CN106619725B - Preparation method of ox gall powder - Google Patents
Preparation method of ox gall powder Download PDFInfo
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- CN106619725B CN106619725B CN201611223038.0A CN201611223038A CN106619725B CN 106619725 B CN106619725 B CN 106619725B CN 201611223038 A CN201611223038 A CN 201611223038A CN 106619725 B CN106619725 B CN 106619725B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a preparation method of ox gall powder, which comprises the following steps: taking 100 parts by weight of the fel bovis seu Bubali extract, adding 50-100 parts by weight of methanol and 800 parts by weight of purified water, stirring uniformly, and heating and refluxing for 1-2 h; adding 20-50 parts by weight of sodium hydroxide, and heating and refluxing for 1-2 h; adding 20-50 parts by weight of activated carbon, and heating and refluxing for 1-2 h; stirring and cooling to normal temperature, and filtering with microporous filter membrane with pore diameter of 1.2 μm; drying in a microwave drying oven, pulverizing the dried product, and packaging. The invention has the beneficial effects that: the produced cow bile powder has less impurities, the cholic acid content is up to 45-53%, and the yield is up to 65-70%.
Description
Technical Field
The invention belongs to the technical field of biological pharmacy, and particularly relates to a preparation method of cow gall powder.
Background
The fel bovis Seu Bubali powder is dried fel bovis Seu Bubali of Bovidae, and has effects of removing liver fire, improving eyesight, promoting bile flow, relaxing bowels, removing toxic substance, and relieving swelling. The preparation method of fel bovis Seu Bubali powder in conventional production process comprises filtering fel bovis Seu Bubali, and drying. However, the method has low bile utilization rate, and the prepared cow bile powder has the problems of more impurities, low cholic acid content, low yield and the like.
Disclosure of Invention
The invention aims to overcome the defects and provide the preparation method of the cow bile powder with less impurities, high cholic acid content and high yield.
In order to achieve the purpose, the invention is implemented according to the following technical scheme:
a preparation method of ox gall powder comprises the following steps:
s1, taking 100 parts by weight of the fel bovis seu Bubali extract, adding 50-100 parts by weight of methanol and 800 parts by weight of purified water, stirring uniformly, and heating and refluxing for 1-2 h;
s2, adding 20-50 parts by weight of sodium hydroxide, and heating and refluxing for 1-2 h;
s3, adding 20-50 parts by weight of activated carbon, and heating and refluxing for 1-2 h;
s4, stirring and cooling to normal temperature, and filtering by adopting a microporous filter membrane, wherein the aperture of the filter membrane is 1.2 mu m;
s5, placing the mixture into a microwave drying box, and drying the mixture for 260min at 120 ℃ to obtain a dried substance;
s6, crushing the obtained dried substance and packaging.
Compared with the prior art, the invention has the beneficial effects that:
the produced cow bile powder has less impurities, the cholic acid content is up to 45-53%, and the yield is up to 65-70%.
Detailed Description
The present invention will be further described with reference to specific examples, which are illustrative of the invention and are not to be construed as limiting the invention.
Example 1
A preparation method of ox gall powder comprises the following steps: taking 100 parts by weight of fel bovis seu Bubali extract, adding 100 parts by weight of methanol and 600 parts by weight of purified water, stirring, and heating and refluxing for 2 h; adding 20 parts by weight of sodium hydroxide, and heating and refluxing for 2 hours; adding 50 parts by weight of activated carbon, and heating and refluxing for 2 hours; stirring and cooling to normal temperature, and filtering with microporous filter membrane with pore diameter of 1.2 μm; drying in a microwave drying oven at 120 deg.C for 260min to obtain dried substance; pulverizing the above dried product, and packaging.
Example 2
A preparation method of ox gall powder comprises the following steps: taking 100 parts by weight of fel bovis seu Bubali extract, adding 50 parts by weight of methanol and 800 parts by weight of purified water, stirring, and heating and refluxing for 1 h; adding 50 parts by weight of sodium hydroxide, and heating and refluxing for 1 h; adding 20 parts by weight of activated carbon, and heating and refluxing for 1 h; stirring and cooling to normal temperature, and filtering with microporous filter membrane with pore diameter of 1.2 μm; drying in a microwave drying oven at 120 deg.C for 260min to obtain dried substance; pulverizing the above dried product, and packaging.
Example 3
A preparation method of ox gall powder comprises the following steps: taking 100 parts by weight of the fel bovis seu Bubali extract, adding 80 parts by weight of methanol and 700 parts by weight of purified water, stirring uniformly, and heating and refluxing for 1.5 h; adding 40 parts by weight of sodium hydroxide, and heating and refluxing for 1.5 h; adding 40 parts by weight of activated carbon, and heating and refluxing for 1.5 hours; stirring and cooling to normal temperature, and filtering with microporous filter membrane with pore diameter of 1.2 μm; drying in a microwave drying oven at 120 deg.C for 250min to obtain dried product; pulverizing the above dried product, and packaging.
The technical solution of the present invention is not limited to the limitations of the above specific embodiments, and all technical modifications made according to the technical solution of the present invention fall within the protection scope of the present invention.
Claims (1)
1. The preparation method of the ox gall powder is characterized by comprising the following steps:
s1, taking 100 parts by weight of the fel bovis seu Bubali extract, adding 50-100 parts by weight of methanol and 800 parts by weight of purified water, stirring uniformly, and heating and refluxing for 1-2 h;
s2, adding 20-50 parts by weight of sodium hydroxide, and heating and refluxing for 1-2 h;
s3, adding 20-50 parts by weight of activated carbon, and heating and refluxing for 1-2 h;
s4, stirring and cooling to normal temperature, and filtering by adopting a microporous filter membrane, wherein the aperture of the filter membrane is 1.2 mu m;
s5, placing the mixture into a microwave drying box, and drying the mixture for 260min at 120 ℃ to obtain a dried substance;
s6, crushing the obtained dried substance and packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611223038.0A CN106619725B (en) | 2016-12-27 | 2016-12-27 | Preparation method of ox gall powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611223038.0A CN106619725B (en) | 2016-12-27 | 2016-12-27 | Preparation method of ox gall powder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106619725A CN106619725A (en) | 2017-05-10 |
| CN106619725B true CN106619725B (en) | 2020-09-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611223038.0A Active CN106619725B (en) | 2016-12-27 | 2016-12-27 | Preparation method of ox gall powder |
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| Country | Link |
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| CN (1) | CN106619725B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357334A (en) * | 2001-04-01 | 2002-07-10 | 浙江青荷生化股份有限公司 | Artificial bear bile powder |
| CN102224935A (en) * | 2011-05-16 | 2011-10-26 | 常德云港生物科技有限公司 | Duck gall powder and preparation method thereof |
-
2016
- 2016-12-27 CN CN201611223038.0A patent/CN106619725B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357334A (en) * | 2001-04-01 | 2002-07-10 | 浙江青荷生化股份有限公司 | Artificial bear bile powder |
| CN102224935A (en) * | 2011-05-16 | 2011-10-26 | 常德云港生物科技有限公司 | Duck gall powder and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN106619725A (en) | 2017-05-10 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of cattle bile powder Effective date of registration: 20221109 Granted publication date: 20200915 Pledgee: Wenxian Rural Credit Cooperative Association Renmin Road Credit Cooperative Pledgor: Henan Liwei Biological Pharmaceutical Co.,Ltd. Registration number: Y2022980021218 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |