CN106619967A - Anti-fever toxin-eliminating oral liquid and preparation method thereof - Google Patents
Anti-fever toxin-eliminating oral liquid and preparation method thereof Download PDFInfo
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- CN106619967A CN106619967A CN201611096363.5A CN201611096363A CN106619967A CN 106619967 A CN106619967 A CN 106619967A CN 201611096363 A CN201611096363 A CN 201611096363A CN 106619967 A CN106619967 A CN 106619967A
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- 239000007788 liquid Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 206010037660 Pyrexia Diseases 0.000 title abstract description 5
- 230000000694 effects Effects 0.000 claims abstract description 13
- 241000196133 Dryopteris Species 0.000 claims abstract description 6
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims abstract description 6
- 108090000790 Enzymes Proteins 0.000 claims description 17
- 102000004190 Enzymes Human genes 0.000 claims description 17
- 229940088598 enzyme Drugs 0.000 claims description 17
- 239000012567 medical material Substances 0.000 claims description 15
- 230000000692 anti-sense effect Effects 0.000 claims description 11
- 238000000108 ultra-filtration Methods 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 8
- 239000006228 supernatant Substances 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- -1 pectase Proteins 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 7
- 241000628997 Flos Species 0.000 claims description 6
- 238000005119 centrifugation Methods 0.000 claims description 6
- 239000012510 hollow fiber Substances 0.000 claims description 6
- 238000001471 micro-filtration Methods 0.000 claims description 6
- 239000010231 banlangen Substances 0.000 claims description 5
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- 102000013142 Amylases Human genes 0.000 claims description 2
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- 238000013329 compounding Methods 0.000 claims description 2
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- 244000144977 poultry Species 0.000 abstract description 10
- 229960005486 vaccine Drugs 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 2
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- 229940106157 cellulase Drugs 0.000 description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/233—Bupleurum
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/634—Forsythia
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- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A61K2236/10—Preparation or pretreatment of starting material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention belongs to the technical field of veterinary medicine, and discloses anti-fever toxin-eliminating oral liquid and a preparation method thereof. Per 1000ml of oral liquid is prepared from the following medicinal materials in proportion by weight: 300 to 350g of radix scutellariae, 250 to 300g of fructus gardeniae, 200 to 250g of isatis roots, 200 to 250g of fructus forsythiae, 200 to 250g of rhizoma dryopteris crassirhizomae, 200 to 250g of wild chrysanthemum flowers, 200 to 250g of radix bupleuri and 200 to 250g of herba houttuyniae. The oral liquid provided by the invention has the advantages that through study and application for near three years, the curative effect in aspects of preventing and controlling poultry cold and fever is exact; the disease condition can be effectively prevented and controlled; the economic loss is reduced; the cost is low; the oral liquid is suitable for being popularized in poultry culture; the defects of vaccine and other medicine are overcome; the clinic trouble of culture farmers can be avoided.
Description
Technical field
The invention belongs to veterinary medicine technical field, and in particular to a kind of anti-sense Toxin-Vanquishing oral liquid and preparation method.
Background technology
At present the technical merit of poultry vaccine is improved constantly, and the common virosiss of poultry can nearly all use vaccine immunity
To prevent, but seasonal variations, improper ventilation, turn the flu that temperature change Jing that the factors such as group cause often causes poultry.And catch a cold
At the beginning of, culturist tends not to discovery in time, so as to cause pathogenic factor from outward appearance to inner essence, causes poultry heating.The common clinic of broiler
Show as feed intake decline, drinking-water reduction, in disorder spiritual depressed, feather, informer's elongation, eyelid cyanosis, cockscomb and wattle rubescent
Or cyanosis；The visible poultry trachea of clinical cut open inspection and larynx is rubescent, congested lungs or bleeding, hydropericardium, Liver and kidney are congested, intestinal slurry
Face blood vessel anger, the hyperemia of intestinal mucosa face or bleeding；It is especially most commonly seen in the later stage of broiler breeding, the now death of poultry
Rate is also very high, has a strong impact on the productivity effect of broiler.The common egg drop reduction of laying hen, eggshell quality are poor, or even occur a large amount of broken
Egg and soft-shelled egg, the death rate of laying hen also substantially increases, and the economic loss thus brought is very serious.
The dominant ideas of Chinese veterinarian are " preventive treatment of disease ", and its Traditional Thinking realizes dialectical treatmert by " science, method, prescription, drugs "
Thought.Cold, fever belongs to exterior syndrome in the traditional Chinese medical science, and Chinese medicinal formulae has extraordinary curative effect in clinic, and medicine makes
Side effect with during is very little, and without drug residue, the food safety to ensureing animal is very helpful, while the traditional Chinese medical science
The clinical practice of thousand of years also demonstrates that Chinese medicine has the unique advantage of prevention of diseae, preventing exacerbation after being taken ill, in practice with good
Market application foreground.
The content of the invention
The present invention is intended to provide a kind of anti-sense Toxin-Vanquishing oral liquid and preparation method, in order to make up existing vaccine and medicine
The deficiency of cold, fever prevention effect of the product to causing after poultry infection, solves clinical problem.
For achieving the above object, the technical scheme that the present invention takes is as follows：
Anti- sense Toxin-Vanquishing oral liquid（A kind of Chinese medicine oral liquid of preventing and treating fowl cough heating）, per 1000ml oral liquids by following weight
Each medical material of proportioning is made：300 ~ 350g of Radix Scutellariae, 250 ~ 300g of Fructus Gardeniae, 200 ~ 250g of Radix Isatidis, 200 ~ 250g of Fructus Forsythiae, bracken are passed through
200 ~ 250g of crowd, 200 ~ 250g of Flos Chrysanthemi Indici, 200 ~ 250g of Radix Bupleuri, 200 ~ 250g of Herba Houttuyniae.
Preferably, the weight ratio of each medical material is Radix Scutellariae: Fructus Gardeniae: Radix Isatidis: Fructus Forsythiae: Rhizoma Dryopteris Crassirhizomatiss: Flos Chrysanthemi Indici: Radix Bupleuri: fish
Raw meat grass is=1.5: 1.3: 1: 1: 1: 1: 1: 1.
Preparation method, comprises the steps：
（1）Each medical material is weighed by the weight proportion, is crushed, sieved（It is preferred that 20 ~ 40 mesh）；
（2）Water intaking（It is preferred that 6 ~ 10 times of each medical material gross weight）80 ~ 85 DEG C are heated to, step is added（1）In sieve after medical material,
Constant temperature soaks 10 ~ 30 minutes；
（3）By step（2）Gained medicinal liquid is cooled to 45 ~ 50 DEG C, adjusts pH to 4.5 ~ 5.0, and addition total enzyme activity is 40000-
The compound enzyme of 90000U, stirs, and digests 1 ~ 3h, and then heating to 75 ~ 80 DEG C carries out enzyme-deactivating process；The compound enzyme is
Two or more compounding in cellulase, hemicellulase, pectase, amylase, Viscozyme L compound enzymes；
（4）By step（3）Medicinal liquid is decocted for several times after enzymolysis, is merged and is decocted filtrate, and centrifugal treating obtains supernatant；
（5）By step（4）Gained supernatant carries out microfiltration, ultrafiltration；
（6）By step（5）Filtrate reduced in volume is 1.08 ~ 1.10 to 60 DEG C of relative densities after ultrafiltration；
（7）By step（6）Medicinal liquid adds water and is settled to 1000mL after concentrating under reduced pressure, and then fill, the anti-sense Toxin-Vanquishing of sterilizing, thus obtaining the product are oral
Liquid.
Preferably, step（3）In, adjust pH value for 35 ~ 45% citric acid water with mass fraction.
Preferably, step（4）In, during centrifugation, centrifugal rotational speed is 4000 ~ 6000r/min, centrifugation time is 10 ~ 20min.
Preferably, step（5）In, adopting aperture for 0.45 micron of microporous filter membrane carries out microfiltration.
Preferably, adopt molecular cut off carries out ultrafiltration for the polypropylene hollow fiber post of 60000 dalton.
Using method：According to the ratio of anti-200 kilograms of the sense Toxin-Vanquishing oral liquid drinking-water of every 250ml, drink is mixed, be used in conjunction 3 ~ 5 days.
Beneficial effects of the present invention：Oral liquid of the present invention by the research application of nearly 3 years, in prevention and control fowl cough heating side
Face determined curative effect, can carry out effective prevention and control to the state of an illness, reduce economic loss and cost is relatively low, be adapted to be pushed away in poultry farming
Extensively, the deficiency of vaccine and other drugs is made up, the clinical puzzlement of culturist is solved.
Specific embodiment
Technical scheme is described in further detail below in conjunction with specific embodiment, but the protection model of the present invention
Enclose and be not limited thereto.
Embodiment 1
By taking the anti-sense Toxin-Vanquishing oral liquids of 1000mL as an example, its preparation method is as follows：
（1）Weigh each medical material：Radix Scutellariae 330g, Fructus Gardeniae 280g, Radix Isatidis 220g, Fructus Forsythiae 220g, Rhizoma Dryopteris Crassirhizomatiss 220g, Flos Chrysanthemi Indici
220g, Radix Bupleuri 220g, Herba Houttuyniae 220g, above medical material is mixed, and is crushed together, crosses 20 mesh sieves；
（2）The purified water of 6 times of material gross weight of getting it filled is heated to 80 DEG C, adds step（1）In sieve after medical material, constant temperature immersion 10
Minute；
（3）By step（2）Gained medicinal liquid is cooled to 45 DEG C, and with the citric acid water that mass fraction is 40% pH to 4.5 is adjusted, and adds
Compound enzyme（Cellulase 1g, enzyme activity is 20000U/g；Pectase 0.5g, enzyme activity is 50000U/g）, stir, 1h is digested,
Then heating to 75 DEG C carries out enzyme-deactivating process；
（4）By step（3）Medicinal liquid is decocted twice by decocting for Chinese herbal medicine mode of the prior art after enzymolysis, and 1h is decocted for the first time, the
It is secondary to add the decocting of 6 times of medicinal residues weight to boil 0.5h, filtrate merging will be twice decocted, 5000r/min centrifugation 15min obtain supernatant
Liquid；
（5）By step（4）Gained supernatant crosses microporous filter membrane and carries out microfiltration, and filter sizes are 0.45 micron；Then polypropylene is used
Hollow fiber column carries out ultrafiltration and removes big molecular impurity, and polypropylene hollow fiber post molecular cut off is 60000 dalton；
（6）By step（5）Filtrate reduced in volume to relative density is 1.08 after ultrafiltration（60℃）；
（7）By step（6）Medicinal liquid adds distilled water to be settled to 1000mL after concentrating under reduced pressure, then fill, the anti-sense Toxin-Vanquishing of sterilizing, thus obtaining the product
Oral liquid finished product.
Embodiment 2
By taking the anti-sense Toxin-Vanquishing oral liquids of 1000mL as an example, its preparation method is as follows：
（1）Weigh each medical material：Radix Scutellariae 300g, Fructus Gardeniae 260g, Radix Isatidis 200g, Fructus Forsythiae 200g, Rhizoma Dryopteris Crassirhizomatiss 200g, Flos Chrysanthemi Indici
200g, Radix Bupleuri 200g, Herba Houttuyniae 200g, above medical material is mixed, and is crushed together, crosses 30 mesh sieves；
（2）The purified water of 10 times of material gross weight of getting it filled is heated to 85 DEG C, adds step（1）In sieve after medical material, constant temperature immersion
30 minutes；
（3）By step（2）Gained medicinal liquid is cooled to 50 DEG C, and with the citric acid water that mass fraction is 40% pH to 5.0 is adjusted, and adds
Compound enzyme（Cellulase 1g, enzyme activity is 20000U/g；Pectase 0.5g, enzyme activity is 50000U/g；Viscozyme L compound enzymes
0.5g, enzyme activity is 60000U/g）, stir, 1h is digested, then heating to 80 DEG C carries out enzyme-deactivating process；
（4）By step（3）Medicinal liquid is decocted twice by decocting for Chinese herbal medicine mode of the prior art after enzymolysis, and 1h is decocted for the first time, the
It is secondary to add the decocting of 8 times of medicinal residues weight to boil 1h, filtrate merging will be twice decocted, 5000r/min centrifugation 15min obtain supernatant；
（5）By step（4）Gained supernatant crosses microporous filter membrane and carries out microfiltration, and filter sizes are 0.45 micron；Then polypropylene is used
Hollow fiber column carries out ultrafiltration and removes big molecular impurity, and polypropylene hollow fiber post molecular cut off is 60000 dalton；
（6）By step（5）Filtrate reduced in volume to relative density is 1.10 (60 DEG C) after ultrafiltration；
（7）By step（6）Medicinal liquid adds distilled water to be settled to 1000mL after concentrating under reduced pressure, then fill, the anti-sense Toxin-Vanquishing of sterilizing, thus obtaining the product
Oral liquid finished product.
Zoopery
Dalian Wafangdian City white meat-type chickens autotrophy field, raises AA white meat-type chickens 40000（2, each 20000）, 28 ages in days,
2 almost simultaneously there is feed intake decline, drinking-water reduction, in disorder spiritual depressed, feather, informer's elongation, eyelid cyanosis, chicken in jumpbogroup
It is preced with or cyanosis rubescent with wattle.The visible poultry trachea of clinical cut open inspection and larynx is rubescent, congested lungs or bleeding, hydropericardium, liver
The nephremia, intestinal serosal surface blood vessel anger are opened, intestinal mucosa face is congested or bleeding.To prevent and the mixed sense symptom of influenza, by chicken
It is divided into two groups and takes corresponding quarantine measures.Matched group not medication；Treatment group is oral according to the anti-sense Toxin-Vanquishing of every 250ml embodiments 2
Liquid 200 kilograms of drinking-water dosed administration 5 days, free choice feeding and drinking-water.
As a result find：
1st, the 4th day feed intake that is near the mark substantially for the treatment of group, matched group is still not up to standard feed intake on the 7th day, with matched group phase
Than treatment group's feed intake recovers fast；
2nd, to medication the 3rd day, the listless chicken for the treatment of group（Swelling around the eyes, slow-witted vertical, first hair）Total 729 with hat whisker cyanosis chicken, matched group is
1150, the listless chicken for the treatment of group reduces by 36% or so with hat whisker cyanosis chicken compared with matched group, achieves the therapeutic effect of relative ideal.
Claims (7)
1. it is anti-to feel Toxin-Vanquishing oral liquid, it is characterised in that to be made up of each medical material of following weight proportioning per 1000ml oral liquids：Radix Scutellariae
300 ~ 350g, 250 ~ 300g of Fructus Gardeniae, 200 ~ 250g of Radix Isatidis, 200 ~ 250g of Fructus Forsythiae, 200 ~ 250g of Rhizoma Dryopteris Crassirhizomatiss, Flos Chrysanthemi Indici 200 ~
250g, 200 ~ 250g of Radix Bupleuri, 200 ~ 250g of Herba Houttuyniae.
2. it is anti-as claimed in claim 1 to feel Toxin-Vanquishing oral liquid, it is characterised in that the weight ratio of each medical material is Radix Scutellariae: Fructus Gardeniae: plate
Lan Gen: Fructus Forsythiae: Rhizoma Dryopteris Crassirhizomatiss: Flos Chrysanthemi Indici: Radix Bupleuri: Herba Houttuyniae is=1.5: 1.3: 1: 1: 1: 1: 1: 1.
3. it is a kind of to prepare the anti-method for feeling Toxin-Vanquishing oral liquid as claimed in claim 1 or 2, it is characterised in that to comprise the steps：
（1）Each medical material is weighed by the weight proportion, is crushed, sieved；
（2）Water intaking is heated to 80 ~ 85 DEG C, adds step（1）In sieve after medical material, constant temperature soak 10 ~ 30 minutes；
（3）By step（2）Gained medicinal liquid is cooled to 45 ~ 50 DEG C, adjusts pH to 4.5 ~ 5.0, and addition compound enzyme is to total enzyme activity
40000-90000U, stirs, and digests 1 ~ 3h, and then heating to 75 ~ 80 DEG C carries out enzyme-deactivating process；The compound enzyme is fibre
Two or more compounding in the plain enzyme of dimension, hemicellulase, pectase, amylase, Viscozyme L compound enzymes；
（4）By step（3）Medicinal liquid is decocted for several times after enzymolysis, is merged and is decocted filtrate, and centrifugal treating obtains supernatant；
（5）By step（4）Gained supernatant carries out microfiltration, ultrafiltration；
（6）By step（5）Filtrate reduced in volume is 1.08 ~ 1.10 to 60 DEG C of relative densities after ultrafiltration；
（7）By step（6）Medicinal liquid adds water and is settled to 1000mL after concentrating under reduced pressure, and then fill, the anti-sense Toxin-Vanquishing of sterilizing, thus obtaining the product are oral
Liquid.
4. preparation method as claimed in claim 3, it is characterised in that：Step（3）In, with the Fructus Citri Limoniae that mass fraction is 35 ~ 45%
Sour water adjusts pH value.
5. preparation method as claimed in claim 3, it is characterised in that：Step（4）In, during centrifugation, centrifugal rotational speed be 4000 ~
6000r/min, centrifugation time are 10 ~ 20min.
6. preparation method as claimed in claim 3, it is characterised in that：Step（5）In, aperture is adopted for 0.45 micron of micropore
Filter membrane carries out microfiltration.
7. preparation method as claimed in claim 3, it is characterised in that：Molecular cut off is adopted for poly- the third of 60000 dalton
Alkene hollow fiber column carries out ultrafiltration.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050265A (en) * | 2017-06-06 | 2017-08-18 | 河南牧翔动物药业有限公司 | A kind of preparation method of Sang Ren oral liquid for clearing away lung-heat for animals |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919914A (en) * | 2014-04-15 | 2014-07-16 | 河南牧翔动物药业有限公司 | Method for preparing veterinary heat-clearing and detoxifying oral liquid |
| CN104491124A (en) * | 2014-12-11 | 2015-04-08 | 河南牧翔动物药业有限公司 | Veterinary compound herba houttuyniae oral liquid and preparation method thereof |
-
2016
- 2016-12-02 CN CN201611096363.5A patent/CN106619967B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919914A (en) * | 2014-04-15 | 2014-07-16 | 河南牧翔动物药业有限公司 | Method for preparing veterinary heat-clearing and detoxifying oral liquid |
| CN104491124A (en) * | 2014-12-11 | 2015-04-08 | 河南牧翔动物药业有限公司 | Veterinary compound herba houttuyniae oral liquid and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050265A (en) * | 2017-06-06 | 2017-08-18 | 河南牧翔动物药业有限公司 | A kind of preparation method of Sang Ren oral liquid for clearing away lung-heat for animals |
| CN107050265B (en) * | 2017-06-06 | 2020-06-19 | 河南牧翔动物药业有限公司 | Preparation method of mulberry kernel lung-clearing oral liquid for livestock |
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