CN106619562A - 一种肠溶性胶囊材料 - Google Patents

一种肠溶性胶囊材料 Download PDF

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Publication number
CN106619562A
CN106619562A CN201611073642.XA CN201611073642A CN106619562A CN 106619562 A CN106619562 A CN 106619562A CN 201611073642 A CN201611073642 A CN 201611073642A CN 106619562 A CN106619562 A CN 106619562A
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Prior art keywords
parts
intestinal
gelatin
capsule material
following components
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Pending
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CN201611073642.XA
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Inventor
张顺伟
唐进六
陈伟
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XUHUA PHARMACEUTICAL CO Ltd SICHUAN
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XUHUA PHARMACEUTICAL CO Ltd SICHUAN
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Priority to CN201611073642.XA priority Critical patent/CN106619562A/zh
Publication of CN106619562A publication Critical patent/CN106619562A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)

Abstract

本发明公开了一种肠溶性胶囊材料，其包括以下组分：明胶，聚醋酸乙烯酯，羟丙基纤维素，甘油，水，聚氧乙烯，果胶。本发明的材料性能温和，明胶使用量相对较低，肠道吸收好，可有效降低对患者肠道的损伤。

Description

一种肠溶性胶囊材料
技术领域
本发明涉及药用材料的技术领域，特别涉及药用胶囊材料的技术领域。
背景技术
部分药物需要以粉末、微小颗粒等形式被患者服用，为解决其服用难度，药用胶囊由此产生。药用胶囊可将粉末或颗粒状药物封存于内，以整体的形式被患者吞服，其后在肠道内被消化吸收，虽然这种吸收形式避免了药物对患者胃部的刺激与损伤，但同时增加了患者肠道的负荷和对患者肠道的刺激。
发明内容
本发明的目的在于提出一种可有效降低对患者肠道的刺激的肠溶性药用胶囊材料。
本发明的技术方案如下：
一种肠溶性胶囊材料，包括以下组分：明胶，聚醋酸乙烯酯，羟丙基纤维素，甘油，水，聚氧乙烯，果胶。
优选的是：按质量份计，包括以下组分：按质量份计，包括以下组分：明胶10～25份，聚醋酸乙烯酯1.5～5份，羟丙基纤维素2～2.5份，甘油7～10份，水7～20份，聚氧乙烯1.5～2.5份，果胶5～10份。
另外优选的是：所述聚氧乙烯的分子量为3000～8000。
本发明的材料性能温和，明胶使用量相对较低，肠道吸收好，可有效降低对患者肠道的损伤。
具体实施方式
实施例1
一种肠溶性胶囊材料，按质量份计，包括以下组分：明胶10份，聚醋酸乙烯酯1.5份，羟丙基纤维素2份，甘油7份，水7份，聚氧乙烯1.5份，果胶5份，其中聚氧乙烯分子量为3000。
实施例2
一种肠溶性胶囊材料，按质量份计，包括以下组分：明胶25份，聚醋酸乙烯酯5份，羟丙基纤维素2.5份，甘油10份，水20份，聚氧乙烯2.5份，果胶10份，其中聚氧乙烯分子量为8000。

Claims (3)

1.一种肠溶性胶囊材料，其特征在于：包括以下组分：明胶，聚醋酸乙烯酯，羟丙基纤维素，甘油，水，聚氧乙烯，果胶。
2.根据权利要求1所述的肠溶性胶囊材料，其特征在于：按质量份计，包括以下组分：明胶10～25份，聚醋酸乙烯酯1.5～5份，羟丙基纤维素2～2.5份，甘油7～10份，水7～20份，聚氧乙烯1.5～2.5份，果胶5～10份。
3.根据权利要求2所述的肠溶性胶囊材料，其特征在于：所述聚氧乙烯的分子量为3000～8000。
CN201611073642.XA 2016-11-29 2016-11-29 一种肠溶性胶囊材料 Pending CN106619562A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201611073642.XA CN106619562A (zh) 2016-11-29 2016-11-29 一种肠溶性胶囊材料

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201611073642.XA CN106619562A (zh) 2016-11-29 2016-11-29 一种肠溶性胶囊材料

Publications (1)

Publication Number Publication Date
CN106619562A true CN106619562A (zh) 2017-05-10

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101461792A (zh) * 2008-12-30 2009-06-24 吴国庆 明胶肠溶胶囊壳材料
CN101708172A (zh) * 2009-12-17 2010-05-19 安徽黄山胶囊有限公司 一种肠溶空心胶囊
CN102119026A (zh) * 2008-06-13 2011-07-06 葛兰素集团有限公司 羟丙基纤维素胶囊壳
CN103919752A (zh) * 2014-05-07 2014-07-16 娄志 一种植物肠溶性胶囊壳
CN103977412A (zh) * 2014-04-23 2014-08-13 湖南尔康正阳药用胶囊有限公司 一种肠溶性胶囊材料组合物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102119026A (zh) * 2008-06-13 2011-07-06 葛兰素集团有限公司 羟丙基纤维素胶囊壳
CN101461792A (zh) * 2008-12-30 2009-06-24 吴国庆 明胶肠溶胶囊壳材料
CN101708172A (zh) * 2009-12-17 2010-05-19 安徽黄山胶囊有限公司 一种肠溶空心胶囊
CN103977412A (zh) * 2014-04-23 2014-08-13 湖南尔康正阳药用胶囊有限公司 一种肠溶性胶囊材料组合物
CN103919752A (zh) * 2014-05-07 2014-07-16 娄志 一种植物肠溶性胶囊壳

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
周建平等: "《药剂学》", 31 March 2007, 东南大学出版社 *
赵淑富等: ""肠溶胶囊"", 《明胶科学与技术》 *

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