CN106662589B - 先兆子痫的早期检测 - Google Patents

先兆子痫的早期检测 Download PDF

Info

Publication number
CN106662589B
CN106662589B CN201580021153.7A CN201580021153A CN106662589B CN 106662589 B CN106662589 B CN 106662589B CN 201580021153 A CN201580021153 A CN 201580021153A CN 106662589 B CN106662589 B CN 106662589B
Authority
CN
China
Prior art keywords
anxa2
level
eclampsia
test sample
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201580021153.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN106662589A (zh
Inventor
卡洛斯·西蒙
塔玛拉·加里多
安东尼奥·佩利塞尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Equipo IVI Investigacion SL
Original Assignee
Equipo IVI Investigacion SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Equipo IVI Investigacion SL filed Critical Equipo IVI Investigacion SL
Priority to CN201910597754.2A priority Critical patent/CN110927385A/zh
Publication of CN106662589A publication Critical patent/CN106662589A/zh
Application granted granted Critical
Publication of CN106662589B publication Critical patent/CN106662589B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201580021153.7A 2014-03-21 2015-03-19 先兆子痫的早期检测 Expired - Fee Related CN106662589B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910597754.2A CN110927385A (zh) 2014-03-21 2015-03-19 先兆子痫的早期检测

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461968728P 2014-03-21 2014-03-21
US61/968,728 2014-03-21
US201461969520P 2014-03-24 2014-03-24
US61/969,520 2014-03-24
PCT/IB2015/001404 WO2015166353A2 (en) 2014-03-21 2015-03-19 Early detection of preeclampsia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201910597754.2A Division CN110927385A (zh) 2014-03-21 2015-03-19 先兆子痫的早期检测

Publications (2)

Publication Number Publication Date
CN106662589A CN106662589A (zh) 2017-05-10
CN106662589B true CN106662589B (zh) 2019-07-30

Family

ID=54147245

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580021153.7A Expired - Fee Related CN106662589B (zh) 2014-03-21 2015-03-19 先兆子痫的早期检测
CN201910597754.2A Pending CN110927385A (zh) 2014-03-21 2015-03-19 先兆子痫的早期检测

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201910597754.2A Pending CN110927385A (zh) 2014-03-21 2015-03-19 先兆子痫的早期检测

Country Status (8)

Country Link
US (1) US20170097358A1 (https=)
EP (1) EP3120152A2 (https=)
JP (1) JP6684263B2 (https=)
CN (2) CN106662589B (https=)
BR (1) BR112016021630A2 (https=)
CA (1) CA2943284A1 (https=)
MX (1) MX384485B (https=)
WO (1) WO2015166353A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010010201A1 (es) 2008-07-22 2010-01-28 Equipo Ivi Investigacion Sl Perfil de expresion genetica como marcador de la receptividad endometrial
CN107073040A (zh) 2014-06-17 2017-08-18 艾基诺米公司 子宫内膜病理状况中的干细胞治疗
CA3074808A1 (en) * 2017-09-05 2019-03-14 Igenomix S.L. Methods and devices for detecting biomarkers associated with preeclampsia
EP3781144A4 (en) * 2018-03-06 2022-01-12 The Feinstein Institutes for Medical Research METHODS TO DETECT AND TREAT ENDOMETRIOSIS
CN114990038B (zh) * 2022-05-24 2023-06-27 郑州大学 一种细菌外膜囊泡及其在制备先兆子痫治疗药物中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101290321A (zh) * 2008-04-11 2008-10-22 中国医学科学院肿瘤研究所 膜联蛋白a2的血清检测方法、检测试剂盒及其应用
CN101889205A (zh) * 2007-07-27 2010-11-17 卡瓦迪斯有限责任公司 用于心血管事件的蛋白质标志物
WO2013081554A1 (en) * 2011-11-30 2013-06-06 Agency For Science, Technology And Research Gm1 ganglioside to annexin v microparticle polypeptide ratio for biological monitoring
CN103436552A (zh) * 2013-09-10 2013-12-11 浙江大学 一种人源annexin A2的生产方法及其应用
WO2014001244A1 (en) * 2012-06-27 2014-01-03 Roche Diagnostics Gmbh MEANS AND METHODS APPLYING sFlt-1/PlGF OR ENDOGLIN/PlGF RATIO TO RULE-OUT ONSET OF PREECLAMPSIA WITHIN A CERTAIN TIME PERIOD

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712103A (en) * 1995-02-13 1998-01-27 Regents Of The University Of California Diagnostic assay for the prediction of preeclampsia
IL127896A0 (en) * 1998-12-31 1999-10-28 Gail Laster A novel treatment for preeclampsia and related diseases
WO2007030889A1 (en) * 2005-09-15 2007-03-22 Victor Voroteliak Method of diagnosing pre-eclampsia
WO2008134881A1 (en) * 2007-05-05 2008-11-13 The University Of Western Ontario Methods for the detection of preeclampsia
WO2009143633A1 (en) 2008-05-30 2009-12-03 Institut De Recherches Cliniques De Montreal Pcsk9 inhibitors and methods of use thereof
CN110208540B (zh) * 2008-10-31 2024-02-09 耶鲁大学 子痫前期检测和治疗的方法和组合物
US20120107825A1 (en) * 2010-11-01 2012-05-03 Winger Edward E Methods and compositions for assessing patients with reproductive failure using immune cell-derived microrna
WO2012115885A1 (en) * 2011-02-22 2012-08-30 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101889205A (zh) * 2007-07-27 2010-11-17 卡瓦迪斯有限责任公司 用于心血管事件的蛋白质标志物
CN101290321A (zh) * 2008-04-11 2008-10-22 中国医学科学院肿瘤研究所 膜联蛋白a2的血清检测方法、检测试剂盒及其应用
WO2013081554A1 (en) * 2011-11-30 2013-06-06 Agency For Science, Technology And Research Gm1 ganglioside to annexin v microparticle polypeptide ratio for biological monitoring
WO2014001244A1 (en) * 2012-06-27 2014-01-03 Roche Diagnostics Gmbh MEANS AND METHODS APPLYING sFlt-1/PlGF OR ENDOGLIN/PlGF RATIO TO RULE-OUT ONSET OF PREECLAMPSIA WITHIN A CERTAIN TIME PERIOD
CN103436552A (zh) * 2013-09-10 2013-12-11 浙江大学 一种人源annexin A2的生产方法及其应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Decidual-Secreted Factors Alter Invasive Trophoblast Membrane and Secreted Proteins Implyinga Role for Decidual Cell Regulation of Placentation;Ellen Melaleuca Menkhorst， et al;《PLoS ONE》;20120216;第7卷;e31418 *
Hong Xin et al.Alterations of profibrinolytic receptor annexin A2 inpre-eclampsia: A possible role in placental thrombin formation.《hrombosis Research》.2011,第129卷第563-567页. *
Prophylaxis of Recurrent Preeclampsia: Low-Molecular-Weight Heparin plus Low-Dose Aspirin versus Low-Dose Aspirin Alone;Ferrazzani Sergio，et al;《Hypertension in Pregnancy》;20060101;第25卷;摘要，第123页讨论部分 *

Also Published As

Publication number Publication date
JP6684263B2 (ja) 2020-04-22
WO2015166353A2 (en) 2015-11-05
WO2015166353A3 (en) 2016-01-21
CA2943284A1 (en) 2015-11-05
EP3120152A2 (en) 2017-01-25
BR112016021630A2 (pt) 2020-02-27
CN106662589A (zh) 2017-05-10
JP2017513021A (ja) 2017-05-25
CN110927385A (zh) 2020-03-27
US20170097358A1 (en) 2017-04-06
MX384485B (es) 2025-03-14
MX2016012278A (es) 2017-04-27

Similar Documents

Publication Publication Date Title
Evans et al. Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor
CN106662589B (zh) 先兆子痫的早期检测
Xiao et al. Expression of integrin β3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window
Lian et al. Matrix metalloproteinase 1 in pre-eclampsia and fetal growth restriction: reduced gene expression in decidual tissue and protein expression in extravillous trophoblasts
Siddiqui et al. Decorin over-expression by decidual cells in preeclampsia: a potential blood biomarker
Audette et al. Dexamethasone stimulates placental system A transport and trophoblast differentiation in term villous explants
Menzies et al. Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor
Wang et al. Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse
Morelli et al. Tissue expression and serum levels of periostin during pregnancy: a new biomarker of embryo–endometrial cross talk at implantation
Novembri et al. Placenta expresses anti-Müllerian hormone and its receptor: sex-related difference in fetal membranes
Huang et al. Increased Krüppel-like factor 12 in recurrent implantation failure impairs endometrial decidualization by repressing Nur77 expression
Chang et al. PLAC1 is involved in human trophoblast syncytialization
Hattori et al. Comparison of follicular fluid and serum anti-Mullerian hormone levels as predictors of the outcome of assisted reproductive treatment
Wölfler et al. A predictive model for endometriosis
Li et al. Role of kisspeptin/GPR54 in the first trimester trophoblast of women with a history of recurrent spontaneous abortion
Li et al. ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition
Motawea et al. Human placenta expresses α2-adrenergic receptors and may be implicated in pathogenesis of preeclampsia and fetal growth restriction
Sahlin et al. Impaired leukocyte influx in cervix of postterm women not responding to prostaglandin priming
Zhu et al. Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth
Bischof et al. Implantation of the Human Embryo: Research Lines and Models: From the Implantation Research Network ‘Fruitful’
Kou et al. Association between HIF‐1α, BNIP3, and autophagy in the chorionic villi of missed abortion
US20130130278A1 (en) Detection of risk for pregnancy-related medical conditions
HK40026831A (en) Early detection of preeclampsia
Bilen et al. Do follicular fluid gelatinase levels affect fertilization rates and oocyte quality?
WO2023176923A1 (ja) 着床能の検出方法および着床障害の予測方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20190730

CF01 Termination of patent right due to non-payment of annual fee