CN106632588A - 一种聚乙二醇修饰蛋白的纯化工艺 - Google Patents
一种聚乙二醇修饰蛋白的纯化工艺 Download PDFInfo
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- CN106632588A CN106632588A CN201510536560.3A CN201510536560A CN106632588A CN 106632588 A CN106632588 A CN 106632588A CN 201510536560 A CN201510536560 A CN 201510536560A CN 106632588 A CN106632588 A CN 106632588A
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Abstract
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目的产物名称 | 一步离子交换层析纯化工艺 | 先超滤后离子交换层析法纯化工艺 |
M-SC-10K-ASP | 51% | 85% |
M-SPA-5K-ASP | 53% | 81% |
M-SPA-10K-ASP | 55% | 83% |
M-SCM-5K-ASP | 50% | 84% |
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CN201510536560.3A CN106632588A (zh) | 2015-08-27 | 2015-08-27 | 一种聚乙二醇修饰蛋白的纯化工艺 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108634089A (zh) * | 2018-01-11 | 2018-10-12 | 合肥工业大学 | 一种低致敏高凝胶性豆类蛋白粉的制备方法 |
CN114316019A (zh) * | 2021-12-10 | 2022-04-12 | 河北菲尼斯生物技术有限公司 | 一种通过离子交换层析制备peg修饰的il-2的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1673230A (zh) * | 2004-03-24 | 2005-09-28 | 中国科学院过程工程研究所 | 重组人复合干扰素-聚乙二醇偶联物的制备及其偶联产物 |
CN102634492A (zh) * | 2011-02-14 | 2012-08-15 | 重庆富进生物医药有限公司 | 聚乙二醇化犬源尿酸氧化酶类似物及其制备方法和应用 |
CN103923898A (zh) * | 2014-04-17 | 2014-07-16 | 江南大学 | 一种peg修饰的重组精氨酸脱亚胺酶及其制备方法和应用 |
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2015
- 2015-08-27 CN CN201510536560.3A patent/CN106632588A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1673230A (zh) * | 2004-03-24 | 2005-09-28 | 中国科学院过程工程研究所 | 重组人复合干扰素-聚乙二醇偶联物的制备及其偶联产物 |
CN102634492A (zh) * | 2011-02-14 | 2012-08-15 | 重庆富进生物医药有限公司 | 聚乙二醇化犬源尿酸氧化酶类似物及其制备方法和应用 |
CN103923898A (zh) * | 2014-04-17 | 2014-07-16 | 江南大学 | 一种peg修饰的重组精氨酸脱亚胺酶及其制备方法和应用 |
Non-Patent Citations (5)
Title |
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FEE CJ等: "《PEG-proteins: Reaction engineering and separation issues》", 《CHEMICAL ENGINEERING SCIENCE》 * |
TAN YY等: "《Polyethylene glycol conjugation of recombinant methioninase for cancer therapy》", 《PROTEIN EXPRESSION AND PURIFICATION》 * |
叶贤龙等: "《聚乙二醇修饰的成纤维细胞生长因子-21的降血糖作用》", 《生物化学与生物物理进展》 * |
张淳: "《PEG修饰人犬嵌合尿酸酶结构功能研究及临床前药理学评价》", 《中国博士学位论文全文数据库》 * |
舒雅俊等: "《聚乙二醇化海葵神经毒素的修饰反应条件及药效研究》", 《聚乙二醇化海葵神经毒素的修饰反应条件及药效研究》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108634089A (zh) * | 2018-01-11 | 2018-10-12 | 合肥工业大学 | 一种低致敏高凝胶性豆类蛋白粉的制备方法 |
CN114316019A (zh) * | 2021-12-10 | 2022-04-12 | 河北菲尼斯生物技术有限公司 | 一种通过离子交换层析制备peg修饰的il-2的方法 |
CN114316019B (zh) * | 2021-12-10 | 2024-05-03 | 河北菲尼斯生物技术有限公司 | 一种通过离子交换层析制备peg修饰的il-2的方法 |
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Effective date of registration: 20190628 Address after: 213125 No. 518 Yunhe Road, Xinbei District, Changzhou City, Jiangsu Province Applicant after: ZonHon Biopharma Institute Inc. Address before: 213125 No. 518 Yunhe Road, Xinbei District, Changzhou City, Jiangsu Province Applicant before: ZonHon Biopharma Institute Inc. Applicant before: Jiangsu Jingsen Biomedical New Materials Technology Co., Ltd. |