CN106667499A - Automatic biochemical analyzer - Google Patents
Automatic biochemical analyzer Download PDFInfo
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- CN106667499A CN106667499A CN201610414754.0A CN201610414754A CN106667499A CN 106667499 A CN106667499 A CN 106667499A CN 201610414754 A CN201610414754 A CN 201610414754A CN 106667499 A CN106667499 A CN 106667499A
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- Prior art keywords
- blood oxygen
- oxygen saturation
- blood
- skin
- colour
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
Abstract
The invention relates to an automatic biochemical analyzer. A measuring table comprises a facial skin color detection device, a blood glucose monitoring device, a blood oxygen saturation monitoring device and an MSP430 single chip microcomputer. The facial skin color detection device is used for determining the skin color grade of a detected person based on facial recognition of the detected person; the blood glucose monitoring device is used for monitoring blood glucose data of the detected person; the blood oxygen saturation monitoring device is used for determining the blood oxygen saturation grade of the detected person; the MSP430 single chip microcomputer is connected with the facial skin color detection device and the blood oxygen saturation monitoring device, and used for determining the blood oxygen supplying status of the detected person based on the skin color grade and the blood oxygen saturation grade. By means of the automatic biochemical analyzer, the two physiological parameters, namely the blood glucose and the blood oxygen saturation, can be simultaneously and accurately measured.
Description
The present invention be Application No. 201510750367.X, the applying date be on November 6th, 2015, it is entitled " it is complete from
The divisional application of the patent of Automatic Biochemical Analyzer ".
Technical field
The present invention relates to medical Instrument field, more particularly to a kind of automatic clinical chemistry analyzer.
Background technology
Due to hazardness of the anoxia to people's body, blood oxygen saturation detecting instrument is always Medical Instruments developer's emphasis
One of problem of research and development.
However, blood oxygen saturation detecting instrument detection object of the prior art is single, circuit structure redundancy high and
Detection mechanism is not comprehensive enough, the effect on driving birds is not good for causing blood oxygen saturation to detect, it is impossible to meet the current demand of patient and hospital.People
Need the blood oxygen saturation armarium that performance is more perfect, cost performance is higher.
Therefore, the present invention proposes a kind of automatic clinical chemistry analyzer, optimizes current blood oxygen saturation detecting instrument
Structure, the detection of blood sugar concentration is incorporated in blood oxygen saturation detection, particular, it is important that employing high-precision image recognition
Technology is identified to the colour of skin of tested personnel, one of factor that the colour of skin is detected as blood oxygen saturation, considers blood oxygen
The testing result of saturation, so as to widen the physiological parameter project of detection, improves the accuracy of testing result.
The content of the invention
In order to solve the technical problem of prior art presence, the invention provides a kind of automatic clinical chemistry analyzer, improves
The structure of current blood oxygen saturation detecting instrument, blood sugar test is incorporated in blood oxygen saturation detection, improves blood oxygen saturation
Accuracy of detection, meanwhile, the colour of skin of tested personnel is identified using targetedly image recognition technology, using the colour of skin as
One of factor of blood oxygen saturation detection so that the testing result of blood oxygen saturation is difficult to be disturbed by single factors.
According to an aspect of the present invention, there is provided a kind of automatic clinical chemistry analyzer, the measuring table includes facial skin
Color testing equipment, blood glucose monitoring device, blood oxygen saturation monitoring device and MSP430 single-chip microcomputers, the blee testing equipment
For determining the colour of skin grade of tested personnel based on the facial recognition of tested personnel, the blood glucose monitoring device is used for tested person
The blood glucose level data of member is monitored, and the blood oxygen saturation monitoring device is used to determine the blood oxygen saturation grade of tested personnel,
The MSP430 single-chip microcomputers are connected respectively with the blee testing equipment and the blood oxygen saturation monitoring device, based on institute
State colour of skin grade and the blood oxygen saturation grade determines the blood oxygen supply condition of tested personnel.
More specifically, in the automatic clinical chemistry analyzer, including：SD storage cards, have prestored default colour of skin power
Weight, default blood oxygen saturation weight, default balance lower threshold, default balance upper limit threshold and facial tonal range, the face
Portion's tonal range is used for the human body face and background separation in image, and it is equal that the SD storage cards have also prestored four kinds of colours of skin
Value is interval and four kinds of blood oxygen saturation intervals, and four kinds of colour of skin mean value intervals correspond to respectively four kinds of colour of skin grades, described four kinds
Blood oxygen saturation is interval to correspond to respectively four kinds of blood oxygen saturation grades；Picture pick-up device is used for tested personnel's face shots to obtain
Tested personnel's face-image；Blee testing equipment include the sub- equipment of Daubechies wavelet filterings, the sub- equipment of medium filtering,
Change of scale enhancer equipment, the sub- device of skin cluster, the sub- equipment of Target Segmentation and colour of skin grade recognize sub- device；It is described
The sub- equipment of Daubechies wavelet filterings is connected with the picture pick-up device, is based on for adopting to tested personnel's face-image
The wavelet filtering of 2 rank Daubechies wavelet basiss is processed, to filter tested personnel's face-image in Gaussian noise, obtain
Wavelet filtering image；The sub- equipment of the medium filtering is connected with the sub- equipment of the Daubechies wavelet filterings, for described
Wavelet filtering image perform median filter process, to filter the wavelet filtering image in scattering composition, obtain medium filtering
Image；The change of scale enhancer equipment is connected with the sub- equipment of the medium filtering, for holding to the medium filtering image
Row change of scale enhancement process, to strengthen image in target and background contrast, obtaining strengthens image；Target Segmentation
Equipment is connected respectively with the change of scale enhancer equipment and the SD storage cards, by grey scale pixel value in the enhancing image
The facial subimage of all pixels composition in the range of the facial gray scale, the facial subimage is from tested personnel face
Separate at the background of image and obtain；The sub- device of the skin cluster is connected with the sub- device of the Target Segmentation, for facial subgraph
Picture, the brightness of its all pixels is added up and divided by the quantity of its all pixels to obtain target colour of skin average；Described colour of skin etc.
The sub- device of level identification is connected respectively with the sub- device of the skin cluster and the SD storage cards, by the target colour of skin average and four
The matching of colour of skin mean value interval is planted, the colour of skin grade corresponding to the colour of skin mean value interval of output matching is defeated as target colour of skin grade
Go out；Direct Digital Frequency Synthesizers, for producing sine wave signal that frequency and phase place can adjust using as rf frequency source
Use as mixing；Pulse-series generator, for producing pulse train；Frequency mixer, with the Direct Digital Frequency Synthesizers
Connect respectively with the pulse-series generator, mixed modulated is carried out to sine wave signal using pulse train；Power amplifier,
It is connected with the frequency mixer, for the signal after mixed modulated to be amplified；Switching Power Supply, as probe and power amplifier
Between interface circuit, by the signal loading after amplification to probe radio-frequency receiving-transmitting coil in；Nd-Fe-B permanent magnetic type magnet structure,
The uniform static magnetic field of one field intensity of generation in the space for accommodating tested personnel's finger；Probe, is placed on tested personnel's finger
Position, winds radio-frequency receiving-transmitting coil the signal of loading to be sent in the Nd-Fe-B permanent magnetic type magnet structure, produces nuclear-magnetism and is total to
Shake phenomenon, be additionally operable to send the deamplification obtained after Hydrogen Proton resonance in tested personnel's finger；Near infrared light is launched
Device, is arranged on tested personnel's finger fingertip blood capillary position, is connected with light source driving circuit, for based on light source driving circuit
The LED control signal of transmission, launches near infrared light；Light source driving circuit, is connected with the near infrared light emitter, for
The near infrared light emitter sends LED control signal；Near infrared light receptor, is arranged on tested personnel's finger fingertip, position
In the relative position of the light emitting diode, for receiving the near infrared light after tested personnel's finger fingertip blood capillary is transmitted；
Parameter extraction equipment, is connected respectively with the near infrared light emitter and the near infrared light receptor, based on the near red of transmitting
Outer light and the light attenuation degree of the near infrared light of transmission, calculate the HbO2 Oxyhemoglobins content in tested personnel's blood and reduction
Content of hemoglobin；MSP430 single-chip microcomputers, are connected with the probe, receive the deamplification, analyze the deamplification
Spectral line, and calculate wherein glucose proportion, so as to obtain the blood sugar concentration of tested personnel, the MSP430 single-chip microcomputers also with
The parameter extraction equipment, the SD storage cards and the blee testing equipment connect respectively, based on HbO2 Oxyhemoglobins
Content and the blood oxygen saturation of reduced hemoglobin cubage tested personnel；The MSP430 single-chip microcomputers work as the blood sugar concentration
In default blood glucose upper concentration, send the too high identification signal of blood sugar concentration, when the blood sugar concentration it is dense in default blood glucose lower limit
When spending, the too low identification signal of blood sugar concentration is sent；Wherein, the MSP430 single-chip microcomputers will calculate the blood oxygen saturation and institute that obtain
State four kinds of blood oxygen saturation intervals to be matched, by the blood oxygen saturation grade corresponding to the blood oxygen saturation that the match is successful interval
As target blood oxygen saturation grade；Wherein, the MSP430 single-chip microcomputers are by target colour of skin grade and default colour of skin multiplied by weight,
By target blood oxygen saturation grade and default blood oxygen saturation multiplied by weight, by two product additions to obtain total trade-off value, when
When total trade-off value is less than or equal to default balance lower threshold, hypoxemia identification signal is sent, when total trade-off value is more than or equal to pre-
If during balance upper limit threshold, sending blood oxygen excessively identification signal；Wherein, the frequency synthesis that Direct Digital Frequency Synthesizers are adopted
From the one kind in direct digital synthesizers, analog phase-locked look and digital phase-locked loop.
More specifically, in the automatic clinical chemistry analyzer：The radio-frequency receiving-transmitting coil of the probe winding is birdcage line
One kind in circle, toroidal winding, saddle-shaped coils, phased array coils and annulus.
More specifically, in the automatic clinical chemistry analyzer, the measuring table also includes：Wireless communication interface, with
The MSP430 single-chip microcomputers connection, for the too high identification signal of wireless transmission blood sugar concentration, the too low identification signal of blood sugar concentration, blood
Hypoxgia recognizes signal or blood oxygen excessively identification signal.
More specifically, in the automatic clinical chemistry analyzer：Picture pick-up device includes domed transparent cover, floor light
Equipment and CMOS camera.
More specifically, in the automatic clinical chemistry analyzer：The domed transparent cover is used to accommodate the auxiliary photograph
Pine torch equipment and the CMOS camera, the sub- equipment of the floor light is that the shooting provided auxiliary of the CMOS camera is shone
Bright, the CMOS camera is to tested personnel's face shots obtaining tested personnel's face-image.
Description of the drawings
Embodiment of the present invention is described below with reference to accompanying drawing, wherein：
Fig. 1 is the block diagram of the first embodiment of the automatic clinical chemistry analyzer of the present invention.
Reference：1 blee testing equipment；2 blood glucose monitoring devices；3 blood oxygen saturation monitoring devices；4 MSP430
Single-chip microcomputer
Specific embodiment
The embodiment of the automatic clinical chemistry analyzer of the present invention is described in detail below with reference to accompanying drawings.
Because many clinical diseases can cause the shortage of oxygen supply, the eubolism of cell is directly affected, it is serious
The life of people can be also threatened, so the real-time monitoring of blood oxygen saturation is extremely important in clinical rescue.To blood in prior art
Oxygen saturation measurements method is advanced row human blood collection, recycles blood gas analyzer to carry out electro chemical analysis, measures blood oxygen pressure
Calculate blood oxygen saturation.This method is cumbersome, and can not continuously be monitored.
Also there are some finger cot type photoelectric sensors in prior art, during measurement, only need to by sensor sleeve on finger,
By the use of finger as the transparent vessel for containing hemoglobin, using the HONGGUANG of wavelength 660nm and the near infrared light of 940nm as penetrating
Enter light source, determine by the light conductive strength of tissue bed to calculate hemoglobin concentration and blood oxygen saturation.
But, all there is following defect in blood oxygen saturation detection scheme of the prior art：Blood oxygen saturation can only be entered
Row detection, the object of detection is relatively simple；Testing mechanism falls behind, and structural redundancy is too high, and precision can not meet what is increased increasingly
Accuracy requirement；Particular, it is important that uniquely changing to the detection mechanism of blood oxygen saturation, blood oxygen can only be determined by a factor
Saturation, the inadequate science of detection process.
For this purpose, the present invention constructs a kind of automatic clinical chemistry analyzer, backward blood oxygen saturation detector can be improved
The structure of device, the detection of blood sugar concentration is dissolved in blood oxygen saturation detection, widens the scope of the physiological parameter of detection, improves
The accuracy of detection of blood oxygen saturation, in addition it is possible to photoelectric sense technology and image recognition technology are combined determine blood oxygen saturation
The concentration of degree, so as to avoid the possibility to tested personnel's mistaken diagnosis.
Fig. 1 be the present invention automatic clinical chemistry analyzer first embodiment block diagram, the measuring table bag
Include blee testing equipment, blood glucose monitoring device, blood oxygen saturation monitoring device and MSP430 single-chip microcomputers, the blee
Testing equipment is used to determine the colour of skin grade of tested personnel based on the facial recognition of tested personnel that the blood glucose monitoring device to be used for
The blood glucose level data of tested personnel is monitored, the blood oxygen saturation monitoring device is used to determine the blood oxygen saturation of tested personnel
Degree grade, the MSP430 single-chip microcomputers connect respectively with the blee testing equipment and the blood oxygen saturation monitoring device
Connect, the blood oxygen supply condition of tested personnel is determined based on the colour of skin grade and the blood oxygen saturation grade.
Then, continuing the concrete structure of the second embodiment of the automatic clinical chemistry analyzer to the present invention is carried out further
Explanation.
The measuring table includes：SD storage cards, prestored default colour of skin weight, default blood oxygen saturation weight,
Default balance lower threshold, default balance upper limit threshold and facial tonal range, the facial gray scale scope is used in image
Human body face and background separation, the SD storage cards have also prestored four kinds of colour of skin mean value intervals and four kinds of blood oxygen saturations
Interval, four kinds of colour of skin mean value intervals correspond to respectively four kinds of colour of skin grades, and four kinds of blood oxygen saturations interval corresponds to respectively
Four kinds of blood oxygen saturation grades.
The measuring table includes：Picture pick-up device, for being schemed with obtaining tested personnel's face to tested personnel's face shots
Picture.
The measuring table includes：Blee testing equipment, including the filter of the sub- equipment of Daubechies wavelet filterings, intermediate value
Marble equipment, change of scale enhancer equipment, the sub- device of skin cluster, the sub- equipment of Target Segmentation and colour of skin grade recognize sub- device
Part；The sub- equipment of the Daubechies wavelet filterings is connected with the picture pick-up device, for tested personnel's face-image
Using based on 2 rank Daubechies wavelet basiss wavelet filtering process, to filter tested personnel's face-image in Gauss
Noise, obtains wavelet filtering image；The sub- equipment of the medium filtering is connected with the sub- equipment of the Daubechies wavelet filterings, uses
In to the wavelet filtering image perform median filter process, to filter the wavelet filtering image in scattering composition, obtain
Medium filtering image；The change of scale enhancer equipment is connected with the sub- equipment of the medium filtering, for filtering to the intermediate value
Ripple image performs change of scale enhancement process, to strengthen image in target and background contrast, obtaining strengthens image；The mesh
The sub- equipment of mark segmentation is connected respectively with the change of scale enhancer equipment and the SD storage cards, by picture in the enhancing image
All pixels composition facial subimage of the plain gray value in the range of the facial gray scale, the facial subimage is from described tested
Separate at the background of personnel's face-image and obtain；The sub- device of the skin cluster is connected with the sub- device of the Target Segmentation, for
Facial subimage, the brightness of its all pixels is added up and divided by the quantity of its all pixels to obtain target colour of skin average；Institute
State colour of skin grade and recognize that sub- device is connected respectively with the sub- device of the skin cluster and the SD storage cards, by the target colour of skin
Average is matched with four kinds of colour of skin mean value intervals, and the colour of skin grade corresponding to the colour of skin mean value interval of output matching is used as the target colour of skin
Grade is exported.
The measuring table includes：Direct Digital Frequency Synthesizers, for producing the sine that frequency and phase place can be adjusted
Ripple signal as mixing as rf frequency source to use；Pulse-series generator, for producing pulse train；Frequency mixer, with
The Direct Digital Frequency Synthesizers and the pulse-series generator connect respectively, and sine wave signal is entered using pulse train
Row mixed modulated；Power amplifier, is connected with the frequency mixer, for the signal after mixed modulated to be amplified.
The measuring table includes：Switching Power Supply, as the interface circuit between probe and power amplifier, after amplification
Signal loading to probe radio-frequency receiving-transmitting coil in；Nd-Fe-B permanent magnetic type magnet structure, in the sky for accommodating tested personnel's finger
It is interior to produce the uniform static magnetic field of field intensity；Probe, is placed on tested personnel's finger position, winding radio-frequency receiving-transmitting coil with
The signal of loading is sent in the Nd-Fe-B permanent magnetic type magnet structure, nmr phenomena is produced, is additionally operable to through tested
The deamplification obtained after Hydrogen Proton resonance in personnel's finger is sent.
The measuring table includes：Near infrared light emitter, is arranged on tested personnel's finger fingertip blood capillary position, with
Light source driving circuit connects, and for the LED control signal sent based on light source driving circuit, launches near infrared light；Light source drives
Circuit, is connected with the near infrared light emitter, for sending LED control signal to the near infrared light emitter；Near-infrared
Optical receiver, is arranged on tested personnel's finger fingertip, positioned at the relative position of the light emitting diode, for receiving transmission quilt
Near infrared light after survey personnel's finger fingertip blood capillary.
The measuring table includes：Parameter extraction equipment, receives with the near infrared light emitter and the near infrared light
Device connects respectively, the light attenuation degree of the near infrared light of near infrared light and transmission based on transmitting, calculates tested personnel's blood
In HbO2 Oxyhemoglobins content and reduced hemoglobin content.
The measuring table includes：MSP430 single-chip microcomputers, are connected with the probe, receive the deamplification, analyze institute
The spectral line of deamplification is stated, and calculates wherein glucose proportion, it is described so as to obtain the blood sugar concentration of tested personnel
MSP430 single-chip microcomputers are also connected respectively with the parameter extraction equipment, the SD storage cards and the blee testing equipment,
Based on HbO2 Oxyhemoglobins content and the blood oxygen saturation of reduced hemoglobin cubage tested personnel；The MSP430 monolithics
Machine sends the too high identification signal of blood sugar concentration, when the blood sugar concentration when the blood sugar concentration is in default blood glucose upper concentration
In default blood glucose least concentration, the too low identification signal of blood sugar concentration is sent.
Wherein, the MSP430 single-chip microcomputers enter the blood oxygen saturation for calculating acquisition with four kinds of blood oxygen saturation intervals
Row matching, using the blood oxygen saturation grade corresponding to the blood oxygen saturation interval that the match is successful as target blood oxygen saturation etc.
Level；Wherein, the MSP430 single-chip microcomputers are by target colour of skin grade and default colour of skin multiplied by weight, by target blood oxygen saturation grade
With default blood oxygen saturation multiplied by weight, by two product additions to obtain total trade-off value, when total trade-off value is less than or equal to default
During balance lower threshold, hypoxemia identification signal is sent, when total trade-off value is more than or equal to default balance upper limit threshold, sent
Blood oxygen excessively recognizes signal.
Wherein, the frequency synthesis that Direct Digital Frequency Synthesizers are adopted from direct digital synthesizers, analog phase-locked look and
One kind in digital phase-locked loop.
Alternatively, in the measuring table：The radio-frequency receiving-transmitting coil of the probe winding is birdcage coil, spiral pipeline
One kind in circle, saddle-shaped coils, phased array coils and annulus；The measuring table also includes：Wireless communication interface, with
The MSP430 single-chip microcomputers connection, for the too high identification signal of wireless transmission blood sugar concentration, the too low identification signal of blood sugar concentration, blood
Hypoxgia recognizes signal or blood oxygen excessively identification signal；Picture pick-up device include domed transparent cover, the sub- equipment of floor light and
CMOS camera；And, the domed transparent cover is used to accommodate the sub- equipment of the floor light and the CMOS camera, institute
The shooting provided auxiliary illumination that the sub- equipment of floor light is the CMOS camera is stated, the CMOS camera is to tested personnel face
Portion shoots to obtain tested personnel's face-image.
In addition, blood oxygen saturation is the capacity of the HbO2 Oxyhemoglobins combined by oxygen in blood accounts for all combinative blood red
The concentration of blood oxygen in the percentage ratio of protein capacity, i.e. blood, it is the important physiological parameter of breath cycle.And feature oxygen saturation
The ratio for HbO2 concentration and HbO2+Hb concentration is spent, percent shared by HbO2 Oxyhemoglobins is different from.Therefore, arterial blood oxygen is monitored
The oxygen of lung can be closed for saturation and hemoglobin oxygen carrying capacity is estimated.The blood oxygen saturation of normal human's arterial blood is
98%, venous blood is 75%.
The metabolic processes of human body are biological oxidation processes, and the oxygen wanted needed for metabolic processes, it is by exhaling
Desorption system enters blood of human body, and the hemoglobin in blood rbc, is combined into HbO2 Oxyhemoglobins, then to be transported to human body each
In portion of tissue cell.Blood carries the ability of conveying oxygen and is weighed with blood oxygen saturation.
Using the automatic clinical chemistry analyzer of the present invention, fall for blood oxygen saturation detecting instrument structure in prior art
Afterwards, detection object is few and detects the single technical problem of mechanism, refer to high accuracy, targetedly image recognition apparatus are to quilt
The colour of skin of survey personnel is identified, and is dissolved in the detection process of blood oxygen saturation, meanwhile, addition blood sugar test equipment is simultaneously excellent
Change existing detection structure, so as to improve the performance of blood oxygen saturation detecting instrument on the whole, while having widened its detection
Scope.
Although it is understood that the present invention is disclosed as above with preferred embodiment, but above-described embodiment and being not used to
Limit the present invention.For any those of ordinary skill in the art, under without departing from technical solution of the present invention ambit,
All many possible variations and modification are made to technical solution of the present invention using the technology contents of the disclosure above, or be revised as
With the Equivalent embodiments of change.Therefore, every content without departing from technical solution of the present invention, according to the technical spirit pair of the present invention
Any simple modification made for any of the above embodiments, equivalent variations and modification, still fall within the scope of technical solution of the present invention protection
It is interior.
Claims (2)
1. a kind of automatic clinical chemistry analyzer, the measuring table includes blee testing equipment, blood glucose monitoring device, blood oxygen
Saturation monitoring device and MSP430 single-chip microcomputers, the facial recognition that the blee testing equipment is used for based on tested personnel is true
Determine the colour of skin grade of tested personnel, the blood glucose monitoring device is used to be monitored the blood glucose level data of tested personnel, the blood
Oxygen saturation monitoring device is used to determine the blood oxygen saturation grade of tested personnel, the MSP430 single-chip microcomputers and the facial skin
Color testing equipment and the blood oxygen saturation monitoring device connect respectively, based on the colour of skin grade and described blood oxygen saturation etc.
Level determines the blood oxygen supply condition of tested personnel.
2. automatic clinical chemistry analyzer as claimed in claim 1, it is characterised in that the measuring table includes：
SD storage cards, have prestored default colour of skin weight, default blood oxygen saturation weight, have preset balance lower threshold, preset
Balance upper limit threshold and facial tonal range, the facial gray scale scope is used for the human body face and background separation in image,
The SD storage cards have also prestored four kinds of colour of skin mean value intervals and four kinds of blood oxygen saturation intervals, four kinds of colour of skin averages
Interval to correspond to four kinds of colour of skin grades respectively, four kinds of blood oxygen saturations are interval to correspond to respectively four kinds of blood oxygen saturation grades；
Picture pick-up device is used for tested personnel's face shots to obtain tested personnel's face-image；
Blee testing equipment includes that the sub- equipment of Daubechies wavelet filterings, the sub- equipment of medium filtering, change of scale strengthen
The sub- device of sub- equipment, skin cluster, the sub- equipment of Target Segmentation and colour of skin grade recognize sub- device；The Daubechies small echos filter
Marble equipment is connected with the picture pick-up device, for little using 2 rank Daubechies are based on to tested personnel's face-image
The wavelet filtering of ripple base is processed, to filter tested personnel's face-image in Gaussian noise, obtain wavelet filtering image；Institute
State the sub- equipment of medium filtering to be connected with the sub- equipment of the Daubechies wavelet filterings, for performing the wavelet filtering image
Median filter process, to filter the wavelet filtering image in scattering composition, obtain medium filtering image；The change of scale
Enhancer equipment is connected with the sub- equipment of the medium filtering, for performing at change of scale enhancing to the medium filtering image
Reason, to strengthen image in target and background contrast, obtaining strengthens image；The sub- equipment of the Target Segmentation becomes with the yardstick
Change enhancer equipment and the SD storage cards connect respectively, by grey scale pixel value in the enhancing image in the facial gray scale model
The facial subimage of all pixels composition in enclosing, the facial subimage is separated from the background of tested personnel's face-image
Obtain；The sub- device of the skin cluster is connected with the sub- device of the Target Segmentation, for facial subimage, by its all pixels
Brightness adds up and divided by the quantity of its all pixels to obtain target colour of skin average；The colour of skin grade recognize sub- device with it is described
The sub- device of skin cluster and the SD storage cards connect respectively, by the target colour of skin average and four kinds of colour of skin mean value intervals
Match somebody with somebody, the colour of skin grade corresponding to the colour of skin mean value interval of output matching is exported as target colour of skin grade；
Direct Digital Frequency Synthesizers, for producing sine wave signal that frequency and phase place can adjust using as rf frequency source
Use as mixing；
Pulse-series generator, for producing pulse train；
Frequency mixer, is connected respectively, using pulse train with the Direct Digital Frequency Synthesizers and the pulse-series generator
Mixed modulated is carried out to sine wave signal；
Power amplifier, is connected with the frequency mixer, for the signal after mixed modulated to be amplified；
Switching Power Supply, as the interface circuit between probe and power amplifier, by the penetrating to probe of the signal loading after amplification
In frequency dispatch coil；
Nd-Fe-B permanent magnetic type magnet structure, the uniform static-magnetic of one field intensity of generation in the space for accommodating tested personnel's finger
；
Probe, is placed on tested personnel's finger position, winds radio-frequency receiving-transmitting coil the signal of loading is sent into into the neodymium iron boron
In permanent-magnet type magnet structure, nmr phenomena is produced, be additionally operable to obtain after Hydrogen Proton resonance in tested personnel's finger
Deamplification send；
Near infrared light emitter, is arranged on tested personnel's finger fingertip blood capillary position, is connected with light source driving circuit, is used for
Based on the LED control signal that light source driving circuit sends, launch near infrared light；
Light source driving circuit, is connected with the near infrared light emitter, for sending luminous control to the near infrared light emitter
Signal processed；
Near infrared light receptor, is arranged on tested personnel's finger fingertip, positioned at the relative position of the light emitting diode, is used for
Receive the near infrared light after transmission tested personnel's finger fingertip blood capillary；
Parameter extraction equipment, is connected respectively with the near infrared light emitter and the near infrared light receptor, based on transmitting
Near infrared light with transmission near infrared light light attenuation degree, calculate tested personnel's blood in HbO2 Oxyhemoglobins content and
Reduced hemoglobin content；
MSP430 single-chip microcomputers, are connected with the probe, receive the deamplification, analyze the spectral line of the deamplification, and count
Calculate wherein glucose proportion, so as to obtain the blood sugar concentration of tested personnel, the MSP430 single-chip microcomputers also with the parameter
Extraction equipment, the SD storage cards and the blee testing equipment connect respectively, based on HbO2 Oxyhemoglobins content and also
Former content of hemoglobin calculates the blood oxygen saturation of tested personnel；The MSP430 single-chip microcomputers are when the blood sugar concentration is in default blood
During sugared upper concentration, the too high identification signal of blood sugar concentration is sent, when the blood sugar concentration is in default blood glucose least concentration, sent
The too low identification signal of blood sugar concentration；
Wherein, the MSP430 single-chip microcomputers will calculate the blood oxygen saturation that obtains and four kinds of blood oxygen saturation intervals and carry out
Match somebody with somebody, using the blood oxygen saturation grade corresponding to the blood oxygen saturation interval that the match is successful as target blood oxygen saturation grade；
Wherein, the MSP430 single-chip microcomputers are by target colour of skin grade and default colour of skin multiplied by weight, by target blood oxygen saturation etc.
Level and default blood oxygen saturation multiplied by weight, by two product additions to obtain total trade-off value, when total trade-off value is less than or equal to pre-
If during balance lower threshold, sending hypoxemia identification signal, when total trade-off value is more than or equal to default balance upper limit threshold, send out
Bleeding oxygen excess recognizes signal；
Wherein, direct digital synthesizers, analog phase-locked look and numeral are selected in the frequency synthesis that Direct Digital Frequency Synthesizers are adopted
One kind in phaselocked loop；
The radio-frequency receiving-transmitting coil of the probe winding is birdcage coil, toroidal winding, saddle-shaped coils, phased array coils and ring
One kind in shape coil；
Wireless communication interface, is connected with the MSP430 single-chip microcomputers, for the too high identification signal of wireless transmission blood sugar concentration, blood glucose
The too low identification signal of concentration, hypoxemia identification signal or blood oxygen excessively recognize signal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610414754.0A CN106667499A (en) | 2015-11-06 | 2015-11-06 | Automatic biochemical analyzer |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510750367.XA CN105433956A (en) | 2015-11-06 | 2015-11-06 | Full-automatic biochemical analyzer |
| CN201610414754.0A CN106667499A (en) | 2015-11-06 | 2015-11-06 | Automatic biochemical analyzer |
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| CN201510750367.XA Division CN105433956A (en) | 2015-11-06 | 2015-11-06 | Full-automatic biochemical analyzer |
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| CN106667499A true CN106667499A (en) | 2017-05-17 |
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| CN201510750367.XA Pending CN105433956A (en) | 2015-11-06 | 2015-11-06 | Full-automatic biochemical analyzer |
| CN201610414754.0A Withdrawn CN106667499A (en) | 2015-11-06 | 2015-11-06 | Automatic biochemical analyzer |
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| CN201510750367.XA Pending CN105433956A (en) | 2015-11-06 | 2015-11-06 | Full-automatic biochemical analyzer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4875486A (en) * | 1986-09-04 | 1989-10-24 | Advanced Techtronics, Inc. | Instrument and method for non-invasive in vivo testing for body fluid constituents |
| EP1241985B1 (en) * | 1999-12-28 | 2008-10-08 | Pindi Products, Inc. | Method and apparatus for non-invasive analysis of blood glucose |
| TW200632320A (en) * | 2005-01-14 | 2006-09-16 | Bayer Healthcare Llc | Methods of in vitro analysis using time-domain nmr spectroscopy |
| CN103251393A (en) * | 2012-02-17 | 2013-08-21 | 钱军 | Portable blood oxygen, blood sugar and pulse measuring system and manufacture method thereof |
| WO2015018657A1 (en) * | 2013-08-06 | 2015-02-12 | Koninklijke Philips N.V. | System and method for extracting physiological information from remotely detected electromagnetic radiation |
| CN203647348U (en) * | 2013-12-09 | 2014-06-18 | 上海德尔格医疗器械有限公司 | Oxygen saturation detecting instrument |
| CN104617478B (en) * | 2015-01-15 | 2018-05-18 | 武汉洛芙科技股份有限公司 | A kind of Poewr control method of laser therapeutic equipment |
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