CN106620143A - Traditional Chinese medicine composition for treating livestock and poultry cough asthma and preparation method of composition - Google Patents

Traditional Chinese medicine composition for treating livestock and poultry cough asthma and preparation method of composition Download PDF

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CN106620143A
CN106620143A CN201611245484.1A CN201611245484A CN106620143A CN 106620143 A CN106620143 A CN 106620143A CN 201611245484 A CN201611245484 A CN 201611245484A CN 106620143 A CN106620143 A CN 106620143A
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chinese medicine
radix
composition
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牛卫宁
尹朋
梁冰
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Most Cas (beijing) Technology Development Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention relates to traditional Chinese medicine composition for treating livestock and poultry cough asthma and a preparation method of the composition. The composition is prepared from traditional Chinese medicine raw materials in parts by weight as follows: 100-300 parts of cynanchum glaucescens, 100-200 parts of flos inulae, 100-200 parts of radix ranunculi ternati, 100-200 parts of scutellaria baicalensis, 50-150 parts of flos chrysanthemi, 50-150 parts of sea buckthorn, 50-150 parts of rhizoma dioscoreae and 0-100 parts of radix glycyrrhizae. According to the technical scheme, the composition adopts a reasonable formula and is simple to prepare; the pure traditional Chinese medicine composition has no toxic or side effects, drug residues and drug resistance. Clinical application proves that the composition has special effects on preventing and treating livestock and poultry respiratory diseases.

Description

A kind of Chinese medicine composition for treating poultry cough with asthma and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition for preventing and treating poultry cough with asthma and preparation method thereof, more particularly to one kind can Treat the Chinese medicine composition that various phlegm syndromes cause animal to cough.
Background technology
Animal respiratory disease is mainly caused by mycoplasma, antibacterial, virus, bad environments such as ammonia concentration is excessive etc. A kind of common disease, clinical manifestation is characterized with infecting poultry breathing rale, cough, flowing nose liquid;Pathological change is mainly manifested in Trachea and bronchus have serosity or mucuss exudate, airsacculitis, pericarditiss, perihepatitis, pneumonia etc..The disease is to livestock and poultry breeding industry It is very harmful.
At present, treat the disease and be most commonly used that various antibacterials, such as oxytetracycline, chloromycetin, penicillin, streptomycin, quinoline Promise ketone etc., because antibacterials generally have the shortcomings that toxic and side effects are relatively strong and are also easy to produce drug resistance, decline evident in efficacy, and In animal body, its animal products quality does not reach nuisanceless requirement to drug residue, affects outlet and the people of animal products Health.And the antiviral agents Ministry of Agriculture has forbidded strictly to use.Chinese medicine is because powder particle diameter is big or prescription is unreasonable, biological utilisation Degree is low, works relatively slow, and effect is less desirable.
Therefore it is field scientific research technical staff's urgency to research and develop a kind of pharmaceutical composition of effective preventing and treating animal respiratory disease One of new problem to be solved.
The content of the invention
In order to solve the above problems, present invention aim at provide a kind of Chinese medicine composition for preventing and treating poultry cough with asthma and Its preparation method.
For achieving the above object, the technical solution adopted in the present invention is as follows:
A kind of Chinese medicine composition for preventing and treating poultry cough with asthma, is prepared from by the raw material of Chinese medicine medicine of following weight proportion, Rhizoma Cynanchi Stauntonii 100-300 parts, Flos Inulae 100-200 parts, Radix Ranunculi Ternati 100-200 parts, Radix Scutellariae 100-200 parts, Flos Chrysanthemi 50-150 parts, Fructus Hippophae 50-150 parts, Rhizoma Dioscoreae 50-150 parts, Radix Glycyrrhizae 0-100 parts.
Preferably, it is prepared from by the raw material of Chinese medicine medicine of following weight proportion, Rhizoma Cynanchi Stauntonii 150-250 parts, Flos Inulae 120-180 Part, Radix Ranunculi Ternati 120-180 parts, Radix Scutellariae 120-180 parts, Flos Chrysanthemi 80-120 parts, Fructus Hippophae 80-120 parts, Rhizoma Dioscoreae 80-120 parts, Radix Glycyrrhizae 20-80 parts.
It is furthermore preferred that being prepared from by the raw material of Chinese medicine medicine of following weight proportion, 200 parts of Rhizoma Cynanchi Stauntonii, 150 parts of Flos Inulae, cat 150 parts of pawl grass, 150 parts of Radix Scutellariae, 100 parts of Flos Chrysanthemi, 100 parts of Fructus Hippophae, 100 parts of Rhizoma Dioscoreae, 50 parts of Radix Glycyrrhizae.
In composition described above, drug weight is, with crude drug calculating, can to increase according to corresponding proportion in production or reduce, such as Large-scale production can by kilogram in units of, or in units of ton, small-scale production can also be in units of milligram, and weight can be with Increase reduces, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above proportioning is obtained through science screening, fat or thin for special circumstances, such as serious symptom or mild Little, the proportioning of the amount of composition can be accordingly adjusted, increase or decrease less than 100%, drug effect is constant.
Single medicinal material in composition described above, especially ministerial drug and adjuvant drug, it is also possible to by appropriate with the identical property of medicine Medicine is replaced, and its medicine effect of the Chinese medicine preparation after replacement is constant.
The Chinese medicine composition of the present invention, when pharmaceutical preparation is prepared into, can add if necessary pharmaceutically acceptable carrier, press Prepare according to the routine techniquess of galenic pharmacy.Chinese medicine part therein can be prepared using raw material of Chinese medicine medicine, it is also possible to by altogether Obtain with raw material of Chinese medicine is extracted, it is also possible to obtain by other means, such as:By crushing, squeezing, calcine, grind, sieve, ooze Filter, extract, water extraction, alcohol extraction, ester is carried, ketone is carried, chromatographed etc., and method obtains active Chinese drug component material, these active Chinese drug component materials can be The material of extractum form, can be dry extract can also be fluid extract, according to preparation it is different need to determine to make it is different dense Degree.
The pharmaceutical dosage forms of the present invention, are present in a unit, and the unit dosage form refers to the list of preparation Position, such as tablet per piece, every capsule of capsule, per bag of granule etc..
The Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms include:Tablet, capsule, granule Agent, pill, powder, unguentum, sublimed preparation, powder, injection, suppository, spray, drop, patch.The preparation of the present invention, preferably It is peroral dosage form, such as:Capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc..
The compound Chinese medicinal preparation of the present invention, the preparation of its oral administration can contain conventional excipient, such as binding agent, fill out Fill agent, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent.Applicable filler include starch, Sucrose, cellulose, mannitol, the Lactose filler similar with other.Suitable disintegrating agent includes starch, polyvinylpyrrolidine Ketone and starch derivatives, such as sodium starch glycollate.Suitable lubricant includes, such as magnesium stearate.Can be filled out by mixing Fill, the conventional method such as tabletting prepares solid oral composition.Being mixed repeatedly is distributed in can active substance entirely to use In those compositionss of a large amount of filleies;Conventional adjunct ingredient includes:Mannitol, Sorbitol, sodium pyrosulfite, bisulfite Sodium, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, injection Vitamin B_6 DTA disodiums, Ethylenediaminetetraacetic Acid Calcium Salt, monoacidic base gold The carbonate of category, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, Sodium Chloride, potassium chloride, Sodium lactate, xylitol, maltose, glucose, Fructose, dextran, glycine, starch, sucrose, Lactose, mannitol, silicon spread out Biology, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, Calcium Carbonate, carbonic acid Hydrogen calcium, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, Magnesium stearate etc..
The preparation of the present invention determines usage and dosage according to condition when in use, can take 1-2 time daily, presses per kilogram body every time Weight 0.5-3g dosage.
Present invention also offers a kind of preparation method of the Chinese medicine composition of described preventing and treating poultry cough with asthma, it is characterised in that Step is as follows:
1) Rhizoma Cynanchi Stauntonii of recipe quantity, Flos Inulae, Radix Ranunculi Ternati, Radix Scutellariae, Flos Chrysanthemi, Fructus Hippophae, Rhizoma Dioscoreae, the taste medical material of Radix Glycyrrhizae 8 are weighed and plus 10 Times amount decocting boils 3 times, 2 hours every time, merges decoction liquor, filtration, stands overnight, leaching supernatant, and concentrating under reduced pressure is dried to Cream;
2) dry cream is ground into into fine powder, crosses 100 mesh sieves, add appropriate amount of auxiliary materials, mixed, prepare capsule, powder, granule Or tablet.
Present invention also offers described Chinese medicine composition is in the medicine for treating or preventing poultry to cough is prepared Using.
Medicine is constituted and analyzed:
In the Chinese medicine composition of the present invention, Rhizoma Cynanchi Stauntonii is monarch drug, and Flos Inulae, Radix Ranunculi Ternati are ministerial drug, Radix Scutellariae, Flos Chrysanthemi, Fructus Hippophae, mountain Medicine is adjuvant drug, and Radix Glycyrrhizae is to make medicine.
Rhizoma Cynanchi Stauntonii:For asclepiadaceae plant rhizoma et radix cynanchi stauntoni Cynanchum stauntonii (Decne.) Schltr, ex L é vl. Or leaves of Daphne genkwa Rhizoma Cynanchi Stauntonii Cynanchum glaucescens.(Decne.) dry rhizome and root of Han.-Mazz..Autumn excavation, Clean, dry.Acrid in the mouth, hardship, slightly warm in nature.Return lung Jing.With sending down the abnormal ascending QI, expectorant, cough-relieving effect.It is mainly used in lung qi and stops up real, cough Abundant expectoration, fullness in the chest dyspnea with rapid respiration.《Do not record》:Main chest side of body is against gas, cough with dyspnea.《Tang materia medica》:Your Majesty's gas is rushed in larynx, and breathing is wild.《Fujian Chinese herbal medicine》:Gas consumption product, invigorating the spleen and regulating the stomach.Leaves of Daphne genkwa Rhizoma Cynanchi Stauntonii contains triterpenoid saponin.
Flos Inulae:For feverfew Flos Inulae Inula japonica Thunb. or Eurasia trip Flos Inulae Inula The dry capitulum of britannica L..Summer, season in autumn two, the flowers are in blossom harvests when putting, and removes impurity, dries in the shade or dries.Bitter in the mouth, It is pungent, salty, slightly warm in nature.Return lung, spleen, stomach, large intestine channel.With sending down the abnormal ascending QI, expectorant, water-filling, preventing or arresting vomiting effect.It is mainly used in cough due to wind and cold, Phlegm retention stores knot, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum, vomits gas, epigastric oppression and rigidity.《Book on Chinese herbal medicine invention》:Drink, eliminating stagnation are led in Flos Inulae, expectorant The taste of promoting the circulation of QI.《Collected statements on the herbal foundation》:Flos Inulae, expectorant is relieved oedema or abdominal distension through diuresis or purgation, the descending medicine of promoting the circulation of QI.Main cardiopulmonary stagnation of QI, the lower fullness sensation due to deficiency of the side of body, ties in the heart The diseases such as expectorant, fullness and hardness of the abdomen eructation, or heart spleen latent fluid-retention, bladder prolonged fluid-retention, retained water.Containing chrysoeriol, patuletin, luteolin, Quercetin Deng.
Radix Ranunculi Ternati:This product is the dried root of the little Mao of Mao Moke plants not Ranunculus ternatus Thunb..Spring Section excavation, removes fibrous root and silt, dries.It is sweet in the mouth, pungent, it is warm in nature.Return liver, Jing.With dissipating phlegm and resolving masses, removing toxic substances and promoting subsidence of swelling effect.It is main It is used for scrofula subcutaneous nodule, furuncle swelling toxin, snake bite and insect sting.
Radix Scutellariae:For the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Spring, Qiu Erji Excavation, removes fibrous root and silt, and rough bark is hit after solarization, dries.Bitter in the mouth, it is cold in nature.Return lung, gallbladder, spleen, large intestine, small intestine meridian.With clear Hot dampness, eliminating fire and detoxication, hemostasis, antiabortive effect.It is mainly used in hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, lung Heat cough, hyperpyrexia excessive thirst, blood-head tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Zhu Zhenheng:Expectorant, false its pathogenic fire reducing drop in Radix Scutellariae.《Detailed outline》: Clean ancient Zhang Shi says Radix Scutellariae purte the white, and it is wet to be in harmony spleen;Eastern wall Li Shi speeches Radix Scutellariae controls lung-fire, and bar a kind of reed mentioned in ancient books controls large intestine fire.Principle active component:It is yellow Ketone compounds.Such as baicalin (baicalein), neobaicalein (neobaicalein), i.e. skullcapflavone II (skullcapflavone II), baicalin (baicalin), wogonin (wogonin), wogonoside (wogono-side), Oroxylin A (oroxylin, oroxylin A), 7- methoxyl group baicalins (7-methoxbaic alein)
Flos Chrysanthemi:For the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..The 9-11 months Harvest in batches when spending in full bloom, dry in the shade or dry, or dry after smoked, steaming.Medical material is different with processing method by the place of production, is divided into " milli Chrysanthemum ", " Flos Chrysanthemi ", " Flos Chrysanthemi ", " Flos Chrysanthemi ".Sweet in the mouth, hardship, cold nature.Return lung, Liver Channel.With scattered wind heat clearing away, flat liver improving eyesight effect. It is mainly used in anemopyretic cold, dizziness of having a headache, conjunctival congestion and swelling pain, eyes is dim-sighted.Containing stachydrine, wooden grass glycoside, cosmosiin, gland The compositions such as fat purine, choline, glycoside, are especially enriched in volatile oil, and oil predominantly chrysanthanone, Borneolum Syntheticum, Borneolum Syntheticum caproate etc. Material.
Fructus Hippophae:It is the Mongols, Tibetan conventional crude drugs.For Elaeangnaceae plant Fructus Hippophae Hippophae rhamnoides L. Dry mature fruit.Harvest when autumn, two season of winter fruit maturation or adfreezing, remove impurity, be dried or be dried after steaming.It is sour in the mouth, puckery, It is warm in nature.Returns spleen, stomach, lung, heart channel.With eliminating phlegm and stopping cough, relieving dyspepsia, promoting blood circulation to remove blood stasis effect.It is mainly used in cough with copious phlegm, digests Bad, abdominal pain due to retention of food, blood stasis closed is fallen and flutters congestive edema.Sea buckthorn fruit is nutritious, according to surveying and determination containing various dimension lifes in its fruit The various aminoacid of element, fatty acid, trace element, sub- oil element, Fructus Hippophae flavone, superoxides isoreactivity material and needed by human body.
Rhizoma Dioscoreae:For the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..Winter stem and leaf is withered After excavate, cut macroradical head, clean, remove crust and fibrous root, be dried;Also have select hypertrophy straight to be dried Rhizoma Dioscoreae, in putting clear water, It is dipped into without the dry heart, it is vexed, two ends are trimmed, it is twisted into plank cylindric, dry, polishing, practise and claim " light yam ".Sweet in the mouth, it is mild-natured.Return Spleen, lung, kidney channel.With spleen reinforcing nourishing the stomach, engender liquid and benefic lung, the kidney invigorating arresting seminal emission effect.It is mainly used in spleen eating less, incessant chronic diarrhea, the deficiency of the lung Breath with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, loose stool of having loose bowels, leucorrhea Excessively.《Book on Chinese herbal medicine is just》:Rhizoma Dioscoreae, energy spleen invigorating qi-restoratives is grown essence and is reinforced the kidney, and controls weakness, treats five kinds of strain and seven kinds of impairment.《Medicineization justice》:Rhizoma Dioscoreae, Temperature compensation and it is rapid, micro-perfume and it is not dry, followed the work(for adjusting lung, control deficiency of the lung chronic cough, it is what reliable.Rhizoma Dioscoreae tuber contains diosgenin (diosgenin)0.012%, dopamine (dopamine), hydrochloric acid Rhizoma Dioscoreae alkali (batatasine hydrochloride), polyphenol Oxidase (polyphenoloxidase), allantoin (allantoin) stops wooden fork element (abscisin) II etc..
Radix Glycyrrhizae:For glycyrrhizic legume Glycyrrhiz uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat.'s or Glycyrrhiza glabra L. Glycyrrhiza gla-bra L. is dried report and rhizome.Spring, the excavation of two seasons of product, remove Fibrous root, dries.Sweet in the mouth, it is mild-natured.GUIXIN.Lung, spleen, stomach.With invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, Coordinating the actions of various ingredients in a prescription effect.It is mainly used in weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, institute's abdomen, four limbs contraction, carbuncle Swollen sore, alleviates drug toxicity, strong.《Collected statements on the herbal foundation》:Radix Glycyrrhizae, and middle QI invigorating, the medicine of qi-restoratives removing toxic substances.Strengthening the spleen and stomach, Gu in The weakness with emaciation of gas, assists negative and positive, and uncomfortable battalion to defend.Containing glycyrrhizin (glycyrrhizin), glycyrrhizic acid (glycyrrhinic Acid), enoxolone (glycyrrhetic acid, glycyrrhetinic acid), liquiritin (liquiritin, Liquiritin), glycyrrhizin (liquiritigenin), glycyramarin (glycyamarin), isoliquiritin (iso- Liquiritin), dihydroxy enoxolone (dihydroxyglycyrrhetic acid, i.e. grabric acid), Radix Glycyrrhizae west Fixed (licoricidin), glycyrol (glycyrol), 5-0- methyl glycyrols (5-0-methyl glycerol), isoglycyrol (iso-glycyrol) etc..
The invention has the advantages that:
A kind of Chinese medicine composition for preventing and treating poultry cough with asthma disclosed by the invention, reasonable recipe is prepared simple;Pure Chinese medicine Compositionss have no toxic side effect, drug residue free, have no drug resistance.Clinical practice proves have well to preventing and treating livestock and birds respiratory disease Effect.
Specific embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
A kind of Chinese medicine composition for preventing and treating poultry cough with asthma, including:Rhizoma Cynanchi Stauntonii 200g, Flos Inulae 150g, Radix Ranunculi Ternati 150g, Radix Scutellariae 150g, Flos Chrysanthemi 100g, Fructus Hippophae 100g, Rhizoma Dioscoreae 100g, Radix Glycyrrhizae 50g, its concrete preparation method is as follows:
1) Rhizoma Cynanchi Stauntonii of recipe quantity, Flos Inulae, Radix Ranunculi Ternati, Radix Scutellariae, Flos Chrysanthemi, Fructus Hippophae, Rhizoma Dioscoreae, the taste medical material of Radix Glycyrrhizae 8 are weighed and plus 10 Again amount decocting is boiled three times, 2 hours every time, merges decoction liquor, and filtration is evaporated to relative density 1.15~1.30 (50 DEG C), It is dried to dry cream.
2) dry cream is ground into into fine powder, crosses 100 mesh sieves, add appropriate amount of auxiliary materials, mixed, prepare capsule, powder, granule Or tablet.
Embodiment 2
A kind of Chinese medicine composition for preventing and treating poultry cough with asthma, including:Rhizoma Cynanchi Stauntonii 250g, Flos Inulae 150g, Radix Ranunculi Ternati 100g, Radix Scutellariae 100g, Flos Chrysanthemi 100g, Fructus Hippophae 100g, Rhizoma Dioscoreae 100g, Radix Glycyrrhizae 100g, its concrete preparation method is as follows:
1) Rhizoma Cynanchi Stauntonii of recipe quantity, Flos Inulae, Radix Ranunculi Ternati, Radix Scutellariae, Flos Chrysanthemi, Fructus Hippophae, Rhizoma Dioscoreae, the taste medical material of Radix Glycyrrhizae 8 are weighed and plus 10 Again amount decocting is boiled three times, 2 hours every time, merges decoction liquor, and filtration is evaporated to relative density 1.21~1.27 (50 DEG C), It is dried to dry cream.
2) dry cream is ground into into fine powder, crosses 100 mesh sieves, add appropriate amount of auxiliary materials, mixed, prepare capsule, powder, granule Or tablet.
Embodiment 3
A kind of Chinese medicine composition for preventing and treating poultry cough with asthma, including:Rhizoma Cynanchi Stauntonii 200g, Flos Inulae 180g, Radix Ranunculi Ternati 150g, Radix Scutellariae 150g, Flos Chrysanthemi 100g, Fructus Hippophae 100g, Rhizoma Dioscoreae 100g, Radix Glycyrrhizae 20g, its concrete preparation method is as follows:
Weigh the Rhizoma Cynanchi Stauntonii of recipe quantity, Flos Inulae, Radix Ranunculi Ternati, Radix Scutellariae, Flos Chrysanthemi, Fructus Hippophae, Rhizoma Dioscoreae, the taste medical material of Radix Glycyrrhizae 8 plus 10 times Amount decocting is boiled three times, 2 hours every time, merges decoction liquor, and filtration is evaporated to the clear of relative density 1.05~1.15 (50 DEG C) Cream, plus ethanol makes alcohol content to 60%~70%, stands 24~48 hours, filters, filtrate recycling ethanol is to without alcohol taste, plus 1- 3 ‰ preservative, adds water to 1000ml, makes oral liquid.
Embodiment 4
A kind of Chinese medicine composition for preventing and treating poultry cough with asthma, including:Rhizoma Cynanchi Stauntonii 200g, Flos Inulae 150g, Radix Ranunculi Ternati 150g, Radix Scutellariae 150g, Flos Chrysanthemi 100g, Fructus Hippophae 100g, Rhizoma Dioscoreae 100g, Radix Glycyrrhizae 50g, its concrete preparation method is as follows:
The flavour of a drug of above-mentioned recipe quantity are weighed, be dry, pulverize, cross 100 mesh sieves, make powder.
Test example 1
Clinical experiment animal, in the DLY tri-crossbreeding 100 of 40kg-50kg, is faced from 100-120 ages in days, body weight Bed symptom occurs breathing, coughs, generates heat for pig, inappetence or without appetite.The isolation of ill pig is individually raised, feeding full price is raised Material, and it is randomly divided into 5 groups, 20 per group, 5 groups of feeding environments are identical, and experimental period is carried out altogether 7 days;Blank control group is not Any process is done, drug control group is used according to an instruction treatment with institute's control drug " datura flower asthma relieving powder ";Test group 1 is feeding Prepared by the embodiment of the present invention 1 dissipates, and test group 2 lacks dissipating for monarch drug preparation for feeding by embodiment 1, and test group 3 is feeding by real Apply example 1 lack ministerial drug preparation dissipate, day dose be:Per 100g spices 1kg feedings, 2 times a day.Pass through gastrointestinal absorption after oral Reach the purpose for the treatment of disease.
Efficacy assessment standard:
Recovery from illness:Jing is treated, and clinical symptoms are wholly absent, and spirit, appetite recover normal
Effectively:Jing is treated, clinical symptom remission, and spirit, appetite are gradually recovered.
It is invalid:Jing is treated, and clinical symptoms are without alleviation, and spirit, appetite are without improvement or even dead.
The present invention of table 1 treats the situation contrast of porcine respiratory disease with other medicines:
Group Number of cases Recovery from illness Effectively It is invalid Effective percentage %
Blank control group 20 0 2 18 10
Datura flower asthma relieving powder group 20 13 3 4 80
Test group 1 20 15 2 3 85
Test group 2 20 1 3 16 20
Test group 3 20 4 6 10 50
Conclusion:Result of the test shows that the Chinese medicine composition in the present invention prevents and treats poultry cough with asthma effect is significant.
Test example 2
Clinical experiment animal selects 3 week old chickens, and clinical symptoms are decreased obviously for feed intake, spiritual depressed, unilateral or bilateral Nasal sinuses, eyelid swelled, cough, sneeze, constantly get rid of head, dyspnea.The isolation of ill chicken is individually raised, feeding full price is raised Material, and it is randomly divided into 5 groups, 100 per group, 5 groups of feeding environments are identical, and experimental period is carried out altogether 7 days;Blank control group is not Any process is done, drug control group is used according to an instruction treatment with institute's control drug " Maxingshigan oral liquid ";Will be by this Bright test example 1 prepare the feeding of test group 1,2,3 illness chicken, day dose be:It is daily 1-2 time per 100g spices 1kg feedings; The purpose for the treatment of disease is reached after oral by gastrointestinal absorption.
Efficacy assessment standard:
It is invalid:Spirit is highly depressed, drives to walk, and appetite is remarkably decreased, and gets rid of head, cough, sneeze, trachea rale.Cut open Visible annulus trachealises hyperemia, bleeding are examined, there is more serosity, Catarrhal and cheesy exudate;Visible bleeding in pulmonary's bronchus, Kidney urate deposition.It is inefficiency that invalid chicken number accounts for the percentage ratio of this group of chicken number.
Effectively:Spiritual preferably appetite is gradually recovered, and a small amount of chicken gets rid of head, cough, sneeze.Cut open inspection observes visible trachea A small amount of serosity and Catarrhal mucus, annulus trachealises are slight congested, rubescent, and kidney urate is deposited on a small quantity.Effectively chicken number accounts for this The percentage ratio of group chicken number is effective percentage.
Recovery from illness:Spirit, appetite, breathing recover normal, the tissue no abnormality seen such as cut open inspection trachea-bronchial epithelial cell, lungs, kidney. It is cure rate that recovery from illness chicken number accounts for the percentage ratio of this group of chicken number.
Total effective rate:The percentage ratio of this group of chicken number is effectively accounted for recovery from illness chicken number summation.
Table 2 is the situation contrast that the present invention and other medicines treat chicken respiratory tract disease:
Group Mortality rate % Cure rate % At the end of have symptom rate %
Blank control group 15 0 85
Drug control group 9 83 8
Test group 1 5 90 5
Test group 2 13 6 81
Test group 3 8 28 64
This clinical effectiveness statistical analysis, the composition treatment chicken respiratory tract disease effect is significant of test group of the present invention 1.This Bright to be found surprisingly that, the collocation of each component of the present invention has synergistic function.
Although the present invention is described in detail above to have used general explanation and specific embodiment, at this On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore, Without departing from theon the basis of the spirit of the present invention these modifications or improvements, belong to the scope of protection of present invention.

Claims (7)

1. a kind of Chinese medicine composition for preventing and treating poultry cough with asthma, it is characterised in that:The Chinese medicine composition is matched somebody with somebody by following weight The raw material of Chinese medicine medicine of ratio is prepared from, Rhizoma Cynanchi Stauntonii 100-300 parts, Flos Inulae 100-200 parts, Radix Ranunculi Ternati 100-200 parts, Radix Scutellariae 100- 200 parts, Flos Chrysanthemi 50-150 parts, Fructus Hippophae 50-150 parts, Rhizoma Dioscoreae 50-150 parts, Radix Glycyrrhizae 0-100 parts.
2. a kind of Chinese medicine composition for preventing and treating poultry cough with asthma as claimed in claim 1, it is characterised in that:The Chinese medicine group Compound is prepared from by the raw material of Chinese medicine medicine of following weight proportion, Rhizoma Cynanchi Stauntonii 150-250 parts, Flos Inulae 120-180 parts, Radix Ranunculi Ternati 120-180 parts, Radix Scutellariae 120-180 parts, Flos Chrysanthemi 80-120 parts, Fructus Hippophae 80-120 parts, Rhizoma Dioscoreae 80-120 parts, Radix Glycyrrhizae 20-80 parts.
3. a kind of Chinese medicine composition for preventing and treating poultry cough with asthma as claimed in claim 1, it is characterised in that:The Chinese medicine group Compound is prepared from by the raw material of Chinese medicine medicine of following weight proportion, 200 parts of Rhizoma Cynanchi Stauntonii, 150 parts of Flos Inulae, 150 parts of Radix Ranunculi Ternati, Radix Scutellariae 150 parts, 100 parts of Flos Chrysanthemi, 100 parts of Fructus Hippophae, 100 parts of Rhizoma Dioscoreae, 50 parts of Radix Glycyrrhizae.
4. compositionss according to claim 1, it is characterised in that:The compositionss are any pharmaceutically useful dosage forms.
5. compositionss according to claim 4, it is characterised in that:The dosage form is selected from:Tablet, capsule, granule, ball Agent, powder, unguentum, sublimed preparation, powder, solution, injection, suppository, spray, drop, patch.
6. the preparation method of compositionss according to claim 1, it is characterised in that:The step of preparation method, is as follows: Rhizoma Cynanchi Stauntonii, Flos Inulae, Radix Ranunculi Ternati, Radix Scutellariae, Flos Chrysanthemi, Fructus Hippophae, Rhizoma Dioscoreae, the taste medical material of Radix Glycyrrhizae 8 add 8-12 times to measure decocting to boil 1-4 time, every time 1-3 hours, merge decoction liquor, and filtration, concentrating under reduced pressure is dried to dry cream;Dry cream is ground into into fine powder, is sieved, add adjuvant, mixed It is even, prepare capsule, powder, granule or tablet.
7. the preparation method of compositionss according to claim 1, it is characterised in that:The step of preparation method, is as follows: Rhizoma Cynanchi Stauntonii, Flos Inulae, Radix Ranunculi Ternati, Radix Scutellariae, Flos Chrysanthemi, Fructus Hippophae, Rhizoma Dioscoreae, the taste medical material of Radix Glycyrrhizae 8 add 8-12 times to measure decocting to boil 1-4 time, every time 1-3 hours, merge decoction liquor, and filtration is evaporated to relative density 1.05~1.20, plus ethanol make alcohol content to 50%~ 80%, 24-72 hours are stood, filter, decompression recycling ethanol plus 1~3 ‰ preservative to without alcohol taste, adds water to 1000ml, essence Filter, makes oral liquid, infusion liquid.
CN201611245484.1A 2016-12-29 2016-12-29 Traditional Chinese medicine composition for treating livestock and poultry cough asthma and preparation method of composition Pending CN106620143A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104857240A (en) * 2015-06-04 2015-08-26 夏征梅 Traditional Chinese medicine decoction for treating chronic bronchitis
CN105853875A (en) * 2016-03-30 2016-08-17 苏州市天灵中药饮片有限公司 Cough relieving and phlegm resolving paste and preparation method thereof
CN106237056A (en) * 2016-08-31 2016-12-21 亳州市庆聚药业销售有限公司 A kind of Chinese medicine decoction treating chronic bronchitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104857240A (en) * 2015-06-04 2015-08-26 夏征梅 Traditional Chinese medicine decoction for treating chronic bronchitis
CN105853875A (en) * 2016-03-30 2016-08-17 苏州市天灵中药饮片有限公司 Cough relieving and phlegm resolving paste and preparation method thereof
CN106237056A (en) * 2016-08-31 2016-12-21 亳州市庆聚药业销售有限公司 A kind of Chinese medicine decoction treating chronic bronchitis

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