CN106589148A - 一种窄分布羟乙基淀粉的制备方法 - Google Patents
一种窄分布羟乙基淀粉的制备方法 Download PDFInfo
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- CN106589148A CN106589148A CN201611222970.1A CN201611222970A CN106589148A CN 106589148 A CN106589148 A CN 106589148A CN 201611222970 A CN201611222970 A CN 201611222970A CN 106589148 A CN106589148 A CN 106589148A
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- CN
- China
- Prior art keywords
- starch
- hetastarch
- preparation
- molecular weight
- narrow ditribution
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- Granted
Links
- 229920001612 Hydroxyethyl starch Polymers 0.000 title claims abstract description 80
- 238000002360 preparation method Methods 0.000 title claims abstract description 43
- 229940050526 hydroxyethylstarch Drugs 0.000 title claims abstract description 13
- 229920002472 Starch Polymers 0.000 claims abstract description 57
- 239000008107 starch Substances 0.000 claims abstract description 57
- 235000019698 starch Nutrition 0.000 claims abstract description 57
- 238000000034 method Methods 0.000 claims abstract description 26
- 238000006467 substitution reaction Methods 0.000 claims abstract description 21
- 238000006243 chemical reaction Methods 0.000 claims abstract description 18
- 230000007062 hydrolysis Effects 0.000 claims abstract description 18
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 18
- 238000012216 screening Methods 0.000 claims abstract description 15
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 230000008569 process Effects 0.000 claims abstract description 11
- 239000002253 acid Substances 0.000 claims abstract description 6
- 230000001681 protective effect Effects 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000008367 deionised water Substances 0.000 claims abstract description 3
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 3
- -1 ethoxyl Chemical group 0.000 claims abstract description 3
- 229940027278 hetastarch Drugs 0.000 claims description 67
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 37
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 23
- 239000012528 membrane Substances 0.000 claims description 19
- 229920002261 Corn starch Polymers 0.000 claims description 16
- 239000008120 corn starch Substances 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 13
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 12
- 238000000926 separation method Methods 0.000 claims description 12
- 239000000376 reactant Substances 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 230000004044 response Effects 0.000 claims description 9
- 239000000725 suspension Substances 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 7
- 239000007789 gas Substances 0.000 claims description 7
- 229920002521 macromolecule Polymers 0.000 claims description 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 6
- 229920012266 Poly(ether sulfone) PES Polymers 0.000 claims description 6
- 238000005227 gel permeation chromatography Methods 0.000 claims description 6
- SZIFAVKTNFCBPC-UHFFFAOYSA-N 2-chloroethanol Chemical group OCCCl SZIFAVKTNFCBPC-UHFFFAOYSA-N 0.000 claims description 5
- 239000002033 PVDF binder Substances 0.000 claims description 5
- 230000014759 maintenance of location Effects 0.000 claims description 5
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 240000003183 Manihot esculenta Species 0.000 claims description 2
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 claims description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 229920001592 potato starch Polymers 0.000 claims description 2
- 229910001873 dinitrogen Inorganic materials 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 7
- 239000000413 hydrolysate Substances 0.000 abstract description 5
- 239000007788 liquid Substances 0.000 abstract description 5
- 238000013461 design Methods 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 30
- 238000009826 distribution Methods 0.000 description 20
- 238000005457 optimization Methods 0.000 description 9
- 150000003384 small molecules Chemical group 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000004744 fabric Substances 0.000 description 5
- 238000000108 ultra-filtration Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 238000005903 acid hydrolysis reaction Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229920000945 Amylopectin Polymers 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 235000009392 Vitis Nutrition 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000004260 weight control Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B35/00—Preparation of derivatives of amylopectin
- C08B35/04—Ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201611222970.1A CN106589148B (zh) | 2016-12-27 | 2016-12-27 | 一种窄分布羟乙基淀粉的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611222970.1A CN106589148B (zh) | 2016-12-27 | 2016-12-27 | 一种窄分布羟乙基淀粉的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN106589148A true CN106589148A (zh) | 2017-04-26 |
CN106589148B CN106589148B (zh) | 2019-04-12 |
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CN201611222970.1A Active CN106589148B (zh) | 2016-12-27 | 2016-12-27 | 一种窄分布羟乙基淀粉的制备方法 |
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CN (1) | CN106589148B (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1840547A (zh) * | 2005-12-29 | 2006-10-04 | 天津协和生物科技发展有限公司 | 用于不同分子量和不同替代度的羟乙基淀粉的制备方法 |
CN1926155A (zh) * | 2004-03-01 | 2007-03-07 | B·布朗·梅尔松根有限公司 | 羟乙基淀粉 |
CN102617744A (zh) * | 2012-04-07 | 2012-08-01 | 山东齐都药业有限公司 | 一种窄分布中分子量羟乙基淀粉的制备方法 |
-
2016
- 2016-12-27 CN CN201611222970.1A patent/CN106589148B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1926155A (zh) * | 2004-03-01 | 2007-03-07 | B·布朗·梅尔松根有限公司 | 羟乙基淀粉 |
CN1840547A (zh) * | 2005-12-29 | 2006-10-04 | 天津协和生物科技发展有限公司 | 用于不同分子量和不同替代度的羟乙基淀粉的制备方法 |
CN102617744A (zh) * | 2012-04-07 | 2012-08-01 | 山东齐都药业有限公司 | 一种窄分布中分子量羟乙基淀粉的制备方法 |
Non-Patent Citations (1)
Title |
---|
任传杰等: ""不同截留分子量超滤膜对羟乙基淀粉130/0.4的超滤效果比较"", 《药学研究》 * |
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Publication number | Publication date |
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CN106589148B (zh) | 2019-04-12 |
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Address after: Building 1, No. 3 Huagongyuan Fourth Road, Huagongyuan Science and Technology Park, Donghu New Technology Development Zone, Wuhan City, Hubei Province, 430223 Patentee after: Wuhan University of Science and Technology Life Technology Co.,Ltd. Country or region after: China Patentee after: TIANJIN HAOYANG HUAKE BIOTECHNOLOGY Co.,Ltd. Address before: No. 3 Huagongyuan Fourth Road, Huazhong University of Science and Technology Science Park, Donghu Development Zone, Wuhan City, Hubei Province, 430223 Patentee before: WUHAN HUST LIFE SCIENCE & TECHNOLOGY Co.,Ltd. Country or region before: China Patentee before: TIANJIN HAOYANG HUAKE BIOTECHNOLOGY Co.,Ltd. |