includes the first reflection unit and the second reflection unit, first reflection
Device and the second reflection unit are provided separately, and first reflection unit is located on the extended line of the end of the first fibre bundle 21, institute
The second reflection unit is stated on the extended line of the end of the second fibre bundle 22, the reflection unit is level crossing, namely first is anti-
Injection device is the first level crossing 41, and second reflection unit is the second level crossing 42.The angle of inclination of the reflection unit is
60 ° -80 °, for example, 60 °, 65 °, 70 °, 75 °, 80 ° angularly namely in the present embodiment, first level crossing 41 inclines
Rake angle be 60 ° -80 °, for example, 60 °, 65 °, 70 °, 75 °, 80 ° angularly, the angle of inclination of second level crossing 42 is
60 ° 80 °, for example, 60 °, 65 °, 70 °, 75 °, 80 ° angularly.Within this range, the laser of the reflection unit reflection is in sample
The irradiation area on this surface is larger with the overlapping area of the search coverage of ultrasonic probe 10, for example, reach search coverage area
70%, or even 100%, now the irradiation area is completely overlapped with the search coverage.
In the present embodiment, the smooth sonic probe also includes holder 30, first fibre bundle 21, the second fibre bundle 22
It is arranged on ultrasonic probe 10 by holder 30 with reflection unit.The holder 30 is, for example, clip.So as to the first optical fiber
Beam 21, the second fibre bundle 22 and reflection unit can surely lean on ultrasonic probe 10.
In the present embodiment, the smooth sonic probe also includes coating unit 50, and the coating unit 50 constitutes the optoacoustic
The shell of probe, the coating unit 50 is used to coat the ultrasonic probe 10, fibre bundle and reflection unit, so that described super
Sonic probe 10, fibre bundle and reflection unit form one, can prevent fibre bundle, reflection unit etc. from damaging, and can protect
Ultrasonic probe 10.In the present embodiment, the fibre bundle has certain distance with the inner surface of the coating unit 50.
In the present embodiment, gap 60, institute are provided between the outer surface of the ultrasonic probe 10 and the inner surface of coating unit 50
State fibre bundle and the reflection unit is located in the gap 60, male part is filled with the gap 60, in the present embodiment,
The male part is, for example, water.
One embodiment of the invention additionally provides a kind of photoacoustic imaging system, and the photoacoustic imaging system is filled including laser
Put, light path system, light sonic probe and imaging device, the generating device of laser is used to send laser, and the laser swashs for pulse
Light, the light path system is used to transmitting the laser that the generating device of laser sends and includes to light sonic probe, the light path system
Optical module, the optical module is, for example, lens, speculum etc., and the smooth sonic probe is above-mentioned light sonic probe, the light
The laser of the fibre bundle receiving light path system transfers in sonic probe, namely the laser coupled of light path system transmission enters into the first light
The head end of the fibre bundle 22 of fine beam 21 and second, the ultrasonic probe 10 is used to receive the ultrasonic wave that sample sends, namely for connecing
The photoacoustic signal that sample sends is received, photoacoustic signal is converted to electric signal by the ultrasonic probe 10；The imaging device is used to connect
The signal of the transmission of ultrasonic probe 10 is received, to obtain high-quality image.
It should be noted that each embodiment in this specification is described by the way of progressive, each embodiment weight
Point explanation is all difference with other embodiments, between each embodiment identical similar part mutually referring to.
For device embodiment, because it is substantially similar to embodiment of the method, so description is fairly simple, related part referring to
The part explanation of embodiment of the method.
By the description of above-described embodiment, the present invention has advantages below：
Because the present embodiment has reflection unit, and reflection unit is located at the first fibre bundle end and the second fibre bundle end
Extended line on, namely there is a certain distance in reflection unit and the first fibre bundle end and the second fibre bundle end so that, from
The laser of the first fibre bundle end and the second fibre bundle outgoing reflexes to ultrasonic probe after space development by reflection unit respectively
Lower section, it is oblique to be mapped to sample surface, and different depth inspires photoacoustic signal in sample, produced photoacoustic signal is ultrasonic
Probe is received, and laser is more than search coverage area with ultrasonic probe search coverage overlapping area in the irradiation area of sample surface
30%, the overlapping area than prior art is more, so that imaging effect is more satisfactory；And, the present embodiment realizes not notable
Increase the size of ultrasonic probe, the position irradiated the need for laser to be simply and efficiently delivered to sample.
It is understood that the above embodiment of the present invention is not in the case where conflicting, can combine to obtain more
Many embodiments.
In the description of the invention, it is to be understood that term " " center ", " on ", D score, " vertical ", " level ",
The orientation or position relationship of the instruction such as " top ", " bottom ", " interior ", " outward ", " clockwise ", " counterclockwise " are based on side shown in the drawings
Position or position relationship, are for only for ease of the description present invention and are described with simplified, rather than the device or unit that indicate or imply meaning
Part with specific orientation, with specific azimuth configuration and operation, therefore must be not considered as limiting the invention.This
Outward, term " first ", " second " are only used for describing purpose, and it is not intended that indicating or implying relative importance or implicit finger
The quantity of bright indicated technical characteristic.Thus, " first " is defined, the feature of " second " can be expressed or implicitly include
One or more this feature.In the description of the invention, " multiple " is meant that two or more, unless otherwise bright
It is really specific to limit.
In the present invention, unless otherwise clearly defined and limited, term " installation ", " connected ", " connection ", " fixation " etc.
Term should be interpreted broadly, for example, it may be being fixedly connected, or being detachably connected, or be integrally connected；It can be machine
Tool is connected, or electrically connected；Can be joined directly together, it is also possible to be indirectly connected to by intermediary, can be two units
Connection inside part.For the ordinary skill in the art, can as the case may be understand above-mentioned term in this hair
Concrete meaning in bright.
Above disclosed is only present pre-ferred embodiments, can not limit the right model of the present invention with this certainly
Enclose, therefore the equivalent variations made according to the claims in the present invention, still belong to the scope that the present invention is covered.
Claims (10)
1. a kind of smooth sonic probe, it is characterised in that including：
Ultrasonic probe, it is used to detect the photoacoustic signal that sample sends；
Fibre bundle, it includes the first fibre bundle and the second fibre bundle, and two fibre bundles are respectively positioned at relative the two of ultrasonic probe
Outside, the first fibre bundle and the second fibre bundle are used to transmit laser；
Reflection unit, it is located on the extended line of the first fibre bundle end and the second fibre bundle end, and the reflection unit is inclined
Set, and the central shaft of the reflection unit is more than reflection dress near one end of fibre bundle apart from the distance of ultrasonic probe central shaft
The central shaft put away from fibre bundle one end apart from ultrasonic probe central shaft distance, the reflection unit is used for the first optical fiber
Beam and the laser reflection of the second fibre bundle outgoing are on sample, and the reflection unit is used to make first laser beam and second laser
The laser of beam outgoing is more than search coverage face in the irradiation area of sample surface with the overlapping area of the search coverage of ultrasonic probe
Long-pending 30%.
2. light sonic probe as claimed in claim 1, it is characterised in that first fibre bundle and the second fibre bundle are near reflection
The thickness of device one end is less than the thickness away from reflection unit one end.
3. light sonic probe as claimed in claim 2, it is characterised in that first fibre bundle and the second fibre bundle are near reflection
Device one end is flat.
4. light sonic probe as claimed in claim 1, it is characterised in that the distance of first fibre bundle and ultrasonic probe end
Scope is 5-15mm；Second fibre bundle is 5-15mm with the distance range of ultrasonic probe end.
5. light sonic probe as claimed in claim 1, it is characterised in that the ultrasonic probe is U-shaped, first fibre bundle and
Second fibre bundle is respectively positioned at the flat area of U-shaped ultrasonic probe.
6. light sonic probe as claimed in claim 1, it is characterised in that also including holder, first fibre bundle, the second light
Fine beam and the reflection unit are arranged on ultrasonic probe by holder.
7. light sonic probe as claimed in claim 1, it is characterised in that the ultrasonic probe outer surface and coating unit inner surface
Between be provided with gap, the fibre bundle and the reflection unit are located in the gap, filled with male part in the gap in.
8. light sonic probe as claimed in claim 1, it is characterised in that the angle of inclination of the reflection unit is 60 ° -80 °.
9. light sonic probe as claimed in claim 1, it is characterised in that the reflection unit includes the first level crossing and second flat
Face mirror, first level crossing is located on the extended line of the first fibre bundle end, and second level crossing is located at the second fibre bundle
On the extended line of end.
10. a kind of photoacoustic imaging system, it is characterised in that including generating device of laser, light path system, light sonic probe and imaging dress
Put, wherein,
The generating device of laser is used to send laser；
The light path system gives light sonic probe for transmitting the laser that the generating device of laser sends；
The smooth sonic probe is the light sonic probe as described in claim 1-9 any one, the fibre bundle in the smooth sonic probe
The laser of receiving light path system transfers, the ultrasonic probe is used to receive the ultrasonic wave that sample sends；
Imaging device, its signal for being used to receive ultrasonic probe transmission.
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| CN108420459A (en) * | 2018-02-09 | 2018-08-21 | 武汉艾欧医疗科技有限公司 | A kind of blood vessel endoscope imaging probe and imaging method |
| CN109171660A (en) * | 2018-10-09 | 2019-01-11 | 深圳先进技术研究院 | Photoacoustic imaging probe and application |
| CN110638466A (en) * | 2019-09-17 | 2020-01-03 | 广东普洛宇飞生物科技有限公司 | Positioning device and method |
| WO2021051678A1 (en) * | 2019-09-18 | 2021-03-25 | 声索生物科技(上海)有限公司 | Ultrasonic combined device for biopsy |
| CN113243889A (en) * | 2020-08-10 | 2021-08-13 | 北京航空航天大学 | Method and apparatus for acquiring information of biological tissue |
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