CN106668531A - Hui nationality traditional Chinese medicine six ingredients pills for treating leukaemia and preparation method thereof - Google Patents

Abstract

The invention relates to Hui nationality traditional Chinese medicine six ingredients pills for treating leukaemia and a preparation method thereof. The traditional Chinese medicine six ingredients pills for treating leukaemia are a Chinese herbal medicine product having advantages of environmental protection as well as high science and technology, which take herb of glabrous sarcandra, bushy sophora, pseudobulubs cremastrae seu pleiones and isatis root according to a certain proportion, the above Chinese herbal medicines are mixed, water is added in a mixture, the mixture is decocted, extracted, concentrated, and pelleted to obtain the product. The traditional Chinese medicine six ingredients pills are mainly used for treating leukemia, and treating digestive system cancers such as pharyngolaryngeal cancer, stomach cancer and colorectal cancer, and have the characteristics of moderate flavor and dosage, the selected Chinese herbal medicines are proved for treating cancer by modern medical pharmacological experiments, with low cost, the body function can be fundamentally improved, condition deterioration is prevented, and body health is recovered.

Description

Hui ethnic group's Chinese medicine Six-element leukemia health ball and preparation method thereof

Technical field

Hui ethnic group's Chinese medicine " Six-element leukemia health ball " according to the present invention is a kind of leukemic green high-tech Chinese herbal medicine of prevention and treatment.The invention further relates to the preparation method of the medicine, belongs to traditional Chinese medicine class.

Background technology

According to《China's tumour registration annual report in 2014》Data display, according to China for each person 74 years old life-span calculate, Chinese all one's life suffer from malignant tumour probability be 22%, average minute clock has 6 people to be diagnosed as malignant tumour, and tumour has become a kind of common disease in China.At present the cancer patient of China is about ten thousand people more than 800, and every year with the speed of more than 100 ten thousand people in increase（Also have data to show every year is being increased with the speed of 3,120,000 people）.And the whole world

According to statistics, in the cancer patient of China nearly 8,000,000, although the leukemic incidence of disease and number of the infected are not also first 10, the 5/100000 of population is accounted for per annual morbidity, the people of about 8-9 ten thousand, but death rate height but as the carninomatosis such as lung cancer, liver cancer, the breast cancer for coming top ten, which results in many patients and loses confidence to living.Leukaemia is constantly bred without limit due to malignant cell clone, and a large amount of proliferative cells have spatially tied up ossis, as a result cause marrow failure and body tissue's organ to be done harm to by leaching, such as acid of the same race because leukaemia can produce some body fluid inhibiting factorsFerritinEtc. (isoferritin) suppress normally to makeHaemocytePropagation, thus just generate clinical a series of sings and symptoms.And most terribly be that while that some people's household economy are not short of money, but due to national all of tumour hospital all the year round overstaffed, thus can get one treatment bed, leukaemic that the regular treatment of some famous expert hospitals --- including over-treatment --- can be enjoyed or relatively little of, addsLeukemic treatmentIt is relatively difficult, many also need to HSCT, Umbilical Cord Blood Transplant,Gene therapyDeng so just more making many leukaemics for still having existence leeway accelerate to have moved towards dead road.

Leukemic pathogenic factor substantially has three, and one is chemical factor, and this reason may not be common, because premise must be some chemicals of patient's Long Term Contact, such as benzene, affirmative is compared in the cause leukaemia effect of benzene.Benzene causes acute leukemia based on acute myeloblastic leukemia and erythroleukemia.Two is inherent cause, and this pathogenic factors is not also proved so far, is have leukaemia family history person to account for percentage eight in leukaemic the reason for clinically why so thinking, so can not ignore the reason for be relatively common.Three is virus, and if patient is in early stage other are suffered fromDiseaseIf, such as some tumours, at this time it is possible to leukaemia, because the homologous gene of most vertebrate is all source tumor gene, this is also one of leukemogenic cause of disease.Although leukemic pathogenic factor clinically also has many disputes, above-mentioned three kinds are relatively common.

It is to carry out regular chemotherapy to regular large hospital to treat leukemic best method at present, and the cure rate of ALL can reach the cure rate of more than 80%, ANLL and also can reach 50%.The incurable chronic myelocytic leukemia patient of those chemotherapy, by Hemopoietic Stem Cell Transplantation, can also also have the healing of 50%-60% possible.But various treatment technologies have its own advantage and a deficiency again, such as HSCT technology, the high-risk or recurrent and refractory leukaemic that can make over to cure obtains and cures chance, but have it is expensive, cause the deficiencies such as rejection；And chemotherapy, chemotherapy not only large side effects, patient suffering is difficult to stand, and needs the time of several years, and success rate is nor 100% ...

Leukaemia is a kind of malignant tumour of general.Traditional Chinese medicine has no leukemic name of disease, but with regard to categories such as category " blood trouble ", " deficiency of blood ", " consumptive disease ", " evil cores " more than its clinical manifestation.Leukaemia is at present more refractory disease more, but refractory representative cannot be controlled, and in addition to above-mentioned western medical treatment method, the traditional Chinese medical science also has many effectively treatment methods.Existing clinical proof Chinese medicine relaxes to this sick curative effect to be stablized, and can reduce the toxic and side effect of chemotherapy, does not produce resistance, and leukemic each phase can be applied.The traditional Chinese medical science, according to the whole body feature diagnosis and treatment of patient, goes for various each phase cancer with organic conception.The advantage of Chinese medicine cancer is to be conducive to stablizing the state of an illness, and toxic and side effect is slight, symptom improves more apparent, slows down PD, tumor regression or the longer-term existence of band knurl, and patient is easy to receive and expense is than less expensive.At present doctor trained in Western medicine is also considered as traditional Chinese medicine can contribute to reducing the toxicity of Radiotherapy chemotherapy as the auxiliary treatment of cancer, improve cancer related symptoms, improve life quality, extend life cycle.But exist problem be the traditional Chinese medical science prescription uniformity it is poor, treatment mainly be experience.From in terms of existing proved recipe for cancer, folk prescription, always there is --- majority is more than more than half --- medicine to be all not prove " compatibility " medicine of function for cancer and effect " diagnosis and treatment based on an overall analysis of the illness and the patient's condition " by modern medicine pharmacological evaluation in selected Chinese herbal medicine medicinal material, inventors believe that very improper；And folk prescription, folk prescription cure the disease lean on be test, often stop over the time cured the disease.

The content of the invention

The purpose of the present invention, be aiming at Chinese leukaemic it is medical be difficult to and the traditional Chinese medical science see a doctor it is normative it is poor, it is repeatable it is poor, lack high level evidence-based medicine EBM theory and evidence, thus the situation for waiting deficiency by rule of thumb that is mainly for cancer, propose a kind of new dosage and preparation method, there is provided a kind of from the beginning of prevention, reduce the leukemic incidence of disease, start to slow down its tempo induction its apoptosis of induction from canceration or differentiation reverts to the green high-tech Chinese herbal medicine of normal cell, with very low cost, fundamentally improve physical function, so as to get well.Its sharpest edges are to greatest extent to induce self apoptosis of cancer cell and differentiation, promote it progressively to recover normal condition.In specific formula, also coordinate diagnosis and treatment based on an overall analysis of the illness and the patient's condition, according to leukemic origin cause of formation system " blood trouble ", " deficiency of blood ", " consumptive disease ", the features such as " evil core ", according to the concrete condition of patient, different formulas are respectively adopted, with the method for strengthening vital QI to eliminate pathogenic factors adopting both clearing heat method and tonification method, or boosting qi and nourishing yin, strong spleen and liver, or enriching kidney essence, strengthening spleen, tonifying kidney, or it is clearing heat and detoxicating, it is promoting blood circulation and removing blood stasis, or strengthening the spleen and stomach, strongly invigorating QI and blood ... is accomplished not hindering just clearly, benefit does not stay heresy, there is benefit in clear, giving consideration to both the incidental and fundamental, complement each other, a good internal environment is created to hemopoietic system, to accelerate the recovery of hematopoiesis function, it is empty in healthy tendency to correct, the solidifying poison of heresy is poly- and internal organs imbalance of yin and yang function reduces the deficiency that disequilibrium causes immunologic hypofunction, adjust and improve the immunologic function of body, to reachAdopting both clearing heat method and tonification methodThe purpose of overall suppression disease, so as to improve the overall curative effect and late result of leukemia treating, a kind of green high-tech Chinese herbal medicine formula and compound method that function for cancer and effect are proved by modern medicine pharmacological evaluation is provided for leukaemic, with very low or relatively low cost, fundamentally improve physical function, the deterioration of symptom management simultaneously makes the state of an illness gradually take a turn for the better, and finally recovers healthy.Thus also to patient one select different treatment methods or several method to share particularly traditional Chinese and western medicine to combine the leeway of complex treatment application to consider according to the personal state of an illness, economic situation, personal inclination, to obtaining optimum curative effect, survival rate is easily improved --- particularly more than 5 years survival rates.

Technical scheme proposed by the invention is：

First, leukemic Hui ethnic group's Chinese medicine of described prevention and treatment " Six-element leukemia health ball " and preparation method thereof, is by made by the weight proportion of following Six-element raw material：

Glabrous Sarcandra Herb 30g, subprostrate sophora 30g, edible tulip 5g, celebrating bar pass the summer in a leisurely way 1g,

Radix Isatidis 15g, tomb turn one's head 10g

This side is substantially square for one decoction on the one.In practical application, also the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert " theory can be increased according to the physique of patient and conditions“Dialectical compatibility " medicine.

In view of with this, basic side's decoction decoction of medicinal ingredients amount is big, taste is not good enough, patient is difficult to drink, therefore must be prepared using special process.

2nd, it is by the preparation method that above-mentioned each raw material makes medicine pill of the present invention：

A, extract preparation

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to celebrating bar is passed the summer in a leisurely way, tomb is turned one's head, all amplify 10 times, after clean water, it is placed in BT-2 stainless steels to extract in kettle, plus after 7-9 times of running water, is heated to 100 DEG C of constant temperature and extracts 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.

B, second extraction：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.

C, third time are extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.

（2）, concentration

The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.

（3）, powder processed

Pass the summer in a leisurely way 1g, tomb of celebrating bar is turned one's head 10g and respectively amplify 10 times, is together crushed as end, cross 100 mesh sieves, it is standby.

（4）, dispensing

In 300,000 grades of dust proof workshops, above-mentioned medicinal powder is put in mixer together with aforementioned concentrate and proper honey water and is sufficiently mixed, stir.

(5) drying, crushing

The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.

(6) granulate

The spice being well mixed is inserted in comminutor and is granulated.

(7) whole grain

The particle for making is carried out into whole grain, 35 mesh sieves are crossed.

(8) it is dried

Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.

(9) pill

Dry mixed gained medicine is put into pill in Chinese medicinal pills preparing machine, pill is optimal with below 4mm.

B, packaging

First the pill for making is fitted into vinyon pouch, every bag of 7g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）.

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.

Routine instructions of taking of the invention：Three times a day, 1 bag every time, administered at empty stomach is with (taking half an hour after can not drink water in a large number above-mentioned pill, in order to avoid water down liquid).The pungent grade food larger to gastrointestinal irritation is not eaten during medication.

If this medicine does medicine efficacy enhancing ingredient and takes with pan-fried tomato soup, better.The specific practice of pan-fried tomato soup is：Take from so well-done little tomato（50 grams or so）Chopping, puts 10 grams or so vegetable oil in pot, heat, and is put into appropriate chopped spring onion, salt, pours into be decocted in pot by the tomato of chopping when chopped spring onion blows out fragrance and fries 1-2 minutes, then infuses to be got away into suitable quantity of water and take the dish out of the pot.

The effect of each raw material of the present invention：

Glabrous Sarcandra Herb,Nature and flavorEffect：Taste is pungent, it is mild-natured.It is clearing heat and detoxicating, dispelling wind and eliminating dampness, promoting blood circulation and stopping pain.It is clinicalUsing：Suitable for kinds of tumors, such as the cancer of the esophagus,Cancer of the stomach, colon and rectum carcinoma, cancer of pancreas, liver cancer, acute leukemia etc..

Subprostrate sophora,ForLegume root of subprostrate sophoraRoot.Bitter cold in nature.Effect is to relieve inflammation or internal heat, detoxifying, subsiding a swelling, pain relieving.Cure mainly：Laryngalgia, sore-throat,Larynx numbness,Swelling and aching of gum,Breathe heavily fullHeat is coughed,Jaundice, diarrhea, heat is swollen,Mange, snakeworm dog bite.Its is rightThe cancer of the esophagus、Nasopharyngeal carcinoma, cervical carcinoma,Carcinoma of urinary bladder, leukaemia have inhibitory action.Composition pharmacology：Containing TA about 0.93%, whereinMatrine(Matrine) 0.52%,Oxymatrine(Oxymatrine) 0.35%, Yi JihanD-maackianin-β-D-glucoside(Sophoraponicin)、Red sandalwoodPlain (Pterorepine),Screw oil expeller axleGrass roots glucoside (TrifolirhiZin),Albizzia kalkoraPlain (Maackian), sophoradin (Sophra) etc..DNA and RNA synthesis of the subprostrate sophora to tumour cell has obvious inhibitory action, so as to block the propagation of tumour cell, lymphocyte transformation can be promoted, excite or strengthen the CDCC of lymphocyte, T cell ratio is improved, strengthens or adjust macrophage phagocytic function, moreover it is possible to adjust endocrine, strengthen adrenocortical function, thus affect the occurrence and development of tumour.

Mountain is kind to eat,Nature and flavor are sweet, pungent, cool, mild toxicity.Return liver, kidney, lung, stomach,Large intestine channel.Drug effect：Internal heat anticance,DetumescenceDissipating bind.It is clinicalUsing：Suitable for kinds of tumors, it is mainly used inBreast cancer, also for malignant lymphoma, thyroid cancer,SkinCancer,Cervical carcinoma, nasopharyngeal carcinoma, the cancer of the esophagus, leukaemia,Cancer of the stomachDeng.Additionally, apply also for carbuncle swells serious case of furuncle, scrofula, snake bite and benign tumour, such as thyroid adenoma, cystic hyperplasia of mammary gland, mammary gland fibroma, hemangioma.It is medicinal（1）Internal heat anticance, for carcinoma product poison.

Celebrating bar is passed the summer in a leisurely way,For legumeKe rattanMature seed.Nature and flavorEffect：Gan Liang is clearing heat and detoxicating.It is clinicalUsing：Anticancer, desinsection, the spiral shell that goes out, emetic rush down.

Seed containing sterol, flavones, phenolic constituent,AmmoniaBase acid, organic acid.Its triterpenoid saponin sour water solves Dai Yuan Ke rattan acid (entagenic acid), arabinose and wood sugar；Cu Ke rattan acid carries out sour water solution and obtains free methyl mercaptan (CH (3) SH) and another triterpene sapogenin echinocystic acid (ehinocystic acid).The percentage of various aliphatic acid is contained by seed oilNutmegAcid 0.3%, palmitic acid 9.1%, stearic acid 4.4%, the, Shan Yu acid 1.6%, oleic acid 35.8% of peanut resin acid 1.7%, linoleic acid 46.7%,FlaxAcid 0.4%.

Seed makes paste, and topical application controls body of gland inflammatory swelling, stomachache, there is antipyretic effect, and anesthetic and emetic are made again.Bake after seed water logging and process, narcoticness can be removed and edible.Stem micromicro makees astringent, for wound.Woody part is used for skin disease, and the infusion of stem is washed and controls mange.Cure mainly：Worry, ephrosis, hepatopyretic disease, the heat symptom-complex of nosotoxicosis, from arteries and veins disease.Antitumaous effect：Contain two kinds of toxicity saponins in seed kernel, act on similar, toxicity is equal.Radix Isatidis,Radix Isatidis is bitter, trembles with fear.The thoughts of returning home, stomach.Effect is clearing heat and detoxicating, cool blood, profit pharynx.Its chemical composition is：Woaded blue root containing indigo, indigo red, cupreol,PalmAcid, uridine, hypoxanthine, uracil,Indigo naturalisKetone and daucosterol etc..Its pharmacological action is：This product has inhibitory action to various gram-positive bacterias, Gram-negative bacteria and influenza virus, arboviruse, parotid gland virus.Improving immunocompetence；There is obvious antipyretic response.Indigo red contained by this product has significant leukemia resisting action；Banlangen Polysaccharide can reduce the content of animal used as test serum cholesterol and triglycerides, and reduce MDA contents, so as to prove this product Wheat Protein.

Patrinia heterophylla,(the herb and rhizome of Valerianaceae Patrinia scaniosaefolia platymiscium patrinia heterophylla.) nature and flavorEffect：Bitter, micro- sour and astringent, cold nature.Convergence, eliminating dampness, hemostasis.It is clinicalUsing：Suitable for kinds of tumors, such asCervical carcinoma, ovarian neoplasm, chorioepithelioma, liver cancer, leukaemia etc..

The effect of the present invention：

Cure mainly：Leukaemia, particularly early stage leukaemia, fundamentally improve physical function, and control tumour continues to overgrow and makes it that final disappearance is gradually reduced, so as to recover healthy.

It is simultaneous to control：The cancer in digestive system such as cancer of the stomach, the cancer of the esophagus, throat cancer, cardiac cancer, pylorus cancer, colorectal cancer.

Our the characteristics of is：

1st, flavour of a drug are few, and dosage is little, spend low, do not waste.

2nd, selected flavour of a drug are all to be proved for cancer particularly can to treat leukemic by modern medicine pharmacological evaluation.And then always have in existing proved recipe for cancer, folk prescription --- even more than medicine more than half be all not by modern medicine pharmacological evaluation proved function for cancer and effect.Really it is that the traditional Chinese medical science is seen a doctor by rule of thumb, folk prescription is cured the disease by risk！

3rd, for focus, arrow arrow punching, i.e., selected flavour of a drug all especially grow tender of and hit the bull's eye, and As the medicine took effect, the symptoms lessened.As long as rather than it is for cancer, just jump on the bandwagon, be as a result that " dragon " does not harness the river on the contrary more.

4th, as much as possible " neutralisation ", i.e., selected flavour of a drug generally keep " neutrality ", do not tremble with fear not dry, not hot not cool.Patient can be thus set to suffer less within the cycle of whole medication, pull the devil by the tail less.And if really there is the situation of " getting angry " or " under let out ", then can be directed to concrete individual concrete condition completely, a bit " stopping leak ", the medicine of " fall fire " are specifically solved for interim addition.Rather than imagine at the very start patient may on tell or drop, and some unnecessary medicines are added to prescription, patient is all taken always during very long very long medication, ultimately cause adverse consequences.

The conventional taking dose of the present invention, method are：Three times a day, every time 1 bag, administered at empty stomach is used；The foods larger to gastrointestinal irritation such as relatively more pungent comparison is sweet are eaten during medication.Medicine efficacy enhancing ingredient is done with pan-fried tomato soup to take, it is better.This medicine is a course for the treatment of in three months, typically takes two to three courses for the treatment of, at most takes four courses for the treatment of.

Specific embodiment：Glabrous Sarcandra Herb 30g, subprostrate sophora 30g, edible tulip 5g, Radix Isatidis 15g are respectively amplified into 10 times, after clean water, BT-2 stainless steels is placed in and is extracted in kettle, plus after 7-9 times of running water, be heated to 100 DEG C of constant temperature and extract 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.Extract for second：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.Third time is extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.Concentration：The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.Powder processed：Pass the summer in a leisurely way 1g, tomb of celebrating bar is turned one's head 10g and respectively amplify 10 times, is together crushed as end, cross 100 mesh sieves, it is standby.Dispensing：In 300,000 grades of dust proof workshops, above-mentioned medicinal powder is put in mixer together with aforementioned concentrate and proper honey water and is sufficiently mixed, stir.Drying, crushing：The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.Granulation：The spice being well mixed is inserted in comminutor and is granulated.Whole grain：The particle for making is carried out into whole grain, 35 mesh sieves are crossed.It is dried：Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.Pill：Dry mixed gained medicine is put into pill in Chinese medicinal pills preparing machine, pill is optimal with below 4mm.Packaging：First the pill for making is fitted into vinyon pouch, every bag of 7g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）.Warehouse-in：Irradiated finished product is put in storage by the principle of first in first out.

Claims (2)

1. Hui ethnic group's Chinese medicine Six-element leukemia health ball and preparation method thereof, is by made by the weight proportion of following Six-element raw material：

Glabrous Sarcandra Herb 30g, subprostrate sophora 30g, edible tulip 5g, celebrating bar pass the summer in a leisurely way 1g,

Radix Isatidis 15g, tomb turn one's head 10g

This side is the substantially square of one decoction on the one, in practical application, can also increase the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert " theory according to the physique of patient and conditions“Dialectical compatibility " medicine.

2. the weight proportion of the Hui ethnic group's Chinese medicine Six-element leukemia health ball according to claim 1, it is characterised in that including following preparation processes：

A, extract preparation

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to celebrating bar is passed the summer in a leisurely way, tomb is turned one's head, all amplify 10 times, after clean water, it is placed in BT-2 stainless steels to extract in kettle, plus after 7-9 times of running water, is heated to 100 DEG C of constant temperature and extracts 1 hour or so, extraction fluid, pressure filtration, filtrate is standby；

B, second extraction：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby；

C, third time are extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby；

（2）, concentration

The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby；

（3）, powder processed

Pass the summer in a leisurely way 1g, tomb of celebrating bar is turned one's head 10g and respectively amplify 10 times, is together crushed as end, cross 100 mesh sieves, it is standby；

（4）, dispensing

In 300,000 grades of dust proof workshops, above-mentioned medicinal powder is put in mixer together with aforementioned concentrate and proper honey water and is sufficiently mixed, stir；

(5) drying, crushing

The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves；

(6) granulate

The spice being well mixed is inserted in comminutor and is granulated；

(7) whole grain

The particle for making is carried out into whole grain, 35 mesh sieves are crossed；

(8) it is dried

Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C；

(9) pill

Dry mixed gained medicine is put into pill in Chinese medicinal pills preparing machine, pill is optimal with below 4mm；

B, packaging

First the pill for making is fitted into vinyon pouch, every bag of 7g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）；

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.