CN106633926A - Self-repairing prosthetic material for ultrasonic puncture, and preparation method and application thereof - Google Patents
Self-repairing prosthetic material for ultrasonic puncture, and preparation method and application thereof Download PDFInfo
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- CN106633926A CN106633926A CN201611190028.1A CN201611190028A CN106633926A CN 106633926 A CN106633926 A CN 106633926A CN 201611190028 A CN201611190028 A CN 201611190028A CN 106633926 A CN106633926 A CN 106633926A
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- prosthetic material
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- 239000000463 material Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims abstract description 8
- 229920001222 biopolymer Polymers 0.000 claims abstract description 7
- 239000007864 aqueous solution Substances 0.000 claims description 18
- 238000001574 biopsy Methods 0.000 claims description 13
- 239000000499 gel Substances 0.000 claims description 12
- 238000007493 shaping process Methods 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 108010010803 Gelatin Proteins 0.000 claims description 6
- 239000008273 gelatin Substances 0.000 claims description 6
- 229920000159 gelatin Polymers 0.000 claims description 6
- 235000019322 gelatine Nutrition 0.000 claims description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000004064 recycling Methods 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000005864 Sulphur Substances 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 238000011161 development Methods 0.000 abstract description 2
- 229910000365 copper sulfate Inorganic materials 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 210000004872 soft tissue Anatomy 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 4
- 230000002035 prolonged effect Effects 0.000 description 4
- 230000014621 translational initiation Effects 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 238000009738 saturating Methods 0.000 description 2
- 229920001944 Plastisol Polymers 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000004999 plastisol Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/30—Sulfur-, selenium- or tellurium-containing compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
- Algebra (AREA)
- Computational Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Mathematical Analysis (AREA)
- Mathematical Optimization (AREA)
- Mathematical Physics (AREA)
- Pure & Applied Mathematics (AREA)
- Business, Economics & Management (AREA)
- Educational Administration (AREA)
- Educational Technology (AREA)
- Theoretical Computer Science (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a self-repairing prosthetic material for ultrasonic puncture, and a preparation method and application thereof. The effective ingredients of the prosthetic material are mainly a biopolymer, water and copper sulfate. The self-repairing prosthetic material for ultrasonic puncture is similar to a human body tissue in mechanical attribute; ultrasonic can penetrate; after ultrasonic puncture for many times, the self repairing can be realized; the prosthetic material can be cyclically used; the self-repairing prosthetic material for ultrasonic puncture has a long effective period and can be stored for 3 to 6 months. According to the method, the medical problem is solved by an engineering means; the development of engineering and medical interdiscipline is further promoted. The prosthetic material can realize puncture practice under the ultrasonic guidance; the preparation of the prosthetic material is simple; the cost is low; the self-repairing prosthetic material can be used for teaching guide and practice operation.
Description
Technical field
The invention belongs to biologic medical field, it is related to a kind of prosthetic devices that can replace biologic soft tissue, specially one
Plant selfreparing ultrasonic puncture prosthetic material and its preparation method and application.
Background technology
Cancer, is also malignant tumour, is the disease caused due to the related mechanism malfunction of growth and proliferation of cell, removes
Propagation is not normal, and cancer cell can also locally invade the normal structure of surrounding and be diffused into people even with the circulatory system or lymphatic system
Body its hetero-organization, with great harmfulness.The main method of diagnosis cancer is cell pathology inspection, the inspection firstly the need of
Obtain the tissue samples of target organ.Due to low with spending, wound is little, few intercurrent disease, at present clinical the advantages of heal very fast
The upper prefered method for extracting tissue specimen is aspiration biopsy method.
Aspiration biopsy is actually one and is needled into biologic soft tissue using biopsy and extracts the process of sample.Research is punctured
Biopsy procedure obviously will start with terms of biologic soft tissue and biopsy needle two.However, the mechanical property of different biologic soft tissues
Difference is huge, and the factor such as sex, age, physique also can be impacted to its mechanical property, and this species diversity can not only increase biology
The complexity of soft tissue mechanics performance study, and the analysis to needle point behavior in piercing process can be disturbed unavoidably.The opposing party
Face, because most of biologic soft tissues are opaque body, this considerably increases the difficulty of observation piercing process, actually mostly
The puncture test of biologic soft tissue often will be observed by technologies such as ultrasonic imaging (B ultrasonic), scannings, not only complicate test,
Also improve experimentation cost.
For problem above, an effective method is using can thoroughly ultrasonic, transparent, mechanical property is more
Stable prosthetic material replaces biologic soft tissue as puncture object.Replace biologic soft tissue as puncture mesh using prosthetic devices
Mark, can effectively reduce impact of biological tissue's otherness to aspiration biopsy process analysis procedure analysis, be conducive to simplifying biopsy needle in puncture
Obstacle interference in biopsy procedure, specifies stress deformation situation of the biopsy needle in piercing process, and then by biopsy needle
The means such as structure optimization, inserting needle parameter optimization, puncture error compensation, improve the precision and efficiency of aspiration biopsy.
At present conventional puncture prosthetic material has imitative muscle trajectory test material, plastisol, PVC (polyvinyl chloride), fine jade
Fat etc., but the mechanical attribute of some materials has certain gap compared with live tissue, it is as puncture prosthese and unreliable, and
The needle track that one or many is stayed after puncturing will seriously cause B ultrasonic image quality to decline.
The content of the invention
The technical problem of solution：In order to overcome the defect of prior art, obtain a kind of close with tissue mechanical attribute,
Saturating ultrasound, Jing after repeated ultrasonic is punctured can selfreparing, can recycle, and imitate the prosthetic material of phase length, the invention provides
A kind of selfreparing ultrasonic puncture prosthetic material and its preparation method and application.
Technical scheme：
A kind of preparation method of selfreparing ultrasonic puncture prosthetic material, comprises the steps of：
Under the conditions of (1) 40～50 DEG C, by biopolymer and water by volume 1:5～1:20 mixing, are stirred well to shape
Into the homogeneous aqueous solution；
(2) in the aqueous solution of step (1) add 5%wt～10%wt copper sulphate, continue stir to be completely dissolved with
Biopolymer aqueous solution is well mixed；
(3) pour the mixed solution of step (2) in container cooling shaping, form solid gel；
(4) gel in step (3) is used for after ultrasonic puncture, is heated to dissolving, then cooling shaping, realizes that circulation makes
With.
Preferably, the biopolymer is gelatin.
Preferably, biopolymer and water by volume 1:10 mixing.
Preferably, the mass fraction of copper sulphate is 10%wt.
The selfreparing ultrasonic puncture prosthetic material that arbitrary methods described is prepared.
Application of the described selfreparing ultrasonic puncture prosthetic material in Type B US-guided biopsy.
Beneficial effect：(1) selfreparing ultrasonic puncture prosthetic material of the present invention is close with tissue mechanical attribute,
Saturating ultrasound, Jing after repeated ultrasonic is punctured can selfreparing, can recycle；(2) selfreparing ultrasonic puncture of the present invention is false
The body material effect phase is long, can preserve 3～6 months；(3) the method for the invention solves medical problem using engineering science means, enters
One step has promoted the development of engineering and medical science cross discipline；(4) prosthetic material of the present invention is realized puncturing under ultrasound guidance
Exercise, prosthetic material prepares simple, low cost, can be used for teaching-guiding and exercise operation.
Specific embodiment
Following examples further illustrate present disclosure, but should not be construed as limiting the invention.Without departing substantially from
In the case of spirit of the invention and essence, the modification made to the inventive method, step or condition and replacement belong to the present invention
Scope.If not specializing, the conventional meanses that technological means used is well known to those skilled in the art in embodiment.
Embodiment 1
A kind of preparation method of selfreparing ultrasonic puncture prosthetic material, comprises the steps of：
Under the conditions of (1) 40 DEG C, by gelatin and water by volume 1:20 mixing, are stirred well to form the homogeneous aqueous solution；
(2) copper sulphate of 10%wt is added in the aqueous solution of step (1), is continued to stir to being completely dissolved and biopolymerization
The thing aqueous solution is well mixed；
(3) pour the mixed solution of step (2) in container cooling shaping, form solid gel；
(4) gel in step (3) is used for after ultrasonic puncture, is heated to 50 DEG C of dissolvings, is cooled to 20 DEG C of shapings,
Realize recycling.
The selfreparing ultrasonic puncture prosthetic material prepared by said method.
The prosthetic material can be applied to super refreshing puncture of Type B to be practised, and prolonged shelf life was to 3 months.
Embodiment 2
A kind of preparation method of selfreparing ultrasonic puncture prosthetic material, comprises the steps of：
Under the conditions of (1) 45 DEG C, by gelatin and water by volume 1:10 mixing, are stirred well to form the homogeneous aqueous solution；
(2) copper sulphate of 8%wt is added in the aqueous solution of step (1), is continued to stir to being completely dissolved and biopolymerization
The thing aqueous solution is well mixed；
(3) pour the mixed solution of step (2) in container cooling shaping, form solid gel；
(4) gel in step (3) is used for after ultrasonic puncture, is heated to 50 DEG C of dissolvings, is cooled to 20 DEG C of shapings,
Realize recycling.
The selfreparing ultrasonic puncture prosthetic material prepared by said method.
The prosthetic material can be applied to super refreshing puncture of Type B to be practised, and prolonged shelf life was to 4 months.
Embodiment 3
A kind of preparation method of selfreparing ultrasonic puncture prosthetic material, comprises the steps of：
Under the conditions of (1) 45 DEG C, by gelatin and water by volume 1:5 mixing, are stirred well to form the homogeneous aqueous solution；
(2) copper sulphate of 5%wt is added in the aqueous solution of step (1), is continued to stir to being completely dissolved and biopolymerization
The thing aqueous solution is well mixed；
(3) pour the mixed solution of step (2) in container cooling shaping, form solid gel；
(4) gel in step (3) is used for after ultrasonic puncture, is heated to 50 DEG C of dissolvings, is cooled to 20 DEG C of shapings,
Realize recycling.
The selfreparing ultrasonic puncture prosthetic material prepared by said method.
The prosthetic material can be applied to super refreshing puncture of Type B to be practised, and prolonged shelf life was to 6 months.
Embodiment 4
A kind of preparation method of selfreparing ultrasonic puncture prosthetic material, comprises the steps of：
Under the conditions of (1) 50 DEG C, by gelatin and water by volume 1:5 mixing, are stirred well to form the homogeneous aqueous solution；
(2) copper sulphate of 5%wt is added in the aqueous solution of step (1), is continued to stir to being completely dissolved and biopolymerization
The thing aqueous solution is well mixed；
(3) pour the mixed solution of step (2) in container cooling shaping, form solid gel；
(4) gel in step (3) is used for after ultrasonic puncture, is heated to 50 DEG C of dissolvings, is cooled to 20 DEG C of shapings,
Realize recycling.
The selfreparing ultrasonic puncture prosthetic material prepared by said method.
The prosthetic material can be applied to super refreshing puncture of Type B to be practised, and prolonged shelf life was to 6 months.
Claims (6)
1. a kind of preparation method of selfreparing ultrasonic puncture prosthetic material, it is characterised in that comprise the steps of：
Under the conditions of (1) 40～50 DEG C, by biopolymer and water by volume 1:5～1:20 mixing, are stirred well to be formed
One aqueous solution；
(2) copper sulphate of 5%wt～10%wt is added in the aqueous solution of step (1), continues to stir to being completely dissolved and biology
Aqueous solutions of polymers is well mixed；
(3) pour the mixed solution of step (2) in container cooling shaping, form solid gel；
(4) gel in step (3) is used for after ultrasonic puncture, is heated to dissolving, then cooling shaping, realizes recycling.
2. a kind of preparation method of selfreparing ultrasonic puncture prosthetic material according to claim 1, it is characterised in that institute
Biopolymer is stated for gelatin.
3. the preparation method of a kind of selfreparing ultrasonic puncture prosthetic material according to claim 1, it is characterised in that raw
Thing polymer and water by volume 1:10 mixing.
4. a kind of preparation method of selfreparing ultrasonic puncture prosthetic material according to claim 1, it is characterised in that sulphur
The mass fraction of sour copper is 10%wt.
5. the selfreparing ultrasonic puncture prosthetic material that the arbitrary methods described of Claims 1 to 4 is prepared.
6. application of the selfreparing ultrasonic puncture prosthetic material described in claim 5 in Type B US-guided biopsy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611190028.1A CN106633926A (en) | 2016-12-21 | 2016-12-21 | Self-repairing prosthetic material for ultrasonic puncture, and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611190028.1A CN106633926A (en) | 2016-12-21 | 2016-12-21 | Self-repairing prosthetic material for ultrasonic puncture, and preparation method and application thereof |
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| Publication Number | Publication Date |
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| CN106633926A true CN106633926A (en) | 2017-05-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611190028.1A Pending CN106633926A (en) | 2016-12-21 | 2016-12-21 | Self-repairing prosthetic material for ultrasonic puncture, and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109694566A (en) * | 2017-10-24 | 2019-04-30 | 南京澳德昇医疗科技有限公司 | A kind of ultrasonic puncture polyurethane rubber prosthetic material preparation method and application |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85102256A (en) * | 1985-04-01 | 1986-09-24 | 中国科学院武汉物理研究所 | Ultrasonic testing biosubstances |
| WO2009039307A2 (en) * | 2007-09-19 | 2009-03-26 | The Regents Of The University Of Colorado | Hydrogels and methods for producing and using the same |
| CN103357062A (en) * | 2012-03-26 | 2013-10-23 | 约泰实业股份有限公司 | Fibrous hydrogel and preparation method thereof |
| US20160278734A1 (en) * | 2013-09-10 | 2016-09-29 | Korea Research Institute Of Standards And Science | Unit block for multiple purposes and multiple images, and multi-module medical phantom using unit block |
-
2016
- 2016-12-21 CN CN201611190028.1A patent/CN106633926A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85102256A (en) * | 1985-04-01 | 1986-09-24 | 中国科学院武汉物理研究所 | Ultrasonic testing biosubstances |
| WO2009039307A2 (en) * | 2007-09-19 | 2009-03-26 | The Regents Of The University Of Colorado | Hydrogels and methods for producing and using the same |
| CN103357062A (en) * | 2012-03-26 | 2013-10-23 | 约泰实业股份有限公司 | Fibrous hydrogel and preparation method thereof |
| US20160278734A1 (en) * | 2013-09-10 | 2016-09-29 | Korea Research Institute Of Standards And Science | Unit block for multiple purposes and multiple images, and multi-module medical phantom using unit block |
Non-Patent Citations (2)
| Title |
|---|
| 万人溥: "《采油工程手册（下册）》", 31 August 2000, 石油工业出版社 * |
| 刁有祥 主编: "《鸡场用药手册》", 31 March 2014, 金盾出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109694566A (en) * | 2017-10-24 | 2019-04-30 | 南京澳德昇医疗科技有限公司 | A kind of ultrasonic puncture polyurethane rubber prosthetic material preparation method and application |
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Application publication date: 20170510 |