CN109694566A - A kind of ultrasonic puncture polyurethane rubber prosthetic material preparation method and application - Google Patents
A kind of ultrasonic puncture polyurethane rubber prosthetic material preparation method and application Download PDFInfo
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- CN109694566A CN109694566A CN201711007496.5A CN201711007496A CN109694566A CN 109694566 A CN109694566 A CN 109694566A CN 201711007496 A CN201711007496 A CN 201711007496A CN 109694566 A CN109694566 A CN 109694566A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
- C08L75/04—Polyurethanes
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
- C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
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Abstract
The invention discloses a kind of ultrasonic puncture polyurethane rubber prosthetic material preparation methods and application, the polyurethane rubber prosthetic material simulated human tissue, main component is polyurethane rubber (urethane rubber), shore hardness (Shore A) is 10 to 60A, and its color can be adjusted by the way that different toners is added；During preparing ultrasonic puncture polyurethane rubber prosthetic material, the tumor tissues in various sizes of activated charcoal pellets simulated human tissue can be added.Ultrasonic puncture of the present invention is close with tissue mechanical attribute with polyurethane rubber prosthetic material, the close elasticity with skin, thoroughly ultrasound, can be punctured and be used with repeated ultrasonic；Activated charcoal pellets with bright hyperecho speciality show clearly grey white image in the super imaging of Type B, simulate the tumor tissues in tissue well in Ultrasonic tomography.Ultrasonic puncture of the present invention is good with polyurethane rubber prosthetic material stability, can save 6~36 months；Polyurethane rubber prosthetic material of the present invention realize under ultrasound guidance puncture practice, polyurethane rubber prosthetic material prepare it is simple, at low cost, can be used for teaching-guiding and practice operate.
Description
Technical field
The invention belongs to biologic medical fields, are related to a kind of prosthetic material tissue that can replace biologic soft tissue, specifically
For a kind of ultrasonic puncture polyurethane rubber prosthetic material preparation method and application.
Background technique
Cancer is also malignant tumour, is the related mechanism malfunction due to growth and proliferation of cell and the disease caused, removes
Proliferation is not normal, and cancer cell can also locally invade the normal tissue of surrounding or even pass through the circulatory system or lymphatic system is diffused into people
Its hetero-organization of body has great harmfulness.The main method of diagnosis cancer is cell pathology inspection, the inspection firstly the need of
Target suspicious lesions tissue samples are obtained by puncturing.Needle biopsy method under ultrasound guidance is accurate due to having, quickly,
Spend low, wound is small, and few intercurrent disease heals the advantages that very fast, is widely used in clinically extracting suspicious lesions tissue at present
Sample.
Aspiration biopsy is actually one and is needled into biologic soft tissue using biopsy and extracts the process of sample.Research punctures
Biopsy procedure obviously will start in terms of biologic soft tissue and biopsy needle two.However, the mechanical property of different biologic soft tissues
Difference is huge, and the factors such as gender, age, constitution can also impact its mechanical property, this species diversity not only will increase biology
The complexity of soft tissue mechanics performance study, and can inevitably interfere the analysis to needle point behavior in puncture process.Another party
Face, since most of biologic soft tissues are opaque body, this considerably increases the difficulty of puncture process.So real in clinic
The puncture test of most biologic soft tissue will often be observed by technologies such as ultrasonic imaging (B ultrasound), CT scan on border, to improve
The accuracy of aspiration biopsy greatly reduces the accidental injury probability to other normal tissues.
In view of the above problems, the prosthetic material for just needing to provide a kind of ultrasound is used to repeat to medical personnel,
To further increase the success rate of medical personnel's aspiration biopsy in clinic.Using can thoroughly ultrasound, transparent, mechanical property
The prosthetic material of relatively stable and close biological soft tissue, which will replace biologic soft tissue as the practice object of aspiration biopsy, to be
A kind of very effective method.
Currently used puncture prosthetic material has hyalomitome colloid, plastisol, PVC (polyvinyl chloride), agar, hydrogel
Deng, however the mechanical attribute of some of them material differs too big with true soft tissue, as puncturing, prosthese hardness is really up to the mark；Some
Ultrasonic performance is bad thoroughly for material, has seriously affected the quality of image of ultrasound；Some materials are prohibitively expensive；Some material preparation process
It is excessively complicated；Material also cannot achieve multiple puncture.Polyurethane rubber has that intensity is good, high resiliency, high-wearing feature, resistance to tears
It splits, is ageing-resistant, resistance to ozone, radiation hardness and the advantages that good processing, hardness is also very close to human skin elasticity, also easily
It is cheap in solidification and moulding, it is a kind of ideal prosthetic material instead of soft tissue.
Summary of the invention
The technical issues of solution: in order to overcome the drawbacks of the prior art, obtain it is a kind of close with tissue mechanical attribute,
The close elasticity with skin, ultrasound, energy repeated ultrasonic puncture use thoroughly, and steadily in the long term, cheap, preparation is quick and easy, easily
In molding prosthetic material, the present invention provides a kind of ultrasonic puncture polyurethane rubber prosthetic material preparation methods and application.
Technical solution:
A kind of preparation method of ultrasonic puncture polyurethane rubber prosthetic material comprising the steps of:
(1) under the conditions of 10~40 DEG C of room temperature, by polyurethane rubber A type and polyurethane rubber Type B 1:1~1 by volume:
8 mixing, are quickly stirred well to form uniform viscous solution；
(2) toner is added into the viscous solution of step (1), continues stirring to uniform viscous solution；
(3) the uniform viscous solution of step (2) is poured slowly into container, and by the activated charcoal pellets of different sizes
It is gently put into viscous solution, is suspended in it in viscous solution；
(4) container containing viscous solution in step (3) be put into vacuum barrel carry out vacuum (vacuum degree be 1~80 milli
Meter mercury column(unit of pressure)) deaeration 30~200 minutes, sufficiently remove the bubble in solution；
(5) container containing viscous solution that bubble has been taken off in step (4), which is placed in 20~120 DEG C of incubator, to carry out
Solidification 1~8 hour, forms solid urethaue rubber prosthetic material, and shore hardness (Shore A) is 10 to 60A.
(6) solid urethaue rubber prosthetic material is practiced for ultrasonic puncture in step (5), and may be implemented repeatedly super
Sound punctures practice.
Preferably, the prosthetic material is polyurethane rubber, and raw material is produced from U.S. Smooth-On, the purchase of Inc. company
Product model Series。
Preferably, 1:1 is mixed polyurethane rubber A type by volume with polyurethane rubber Type B.
Preferably, the prosthetic material that toner is used to adjust the suitable appearance color finally obtained is added in viscous solution.
Preferably, the diameter dimension of activated charcoal pellets is 1 centimetre, is suspended in polyurethane rubber vacation as simulation tumor tissues
In body material.
Preferably, the container of viscous solution, which is put into vacuum barrel, carries out vacuum (vacuum degree is 20 millimetress of mercury) deaeration 100
Minute, sufficiently remove the bubble in solution.
Preferably, the shore hardness (Shore A) of the solid urethaue rubber prosthetic material of formation is 10A.
The ultrasonic puncture that any the method prepares polyurethane rubber prosthetic material.
Application of the ultrasonic puncture with polyurethane rubber prosthetic material in Type B US-guided biopsy.
The utility model has the advantages that (1) ultrasonic puncture of the present invention polyurethane rubber prosthetic material and tissue mechanical attribute
Close, close to the elasticity of human skin, ultrasound, can bear repeated ultrasonic and puncture use thoroughly；(2) ultrasonic puncture of the present invention
It is good with polyurethane rubber prosthetic material stability, it can save 6~36 months；(3) the method for the invention is learned to do using engineering
Section solves medical problem, has further pushed the development of engineering Yu medicine cross discipline；(4) polyurethane rubber of the present invention is false
Body material realize under ultrasound guidance puncture practice, prosthetic material prepare it is simple, at low cost, can be used for teaching-guiding and practice grasp
Make.
Specific embodiment
Following embodiment further illustrates the contents of the present invention, but should not be construed as limiting the invention.Without departing substantially from
In the case where spirit of that invention and essence, to modification made by the method for the present invention, step or condition and replaces, belong to the present invention
Range.Unless otherwise specified, the conventional means that technological means used in embodiment is well known to those skilled in the art.
Embodiment 1
A kind of preparation method of ultrasonic puncture polyurethane rubber prosthetic material comprising the steps of:
(1) under the conditions of 10 DEG C of room temperature, by polyurethane rubber A type, 1:1 is mixed by volume with polyurethane rubber Type B, fastly
Speed is stirred well to form uniform viscous solution；
(2) toner (rhodamine B) is added into the viscous solution of step (1), continues stirring to uniform viscous solution；
(3) the uniform viscous solution of step (2) is poured slowly into container, and by the activated charcoal pellets of different sizes
(1 centimetre of diameter) is gently put into viscous solution, is suspended in it in viscous solution；
(4) container containing viscous solution in step (3) be put into vacuum barrel carry out vacuum (vacuum degree be 20 millimeters of mercury
Column) deaeration 30 minutes, sufficiently remove the bubble in solution；
(5) container containing viscous solution that bubble has been taken off in step (4), which is placed in 20 DEG C of incubator, carries out solidification 8
Hour, solid urethaue rubber prosthetic material is formed, shore hardness (Shore A) is 10A.
(6) solid urethaue rubber prosthetic material is practiced for ultrasonic puncture in step (5), and may be implemented repeatedly super
Sound punctures practice.
The ultrasonic puncture polyurethane rubber prosthetic material prepared by the above method.
The prosthetic material can be applied to the practice of Type B ultrasonic puncture, and prolonged shelf life was to 6 months.
Embodiment 2
A kind of preparation method of ultrasonic puncture polyurethane rubber prosthetic material comprising the steps of:
(1) under the conditions of 40 DEG C of room temperature, by polyurethane rubber A type, 1:6 is mixed by volume with polyurethane rubber Type B, fastly
Speed is stirred well to form uniform viscous solution；
(2) toner (phthalocyanine blue) is added into the viscous solution of step (1), continues stirring to uniform viscous solution；
(3) the uniform viscous solution of step (2) is poured slowly into container, and by the activated charcoal pellets of different sizes
(50 millimeters of diameter) is gently put into viscous solution, is suspended in it in viscous solution；
(4) container containing viscous solution in step (3) be put into vacuum barrel carry out vacuum (vacuum degree be 1 millimeter of mercury
Column) deaeration 200 minutes, sufficiently remove the bubble in solution；
(5) container containing viscous solution that bubble has been taken off in step (4), which is placed in 50 DEG C of incubator, carries out solidification 1
Hour, solid urethaue rubber prosthetic material is formed, shore hardness (Shore A) is 40A.
(6) solid urethaue rubber prosthetic material is practiced for ultrasonic puncture in step (5), and may be implemented repeatedly super
Sound punctures practice.The ultrasonic puncture polyurethane rubber prosthetic material prepared by the above method.
The prosthetic material can be applied to the practice of Type B ultrasonic puncture, and prolonged shelf life was to 24 months.
Embodiment 3
A kind of preparation method of ultrasonic puncture polyurethane rubber prosthetic material comprising the steps of:
(1) under the conditions of 30 DEG C of room temperature, by polyurethane rubber A type, 1:8 is mixed by volume with polyurethane rubber Type B, fastly
Speed is stirred well to form uniform viscous solution；
(2) toner (calcein) is added into the viscous solution of step (1), continues stirring to uniform viscous solution；
(3) the uniform viscous solution of step (2) is poured slowly into container, and by the activated charcoal pellets of different sizes
(diameter is 2 centimetres) is gently put into viscous solution, is suspended in it in viscous solution；
(4) container containing viscous solution in step (3) be put into vacuum barrel carry out vacuum (vacuum degree be 80 millimeters of mercury
Column) deaeration 60 minutes, sufficiently remove the bubble in solution；
(5) container containing viscous solution that bubble has been taken off in step (4), which is placed in 120 DEG C of incubator, to be solidified
4 hours, solid urethaue rubber prosthetic material is formed, shore hardness (Shore A) is 60A.
(6) solid urethaue rubber prosthetic material is practiced for ultrasonic puncture in step (5), and may be implemented repeatedly super
Sound punctures practice.The ultrasonic puncture polyurethane rubber prosthetic material prepared by the above method.
The prosthetic material can be applied to the practice of Type B ultrasonic puncture, and prolonged shelf life was to 36 months.
Claims (9)
1. a kind of ultrasonic puncture preparation method of polyurethane rubber prosthetic material, which is characterized in that comprise the steps of:
(1) under the conditions of 10~40 DEG C of room temperature, by polyurethane rubber A type, 1:1~1:8 is mixed by volume with polyurethane rubber Type B
It closes, is quickly stirred well to form uniform viscous solution；
(2) toner is added into the viscous solution of step (1), continues stirring to uniform viscous solution；
(3) the uniform viscous solution of step (2) is poured slowly into container, and gently by the activated charcoal pellets of different sizes
It is put into viscous solution, is suspended in it in viscous solution；
(4) container containing viscous solution in step (3) be put into vacuum barrel carry out vacuum (vacuum degree be 1~80 millimeter of mercury
Column) deaeration 30~200 minutes, sufficiently remove the bubble in solution；
(5) container containing viscous solution that bubble has been taken off in step (4), which is placed in 20~120 DEG C of incubator, to be solidified
1~8 hour, solid urethaue rubber prosthetic material is formed, shore hardness (Shore A) is 10 to 60A.
(6) solid urethaue rubber prosthetic material is practiced for ultrasonic puncture in step (5), and repeated ultrasonic may be implemented and wear
Thorn practice.
2. a kind of preparation method of ultrasonic puncture polyurethane rubber prosthetic material according to claim 1, feature exist
In the prosthetic material is polyurethane rubber, and raw material is from U.S. Smooth-On, the purchase of Inc. company, product type Series。
3. a kind of preparation method of ultrasonic puncture polyurethane rubber prosthetic material according to claim 1, feature exist
In 1:1~1:8 is mixed polyurethane rubber A type by volume with polyurethane rubber Type B.
4. a kind of preparation method of ultrasonic puncture polyurethane rubber prosthetic material according to claim 1, feature exist
In the toner that different colours are added in viscous solution is used to adjust the appearance color of the prosthetic material finally obtained.
5. a kind of preparation method of ultrasonic puncture polyurethane rubber prosthetic material according to claim 1, feature exist
In the diameter dimension of activated charcoal pellets is 10 millimeters~2 centimetres, is suspended in polyurethane rubber prosthese material as simulation tumor tissues
In material.
6. a kind of preparation method of ultrasonic puncture polyurethane rubber prosthetic material according to claim 1, feature exist
In, the container of viscous solution, which is put into vacuum barrel, carries out vacuum (vacuum degree is 1~80 millimetres of mercury) deaeration 30~200 minutes,
Sufficiently remove the bubble in solution.
7. a kind of preparation method of ultrasonic puncture polyurethane rubber prosthetic material according to claim 1, feature exist
In the shore hardness (Shore A) of the solid urethaue rubber prosthetic material of formation is 10 to 60A.
8. the ultrasonic puncture polyurethane rubber prosthetic material that any the method for claim 1~6 prepares.
9. ultrasonic puncture polyurethane rubber prosthetic material answering in Type B US-guided biopsy as claimed in claim 7
With.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111986547A (en) * | 2020-09-08 | 2020-11-24 | 四川大学华西医院 | Preparation method of phantom model for ultrasonic puncture teaching |
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2017
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| CN1915639A (en) * | 2005-08-19 | 2007-02-21 | 中国辐射防护研究院 | Method for fabricating imitated human phantom |
| CN106633926A (en) * | 2016-12-21 | 2017-05-10 | 南京大学 | Self-repairing prosthetic material for ultrasonic puncture, and preparation method and application thereof |
| CN106781944A (en) * | 2016-12-21 | 2017-05-31 | 南京大学 | A kind of ultrasonic puncture experimental model of pH regulation and control and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111986547A (en) * | 2020-09-08 | 2020-11-24 | 四川大学华西医院 | Preparation method of phantom model for ultrasonic puncture teaching |
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Application publication date: 20190430 |