CN106619725A - Preparation method of ox gallbladder powder - Google Patents
Preparation method of ox gallbladder powder Download PDFInfo
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- CN106619725A CN106619725A CN201611223038.0A CN201611223038A CN106619725A CN 106619725 A CN106619725 A CN 106619725A CN 201611223038 A CN201611223038 A CN 201611223038A CN 106619725 A CN106619725 A CN 106619725A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
The invention discloses a preparation method of ox gallbladder powder. The preparation method comprises the following steps: taking 100 parts by weight of ox gallbladder extract and adding 50 to 100 parts by weight of methanol and 500 to 800 parts by weight of purified water; uniformly stirring, and heating and reflowing for 1h to 2h; adding 20 to 50 parts by weight of sodium hydroxide and heating and reflowing for 1h to 2h; adding 20 to 50 parts by weight of active carbon and heating and reflowing for 1h to 2h; stirring and cooling to room temperature; filtering by adopting a micro-porous filtering membrane, wherein the pore diameter of the filtering membrane is 1.2mu.m; putting a product into a microwave drying box and drying; after crushing an obtained dried matter, packaging. The preparation method of the ox gallbladder powder has the beneficial effects that the ox gallbladder powder produced by the preparation method contains less impurity, the content of cholic acid reaches 45 percent to 53 percent and the yield reaches 65 percent to 70 percent.
Description
Technical field
The invention belongs to biological pharmacy technical field, more particularly to a kind of preparation method of bilein.
Background technology
Bilein is the dry product of bovid fel bovis, is clear liver and improved vision, cholagogic defaecation, the function of removing toxicity for detumescence.Pass
The preparation of bilein in the production technology of system is by fel bovis filtration, is drying to obtain.But this kind of method bile utilization rate be not high,
And obtained bilein has that impurity is more, cholic acid content is low, yield is low.
The content of the invention
The purpose of the present invention is that and overcomes above-mentioned deficiency, there is provided a kind of impurity is less, cholic acid content high, yield is higher
The preparation method of bilein.
To reach above-mentioned purpose, the present invention is implemented according to technical scheme below：
A kind of preparation method of bilein, comprises the following steps：
S1. take the ox courage cream that parts by weight are 100 parts, add parts by weight for the methyl alcohol of 50-100 parts, 500-800 parts it is pure
Change water, stir, be heated to reflux 1-2h；
S2. add parts by weight for the NaOH of 20-50 parts, be heated to reflux 1-2h；
S3. add parts by weight for the activated carbon of 20-50 parts, be heated to reflux 1-2h；
S4. stirring is cooled to normal temperature, and using filtering with microporous membrane, the aperture of filter membrane is 1.2 μm；
S5. it is put in microwave drying oven, 120 DEG C are dried 200-260min, obtain dried object；
S6. above-mentioned gained dried object is packed after crushed.
Compared with prior art, beneficial effects of the present invention are：
The bilein impurity that the present invention is produced is less, and cholic acid content is up to 45-53%, and high income reaches 65-70%.
Specific embodiment
With reference to specific embodiment, the invention will be further described, illustrative examples and explanation that here is invented
It is for explaining the present invention but not as a limitation of the invention.
Embodiment 1
A kind of preparation method of bilein, comprises the following steps：The ox courage cream that parts by weight are 100 parts is taken, parts by weight are added
For 100 parts of methyl alcohol, 600 parts of purified water, stir, be heated to reflux 2h；The NaOH that parts by weight are 20 parts is added,
It is heated to reflux 2h；The activated carbon for adding parts by weight to be 50 parts, is heated to reflux 2h；Stirring is cooled to normal temperature, using miillpore filter
Filter, the aperture of filter membrane is 1.2 μm；It is put in microwave drying oven, 120 DEG C are dried 260min, obtain dried object；Above-mentioned gained is done
Dry thing is packed after crushed.
Embodiment 2
A kind of preparation method of bilein, comprises the following steps：The ox courage cream that parts by weight are 100 parts is taken, parts by weight are added
For 50 parts of methyl alcohol, 800 parts of purified water, stir, be heated to reflux 1h；The NaOH that parts by weight are 50 parts is added,
It is heated to reflux 1h；The activated carbon for adding parts by weight to be 20 parts, is heated to reflux 1h；Stirring is cooled to normal temperature, using miillpore filter
Filter, the aperture of filter membrane is 1.2 μm；It is put in microwave drying oven, 120 DEG C are dried 260min, obtain dried object；Above-mentioned gained is done
Dry thing is packed after crushed.
Embodiment 3
A kind of preparation method of bilein, comprises the following steps：The ox courage cream that parts by weight are 100 parts is taken, parts by weight are added
For 80 parts of methyl alcohol, 700 parts of purified water, stir, be heated to reflux 1.5h；Add the hydroxide that parts by weight are 40 parts
Sodium, is heated to reflux 1.5h；The activated carbon for adding parts by weight to be 40 parts, is heated to reflux 1.5h；Stirring is cooled to normal temperature, using micro-
Hole membrane filtration, the aperture of filter membrane is 1.2 μm；It is put in microwave drying oven, 120 DEG C are dried 250min, obtain dried object；Will be above-mentioned
Gained dried object is packed after crushed.
Technical scheme is not limited to the restriction of above-mentioned specific embodiment, and every technology according to the present invention scheme is done
The technology deformation for going out, each falls within protection scope of the present invention.
Claims (1)
1. a kind of preparation method of bilein, it is characterised in that comprise the following steps：
S1. take the ox courage cream that parts by weight are 100 parts, add parts by weight for the methyl alcohol of 50-100 parts, 500-800 parts it is pure
Change water, stir, be heated to reflux 1-2h；
S2. add parts by weight for the NaOH of 20-50 parts, be heated to reflux 1-2h；
S3. add parts by weight for the activated carbon of 20-50 parts, be heated to reflux 1-2h；
S4. stirring is cooled to normal temperature, and using filtering with microporous membrane, the aperture of filter membrane is 1.2 μm；
S5. it is put in microwave drying oven, 120 DEG C are dried 200-260min, obtain dried object；
S6. above-mentioned gained dried object is packed after crushed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611223038.0A CN106619725B (en) | 2016-12-27 | 2016-12-27 | Preparation method of ox gall powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611223038.0A CN106619725B (en) | 2016-12-27 | 2016-12-27 | Preparation method of ox gall powder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106619725A true CN106619725A (en) | 2017-05-10 |
| CN106619725B CN106619725B (en) | 2020-09-15 |
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ID=58831319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611223038.0A Active CN106619725B (en) | 2016-12-27 | 2016-12-27 | Preparation method of ox gall powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106619725B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357334A (en) * | 2001-04-01 | 2002-07-10 | 浙江青荷生化股份有限公司 | Artificial bear bile powder |
| CN102224935A (en) * | 2011-05-16 | 2011-10-26 | 常德云港生物科技有限公司 | Duck gall powder and preparation method thereof |
-
2016
- 2016-12-27 CN CN201611223038.0A patent/CN106619725B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357334A (en) * | 2001-04-01 | 2002-07-10 | 浙江青荷生化股份有限公司 | Artificial bear bile powder |
| CN102224935A (en) * | 2011-05-16 | 2011-10-26 | 常德云港生物科技有限公司 | Duck gall powder and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 于维萍 李守俊主编: "《常用中药词语词典》", 31 July 1998, 山东科学技术出版社 * |
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| CN106619725B (en) | 2020-09-15 |
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Denomination of invention: A preparation method of cattle bile powder Effective date of registration: 20221109 Granted publication date: 20200915 Pledgee: Wenxian Rural Credit Cooperative Association Renmin Road Credit Cooperative Pledgor: Henan Liwei Biological Pharmaceutical Co.,Ltd. Registration number: Y2022980021218 |