CN106620391A - Medicine for treating advanced non-small-cell lung cancer and preparation method of medicine - Google Patents

Abstract

The invention discloses a medicine for treating advanced non-small-cell lung cancer and a preparation method of the medicine. The medicine for treating advanced non-small-cell lung cancer is prepared from raw materials in parts by weight as follows: 20-40 parts of hedyotis diffusa, 20-40 parts of scutellaria barbata, 20-40 parts of herba houttuyniae, 10-20 parts of dried tangerine peel, 20-30 parts of fructus trichosanthis, 10-20 parts of semen coicis, 20-30 parts of semen lepidii, 10-20 parts of radix scutellariae, 10-20 parts of rhizoma anemarrhenae, 10-20 parts of semen armeniacae amarae, 10-20 parts of bulbus fritillaria thunbergii, 20-30 parts of carapax trionycis, 10-20 parts of prunella vulgaris, 20-40 parts of radix astragali, 10-20 parts of codonopsis pilosula, 10-20 parts of rhizoma phragmitis, 10-20 parts of semen persicae, 10-15 parts of fructus perillae and 5-10 parts of radix glycyrrhizae preparata. The medicine has the effects of clearing heat, removing toxins, reducing phlegm, removing blood stasis, tonifying qi and nourishing yin and has functions of resisting tumor, relieving cough, eliminating phlegm and enhancing body immunity. The medicine capsules can relieve symptoms of patients, have exact curative effect and can prolong lifetime of the patients and improve the life quality.

Description

It is a kind of to treat medicine of advanced Non-small cell lung and preparation method thereof

Technical field

The invention belongs to a kind of Chinese medicine preparation and preparation method thereof, especially belongs to one kind and treats advanced Non-small cell lung Medicine and preparation method thereof.

Background technology

It is the first that the incidence of disease of lung cancer occupies global cancer.The incidence of disease of China's lung cancer is 46.08 people/100,000 people, and the death rate is bright It is aobvious in rising trend, have become first cancer mortality reason.Non-small cell lung cancer belongs to one kind of lung cancer, and it includes squama Cancer, gland cancer, large cell carcinoma, compared with small cell carcinoma, its growth of cancer cells division is relatively slow, and diffusion transfer is relatively later.It is non-little thin Born of the same parents' lung cancer accounts for the 80-85% of the total placate of lung cancer, due to patient's early stage non-evident sympton, therefore has been evening during 75% patient assessment Phase, 5 years survival rates less than 2%, its poor prognosis.At present treatment means are that operation, radiotherapy, chemotherapy, targeted therapy, immunity are controlled Treatment, Chinese traditional treatment etc..Early detection person is few, and real operation beneficiary is limited.Chemicotherapy is made in treatment of advanced non-small cell lung cancer For first-selection, but only for the preferable person of life quality scores, for elderly patient, poor quality of life, cardiopulmonary renal insufficiency, Intolerable patient is taboo.Only for gene mutation patient effectively, immunization therapy somewhat expensive, curative effect has targeted therapy It is to be evaluated.Therefore for the treatment of patients with advanced NSCLC in, how to improve the immunity of organisms of patient, righting is dispelled Heresy, boosting qi and nourishing yin, clearing heat and detoxicating, dissipating phlegm and removing blood stasis, softening and resolving hard mass；How to mitigate patients symptomatic, extend patient survival, improve life Bioplasm amount is the difficult problem for needing to solve.

The content of the invention

It is an object of the invention to provide a kind of medicine for treating advanced Non-small cell lung, taking the medicine of the present invention can carry The immunity of organisms of high patients with advanced NSCLC, and can strengthening vital QI to eliminate pathogenic factors, boosting qi and nourishing yin, clearing heat and detoxicating, dissipating phlegm and removing blood stasis, soft Hard dissipating bind；Patients symptomatic can also be mitigated, extend patient survival, quality of making the life better.It is a further object to provide The preparation method of the medicine of the treatment advanced Non-small cell lung.

The technical scheme is that a kind of medicine for treating advanced Non-small cell lung is characterized in that, by following weight The raw material of number proportioning is made：Oldenlandia diffusa 20-40, Sculellaria barbata 20-40, cordate houttuynia 20-40, dried orange peel 10-20, Snakegourd Fruit 20- 30th, coix seed 10-20, lepidium seed 20-30, root of large-flowered skullcap 10-20, wind-weed 10-20, semen armeniacae amarae 10-20, fritillaria thunbergii 10-20, turtle shell 20-30, selfheal 10-20, Radix Astragali 20-40, Radix Codonopsis 10-20, reed rhizome 10-20, peach kernel 10-20, perilla seed 10-15, honey-fried licorice root 5-10；

The parts by weight proportioning of preferred each raw material is：Oldenlandia diffusa 30, Sculellaria barbata 30, cordate houttuynia 30, dried orange peel 20, melon Beach wormwood 20, coix seed 15, lepidium seed 20, the root of large-flowered skullcap 15, the wind-weed 15, semen armeniacae amarae 15, fritillaria thunbergii 20, turtle shell 25, the selfheal 20, Radix Astragali 30th, Radix Codonopsis 15, reed rhizome 20, peach kernel 15, perilla seed 10, honey-fried licorice root 10；

A kind of preparation method of the medicine for treating advanced Non-small cell lung, is characterized in that：Mainly comprise the steps：

A, oldenlandia diffusa, Sculellaria barbata, cordate houttuynia, dried orange peel, Snakegourd Fruit, the heart of a lotus seed are weighed respectively according to described parts by weight proportioning The seed of jog's tears, lepidium seed, the root of large-flowered skullcap, the wind-weed, semen armeniacae amarae, fritillaria thunbergii, turtle shell, selfheal, the Radix Astragali, Radix Codonopsis, reed rhizome, peach kernel, perilla seed, process Radix Glycyrrhizae is standby；

B, the fritillaria thunbergii that step A has been prepared is ground into fine powder, crosses 100 mesh sieves standby；The long-noded pit viper that step A has been prepared Tongue grass, Sculellaria barbata, cordate houttuynia, dried orange peel, Snakegourd Fruit, coix seed, lepidium seed, the root of large-flowered skullcap, the wind-weed, semen armeniacae amarae, turtle shell, selfheal, the Radix Astragali, Radix Codonopsis, reed rhizome, peach kernel, perilla seed, honey-fried licorice root are cleaned up, dried for decocting, and add water for the first time 3-4 ﹙ Chong Liang Bi ﹚, soaks 1- 1.5h, is heated to boiling and decocts 1-1.2h, leaching decocting liquid；Add water for the second time 2-3 ﹙ Chong Liang Bi ﹚, is heated to boiling and decocts 1-1.2h, Leaching decocting liquid, merges the static 48-56 hours precipitation of decocting liquid twice, considers the removal of impurity, and decocting liquid is concentrated into medicinal extract；By gained medicinal extract and originally Particle is made in concentration after fritillaria thunbergii powder prepared by step uniformly mixes, and dries, and by gained granule filling capsule, each capsule is 0.35 gram；

C. capsule prepared by step B is packed, is placed in the shady and cool place of drying and deposits.

Instructions of taking：4-6 grain of oral capsule of the present invention, 3 times a day.

First, the effect of each material medicine and mechanism

Advanced Non-small cell lung belongs to traditional Chinese medical science lung product, lung rock, ceases the category such as beautifully adorned.Inventor think lung cancer with it is scorchingly hot it is close not Can divide, mainly qi and blood phlegm poison is cemented to product, the stasis of blood and change heat, consumption is felt frustrated the moon.Therefore clearing heat and detoxicating, reducing phlegm and resolving masses, dissolving stasis and blood To control its mark, righting yin-nourishing Zhi Qiben.Inventor's research finds that the sick phlegm-heat type person is in the majority, is secondly type of deficiency of both QI and YIN, the two Between often simultaneous see；Cancer poison is the key factor of morbidity, and cancer poison gives birth to phlegm, wet, heat, phlegm wet heat toxin stasis lung network, air flue；Phlegm heat toxin is evil It is cloudy that early stage can injure gas.Interior Jing thinks healthy tendency internal memory, and heresy can not be done.Although advanced lung cancer has the marks such as phlegm heat, phlegm wet, blood stasis real , there is the virtual images such as the deficiency of vital energy, the deficiency of Yin, and simulataneous insufficiency and excessive in various degree in fact in performance.It is evil that phlegm heat toxin should be held over the course for the treatment of, Heat-clearing and detoxifying phlegm-reducing and masses-resolving is given, early supplementing qi and nourishing yin.

Oldenlandia diffusa：Clearing heat and detoxicating, diuresis of blood circulation promoting；Strengthen the immunity of body, suppress the growth of tumour cell, be in fact The good medicine of " clearing heat and detoxicating ".

Sculellaria barbata:Heat-clearing, removing toxic substances, the scattered stasis of blood, hemostasis, inducing diuresis to remove edema, analgesic therapy.

Cordate houttuynia：Clearing heat and detoxicating, inducing diuresis to remove edema.

Dried orange peel：Spread of pungent taste helps to keep warm, fragrant odour is longer than qi-regulating, can enter spleen and lung, therefore can go scattered sluggishness of lung-QI, and can promoting the circulation of qi In width, for lung qi stagnant, chest diaphragm feeling of fullness is stopped up.

Snakegourd Fruit：It is sweet, cold in nature；There are moistening lung eliminating the phlegm, sharp gas width chest effect.

Coix seed：Clearing away heat and eliminating pus, eliminating impediment and relieving pain

Lepidium seed：Purging the lung of pathogenic fire sending down abnormally ascending；Eliminating phlegm and relieving asthma；Inducing diuresis for removing edema；Let out by heresy.

The root of large-flowered skullcap：Heat-clearing and damp-drying drug, detoxicating functions.

The wind-weed:Nourishing Yin and falling fire, moisturize laxation；Control hectic fever due to yin labor heat, cough with lung heat

Semen armeniacae amarae：Antitussive and antiasthmatic, the symptom for improving patients with advanced cancer, extend patient's life cycle.

Fritillaria thunbergii：Return lung, the heart channel of Hang-Shaoyin；Strongly fragrant dissipating bind is opened in a surname's lung heat-clearing, preventing phlegm from forming and stopping coughing；Wind-heat or phlegm-heat cough are cured mainly, throat swells Bitterly, lung carbuncle, goiter and tumor, sore and toxic.

Turtle shell:Taste is salty, cold nature, returns liver and kidney channel, has functions that nourishing and suppressing Yang, softening and resolving hard mass, brings down a fever except steaming；For the moon The hot hectic fever due to yin of heat, the labor of shooting without hitting the target, immunologic function can be improved, promote immunoglobulin (Ig) to be formed, extend antibody existence time.

Selfheal：Have functions that to let out irascibility, mass dissipating and swelling eliminating, clearing heat and detoxicating, expelling phlegm and arresting coughing, cooling blood and hemostasis clearly；Also support The effect of cancer cell processed.

The Radix Astragali：Return lung, the spleen channel.Effect：Invigorating qi for strengthening superficies, inducing diuresis for removing edema, eliminating toxic, myogenic.

Radix Codonopsis：Return lung, the spleen channel；Effect：Bowl spares, beneficial gas are promoted the production of body fluid；There is excitation to nervous system, body can be strengthened and supported Drag.

Reed rhizome：Clearing heat and promoting fluid, preventing or arresting vomiting, relieving restlessness.

Peach kernel：Enter lung, liver, large intestine channel；There are the blood-breaking row stasis of blood, effect of moisturize laxation.

Perilla seed：Cold dispelling is delivered, in promoting the circulation of qi width；Cure mainly：Lower gas Dingchuan, dissolving phlegm of only coughing；Cough for upper gas inverse, wind nitrogen is breathed heavily It is anxious.

Honey-fried licorice root：With in, relieving spasm to stop pain, moistening lung is detoxified, coordinating the drug actions of a prescription for tonifying Qi；With obvious antitussive effect；Eliminating the phlegm is made With also more significant；Also anti-inflammatory analgesic, anti-allergic effects, the hypo acid contained by Radix Glycyrrhizae can block the work of Induced by Carcinogen tumour growth With.

As described above, the principle pathological mechanism lung cancer of advanced Non-small cell lung is inseparable with scorchingly hot, mainly qi and blood Phlegm poison is cemented to product, the stasis of blood and change heat, consumption is felt frustrated the moon.Therefore, to control its mark, righting is supported for clearing heat and detoxicating, reducing phlegm and resolving masses, dissolving stasis and blood Cloudy Zhi Qiben.Selected above-mentioned oldenlandia diffusa of the invention is clearing heat and detoxicating, diuresis of blood circulation promoting, can strengthen the immunity of body, suppresses swollen The growth of oncocyte；Cordate houttuynia is clearing heat and detoxicating, inducing diuresis to remove edema, dissipate stasis of blood hemostasis clearing heat and detoxicating with Sculellaria barbata, detumescence ding-tong, and white Flower HERBA HEDYOTIS DIFFUSAE, cordate houttuynia mutual reinforcement between are, with clearing heat and detoxicating, the scattered stagnation resolvation carbuncle of enhancing, to strengthen the immunity of body, suppress tumour cell Growth is altogether monarch drug in a prescription；The root of large-flowered skullcap is clearing heat and detoxicating to cure mainly the diseases such as cough with lung heat, carbuncle swells furuncle sore, wind-weed clearing heat-fire, nourshing Yin and drynsessmoistening prescription, the two Mutual reinforcement between is use, strengthens the effect of clearing heat and detoxicating cool blood；Turtle shell nourishing and suppressing Yang, softening and resolving hard mass, bring down a fever except steam, immunity of organism work(can be improved Can, promote immunoglobulin (Ig) to be formed, extend antibody existence time；Above-mentioned all medicines share, clearing heat-fire dissipates stagnation resolvation carbuncle, is altogether minister Medicine；Share with monarch drug in a prescription, both strengthened monarch drug in a prescription it is clearing heat and detoxicating the effect of, and yin-nourishing dissipating bind disappears carbuncle；The pungent scattered promoting the circulation of qi profit lung width of perilla seed In, Snakegourd Fruit moistening lung eliminating the phlegm, sharp gas width chest, selfheal lets out clearly irascibility, mass dissipating and swelling eliminating, clearing heat and detoxicating, expelling phlegm and arresting coughing, cooling blood and hemostasis, Fritillaria thunbergii is declared lung heat-clearing, preventing phlegm from forming and stopping coughing, opens strongly fragrant dissipating bind, and semen armeniacae amarae a surname's lung antitussive and antiasthmatic shares its wide chest profit lung, relievings asthma, stops Cough, the effect of dissipate cementing phlegm more very；Coix seed dries, clearing away heat and eliminating pus, eliminating impediment and relieving pain, dried orange peel spread of pungent taste helps to keep warm, fragrant odour is long In qi-regulating, spleen and lung can be entered, can be gone in scattered sluggishness of lung-QI, and energy promoting the circulation of qi width, for lung qi stagnant, chest diaphragm feeling of fullness and taste gas are gathered around The diseases such as stagnant, abdominal fullness and distention, the two mutual reinforcement between is use, further enhance qi-regulating dampness elimination of dispelling, dehumidifying hot adhesion heresy the effect of；The Radix Astragali is mended Superficies-consolidating, inducing diuresis for removing edema, eliminating toxic, myogenic, Radix Codonopsis bowl spares, beneficial gas, promote the production of body fluid, reed rhizome clearing heat and promoting fluid, preventing or arresting vomiting, relieving restlessness, the Radix Astragali, party The effect of ginseng, reed rhizome share its supplementing qi and nourishing yin, strengthen the body resistance to consolidate the constitution is more very；Peach kernel blood circulation and channel invigorating, dispels ecchymosis with the medicine assistant system of pungent-warm It is excessively cold and cool, shield taste are turned round and look at air making-up and spleen enlivening regulating qi-flowing for harmonizing stomach medicine, Central Region is good for, reinforcing earth to generate metal, preventing phlegm from forming and stopping coughing in addition, removing toxic substances dissipates Knot disappear the stasis of blood is altogether adjutant.Honey-fried licorice root moistening lung removing toxic substances, coordinating the drug actions of a prescription, lepidium seed purging the lung of pathogenic fire sending down abnormally ascending, eliminating phlegm and relieving asthma enter lung channel, and the two is to make Medicine plays altogether clearing heat and detoxicating, blood stasis-eliminating and stagnation-dissipating, relieving cough and reducing sputum, supplementing qi and nourishing yin work(with above-mentioned all medicines share.

2nd, the medicine modern pharmacology pharmacodynamic action of above-mentioned treatment advanced Non-small cell lung is showed in the following areas：

Suppress tumour growth：The present invention is from oldenlandia diffusa, Sculellaria barbata, coix seed, selfheal, semen armeniacae amarae, Radix Glycyrrhizae Medicine, pharmacological research confirms there is the effect for suppressing or killing tumour cell；Oldenlandia diffusa, Sculellaria barbata, coix seed, selfheal, Semen armeniacae amarae, Radix Glycyrrhizae are shared the effect of it suppresses or kills the effect of tumour cell more very.

Anti-bacteria and anti-virus：Oldenlandia diffusa, cordate houttuynia, the wind-weed, the clearing heat and detoxicating medicine of the root of large-flowered skullcap that the present invention is selected, long-noded pit viper Tongue grass, cordate houttuynia, the wind-weed, the root of large-flowered skullcap to share play altogether and Pseudomonas aeruginosa, staphylococcus aureus, pneumococcus, shigella dysenteriae etc. caused The inhibitory action of germ.

Kobadrin：The present invention selects Snakegourd Fruit, perilla seed, dried orange peel, Radix Glycyrrhizae, fritillaria thunbergii, almond, Radix Glycyrrhizae to have town respectively Cough, eliminating the phlegm is slow, solve the effect such as respiratory tract smooth muscle spasm；Seven share that its antibechic, eliminating the phlegm be slow, solution respiratory tract smooth muscle spasm it Effect is more very.

Improve tumour blood coagulation disorder：Patients with Advanced Lung Cancer blood clotting mechanism is disorderly, easily causes hypercoagulative state；In the present invention Peach kernel water extract containing peach kernel, amarogentin suppresses platelet aggregation, can vasodilator, improve blood coagulable status, improve micro- following Ring；Also there is Developing restraint to cancer cell.

Strengthen immunity:Numerous researchs confirm that immunologic function is improved can substantially suppress growth of tumour cell；The present invention Middle Radix Codonopsis, the Radix Astragali, honey-fried licorice root are shared and further enhance physique, improve immunity of organisms, and turtle shell turtle shell colloid class turtle shell contains animal Colloid, keratin, aspartic acid, serine, glutamic acid, glycine, 17 kinds of amino acid of alanine etc..Inorganic elements class have iron, Copper, zinc, magnesium, phosphorus, chromium, manganese, aluminium, selenium, iodine etc..Still immunologic function can be improved containing compositions such as vitamin D, fat, carbohydrates, so as to rise To antineoplastic action.

3rd, observation of curative effect：

3.1st, inventor selects the court to be in hospital and makes a definite diagnosis patients with advanced NSCLC 75, and by randomization 2 are divided into Group, wherein treatment group 45, control group 30；Two groups of patient medical histories, age, sex, pathological there are no significant difference, tool There is comparativity (P ＞ 0.05).

3.2nd, treatment method：Treatment group：On the basis of chemotherapy, using 5 tablets/time of capsule of the present invention, 3 times a day；Control group：It is many Western taxol 75mg/m²D1, cis-platinum 75mg/m²d1,q21d；Continuous 2 Cycle Assessments, 1 Ci ﹙ 21 days are 1 Zhou Qi ﹚；After 4 cycles Carry out short-term evaluation.

3.3rd, evaluation criterion and method：Tcm syndrome curative effect：Symptom total mark situation compares (before treatment/treat after) before and after treatment It is effective：Symptom disappears, or symptom integral reduces >=2/3；Effectively：Symptom mitigation, integration reduction >=1/3 ,≤2/3；It is invalid：Symptom Without mitigation or mitigation ＜ 1/3.The change of knurl body is evaluated using international RECIST evaluation criterions；PS scoring changes；Life Quality score.

1 two groups of patient's tcm syndrome comparitive studies of table

Group	It is effective	Effectively	It is invalid	Total effective rate %
					Treatment group	15	20	10	77.78
Control group	7	9	14	53.33

Two groups of data chi-square values are 4.94, P<0.05, P<0.05 is that difference is statistically significant.

2 two groups of patient's objective sign comparitive studies of table

Two groups of data chi-square values are that chi-square value is 0.14, P>0.05

Can be seen that on the basis of chemotherapy from the data of above table, taking capsule oral medicine of the present invention can improve The tcm syndrome curative effects such as patient's heating, cough, expectoration, and compare P with control group<0.05, statistically significant, treatment group is better than Control group；Objective sign observation of curative effect compares, two groups of no difference of science of statistics, P>0.05.

4th, medical record citing；

Example 1, Sun, man, 58 years old, cadre.Make a definite diagnosis right lung gland cancer postoperative 6 months, multicycle chemotherapy was examined later, before 6 months It is inferior lobe of right lung occupy-place in our hospital Jing CT examinations because cough is with cough, uncomfortable in chest, pectoralgia, pathology aspiration biopsy is gland cancer, is diagnosed as Right lung gland cancer (T3N1M0, III A phases) row surgical resection therapy, the postoperative cycle of row TP scheme chemotherapies 6, stable disease.But January suffers from Person's sense right side pectoralgia, uncomfortable in chest；Check CT：The a small amount of hydrops in right side thoracic cavity, indulges phrenic lymph nodes little, it is proposed that two wires maintenance chemotherapy, or Take molecular targeted therapy, patient and family members to refuse, be strongly required the treatment that takes traditional Chinese medicine.Consider patient's chest and hypochondrium, there is pleural effusion Meet pleural effusion diagnosis, tongue nature is light, tongue is thin white, wiry and rolling pulse.Then subtract using rhizoma cyperi inular flower Tonga：Rhizoma cyperi 10g, inular flower 12g, it is alizarin Careless 10g, Radix Angelicae Sinensis 10g, stir-baked FRUCTUS TOOSENDAN 10g, root of Dahurain angelica 12g, root of Chinese wild ginger 3g, corydalis tuber 20g, paniculate swallowwort 10g, Radix Astragali 20g, the root bark of white mulberry 10g, is decocted in water for oral dose, and day is one, takes at twice, totally 5 doses.Further consultation, readme chest and hypochondrium slightly mitigates, but still feels uncomfortable in chest, dry cough, few phlegm. Then added and subtracted with Zhisou San, prescription is as follows：Balloonflower root 6g, aster 10g, tuber of stemona 10g, dried orange peel 10g, schizonepeta 5g, Cynanchum glaucescens 10g, honey-fried licorice root 10g, dandelion 15g, Sculellaria barbata 10g, tuber of pinellia 6g, Poria cocos 10g, windproof 6g, blackberry lily 10g, radix scrophulariae 10g, semen armeniacae amarae 10g, Sang Bai Skin 10g, Bulbus Fritillariae Cirrhosae 6g, is decocted in water for oral dose, and day is one, takes at twice, totally 5 doses.Examine again, patient's cough mitigates, but diet is poor, it is uncomfortable in chest not Relax, cough, abundant expectoration, tongue nature is light, the thin Huang of tongue, wiry and rolling pulse.Again the side of changing is medicine decoction of the present invention, and prescription is as follows：Oldenlandia Careless 30g, Sculellaria barbata 30g, cordate houttuynia 30g, dried orange peel 15g, Snakegourd Fruit 20g, coix seed 15g, lepidium seed 25g, root of large-flowered skullcap 15g, the wind-weed 10g, semen armeniacae amarae 15g, fritillaria thunbergii 15g, turtle shell 30g, selfheal 10g, Radix Astragali 30g, Radix Codonopsis 20g, reed rhizome 10g, peach kernel 20g, purple Perillaseed 15g, honey-fried licorice root 10g.Examine over 5 days after clothes, state mitigation uncomfortable in chest, pectoralgia, cough subtract greatly, and diet increases, take to more than 30 agent, respectively Plant symptom to disappear substantially.Afterwards medicament capsule of the present invention is orally dealt with problems arising from an accident, dead after maintaining 2.5 years.Make the advanced Non-small cell lung Patient survival is obviously prolonged.

Example 2, Wang, man, 65 years old, peasant.Cough, heating are admitted to hospital more than January, and cough, heating occurs in patient after suffering from cold in January. Local clinic gives antibiotic therapy and comes within 10 days institute without taking a turn for the better, and outpatient service looks into T37.9 DEG C, and left collarbone superior gluteal lymph node enlargement is left Pulmonary respiration sound is low, audible and a little rhonchus, CT:Left hilus pulumonis occupy-place, indulges phrenic lymph nodes enlargement, admits to hospital then.Row woods after in hospital Fawn on aspiration biopsy to show：Squamous carcinoma, is diagnosed as the phase of lung squamous cancer IV.Sputum culturing has no bacterial growth after in hospital, does not find acid-fast bacilli. Leucocyte increases：12.0×10⁹/L.Tuberculin test+.Heating, body temperature fluctuation is coughed and tells white between 37.5-38.9 DEG C Sticky phlegm, red tongue body, yellow tongue fur is thick, slippery and rapid pulse.Household only agrees to symptomatic treatment, and then with lung product, (phlegm-heat accumulated in the lung) is dialectical gives clear gold Phlegm-reducing soup is treated, and prescription is as follows：Root of large-flowered skullcap 10g, fructus gardeniae 9g, balloonflower root 6g, root bark of white mulberry 10g, wind-weed 10g, fritillaria thunbergii 10g, Snakegourd Fruit Benevolence 10g, tuber of dwarf lilyturf 10g, Exocarpium Citri Rubrum 9g, Poria cocos 10g, Radix Glycyrrhizae 10g, 3 doses are decocted in water for oral dose, and day is one, takes at twice, and expectoration after clothes mitigates, Still generate heat, though the alexipyretic such as Jing ibuprofen suspensions, warm temporarily to move back, soon rise again, it is considered to tumour heat, the side of changing is medicine of the present invention Decoction, prescription is as follows：Oldenlandia diffusa 30g, Sculellaria barbata 20g, cordate houttuynia 30g, dried orange peel 15g, Snakegourd Fruit 20g, coix seed 15g, Roripa Li 20g, root of large-flowered skullcap 15g, wind-weed 15g, semen armeniacae amarae 15g, fritillaria thunbergii 15g, turtle shell 20g, selfheal 20g, Radix Astragali 30g, Radix Codonopsis 15g, reed rhizome 15g, peach kernel 15g, perilla seed 15g, honey-fried licorice root 5g, paris polyphylla 9g, capsule of weeping forsythia 15g, the root of straight ladybell 15g, it is decocted in water for oral dose, day It is one, take at twice；Totally 5 doses, febrile lysis, body temperature fluctuation is between 36.8-37.5 DEG C.The thinning Huang of tongue fur, spirit improves earlier above. But family numbers of patients insists on requirement discharge, uses medicament capsule of the present invention instead and deals with problems arising from an accident 6 months, and patient's general status are good；Afterwards patient stops Treated with medicament capsule of the present invention；Brain metastes are died from after 3 months.

Example 3, Wang, female, 78 years old, retired worker, on January 20th, 2014 examined because of cough, expectoration, blood-stained sputum January.Lung CT：Right lung occupy-place, 3.2*2.5CM, enhanced CT：Right lung cancer accompanied enlargement of hilar lymph nodes；Transthoracic Biopsy：Gland cancer；Lumbar vertebrae CT:L4 Centrum shifts；Poor appetite, it is weak, become thin, pain in the back；Red tongue body；The thin Huang of tongue, veins is sliding；The traditional Chinese medical science meets pulmonary carcinosis, phlegm-heat accumulated in the lung, Merge deficiency of both vital energy and Yin.Give Chinese medicine and disappear that to be changed to medicament capsule of the present invention oral for long-pending Qing Fei Yin, while taking digestion-promoting stomachic, rose The symptomatic treatments such as pain relieving ointment outer patch, and give the western medicines such as anti-inflammatory, resolving sputum.Patient adheres to taking medicament capsule March of the present invention Remaining, cough, expectoration, hemoptysis symptom disappear, and diet increases, and spirit takes a turn for the better；Afterwards interruption takes medicament capsule of the present invention, on cough Increase, carry out hospital transfusion, take Chinese medicine.Maintain in August, 2016 because of lung cancer development, refusal feed, merge left lower extremity Deep venou Thrombus, pulmonary embolism is dead.

Present invention has the advantages that：The prescription drug constituted using the traditional Chinese medical science of the present invention, raw material is easy to get, and preparation method is simple, Low price；The present invention has functions that clearing heat and detoxicating, dissipating phlegm and removing blood stasis, softening and resolving hard mass, boosting qi and nourishing yin；The present invention also has anti-swollen Knurl, kobadrin, the effect for improving immunity of organisms；Taking medicine decoction of the present invention or capsule can mitigate patients symptomatic, treat Effect is definite stable, extends patient survival, quality of making the life better；Drug administration of the present invention is convenient, and patient absorbs complete after taking Rapidly, have no toxic side effect.It is currently a kind of newtype drug for treating advanced Non-small cell lung.

Specific embodiment

The specific embodiment of the invention is：

Embodiment 1

A, 40 grams of oldenlandia diffusa, 40 grams of Sculellaria barbata, 20 grams of cordate houttuynia, 10 grams of dried orange peel, 30 grams of Snakegourd Fruit, Job's tears are weighed respectively 10 grams of benevolence, 30 grams of lepidium seed, 10 grams of the root of large-flowered skullcap, 20 grams of the wind-weed, 10 grams of semen armeniacae amarae, 20 grams of fritillaria thunbergii, 20 grams of turtle shell, selfheal 20 Gram, 20 grams of the Radix Astragali, 20 grams of Radix Codonopsis, 20 grams of reed rhizome, 10 grams of peach kernel, 10 grams of perilla seed, 10 grams of honey-fried licorice root it is standby；

B, the fritillaria thunbergii that step A has been prepared is ground into fine powder, crosses 100 mesh sieves standby；The long-noded pit viper that step A has been prepared Tongue grass, Sculellaria barbata, cordate houttuynia, dried orange peel, Snakegourd Fruit, coix seed, lepidium seed, the root of large-flowered skullcap, the wind-weed, semen armeniacae amarae, turtle shell, selfheal, the Radix Astragali, Radix Codonopsis, reed rhizome, peach kernel, perilla seed, honey-fried licorice root are cleaned up, dried for decocting, and add water for the first time 3 Bei ﹙ Chong Liang Bi ﹚, soak 1h, plus Heat to boiling decocts 1h, leaching decocting liquid；Add water for the second time 2 Bei ﹙ Chong Liang Bi ﹚, is heated to boiling and decocts 1h, and leaching decocting liquid merges twice Decocting liquid is precipitated for static 48 hours, considers the removal of impurity, and decocting liquid is concentrated into medicinal extract；Fritillaria thunbergii powder prepared by gained medicinal extract and this step is equal Particle is made in concentration after even mixing, dries, and by gained granule filling capsule, each capsule is 0.35 gram；

C. capsule prepared by step B is packed, is placed in the shady and cool place of drying and deposits.

Embodiment 2

A, 30 grams of oldenlandia diffusa, 30 grams of Sculellaria barbata, 30 grams of cordate houttuynia, 20 grams of dried orange peel, 20 grams of Snakegourd Fruit, Job's tears are weighed respectively 15 grams of benevolence, 20 grams of lepidium seed, 15 grams of the root of large-flowered skullcap, 15 grams of the wind-weed, 15 grams of semen armeniacae amarae, 20 grams of fritillaria thunbergii, 25 grams of turtle shell, selfheal 20 Gram, 30 grams of the Radix Astragali, 15 grams of Radix Codonopsis, 20 grams of reed rhizome, 15 grams of peach kernel, 10 grams of perilla seed, 10 grams of honey-fried licorice root it is standby；

B, the fritillaria thunbergii that step A has been prepared is ground into fine powder, crosses 100 mesh sieves standby；The long-noded pit viper that step A has been prepared Tongue grass, Sculellaria barbata, cordate houttuynia, dried orange peel, Snakegourd Fruit, coix seed, lepidium seed, the root of large-flowered skullcap, the wind-weed, semen armeniacae amarae, turtle shell, selfheal, the Radix Astragali, Radix Codonopsis, reed rhizome, peach kernel, perilla seed, honey-fried licorice root are cleaned up, dried for decocting, and add water for the first time 4 Bei ﹙ Chong Liang Bi ﹚, soaks 1.5h, It is heated to boiling and decocts 1.2h, leaching decocting liquid；Add water for the second time 3 Bei ﹙ Chong Liang Bi ﹚, is heated to boiling and decocts 1.2h, and leaching decocting liquid is closed And twice decocting liquid is precipitated for static 56 hours, considers the removal of impurity, decocting liquid is concentrated into medicinal extract；Zhejiang shellfish prepared by gained medicinal extract and this step Particle is made in concentration after female powder uniformly mixes, and dries, and by gained granule filling capsule, each capsule is 0.35 gram；

C. capsule prepared by step B is packed, is placed in the shady and cool place of drying and deposits.

Embodiment 3

A, 20 grams of oldenlandia diffusa, 20 grams of Sculellaria barbata, 40 grams of cordate houttuynia, 20 grams of dried orange peel, 30 grams of Snakegourd Fruit, Job's tears are weighed respectively 20 grams of benevolence, 20 grams of lepidium seed, 20 grams of the root of large-flowered skullcap, 10 grams of the wind-weed, 20 grams of semen armeniacae amarae, 10 grams of fritillaria thunbergii, 30 grams of turtle shell, selfheal 10 Gram, 40 grams of the Radix Astragali, 10 grams of Radix Codonopsis, 10 grams of reed rhizome, 20 grams of peach kernel, 15 grams of perilla seed, 5 grams of honey-fried licorice root it is standby；Remaining step is with real Apply example 2.

Claims (3)

1. a kind of medicine for treating advanced Non-small cell lung, is characterized in that, is made up of the raw material of following portions by weight proportioning：In vain Flower HERBA HEDYOTIS DIFFUSAE 20-40, Sculellaria barbata 20-40, cordate houttuynia 20-40, dried orange peel 10-20, Snakegourd Fruit 20-30, coix seed 10-20, lepidium seed 20-30, root of large-flowered skullcap 10-20, wind-weed 10-20, semen armeniacae amarae 10-20, fritillaria thunbergii 10-20, turtle shell 20-30, selfheal 10-20, the Radix Astragali 20-40, Radix Codonopsis 10-20, reed rhizome 10-20, peach kernel 10-20, perilla seed 10-15, honey-fried licorice root 5-10.

2. a kind of medicine for treating advanced Non-small cell lung according to claim 1, is characterized in that：The weight portion of each raw material Counting proportioning is：Oldenlandia diffusa 30, Sculellaria barbata 30, cordate houttuynia 30, dried orange peel 20, Snakegourd Fruit 20, coix seed 15, the lepidium seed 20, root of large-flowered skullcap 15th, the wind-weed 15, semen armeniacae amarae 15, fritillaria thunbergii 20, turtle shell 25, selfheal 20, the Radix Astragali 30, Radix Codonopsis 15, reed rhizome 20, peach kernel 15, purple perilla Son 10, honey-fried licorice root 10.

3. a kind of preparation method of the medicine for treating advanced Non-small cell lung as claimed in claim 1 or 2, is characterized in that：It is main Comprise the steps：

A, oldenlandia diffusa, Sculellaria barbata, cordate houttuynia, dried orange peel, Snakegourd Fruit, Job's tears are weighed respectively according to described parts by weight proportioning Benevolence, lepidium seed, the root of large-flowered skullcap, the wind-weed, semen armeniacae amarae, fritillaria thunbergii, turtle shell, selfheal, the Radix Astragali, Radix Codonopsis, reed rhizome, peach kernel, perilla seed, process it is sweet Grass is standby；

B, the fritillaria thunbergii that step A has been prepared is ground into fine powder, crosses 100 mesh sieves standby；The oldenlandia that step A has been prepared Grass, Sculellaria barbata, cordate houttuynia, dried orange peel, Snakegourd Fruit, coix seed, lepidium seed, the root of large-flowered skullcap, the wind-weed, semen armeniacae amarae, turtle shell, selfheal, the Radix Astragali, party Ginseng, reed rhizome, peach kernel, perilla seed, honey-fried licorice root are cleaned up, dried for decocting, and add water for the first time 3-4 ﹙ Chong Liang Bi ﹚, soaks 1- 1.5h, is heated to boiling and decocts 1-1.2h, leaching decocting liquid；Add water for the second time 2-3 ﹙ Chong Liang Bi ﹚, is heated to boiling and decocts 1-1.2h, Leaching decocting liquid, merges the static 48-56 hours precipitation of decocting liquid twice, considers the removal of impurity, and decocting liquid is concentrated into medicinal extract；By gained medicinal extract and originally Particle is made in concentration after fritillaria thunbergii powder prepared by step uniformly mixes, and dries, and by gained granule filling capsule, each capsule is 0.35 gram；

C. capsule prepared by step B is packed, is placed in the shady and cool place of drying and deposits.