CN106633711A - Preparation method of degradable medical infusion bag material - Google Patents

Preparation method of degradable medical infusion bag material Download PDF

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Publication number
CN106633711A
CN106633711A CN201610876183.2A CN201610876183A CN106633711A CN 106633711 A CN106633711 A CN 106633711A CN 201610876183 A CN201610876183 A CN 201610876183A CN 106633711 A CN106633711 A CN 106633711A
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bag material
preparation
parts
infusion bag
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CN106633711B (en
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吴蓉蓉
邹玉
薛蕾
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Anhui Jiarui Pharmaceutical Technology Co.,Ltd.
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TRUSYN CHEM-TECH Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/02—Making granules by dividing preformed material
    • B29B9/06—Making granules by dividing preformed material in the form of filamentary material, e.g. combined with extrusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
    • B29C49/0005—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor characterised by the material
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2403/00—Characterised by the use of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08J2403/04—Starch derivatives
    • C08J2403/06—Esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
    • C08J2405/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2475/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
    • C08J2475/04—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/06—Biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/08—Stabilised against heat, light or radiation or oxydation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/14—Gas barrier composition
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
    • C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Hematology (AREA)
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  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The invention discloses a preparation method of a degradable medical infusion bag material, which belongs to the technical field of the preparation of medical materials. The preparation method comprises the following steps: stirring and gelatinizing corn starch, sterile water and salicylic acid, then adding amino acid, lactic acid and triethylamine, heating and stirring to perform the reaction, cooling, discharging, freezing, collecting frozen articles, mixing the collected frozen articles with polyglycolic acid, polyurethane, tea polyphenol and the like, collecting a mixture, granulating, performing film blowing and forming for the particles, thus obtaining the degradable medical infusion bag material. The prepared medical infusion bag material is high in degradability, pollution-free to the environment, good in material air tightness, capable of well blocking oxygen, relatively good in mechanical performance, excellent in puncture resistance, and wide in application range.

Description

A kind of preparation method of degradable medical transfusion bag material
Technical field
The invention discloses a kind of preparation method of degradable medical transfusion bag material, belongs to medical material technology of preparing neck Domain.
Background technology
People are sick unavoidable, and intravenous drip is one of essential therapeutic arsenals.China has played for a long time history The big transfusion Traditional Packing of effect is glass container, and at present the overwhelming majority still continue to use traditional vial, natural rubber plug and Aluminum cap packaging not easy to open.Glass bottle packaging low cost, there is certain superiority, but there are problems that many.Such as production technology Complexity, increased the chance of liquid medicine contamination；Vial cracky, easily causes mould contamination；Natural rubber plug is easily aging, air-tightness Easily fall bits when difference, acupuncture；And the additive and glass material in plug loses in medicinal liquid molten and buffings takes off when medicine is taken out in puncture The particulate matter for falling can block microcirculation in human body, the problems such as can also cause thrombocytolysis bleeding.With composite wood The continuous development of material, except particular/special requirement, is now generally individually infused using plastic infusion bag.
Disposable plastic infusion bag is that special medical grade plastic processing and fabricating is formed, current polrvinyl chloride and polypropylene Two kinds of materials are most widely used, and relative to traditional glass bottle packaging many advantages are presented：(1) injection quality is improved, is subtracted Few infusion reaction；(2) simple production process, efficiency high, reduce the complicated operation in wash bottle, epiphragma, lid plug Deng Ji roads and its Pre-treatment, saves human and material resources, financial resources, and the production cycle shortens, and efficiency is improved；(3) small investment, filling machine is simple, price Low, more mechanical floor space is little, can reduce the area between hundred grades, substantially reduces housing investment；(4) production safety, Sterilisation vapour pressure is low, and temperature is only 108 DEG C, there is water injector in disinfection cabinet again, and cooling is very fast, can completely avoid danger；(5) The characteristics of transfusion bag has small volume, lightweight, chemical stability is good.
Often air-tightness is poor for existing medical infusion bags material, not good to the barrier of oxygen, and transfusion material is easily outer Boundary's oxidation stain, while mechanical performance is undesirable, transfusion bag chance puncture situation is easily damaged, additionally, being difficult after transfusion bag is discarded Degraded, can cause certain pollution to surrounding.
The content of the invention
Present invention mainly solves technical problem：It is poor for current existing medical infusion bags material air-tightness, to oxygen The barrier of gas is not good, mechanical performance is undesirable, transfusion bag not puncture-resistant and it is discarded after it is not degradable, environmental pollution can be caused Problem, there is provided a kind of preparation method of degradable medical transfusion bag material, the method is first by corn starch, sterilized water, bigcatkin willow Acid stirring gelatinizing, subsequently adds aminoacid and lactic acid, the reaction of triethylamine heated and stirred, subsequent cooling discharging and freezing processing, collects Frozen material and polyglycolic acid, polyurethane, tea polyphenols etc. are kneaded, and collecting mixing thing carries out pelletize, subsequently with inflation film manufacturing machine will Grain blowfilm shaping, you can obtain degradable medical transfusion bag material, the obtained medical infusion bags material degradability of the present invention is strong, no Can be to environment, material air-tightness is good, can play preferable insulating effect to oxygen, and the mechanical property of materials compared with It is good, puncture-resistant excellent performance, with wide application space.
In order to solve above-mentioned technical problem, the technical solution adopted in the present invention is：
（1）In mass ratio 1:3, extracting corn starch and sterilized water are put in container, and container is placed in water-bath, add jade The salicylic acid of rice starch quality 0.5～0.8%, design temperature is 65～72 DEG C, and with 120r/min 1～2h of gelatinizing is stirred, and is subsequently divided Not Jia Ru corn starch quality 4.2～4.6% aminoacid and the lactic acid of aseptic water volume 20～30%, continue stir 40～ 50min；
（2）After above-mentioned stirring terminates, the mixture in container is put in autoclave, it is using gaseous mixture that reactor is empty Gas is discharged, and is warming up to 90～95 DEG C, and with 160r/min 30～40min is stirred, and is subsequently added the three of mixture quality 0.6～0.9% Ethamine, continues 2～3h of stirring reaction, then stops agitating heating, naturally cools to room temperature, and discharging and will go out material, to be put into liquid nitrogen cold In jelly machine, 50～70s of freezing processing collects frozen material；The gaseous mixture is nitrogen, ammonia and monosilane by volume 4:2:1 Mix；
（3）Count by weight, take 40～50 parts of polyglycolic acids, 32～36 parts of polyurethane, 16～19 parts of above-mentioned frozen materials, 4～6 Part terpane formyl ethamine, 1～3 part of shitosan, 1～2 part of tea polyphenols and 0.8～1.4 part of castor oil acid, mix homogeneously, then put Enter in plastics processing mill and mix, as 110～115 DEG C, rear roll temperature is 118～122 DEG C to roll temperature, kneads 10～15min, is received before setting Collection mixing thing, obtains compound；
（4）Above-mentioned compound is put into into extruding pelletization in double screw extruder, 105～110 DEG C of an area, two areas 115～120 are set DEG C, three 130～135 DEG C of areas, four 140～150 DEG C of areas, the granule of gained is put into blown film in inflation film manufacturing machine by five 160～175 DEG C of areas Molding, you can obtain degradable medical transfusion bag material.
After testing, up to 20～24MPa, water absorption rate is the obtained degradable medical transfusion bag tensile strength of material of the present invention 0.02～0.08%, elongation at break is 330～350%, and material air-tightness is preferably, and OTR oxygen transmission rate is only 0.5～0.8cm3/ （m2·24h·0.1MPa）.
The invention has the beneficial effects as follows：
（1）Obtained degradable medical transfusion bag material puncture-resistant of the invention, resistance to elevated temperatures are preferable；
（2）Obtained medical infusion bags material of the invention is degradation material, can be degradable after discarding, and environment will not be caused Pollution, and material air-tightness is preferably, and good iris action can be played to oxygen.
Specific embodiment
First in mass ratio 1:3, extracting corn starch and sterilized water are put in container, and container is placed in water-bath, then The salicylic acid of corn starch quality 0.5～0.8% is added, design temperature is 65～72 DEG C, and with 120r/min 1～2h of gelatinizing is stirred, The aminoacid of corn starch quality 4.2～4.6% and the lactic acid of aseptic water volume 20～30% are subsequently separately added into, continue to stir 40 ～50min；After above-mentioned stirring terminates, the mixture in container is put in autoclave, using gaseous mixture by reactor Air is discharged, and is warming up to 90～95 DEG C, and with 160r/min 30～40min is stirred, and is subsequently added mixture quality 0.6～0.9% Triethylamine, continues 2～3h of stirring reaction, then stops agitating heating, naturally cools to room temperature, discharges and will go out material and be put into liquid nitrogen In fridge, 50～70s of freezing processing collects frozen material；The gaseous mixture is nitrogen, ammonia and monosilane by volume 4:2: 1 mixes；Subsequently count by weight, take 40～50 parts of polyglycolic acids, 32～36 parts of polyurethane, 16～19 parts of above-mentioned freezings Thing, 4～6 parts of terpane formyl ethamine, 1～3 part of shitosan, 1～2 part of tea polyphenols and 0.8～1.4 part of castor oil acid, mixing is equal It is even, place in plastics processing mill and mix, as 110～115 DEG C, rear roll temperature is 118～122 DEG C to roll temperature before setting, mixing 10～ 15min, collects mixing thing, obtains compound；Finally above-mentioned compound is put into into extruding pelletization in double screw extruder, sets an area 105～110 DEG C, two 115～120 DEG C of areas, three 130～135 DEG C of areas, four 140～150 DEG C of areas, five 160～175 DEG C of areas, by gained Granule be put into blowfilm shaping in inflation film manufacturing machine, you can degradable medical transfusion bag material.
Example 1
First in mass ratio 1:3, extracting corn starch and sterilized water are put in container, and container is placed in water-bath, are added The salicylic acid of corn starch quality 0.5%, design temperature is 65 DEG C, and with 120r/min gelatinizing 1h is stirred, and is subsequently separately added into Semen Maydiss The lactic acid of the aminoacid of starch quality 4.2% and aseptic water volume 20%, continues to stir 40min；After above-mentioned stirring terminates, will hold Mixture in device is put in autoclave, is discharged reactor air using gaseous mixture, 90 DEG C is warming up to, with 160r/min Stirring 30min, is subsequently added the triethylamine of mixture quality 0.6%, continues stirring reaction 2h, then stops agitating heating, naturally cold But to room temperature, discharge and will go out material and be put in liquid nitrogen freezers, freezing processing 50s collects frozen material；The gaseous mixture is nitrogen Gas, ammonia and monosilane by volume 4:2:1 mixes；Subsequently count by weight, take 40 parts of polyglycolic acids, 32 parts of poly- ammonia Ester, 16 parts of above-mentioned frozen materials, 4 parts of terpane formyl ethamine, 1 part of shitosan, 1 part of tea polyphenols and 0.8 part of castor oil acid, mixing is equal It is even, place in plastics processing mill and mix, as 110 DEG C, rear roll temperature is 118 DEG C to roll temperature, kneads 10min, collects mixing before setting Thing, obtains compound；Finally above-mentioned compound is put into into extruding pelletization in double screw extruder, sets 105 DEG C of an area, two areas 115 DEG C, the granule of gained is put into blowfilm shaping in inflation film manufacturing machine by three 130 DEG C of areas, four 140 DEG C of areas, five 160 DEG C of areas, you can obtaining to drop Solution medical infusion bags material.
After testing, the obtained degradable medical transfusion bag tensile strength of material of the present invention reaches 20MPa, and water absorption rate is 0.02%, Elongation at break is 330%, and material air-tightness is preferably, and OTR oxygen transmission rate is only 0.5cm3/（m2·24h·0.1MPa）.
Example 2
First in mass ratio 1:3, extracting corn starch and sterilized water are put in container, and container is placed in water-bath, are added The salicylic acid of corn starch quality 0.7%, design temperature is 68 DEG C, and with 120r/min gelatinizing 1.5h is stirred, and is subsequently separately added into jade The lactic acid of the aminoacid of rice starch quality 4.4% and aseptic water volume 25%, continues to stir 45min；After above-mentioned stirring terminates, will Mixture in container is put in autoclave, is discharged reactor air using gaseous mixture, 93 DEG C is warming up to, with 160r/ Min stirs 35min, is subsequently added the triethylamine of mixture quality 0.7%, continues stirring reaction 2.5h, then stops agitating heating, Room temperature is naturally cooled to, is discharged and will be gone out material and be put in liquid nitrogen freezers, freezing processing 60s collects frozen material；The mixing Gas is nitrogen, ammonia and monosilane by volume 4:2:1 mixes；Subsequently count by weight, take 45 parts of polyglycolic acids, 34 Part polyurethane, 17 parts of above-mentioned frozen materials, 5 parts of terpane formyl ethamine, 2 parts of shitosans, 1.5 parts of tea polyphenols and 1.1 parts of Oleum Ricini Acid, mix homogeneously is placed in plastics processing mill and mixed, and as 113 DEG C, rear roll temperature is 120 DEG C to roll temperature, kneads 13min before setting, Mixing thing is collected, compound is obtained；Finally above-mentioned compound is put into into extruding pelletization in double screw extruder, sets 108 DEG C of an area, The granule of gained is put into blowfilm shaping in inflation film manufacturing machine by two 118 DEG C of areas, three 133 DEG C of areas, four 145 DEG C of areas, five 168 DEG C of areas, you can Obtain degradable medical transfusion bag material.
After testing, the obtained degradable medical transfusion bag tensile strength of material of the present invention reaches 22MPa, and water absorption rate is 0.05%, Elongation at break is 340%, and material air-tightness is preferably, and OTR oxygen transmission rate is only 0.7cm3/（m2·24h·0.1MPa）.
Example 3
First in mass ratio 1:3, extracting corn starch and sterilized water are put in container, and container is placed in water-bath, are added The salicylic acid of corn starch quality 0.8%, design temperature is 72 DEG C, and with 120r/min gelatinizing 2h is stirred, and is subsequently separately added into Semen Maydiss The lactic acid of the aminoacid of starch quality 4.6% and aseptic water volume 30%, continues to stir 50min；After above-mentioned stirring terminates, will hold Mixture in device is put in autoclave, is discharged reactor air using gaseous mixture, 95 DEG C is warming up to, with 160r/min Stirring 40min, is subsequently added the triethylamine of mixture quality 0.9%, continues stirring reaction 3h, then stops agitating heating, naturally cold But to room temperature, discharge and will go out material and be put in liquid nitrogen freezers, freezing processing 70s collects frozen material；The gaseous mixture is nitrogen Gas, ammonia and monosilane by volume 4:2:1 mixes；Subsequently count by weight, take 50 parts of polyglycolic acids, 36 parts of poly- ammonia Ester, 19 parts of above-mentioned frozen materials, 6 parts of terpane formyl ethamine, 3 parts of shitosans, 2 parts of tea polyphenols and 1.4 parts of castor oil acids, mixing is equal It is even, place in plastics processing mill and mix, as 115 DEG C, rear roll temperature is 122 DEG C to roll temperature, kneads 15min, collects mixing before setting Thing, obtains compound；Finally above-mentioned compound is put into into extruding pelletization in double screw extruder, sets 110 DEG C of an area, two areas 120 DEG C, the granule of gained is put into blowfilm shaping in inflation film manufacturing machine by three 135 DEG C of areas, four 150 DEG C of areas, five 175 DEG C of areas, you can obtaining to drop Solution medical infusion bags material.
After testing, the obtained degradable medical transfusion bag tensile strength of material of the present invention reaches 24MPa, and water absorption rate is 0.08%, Elongation at break is 350%, and material air-tightness is preferably, and OTR oxygen transmission rate is only 0.8cm3/（m2·24h·0.1MPa）.

Claims (1)

1. a kind of preparation method of degradable medical transfusion bag material, it is characterised in that concrete preparation process is：
（1）In mass ratio 1:3, extracting corn starch and sterilized water are put in container, and container is placed in water-bath, add jade The salicylic acid of rice starch quality 0.5～0.8%, design temperature is 65～72 DEG C, and with 120r/min 1～2h of gelatinizing is stirred, and is subsequently divided Not Jia Ru corn starch quality 4.2～4.6% aminoacid and the lactic acid of aseptic water volume 20～30%, continue stir 40～ 50min；
（2）After above-mentioned stirring terminates, the mixture in container is put in autoclave, it is using gaseous mixture that reactor is empty Gas is discharged, and is warming up to 90～95 DEG C, and with 160r/min 30～40min is stirred, and is subsequently added the three of mixture quality 0.6～0.9% Ethamine, continues 2～3h of stirring reaction, then stops agitating heating, naturally cools to room temperature, and discharging and will go out material, to be put into liquid nitrogen cold In jelly machine, 50～70s of freezing processing collects frozen material；The gaseous mixture is nitrogen, ammonia and monosilane by volume 4:2:1 Mix；
（3）Count by weight, take 40～50 parts of polyglycolic acids, 32～36 parts of polyurethane, 16～19 parts of above-mentioned frozen materials, 4～6 Part terpane formyl ethamine, 1～3 part of shitosan, 1～2 part of tea polyphenols and 0.8～1.4 part of castor oil acid, mix homogeneously, then put Enter in plastics processing mill and mix, as 110～115 DEG C, rear roll temperature is 118～122 DEG C to roll temperature, kneads 10～15min, is received before setting Collection mixing thing, obtains compound；
（4）Above-mentioned compound is put into into extruding pelletization in double screw extruder, 105～110 DEG C of an area, two areas 115～120 are set DEG C, three 130～135 DEG C of areas, four 140～150 DEG C of areas, the granule of gained is put into blown film in inflation film manufacturing machine by five 160～175 DEG C of areas Molding, you can obtain degradable medical transfusion bag material.
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108659513A (en) * 2018-05-30 2018-10-16 郭舒洋 A kind of preparation method of choke stretch-proof infusion bag material
CN108743374A (en) * 2018-04-17 2018-11-06 苏州莱士输血器材有限公司 A kind of preparation method being protected from light degradable infusion bag
CN108962521A (en) * 2018-07-13 2018-12-07 吴江市聚盈电子材料科技有限公司 A kind of electromagnetic shielding preparation method of magnetic material

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103739940A (en) * 2013-12-08 2014-04-23 山东天蓝环保科技发展有限公司 Method used for biological treatment of medical abandoned infusion bags

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103739940A (en) * 2013-12-08 2014-04-23 山东天蓝环保科技发展有限公司 Method used for biological treatment of medical abandoned infusion bags

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108743374A (en) * 2018-04-17 2018-11-06 苏州莱士输血器材有限公司 A kind of preparation method being protected from light degradable infusion bag
CN108659513A (en) * 2018-05-30 2018-10-16 郭舒洋 A kind of preparation method of choke stretch-proof infusion bag material
CN108962521A (en) * 2018-07-13 2018-12-07 吴江市聚盈电子材料科技有限公司 A kind of electromagnetic shielding preparation method of magnetic material

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