CN106620402A - 一种肝癌术后用中药组合物及其制备方法 - Google Patents
一种肝癌术后用中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种肝胆外科用中药组合物,尤其涉及一种肝癌术后用中药组合物及其制备方法。内服药物由以下质量份数的组分组成:松花粉5‑8份、桃仁3‑5份、炙甘草5‑10份、八月札3‑5份、当归5‑10份、绞股蓝3‑5份、八角枫3‑5份、天冬3‑5份、阿胶5‑10份、甜菊叶3‑5份、怀山药5‑8份、云芝5‑8份、绿萼梅5‑8份、白术3‑5份、薏苡仁5‑8份、山茱萸5‑8份、龟板3‑5份;外用药物由以下质量份数的组分组成:蓝萼香茶菜3‑5份、石榕3‑5份、红薯叶5‑8份、白芨5‑8份、白背鼠麴草3‑5份、三七3‑5份、薄荷3‑5份、灯盏花3‑5份、刺郎果3‑5份。本发明药物内服药物与外用药物协同作用,内服药物益气、活血、解毒,可以促进外用药物的止血、促进药物愈合之效,同时外用药物能够止血又促进内服药物起效。
Description
技术领域
本发明涉及一种肝胆外科用中药组合物,尤其涉及一种肝癌术后用中药组合物及其制备方法。
背景技术
肝胆外科主要研究肝胆细胞癌、肝胆管结石、肝炎后肝硬化和重型肝炎所致的急性肝功能衰竭等严重威胁国人健康的重大疾病。
中国的肝胆外科结合国人的肝胆疾病特点,在肝细胞癌、肝胆管结石病以及损伤性胆管狭窄等的外科治疗方面已形成较为完善的理论和技术体系。未来肝胆外科的发展将有望在以下方面取得突破:
1.现代生物医学理论和技术的应用将进一步阐明肝脏和胆道的复杂结构和功能。
2.肝胆系肿瘤等重大疾病本质认识的深化,将导致肝胆疾病治疗理论取得创新和突破。
3.肝胆影像评估技术的进步,特别是基于三维影像重建的虚拟手术系统的应用,将显著提高手术的精确度、安全性和彻底性,在围肝门外科、部分肝移植、移植肝胆道并发症等领域的外科治疗技术将取得重大突破。
4.循证医学原理和方法普遍运用,将使经典的理论和治疗方法获得不断改进、补充和完善,疾病治疗模式和规范也将得到重塑。
5.社会经济的进步促使国人健康理念发生转变,更多患者将获得早期诊断和治疗,疾病的预后将得到显著改善。
6.随着以疾病为本的多学科专家团队及联合诊疗机制的建立、完善和普及,将使各类肝胆疾病患者都能获得最优化的系统治疗。
7.经济和学术的全球化将进一步推动东西方肝胆外科的交流与合作,从而实现全球肝胆外科事业的共同繁荣和进步。
目前治疗肝癌的方法有手术、放疗、化疗治疗,手术是主要的治疗方式,但手术后病人元气损伤,还需要进行放疗、化疗等结合治疗,经过创伤后的身体恢复慢、病情易复发。而中药学作为我国的传统医学,具有作用强、见效快、药效持久等优点,且没有依赖性、耐药性以及毒副作用,因此选择一种中药组合物用于肝癌术后恢复,对于治疗肝癌具有十分重要的临床意义。
发明内容
本发明解决的技术问题是目前治疗肝癌的方法有手术、放疗、化疗治疗,手术是主要的治疗方式,但手术后病人元气损伤,还需要进行放疗、化疗等结合治疗,经过创伤后的身体恢复慢、病情易复发。
为解决上述问题,本发明提供一种肝癌术后用中药组合物,由内服药物和外用药物结合使用,其中内服药物由以下质量份数的组分组成:松花粉5-8份、桃仁3-5份、炙甘草5-10份、八月札3-5份、当归5-10份、绞股蓝3-5份、八角枫3-5份、天冬3-5份、阿胶5-10份、甜菊叶3-5份、怀山药5-8份、云芝5-8份、绿萼梅5-8份、白术3-5份、薏苡仁5-8份、山茱萸5-8份、龟板3-5份;外用药物由以下质量份数的组分组成:蓝萼香茶菜3-5份、石榕3-5份、红薯叶5-8份、白芨5-8份、白背鼠麴草3-5份、三七3-5份、薄荷3-5份、灯盏花3-5份、刺郎果3-5份。
进一步优化,内服药物由以下质量份数的组分组成:松花粉7份、桃仁4份、炙甘草8份、八月札4份、当归8份、绞股蓝4份、八角枫4份、天冬4份、阿胶7份、甜菊叶4份、怀山药6份、云芝7份、绿萼梅6份、白术4份、薏苡仁7份、山茱萸6份、龟板4份。
进一步优化,外用药物由以下质量份数的组分组成:蓝萼香茶菜4份、石榕4份、红薯叶6份、白芨7份、白背鼠麴草4份、三七4份、薄荷4份、灯盏花4份、刺郎果4份。
内服药物由以下步骤制成:
(1)药物粉碎加水搅拌:按照比例称取药物,球磨机粉碎后按照料液比1:1-1:5加水搅拌;
(2)压滤:将步骤(1)的混合物经板框压滤机压滤得到液态的药汁和固态的药泥;药汁中含有药材中的水溶性成分,易于人体吸收,后期见效快;
(3)药泥酶解、过滤:将步骤(2)得到的药泥,按照其质量0.05~0.15%的比例加入纤维素酶、转谷氨酰胺酶、β-葡聚糖酶的复合酶制剂,在30℃-50℃条件下酶解5-10h,得到药泥酶解液;药泥中的水不溶性成分经酶解后,更易吸收起效;
(4)混合杀菌:将步骤(2)的药汁和步骤(3)的药泥酶解液按照3:1的比例混合,装袋,高温灭菌即可。
进一步的,所述步骤(1)的粉碎条件为采用球磨机正磨15Min后停机3min,再反磨15min后停机3min,如此反复2次。
进一步的,所述步骤(4)的高温灭菌条件为121℃下灭菌15Min。
外用药物由以下步骤制成:
(1)按照比例称取药物,用60%乙醇作溶剂加水后稀释,采用渗滤法,收集初滤液入瓶A,继续渗滤,直到滤液肉眼观察为无色停止;
(2)收集滤液,在40-60℃减压浓缩至稠膏状,加入瓶A中的初滤液混合后得到混合液;
(3)再用60%的乙醇稀释上述混合液,静置30小时,过滤后,得到上层液体为备用;
(4)将步骤(4)得到的流浸膏剂经过增压泵和精滤器进行过滤,滤液减压蒸馏,蒸馏后的膏剂装袋备用。
进一步的,所述步骤(4)中减压蒸馏后收集90-95℃/2kPa馏分。
使用方法:内服药物每日3次,每次10-30ml;外用药物在口服内服药物后半小时使用,均匀涂抹在手术刀口附近,画圈按摩直至药物吸收,注意不要涂抹到伤口上。
药效分析:
松花粉:性温,味甘。具有益气养血、平肝祛风、收湿、止血的功效;主治头旋眩晕,中虚胃疼,久痢,诸疮湿烂,创伤出血。
桃仁:症瘕结块,肺痈肠痈,跌仆伤痛,经闭痛经,产后瘀痛等症,益气活血,化瘀通络,扩张心脑血管,降血脂,味苦甘而性平,能入心肝大肠,活血祛瘀作用甚广,可用治瘀血阻滞各种敝症。
炙甘草:具有益气滋阴,通阳复脉治疗功效;和中缓急,润肺,解毒,调和诸药;常用于脾胃虚弱,倦怠乏力,心动悸,脉结代,可解附子毒。
八月札:味苦,性平;归肝、胃经;功能舒肝理气,活血止痛,除烦利尿。治肝胃气痛,胃热食呆,烦渴,亦白痢疾,腰痛,胁痛,疝气,窟经,子宫下坠。现代药理研究报道,其对肿瘤细胞有抑制作用。
当归:味甘、辛、温;具有抗缺氧作用;调节机体免疫功能、具有抗癌作用;护肤美容作用;补血活血作用;抑菌、抗动脉硬化作用。
绞股蓝:味甘、苦,性微寒。归肺经、脾经、肾经。能益气,安神,降血压,清热解毒,止咳祛痰。
八角枫:清热解毒,活血散瘀。能祛风除湿、舒筋活络、散瘀止痛,用于风湿痹痛、四肢麻木、跌打损伤;叶用于跌打骨折,外刀伤出血;花用于头风痛及胸腹胀满。
天冬:性寒,味甘,微苦。具有养阴清热,润肺滋肾的功效。用于治阴虚发热、肺痈、消渴等病症。有升高血细胞、增强网状内皮系统吞噬功能和延长抗体存在时间的作用。
阿胶:气微,味微甘;补血滋阴,润燥,止血。用于血虚萎黄,眩晕心悸,心烦不眠,肺燥咳嗽。
甜菊叶:甘,凉。养阴生津,用于胃阴不足,帮助消化,促进胰腺和脾胃功能。
怀山药:健脾益胃、助消化:山药含有淀粉酶、多酚氧化酶等物质,有利于脾胃消化吸收功能,是一味平补脾胃的药食两用之品。不论脾阳亏或胃阴虚,皆可食用。临床上常用治脾胃虚弱、食少体倦、泄泻等病症;2.滋肾益精:山药含有多种营养素,有强健机体,滋肾益精的作用。大凡肾亏遗精,妇女白带多、小便频数等症,皆可。
云芝:甘,淡,微寒;归肝,脾,肺经。功能健脾利湿,止咳平喘,清热解毒,抗肿瘤;主治慢性活动性肝炎,肝硬化,慢性支气管炎,小儿痉挛性支气管炎,咽喉肿痛,多种肿瘤,类风湿性关节炎,白血病。
绿萼梅:微酸,涩,无毒;入肝、肺二经。功效舒肝,和胃,化痰;主治肝胃气痛,食欲不振,头晕,瘰疬。
白术:甘,苦,温。归脾、胃经。补脾气,燥湿,利水,固表止汗,安胎。对S180有抑制作用。适应症肺癌、胃癌、肠癌、肝癌及子宫颈癌等。
薏苡仁:甘、淡,微寒。归脾、胃、肾、肺经。利水渗湿,健脾,舒筋,清热排脓。所含苡仁素有明显的抑制艾氏腹水癌的作用,对S180有抑制作用。适应症各种常见肿瘤。用量15-30g。禾本科植物薏苡仁的成熟种仁。
山茱萸:甘、酸,微温。归肾、肝经。补肾气,益肾精,固精,敛汗,缩尿,止血。动物筛选有一定的抗癌作用。适应症肾癌、肝癌、子宫颈癌及膀胱癌等。
龟板:甘、咸、寒。归肾、肝、心经。补肾肝阴,潜阳,键骨,止血,养血安神。龟板提取物对S180、EC腹水型肝癌有抑制作用。
蓝萼香茶菜:苦、甘,凉。功能清热解毒,活血化瘀;用于感冒,咽喉肿痛,扁桃体炎,胃炎,肝炎,乳腺炎,癌症(食道癌、贲门癌、肝癌、乳腺癌)初起,闭经,跌打损伤,关节痛,蛇虫咬伤。
石榕:辛、淡,凉。功能清热化痰,利水消肿,祛瘀散结。用于支气管炎,哮喘,肺结核,肾炎水肿,胃癌,食道癌,肝癌,乳腺癌,肺癌;外用治跌打损伤,烧烫伤,痈肿疮疖。
红薯叶:具有增强免疫功能、提高机体抗病能力、促进新陈代谢、延缓衰老的作用,同时还有降血糖、通便利尿、升血小板、止血、预防动脉硬化、阻止细胞癌变,催乳解毒,保护视力,预防夜盲的良好保健功能。
白芨:味苦、甘、涩,性寒,归肺、肝、胃经。有收敛止血,消肿生肌之功,用于内外出血诸证及痈肿、烫伤、手足皲裂、肛裂等。
白背鼠麴草:性味甘,凉。功效清热利湿,止血生肌,解毒消肿;主治感冒,咳嗽,头痛,咽喉痛,目赤翳障,膀胱湿热,小便淋痛,带下病,痈肿,疔疮。
三七:止血散瘀,消肿定痛,具有散瘀止血,消肿定痛之功效。主治咯血,吐血,衄血,便血,崩漏,外伤出血,胸腹刺痛,跌仆肿痛。
薄荷:消炎,止痛,止痒,能选择性地刺激人体皮肤或黏膜的冷觉感受器,产生冷觉反射和冷感,引起皮肤黏膜血管收缩。
灯盏花:能通经活络和活血化瘀,扩张脑血管、降低血管阻力,改善脑循环,增加心脑血流量,提高免疫功能,性寒、微苦、甘温辛,具有微寒解毒、祛风除湿、活血化瘀、通经活络、消炎止痛的功效。
刺郎果:苦,辛,性平。功能清热解毒,消炎止痛;主治黄疸型肝炎,胃痛,风湿关节痛,急性结膜炎,咽喉炎,牙周炎,淋巴结炎。
本发明的中药提取物纯属中药制剂,经多年的研究和临床实践证明:内服药物与外用药物协同作用,内服药物益气、活血、解毒,可以促进外用药物的止血、促进药物愈合之效,同时外用药物能够止血通络又促进内服药物起效,比单独使用内服药物和外用药物效果都好。其中内服药物以松花粉、桃仁、炙甘草、八月札、当归的益气活血之效,补充病人体力,促进刀口处血液循环,利于伤口恢复;再以绞股蓝、八角枫、天冬、阿胶的解毒养阴之效,对术后的放疗、化疗毒素进行消化排出,进一步的滋养身体,促进身体恢复;然后以甜菊叶、怀山药、云芝、绿萼梅的健脾和胃之效,促进病人的营养吸收;最后以白术、薏苡仁、山茱萸、龟板的扶正祛邪之效,抑制肿瘤再繁殖,达到药效。外用药物以蓝萼香茶菜、石榕、红薯叶的抑癌效用,直接通过刀口处作用于病灶,辅助内服药物的扶正却邪之效,再以白芨、白背鼠麴草、三七的止血生肌、促进创口愈合之效,再辅以薄荷、灯盏花、刺郎果的消炎杀菌作用,利于术后恢复。以223名肝癌患者为例,在术后使用本发明的中药组合物,比起不使用和单独使用内服药物或外用药物的患者,刀口愈合时间和恢复至出院标准的时间减少约一半,仅1例患者无效,总有效率高达99.6%。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚,下面将结合本发明实施例,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1:
一种肝癌术后用中药组合物,内服药物由以下质量份数的组分组成:松花粉7份、桃仁4份、炙甘草8份、八月札4份、当归8份、绞股蓝4份、八角枫4份、天冬4份、阿胶7份、甜菊叶4份、怀山药6份、云芝7份、绿萼梅6份、白术4份、薏苡仁7份、山茱萸6份、龟板4份;外用药物由以下质量份数的组分组成:蓝萼香茶菜4份、石榕4份、红薯叶6份、白芨7份、白背鼠麴草4份、三七4份、薄荷4份、灯盏花4份、刺郎果4份。
内服药物由以下步骤制成:
(1)药物粉碎加水搅拌:按照比例称取药物,球磨机粉碎后按照料液比1:3加水搅拌;粉碎条件为采用球磨机正磨15Min后停机3min,再反磨15min后停机3min,如此反复2次。
(2)压滤:将步骤(1)的混合物经板框压滤机压滤得到液态的药汁和固态的药泥;药汁中含有药材中的水溶性成分,易于人体吸收,后期见效快;
(3)药泥酶解、过滤:将步骤(2)得到的药泥,按照其质量0.1%的比例加入纤维素酶、转谷氨酰胺酶、β-葡聚糖酶的复合酶制剂,在40℃条件下酶解8h,得到药泥酶解液;药泥中的水不溶性成分经酶解后,更易吸收起效;
(4)混合杀菌:将步骤(2)的药汁和步骤(3)的药泥酶解液按照3:1的比例混合,装袋,高温灭菌即可。高温灭菌条件为121℃下灭菌15Min。
外用药物由以下步骤制成:
(1)按照比例称取药物,用60%乙醇作溶剂加水后稀释,采用渗滤法,收集初滤液入瓶A,继续渗滤,直到滤液肉眼观察为无色停止;
(2)收集滤液,在50℃减压浓缩至稠膏状,加入瓶A中的初滤液混合后得到混合液;
(3)再用60%的乙醇稀释上述混合液,静置30小时,过滤后,得到上层液体为备用;
(4)将步骤(4)得到的流浸膏剂经过增压泵和精滤器进行过滤,滤液减压蒸馏,蒸馏后的膏剂装袋备用。减压蒸馏后收集93℃/2kPa馏分。
实施例2:
一种肝癌术后用中药组合物,内服药物由以下质量份数的组分组成:松花粉5份、桃仁5份、炙甘草5份、八月札5份、当归5份、绞股蓝5份、八角枫3份、天冬5份、阿胶10份、甜菊叶3份、怀山药8份、云芝5份、绿萼梅8份、白术3份、薏苡仁8份、山茱萸5份、龟板5份;外用药物由以下质量份数的组分组成:蓝萼香茶菜3份、石榕5份、红薯叶5份、白芨8份、白背鼠麴草3份、三七5份、薄荷3份、灯盏花5份、刺郎果3份。
内服药物由以下步骤制成:
(1)药物粉碎加水搅拌:按照比例称取药物,球磨机粉碎后按照料液比1:1加水搅拌;粉碎条件为采用球磨机正磨15Min后停机3min,再反磨15min后停机3min,如此反复2次。
(2)压滤:将步骤(1)的混合物经板框压滤机压滤得到液态的药汁和固态的药泥;药汁中含有药材中的水溶性成分,易于人体吸收,后期见效快;
(3)药泥酶解、过滤:将步骤(2)得到的药泥,按照其质量0.15%的比例加入纤维素酶、转谷氨酰胺酶、β-葡聚糖酶的复合酶制剂,在30℃条件下酶解10h,得到药泥酶解液;药泥中的水不溶性成分经酶解后,更易吸收起效;
(4)混合杀菌:将步骤(2)的药汁和步骤(3)的药泥酶解液按照3:1的比例混合,装袋,高温灭菌即可。高温灭菌条件为121℃下灭菌15Min。
外用药物由以下步骤制成:
(1)按照比例称取药物,用60%乙醇作溶剂加水后稀释,采用渗滤法,收集初滤液入瓶A,继续渗滤,直到滤液肉眼观察为无色停止;
(2)收集滤液,在40℃减压浓缩至稠膏状,加入瓶A中的初滤液混合后得到混合液;
(3)再用60%的乙醇稀释上述混合液,静置30小时,过滤后,得到上层液体为备用;
(4)将步骤(4)得到的流浸膏剂经过增压泵和精滤器进行过滤,滤液减压蒸馏,蒸馏后的膏剂装袋备用。减压蒸馏后收集95℃/2kPa馏分。
实施例3:
一种肝癌术后用中药组合物,内服药物由以下质量份数的组分组成:松花粉8份、桃仁3份、炙甘草10份、八月札3份、当归10份、绞股蓝3份、八角枫5份、天冬3份、阿胶10份、甜菊叶3份、怀山药8份、云芝5份、绿萼梅8份、白术3份、薏苡仁8份、山茱萸5份、龟板5份;外用药物由以下质量份数的组分组成:蓝萼香茶菜5份、石榕3份、红薯叶8份、白芨5份、白背鼠麴草5份、三七3份、薄荷5份、灯盏花3份、刺郎果5份。
内服药物由以下步骤制成:
(1)药物粉碎加水搅拌:按照比例称取药物,球磨机粉碎后按照料液比1:5加水搅拌;粉碎条件为采用球磨机正磨15Min后停机3min,再反磨15min后停机3min,如此反复2次。
(2)压滤:将步骤(1)的混合物经板框压滤机压滤得到液态的药汁和固态的药泥;药汁中含有药材中的水溶性成分,易于人体吸收,后期见效快;
(3)药泥酶解、过滤:将步骤(2)得到的药泥,按照其质量0.05%的比例加入纤维素酶、转谷氨酰胺酶、β-葡聚糖酶的复合酶制剂,在350℃条件下酶解5h,得到药泥酶解液;药泥中的水不溶性成分经酶解后,更易吸收起效;
(4)混合杀菌:将步骤(2)的药汁和步骤(3)的药泥酶解液按照3:1的比例混合,装袋,高温灭菌即可。高温灭菌条件为121℃下灭菌15Min。
外用药物由以下步骤制成:
(1)按照比例称取药物,用60%乙醇作溶剂加水后稀释,采用渗滤法,收集初滤液入瓶A,继续渗滤,直到滤液肉眼观察为无色停止;
(2)收集滤液,在60℃减压浓缩至稠膏状,加入瓶A中的初滤液混合后得到混合液;
(3)再用60%的乙醇稀释上述混合液,静置30小时,过滤后,得到上层液体为备用;(4)将步骤(4)得到的流浸膏剂经过增压泵和精滤器进行过滤,滤液减压蒸馏,蒸馏后的膏剂装袋备用。减压蒸馏后收集90℃/2kPa馏分。
Claims (8)
1.一种肝癌术后用中药组合物,其特征在于由内服药物和外用药物结合使用,其中内服药物由以下质量份数的组分组成:松花粉5-8份、桃仁3-5份、炙甘草5-10份、八月札3-5份、当归5-10份、绞股蓝3-5份、八角枫3-5份、天冬3-5份、阿胶5-10份、甜菊叶3-5份、怀山药5-8份、云芝5-8份、绿萼梅5-8份、白术3-5份、薏苡仁5-8份、山茱萸5-8份、龟板3-5份;外用药物由以下质量份数的组分组成:蓝萼香茶菜3-5份、石榕3-5份、红薯叶5-8份、白芨5-8份、白背鼠麴草3-5份、三七3-5份、薄荷3-5份、灯盏花3-5份、刺郎果3-5份。
2.如权利要求1所述的肝癌术后用中药组合物,其特征在于内服药物由以下质量份数的组分组成:松花粉7份、桃仁4份、炙甘草8份、八月札4份、当归8份、绞股蓝4份、八角枫4份、天冬4份、阿胶7份、甜菊叶4份、怀山药6份、云芝7份、绿萼梅6份、白术4份、薏苡仁7份、山茱萸6份、龟板4份。
3.如权利要求1所述的肝癌术后用中药组合物,其特征在于外用药物由以下质量份数的组分组成:蓝萼香茶菜4份、石榕4份、红薯叶6份、白芨7份、白背鼠麴草4份、三七4份、薄荷4份、灯盏花4份、刺郎果4份。
4.一种如权利要求1所述肝癌术后用中药组合物的制备方法,其特征在于内服药物由以下步骤组成:
(1)药物粉碎加水搅拌:按照比例称取药物,球磨机粉碎后按照料液比1:1-1:5加水搅拌;
(2)压滤:将步骤(1)的混合物经板框压滤机压滤得到液态的药汁和固态的药泥;
(3)药泥酶解、过滤:将步骤(2)得到的药泥,按照其质量0.05~0.15%的比例加入纤维素酶、转谷氨酰胺酶、β-葡聚糖酶的复合酶制剂,在30℃-50℃条件下酶解5-10h,得到药泥酶解液;
(4)混合杀菌:将步骤(2)的药汁和步骤(3)的药泥酶解液按照3:1的比例混合,装袋,高温灭菌即可。
5.如权利要求4所述的肝癌术后用中药组合物的制备方法,其特征在于:所述步骤(1)的粉碎条件为采用球磨机正磨15Min后停机3min,再反磨15min后停机3min,如此反复2次。
6.如权利要求4所述的肝癌术后用中药组合物的制备方法,其特征在于:所述步骤(4)的高温灭菌条件为121℃下灭菌15Min。
7.一种如权利要求1所述肝癌术后用中药组合物的制备方法,其特征在于外用药物由以下步骤组成:
(1)按照比例称取药物,用60%乙醇作溶剂加水后稀释,采用渗滤法,收集初滤液入瓶A,继续渗滤,直到滤液肉眼观察为无色停止;
(2)收集滤液,在40-60℃减压浓缩至稠膏状,加入瓶A中的初滤液混合后得到混合液;
(3)再用60%的乙醇稀释上述混合液,静置30小时,过滤后,得到上层液体为备用;
(4)将步骤(4)得到的流浸膏剂经过增压泵和精滤器进行过滤,滤液减压蒸馏,蒸馏后的膏剂装袋备用。
8.如权利要求7所述的肝癌术后用中药组合物的制备方法,其特征在于:所述步骤(4)中减压蒸馏后收集90-95℃/2kPa馏分。
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CN108465022A (zh) * | 2018-06-12 | 2018-08-31 | 李云 | 一种普外科创伤手术辅助治疗中药组合物及其制备方法 |
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