CN106619289B - Acne-removing anti-sensitivity moisturizing composition containing frangipani alcohol extract and preparation method thereof - Google Patents
Acne-removing anti-sensitivity moisturizing composition containing frangipani alcohol extract and preparation method thereof Download PDFInfo
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 50
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 35
- 206010000496 acne Diseases 0.000 title claims abstract description 35
- 239000000203 mixture Substances 0.000 title claims abstract description 33
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- 235000013087 Plumeria rubra Nutrition 0.000 title claims abstract description 27
- 239000000284 extract Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 238000000605 extraction Methods 0.000 title claims abstract description 6
- 244000071969 Plumeria obtusa Species 0.000 title 1
- 244000215777 Plumeria rubra Species 0.000 claims abstract description 26
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- 235000011274 Benincasa cerifera Nutrition 0.000 claims abstract description 11
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- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims abstract description 11
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 10
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
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- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
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- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 1
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- NULAJYZBOLVQPQ-UHFFFAOYSA-N N-(1-naphthyl)ethylenediamine Chemical compound C1=CC=C2C(NCCN)=CC=CC2=C1 NULAJYZBOLVQPQ-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 241000511979 Plumeria Species 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
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- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
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- 229960001285 quercetin Drugs 0.000 description 1
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- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an acne-removing anti-sensitivity moisturizing composition comprising an alcohol extract of frangipani and a preparation method thereof, wherein the composition is prepared by alcohol extraction of the following raw materials in percentage by weight: 5-45% of frangipani, 10-25% of motherwort, 20-25% of white mulberry root-bark, 20-25% of white gourd seed and 5-20% of liquorice. The composition disclosed by the invention has the functions of removing acnes and moisturizing, can effectively solve the problems of inflammation and the like caused by whelks, itchy skin, unhealthy facial skin and the like, and can be matched with different carriers to prepare products such as masks, face creams and the like with the functions.
Description
Technical Field
The invention relates to the technical field of skin care product production, in particular to a formula of a natural plant extract for removing acne, resisting sensitivity and moisturizing and a preparation method thereof.
Background
Whelk, also known as acne in traditional Chinese medicine. The traditional Chinese medicine considers that the acne disease is facial skin, closely related to lung channel and spleen channel, the disease property is mainly excess, and the main pathogenic factors are heat, such as wind heat, lung heat, blood heat, damp heat, blood nodule, phlegm accumulation, lung and stomach heat and the like. Therefore, when the Chinese herbal medicine with the functions of clearing heat, drying dampness, resisting inflammation and relieving itching is used for treatment, the Chinese herbal medicine with the functions of nourishing yin and blood, clearing heat, moistening dryness, dispelling wind, relieving itching, cooling blood and promoting blood circulation is added to regulate the physiological environment of the face, so that the recurrence of the acne can be inhibited.
With the improvement of the living standard of substances, the pursuit of people for beauty is continuously improved, people hope to own healthy skin, particularly the natural acne-removing moisturizing facial mask without the trouble of whelk, and the natural acne-removing moisturizing facial mask with pure plant for removing acnes is expected to be born, care the health of facial skin, ensure the normal sebum secretion and have no trouble of whelk. For a long time, the face with refreshing and healthy is the target of young people, and illegal manufacturers can not radically improve sebum secretion and inhibit whelk by illegally adding products containing antibiotics into anti-whelk products. Other botanical formulations have limited application due to poor anti-acne properties. Therefore, the development of a pure plant formula product capable of maintaining facial health, controlling oil secretion and inhibiting whelk generation has significance and has a wide market.
Disclosure of Invention
The invention aims to provide an acne-removing, anti-allergy and moisturizing composition containing an alcohol extract of frangipani, which has an acne-removing and moisturizing function and can effectively solve the problems of inflammation and the like caused by whelk, skin itch, unhealthy facial skin and the like.
It is another object of the present invention to provide a method for preparing said composition.
The above object of the present invention is achieved by the following technical solutions:
the acne-removing anti-sensitive moisturizing composition containing the frangipani alcohol extract is prepared by alcohol extraction of the following raw materials in percentage by weight:
5-45% of frangipani;
10-25% of motherwort;
20-25% of cortex mori;
20-25% of white gourd kernels;
5-20% of liquorice.
The inventor finds that the compatibility of the five substances has special performance on resisting inflammation and allergy of skin. The alcohol extract of the white gourd kernel and the white mulberry root-bark has good moisturizing effect, and the combination of the frangipani, the motherwort herb and the liquorice has good anti-inflammation and acne-removing effects. The skin moisture is insufficient, which is a cause of inflammation, and the moisture retention effect of the white gourd seeds and the white mulberry root-bark can solve the problem of the balance of the moisture and the oil of the skin; especially for people with sensitive skin, the imbalance of skin moisture and oil is a factor causing acne, and on the basis, the anti-inflammatory effect brought by the frangipani, the motherwort and the liquorice can realize comprehensive care on the skin.
The acne-removing anti-sensitive moisturizing composition is prepared by alcohol extraction of the following raw materials in percentage by weight:
15-45% of frangipani;
10-25% of motherwort;
20-25% of cortex mori;
20-25% of white gourd kernels;
5-15% of liquorice.
The preparation method of the acne-removing anti-allergy moisturizing composition containing the frangipani alcohol extract comprises the following steps:
s1, crushing, mixing and sieving the raw materials;
s2, percolating the crushed raw materials by adopting alcohol, and concentrating percolate into a thick paste to obtain the composition.
Preferably, the sieving is through a 20 mesh sieve.
Preferably, the alcohol is ethanol.
More preferably, the alcohol is a 95% ethanol solution by mass fraction.
The acne-removing anti-allergy moisturizing composition containing the frangipani alcohol extract is applied to preparation of acne-removing anti-allergy moisturizing products.
Preferably, the acne-removing anti-sensitive moisturizing composition containing the frangipani alcohol extract is matched with a carrier to prepare a mask or a cream.
The acne-removing anti-allergy moisturizing mask comprises the acne-removing anti-allergy moisturizing composition comprising the frangipani alcohol extract, a plant preservative and citric acid.
Compared with the prior art, the invention has the following beneficial effects:
according to the invention, through reasonable compatibility of the plant alcohol extract, the effects of acne removal, anti-allergy, moisturizing and the like are realized in all directions from the aspects of moisturizing, anti-inflammation and the like, and the effect of better maintaining the health of skin is achieved; the composition prepared by the invention can be matched with a carrier to prepare various skin care products such as facial masks, face creams and the like.
Drawings
FIG. 1 shows the results of the anti-inflammatory activity test of the plumeria rubra composition.
Detailed Description
The present invention is further illustrated by the following examples, which are not intended to limit the invention in any way. All the technical solutions obtained by using the equivalent substitution or the equivalent transformation should be included in the protection scope of the claims of the present invention.
Example 1
S1, mixing 450 g of frangipani, 100 g of motherwort, 200 g of white mulberry root-bark, 200 g of white gourd seed and 50 g of liquorice, crushing, and sieving with a 20-mesh sieve;
s2, percolating 5000 ml of 95% ethanol, and recovering ethanol from percolate to obtain thick paste to obtain 1000 ml of composition A;
s3, adding a plant preservative into the composition A, and adding citric acid to adjust the pH value to 5.5 to obtain the acne-removing moisturizing mask.
Example 2
S1, mixing 150 g of frangipani, 250 g of motherwort, 200 g of white mulberry root-bark, 250 g of white gourd seed and 150 g of liquorice, crushing, and sieving with a 20-mesh sieve;
s2, percolating 5000 ml of 95% ethanol, and recovering ethanol from percolate to obtain thick paste to obtain 1000 ml of composition B;
s3, adding a plant preservative into the composition B, and adding citric acid to adjust the pH value to 5.5 to obtain the acne-removing moisturizing mask.
Example 3
S1, mixing 250 g of frangipani, 200 g of motherwort, 250 g of white mulberry root-bark, 200 g of white gourd seed and 100 g of liquorice, crushing, and sieving with a 20-mesh sieve;
s2, percolating 5000 ml of 95% ethanol, and recovering ethanol from percolate to obtain thick paste to obtain 1000 ml of composition C;
s3, adding a plant preservative into the composition C, and adding citric acid to adjust the pH value to 5.5 to obtain the acne-removing moisturizing mask.
Comparative example 1 No white gourd seed and white mulberry root bark were added
S1, mixing 150 g of frangipani, 250 g of motherwort and 150 g of liquorice, crushing, and sieving with a 20-mesh sieve;
s2, percolating 5000 ml of 95% ethanol, and recovering ethanol from percolate to obtain thick paste to obtain 1000 ml of composition D;
s3, adding a plant preservative into the composition E, and adding citric acid to adjust the pH value to 5.5 to obtain the acne-removing moisturizing mask.
Comparative example 2 No frangipani, motherwort and licorice were added
S1, mixing 200 g of white mulberry root-bark and 250 g of white gourd seeds, crushing, and sieving with a 20-mesh sieve;
s2, percolating 5000 ml of 95% ethanol, and recovering ethanol from percolate to obtain thick paste to obtain 1000 ml of composition E;
s3, adding a plant preservative into the composition E, and adding citric acid to adjust the pH value to 5.5 to obtain the acne-removing moisturizing mask.
Test of clinical experiments
And (3) inclusion standard: the age is 20-55 years old, male and female. 775 patients with different degrees of acne on face meeting the clinical dermatology standard were selected. 1 treatment course for 4 weeks, 1 time per week.
The curative effect standard is as follows: the skin lesion regression rate is used as a disease curative effect judgment standard, and the calculation formula is as follows according to the nimodipine method:
skin lesion regression rate = [ (pre-treatment integral-post-treatment integral)/pre-treatment integral ] × 100%
Effective rate = (cure + show effect + effective)/total number of cases × 100%
The evaluation is carried out after 1 treatment course respectively, and the specific steps are as follows:
① the recovery rate is more than or equal to 95%, ② has obvious effect that the skin loss regression rate is more than or equal to 70% in 95%, ③ has effective effect that the skin loss regression rate is more than or equal to 50% in 70%, and ④ has no effect that the skin loss regression rate is less than 50% or increase in adverse effect.
The results are shown in Table 1.
TABLE 1 Effect of the embodiment
Anti-inflammatory Activity assay
The anti-inflammatory activity of the mask is characterized by the inhibition rate, the higher the inhibition rate, the better the anti-inflammatory activity.
NO content was determined by griess reaction BV-2 cells were treated with 1ug/ml L PS, 60ug/ml plumeria extract and 60ug/ml plumeria combined extract (composition A of example 1) for 24h, 100ul of supernatant was reacted with 100ul of griess reagent (1% sulfanilamide, 0.1% n-1-naphthylethylenediamine hydrochloride dihydrochloride in 5% phosphoric acid) in the dark at room temperature for 10min, and the optical density was measured at 540nm using a microplate reader (Molecular Devices, USA) and sodium nitrite was used as a standard for calculating nitrite content.
The inhibition rate is the ratio of the added medicine group to the non-added medicine group, and 3ug/ml quercetin is a positive control. Calculated according to equation 1:
formula 1
Wherein,A l PS + sample Represents the optical density of NO after 24 hours of BV-2 cell treatment with L PS and sample;
A untreated Represents the optical density of NO of untreated BV-2 cells;
A LPS represents the optical density of NO after 24 hours treatment of BV-2 cells with L PS;
the detection process was repeated three times and the standard deviation was calculated.
According to the formula 1, it can be seen that,A l PS + sample The smaller the value, the larger the inhibition ratio.
The results of the determination of the NO content are shown in FIG. 1. As can be seen, the anti-inflammatory effect of the frangipani combined extract is better than that of the frangipani extract alone.
Claims (5)
1. The acne-removing anti-allergy moisturizing composition containing the frangipani alcohol extract is characterized by being prepared by alcohol extraction of the following raw materials in percentage by weight:
15-45% of frangipani;
10-25% of motherwort;
20-25% of cortex mori;
20-25% of white gourd kernels;
5-20% of liquorice;
the alcohol is an ethanol solution with the mass fraction of 95%.
2. The method for preparing the acne-removing anti-allergy moisturizing composition containing the frangipani alcohol extract in claim 1 is characterized by comprising the following steps:
s1, crushing, mixing and sieving the raw materials;
s2, percolating the crushed raw materials by adopting alcohol, and concentrating percolate into a thick paste to obtain the composition.
3. The use of the acne removing, anti-allergy and moisturizing composition comprising the alcohol extract of frangipani as claimed in claim 1 in the preparation of an acne removing, anti-allergy and moisturizing product.
4. The use according to claim 3, wherein the acne-removing, anti-allergic and moisturizing product is a mask or a cream.
5. A acne-removing anti-allergy moisturizing mask, which is characterized by comprising the acne-removing anti-allergy moisturizing composition comprising the frangipani alcohol extract, a plant preservative and citric acid according to claim 1.
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|---|---|---|---|---|
| CN101259172A (en) * | 2007-03-06 | 2008-09-10 | 上海家化联合股份有限公司 | Chinese medicinal composition for treating acne, preparation and application thereof |
| CN103720626A (en) * | 2014-01-28 | 2014-04-16 | 陈爱丽 | Fruit-vegetable facial mask and preparation method thereof |
| KR20160076126A (en) * | 2014-12-22 | 2016-06-30 | 주식회사 고운선형 | Acne cosmetic treatment that can be prescribed step by step |
| CN104840812A (en) * | 2015-05-13 | 2015-08-19 | 刘禾青 | External use of traditional Chinese medicine with beauty effect |
| CN105796413A (en) * | 2016-03-17 | 2016-07-27 | 陆娟 | Traditional Chinese medicine facial mask and preparing method thereof |
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| CN106619289A (en) | 2017-05-10 |
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