CN106582439A - Intelligent integrated mixed pharmaceutical experiment system - Google Patents

Intelligent integrated mixed pharmaceutical experiment system Download PDF

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Publication number
CN106582439A
CN106582439A CN201611139355.4A CN201611139355A CN106582439A CN 106582439 A CN106582439 A CN 106582439A CN 201611139355 A CN201611139355 A CN 201611139355A CN 106582439 A CN106582439 A CN 106582439A
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CN
China
Prior art keywords
dedusting case
dust
machine
intelligent integrated
granulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201611139355.4A
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Chinese (zh)
Inventor
刘振峰
赖小锋
易小禄
杨春艳
赖勇
黄建祥
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yichun Wanshen Pharmaceutical Machinery Co Ltd
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Yichun Wanshen Pharmaceutical Machinery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yichun Wanshen Pharmaceutical Machinery Co Ltd filed Critical Yichun Wanshen Pharmaceutical Machinery Co Ltd
Priority to CN201611139355.4A priority Critical patent/CN106582439A/en
Publication of CN106582439A publication Critical patent/CN106582439A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)

Abstract

The invention discloses a mobile pharmaceutical experiment system integrated machine in a laboratory. The mobile pharmaceutical experiment system integrated machine reduces pollution risks, reduces the labor intensity and is highly integratedly controlled. The machine includes a wet mixing granulator, a wet straightening granulator, a dryer, a vacuum feeding machine, a dry straightening granulator, a hopper mixer and a control management system, and is characterized in that the wet mixing granulator, the wet straightening granulator, the dryer, the vacuum feeding machine, the dry straightening granulator and the hopper mixer are connected with each other and the whole sealed connection production is achieved. The vacuum feeding machine is installed on one side of the dryer and comprises a pulse dust removal filter and a buffer storage tank, the dry straightening granulator is installed on a lower end interface of the vacuum feeding machine through a clamp, and the hopper mixer is installed on a lower end interface of the dry granulator.

Description

Intelligent integrated formula mixes pharmacy experimental system
Technical field
The present invention relates to a kind of pharmacy system.More particularly to a kind of intelligent integrated formula mixes pharmacy experimental system.
Background technology
Existing pharmaceutical device or system are generally all that distributing is arranged in corresponding Factory Building, one side floor space Greatly, Factory Building Construction Bank high cost, simultaneously because distributing is arranged brings certain difficulty to encapsulating production.Particularly laboratory at this stage Pharmaceutical equipment is few because of raw material dosage, relative to production big type all do it is smaller because it is smaller these equipment all Put with unit pattern, such unit layout there are 3 weak points:Experiment material interface first between equipment and equipment is not It is easy to closely pipeline closed connection, the turnover of material to need a dead lift to operate, exposure under air, and has certain thing Material loss, this for some are for dampness is than more sensitive medicine, consequence be it is very serious, second point be every equipment all There is single control system, every machine will fill touch screen etc., so cause the repetition and waste of external resource and control hardware, the 3 points, equipment is installed will certain clearance space, and unit is more, and the space of occupancy is more.Lab space is relatively small, Stand-alone device is too many so that area loss is larger.And original of some integrated equipments of existing release in structure composition structure Cause, it uses operational effect unsatisfactory, need into next step to improve and improve part.Pursuit one such as simply collects Into, and be packed together in each device with cluster so that material circulation is not smooth during operation, and maintenance maintenance is difficult.
The content of the invention
The invention aims to overcome the above-mentioned deficiency of prior art, there is provided one kind reduces pollution risk, mitigate labor Fatigue resistance, highly integrated control and moveable intelligent integrated formula mixing pharmacy experimental system.
Intelligent integrated formula of the present invention mixing pharmacy experimental system includes some being made up of corresponding device respectively Subsystem, some subsystems implement concentrated controling management by an integrated control system, and its device includes vacuum Feeder, is characterized in that the vacuum feeder for one and lifts vacuum feeding dust removal machine, and lifting vacuum feeding dust removal machine includes removing Dust hood shell, pulley rotary support, hand control device, dust-removal cloth-bag, pulsed dust-removing device, its pulsed dust-removing device includes removing Dust hood shell and the passage on dedusting case, at the top of the dedusting case inlet scoop is offered, and its dedusting case leads to Cross inlet scoop to connect with corresponding vacuum feeder.
The bottom transporting mouth of the dedusting case it is corresponding with the charging aperture of corresponding charging barrel can air-tightness connection, its external diameter One end of the passage of the corresponding internal diameter of the lower port of remote little dedusting case, insert and extend from the inner chamber of dedusting case and remove The lower end port of dust hood shell.
The other end of the passage extends outside dedusting case from the corresponding side wall of dedusting case, and passage Other end cover wall corresponding to dedusting case is connected for air-tightness.
Described its pulsed dust-removing device includes some dust-removal cloth-bags in dedusting case, and pulse control unit is included It is connected to the control valve and its corresponding pulses controller of dust-removal cloth-bag.
The corresponding side of the dedusting case is connected with a relief valve, negative in its dedusting case and side's cone bucket to control The pressure limit.
The present invention this have the advantage that due to above-mentioned technical proposal, all wet mixing pelletizers of production system, dry Pass through respective tube between each subsystem hardwares such as method pelletizing machine, drying machine, vacuum feeder, dry method pelletizing machine, hopper mixer Road connects in order, and in whole work process whole closed line is realized, substantially reduces dirt of the material in production and circular flow Dye risk, the highly integrated control of each technique, resource requirement unification supply.
Description of the drawings
Accompanying drawing 1 is that this intelligent integrated formula mixes pharmacy experimental system structural representation.Fig. 2 is the row of the drying machine of the present invention The example structure schematic diagram of wind dust pelletizing system one.Fig. 3 is the vacuum feeder structural representation in one embodiment of the invention.Fig. 4 For another example structure schematic diagram of drying machine of the present invention.
Specific embodiment
The present invention is described in detail below in conjunction with the accompanying drawings.
As shown in Figure 1.Intelligent integrated formula of the present invention mixing pharmacy experimental system its on-site producing devices(System)It is integrated Formula mixture manufacturing line, whole production line or system are divided into some respectively including the subsystem of corresponding equipment, its each subsystem by it System is mutually corresponded to successively or connected by technique sequencing, each to be connected by being flexible coupling accordingly, wired hose connection and/or block Bind round closed hardwired mode to be attached, form integral type mixture manufacturing line.Each subsystem is implemented by an integrated control system All round process full automatic working management control.Each subsystem or its it is corresponding main and/or additionally arrange it is standby also or device is all arranged On a platform, its platform is a mobile platform.
The operation position of all subsystems is all exposed, the mutual level of relevant device or device of each subsystem or/ With the outer surface for being installed vertically on mobile platform, the power section of its device is all built-in.Both full packaged type had been realized Production, but for need to be provided during artificial intervention may and conveniently.
Its subsystem includes respectively wet-mixed granulation subsystem, wet method granulate subsystem, is dried subsystem, vacuum feeding Subsystem, dry method granulate subsystem and hopper mixing subsystem.
Its wet-mixed granulation subsystem, wet method granulate subsystem, to be dried subsystem, vacuum feeding subsystem, dry method whole ParticIe system and hopper mixing subsystem are respectively by wet mixing pelletizer 2, wet method pelletizing machine 3, drying machine 5, vacuum feeder 7th, dry method pelletizing machine 8 and hopper mixer 9 are constituted as the main equipment of on-site producing devices.
The concrete structure and the mode of production of the present embodiment is as illustrated in fig. 1 and 2.I.e.:Its integral type mixing life in the present embodiment Producing line comprising by technique sequencing successively mutually correspond to or connect wet-mixed granulation subsystem, wet method granulate subsystem, It is dried subsystem, vacuum feeding subsystem, dry method granulate subsystem and hopper mixing subsystem.Its each subsystem is by locally controlling Management level or its main control computer implement control by intelligent controller 11.Its wet-mixed granulation subsystem, wet method granulate System, subsystem, vacuum feeding subsystem, dry method granulate subsystem and hopper mixing subsystem are dried respectively by wet-mixed system Grain machine 2, wet method pelletizing machine 3, drying machine 5, vacuum feeder 7, dry method pelletizing machine 8 and hopper mixer 9 are used as main equipment device And constitute.
The wet mixing pelletizer 2 of each subsystem, wet method pelletizing machine 3, drying machine 5, vacuum feeder 7, dry method pelletizing machine 8 By the connection in order such as corresponding pipeline and the relevant hardware devices such as hopper mixer 9 between.
The corresponding input of field control layer or its intelligent controller 11 respectively by corresponding electric signal line with it is each Subsystem including wet mixing pelletizer 2, wet method pelletizing machine 3, drying machine 5, vacuum feeder 7, dry method pelletizing machine 8 and hopper Electric signal detector of the mixer 9 in interior all relevant devices or device(Sensor)Connection.Field control layer or its intelligence Can controller corresponding outfan respectively by corresponding electric signal line and the wet mixing pelletizer 2 of each subsystem, wet Method pelletizing machine 3, drying machine 5, vacuum feeder 7, dry method pelletizing machine 8 and hopper mixer 9 and its corresponding auxiliary device are interior The executor of all relevant devices or device is connected.Its executor includes servo amplifier, autocontrol valve, regulating valve, electricity Stream, voltage regulator, motor speed actuator, variable frequency adjustment device etc..
The wet mixing pelletizer 2 of each subsystem, wet method pelletizing machine 3, drying machine 5, vacuum feeder 7, dry method pelletizing machine 8 Equally provide corresponding resource or power by the control of its integrated control system is unified with the grade of hopper mixer 9 relevant device, such as water, The resource requirements such as electricity, gas.That is the resource requirement or power of each subsystem of full scale production line or production system, such as water, electricity, gas Resource requirement(It is arranged on mobile platform)Supplied by mobile platform unification.
Implement whole-process automatic monitoring operation to the whole production process including subsystems by integrated control system Management control.Wet mixing pelletizer 2, wet method pelletizing machine 3, drying machine 5, vacuum feeder 7, the mixing of dry method pelletizing machine 8, hopper Machine 9 and field control layer 2 or its PLC 11 are fully integrated and are installed on same mobile platform 1.
The working position of all subsystems all exposes, and is horizontally or vertically installed on the outer surface of mobile platform, power part Divide all built-in.The material of wet mixing pelletizer in stirring paddle and self gravitation effect, bottom discharge, in wet granulator.
Wet mixing pelletizer 2 is connected with each other with wet method pelletizing machine 3 in upper-lower position.Wet mixing pelletizer is whole with wet method Grain machine, uses the closed Hard link of clip between vacuum feeder and dry method pelletizing machine.
Vacuum feeder 7 installs the top that is placed in dry method pelletizing machine 8 with bottom is mutually presented.The material of dry method pelletizing machine 8 Entered in drying machine by the closed line of wired hose under self gravitation effect,.
Drying machine 5 is connected with each other with vacuum feeder 7 by wired hose 11.Material in drying machine 5 is in gravity and very Entered in vacuum feeder by the airtight connection of wired hose 11 under the suction function of empty feeder 7.
Material in vacuum feeder under gravity, through exit butterfly valve dry method pelletizing machine is entered.
Dry method pelletizing machine 8 is installed in vertical state the top of hopper mixer 9.Dry method pelletizing machine 8 and hopper mixer 9 12 it is connected with each other by being flexible coupling.The material of dry method pelletizing machine is mixed into material bin through being flexible coupling for lower port under gravity Conjunction machine.
Mobile platform is integrated together all subsystems of production line, saves big quantity space, and Moving caster is arranged at bottom, pacifies Dress is put flexibly.All apparatus for production line and its field control layer or its PLC are integrated on a mobile platform, it is to avoid Wasting time and energy when artificial intervention is needed waits inconvenience.
The integrated control system of the present invention includes PLC, and the PLC includes touch screen.The present invention can be answered For the granulation of pharmaceutical industry pharmaceutical workshop, it is dried, granulate, mixed processes, collection granulation is dried the functions such as granulate mixing and is Integrally, PLC touch screens centralized Control, the detection of each operation result, can continuously line production.Laboratory be can be applicable to as medicine The experimental system that product are researched and produced, is equally applicable to general field size formula pharmaceutical production, at the same be also applied for food, chemical industry, The industries such as agricultural.
In the embodiment of the present invention 2.As shown in Figure 2.Its drying machine includes air inlet system and exhausting-dusting system, and its air draft is removed Dirt system includes air exhaust passage 19, pants type airduct 15 and air-introduced machine 16 etc., and two entrances of pants type airduct 15 are connected to air exhaust passage 19 opposite sides positions, the outlet of pants type airduct 15 is connected to the entrance of air-introduced machine 16, and the outlet of air-introduced machine 16 is connected with an expansion Pipe silencer 17 is opened, pants type airduct 15 is provided with the canvas of dust removal and filtration with the exit of air exhaust passage 19 of exhausting-dusting system 4 Cover.The wind conveyed by air inlet system reaches exhausting-dusting system after being dried to corresponding material, afterwards will through canvas shroud 8 Jing pants type airduct, air-introduced machine enter expansion pipe silencer and carry out noise elimination process after dust-filtering, reduce outer row after noise.This Example remaining structure etc. can be similar with above-described embodiment.
In the embodiment of the present invention 3.As shown in Figure 3.Its vacuum feeder is a lifting vacuum feeding dust removal machine.Including dedusting Case 38, pulley rotary support, hand control device 31, dust-removal cloth-bag 34, pulsed dust-removing device etc..Its pulsed dust-removing device Including dedusting case 38 and the passage on dedusting case 39, the top of dedusting case 28 offers an inlet scoop 35, its Dedusting case is connected by inlet scoop with corresponding vacuum feeder.The bottom transporting mouth of dedusting case 38 and corresponding charging barrel (Side's cone bucket)37 charging aperture correspondence can air-tightness connection, the corresponding internal diameter of the lower port of the remote little dedusting case 38 of its external diameter The lower end port of dedusting case 38 is inserted and extended in one end of passage 39, the inner chamber from dedusting case 38(To charging barrel Chamber), extend outside dedusting case from the corresponding side wall of dedusting case 38 as the other end of the passage 39 of charging aperture, and The other end cover wall corresponding to dedusting case of passage 39 is connected for air-tightness.
Its pulsed dust-removing device includes some dust-removal cloth-bags 34 in dedusting case 28, and pulse control unit 33 includes There is the control valve and its corresponding pulses controller for being connected to dust-removal cloth-bag.
The corresponding side of its dedusting case 38 is connected with a relief valve, negative in its dedusting case and side's cone bucket to control The pressure limit.Its dedusting case 38 can be by being connected to pulley mechanism between dust-removal cloth-bag 34 and pulley rotary support, Yi Jilian It is rotary that the hand control device 31 that is connected between pulley mechanism and pulley rotary support is rotatable, lift is connected to pulley In frame.
During feeding, dedusting case is bored at the charging aperture of bucket by the hand control device side of moving to, and make dedusting case Lower port is docked with the charging aperture air-tightness of side's cone bucket, and is fixed with clip.Using other end as charging aperture of passage With corresponding turnover barrel connection, you can other side bores bucket vacuum feeding.Pulse can be arranged by pulse control unit in feeding process Dedusting time and pulse dust removal are spaced.During feeding frame rotation is not moved away from just cone bucket by hand control device, does not account for work Make space.
In the embodiment of the present invention 4.As shown in Figure 4.Its drying machine includes the cylinder 42 of housing 41, enclosure interior, is arranged on The buncher 43 in cylinder back-end portion, its buncher is by integrated control system control, and air-introduced machine is described by electromagnetic valve connection Also there is heater, warm and humid sensor, dust pelletizing system and dehumidification system, housing sidepiece has in the rear end of cylinder, the housing Tangent air draft passage 44 cylindrical with the cylinder, cylinder inboard wall has the discontinuous twi-tier blade 45 that Bidirectional helical is distributed; Case inside has heat-insulation layer, and housing bottom is loose structure;Cylinder is by conical leading portion, cylindrical midsection and conical back segment Composition, has feed inlet and outlet 46 on the leading portion, also there are some materials to derive plate 47 on leading portion inwall, and back segment connects by one Spindle connects the buncher 43, has some circular holes or elongated hole on cylinder;
Twi-tier blade is made up of two panels identical porous helical blade and two panels triangular piece, and the helical blade is by a circular arc Constitute in, inner edge always and two straight sides of identical, two helical blades are connected to each other by the inner edge Into V shape bars, the angle certain angle between the helical blade after two connections(25-40 degree), the shape of two triangular pieces Shape is identical with the both ends of the surface shape of the V shapes bar, and two triangular pieces are isosceles triangle, two waist respectively with V shape bars Two sides welding of end face, what the arc-shaped edges of two helical blades were parallel to each other is welded on the inwall in the stage casing, two etc. Weld with the inwall in the stage casing on the base of lumbar triangle shape;The position that the twi-tier blade is welded with cylinder does not have barrel; The twi-tier blade of bidirectional screw distribution includes the bilayer of at least one left-handed twi-tier blade and at least one dextrorotation Angle between the axis in blade, the twi-tier blade and the stage casing is 60 degree.
During work, the hot blast temperature that electromagnetic valve air-introduced machine is blown in cylinder is controlled at corresponding temperature, from charging aperture Load material into cylinder, the air outlet of electromagnetic valve air-introduced machine is docked with the discharging opening of cylinder, cylinder is rotated forward, cylinder Internal warm and humid sensor real-time monitoring cylinder body temperature and humidity changes, and by integrated control system(Such as PLC control System), you can drying is automatically performed, cylinder exports dry material by rotating backward.

Claims (5)

1. a kind of intelligent integrated formula mixes pharmacy experimental system, including some subsystems being made up of corresponding device respectively System, some subsystems implement concentrated controling management by an integrated control system, and its device includes vacuum feeding Machine, is characterized in that the vacuum feeder for one and lifts vacuum feeding dust removal machine, and lifting vacuum feeding dust removal machine includes dust excluding hood Shell, pulley rotary support, hand control device, dust-removal cloth-bag, pulsed dust-removing device, its pulsed dust-removing device includes dust excluding hood Shell and the passage on dedusting case, at the top of the dedusting case inlet scoop is offered, and its dedusting case is by inhaling Air port connects with corresponding vacuum feeder.
2. according to claim 1 intelligent integrated formula mixes pharmacy experimental system, it is characterized in that the bottom of the dedusting case Transporting mouth it is corresponding with the charging aperture of corresponding charging barrel can air-tightness connection, the lower port of the remote little dedusting case of its external diameter it is corresponding Internal diameter passage one end, the lower end port of dedusting case is inserted and extended from the inner chamber of dedusting case.
3. according to claim 1 intelligent integrated formula mixes pharmacy experimental system, it is characterized in that the other end of the passage Extend outside dedusting case from the corresponding side wall of dedusting case, and the corresponding cover of the other end of passage and dedusting case Wall is connected for air-tightness.
4. according to claim 1 intelligent integrated formula mixes pharmacy experimental system, it is characterized in that described its pulsed dust-removing device Including some dust-removal cloth-bags in the dedusting case, pulse control unit include the control valve that is connected to dust-removal cloth-bag and its Corresponding pulses controller.
5. according to claim 1 intelligent integrated formula mixes pharmacy experimental system, it is characterized in that the corresponding of the dedusting case Side be connected with a relief valve, with control its dedusting case and side cone bucket in the negative pressure limit.
CN201611139355.4A 2016-12-12 2016-12-12 Intelligent integrated mixed pharmaceutical experiment system Pending CN106582439A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110975751A (en) * 2019-12-06 2020-04-10 宜春万申制药机械有限公司固体制剂制造装备工业设计中心 Granulating and drying integrated machine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560122A (en) * 1993-06-03 1996-10-01 Dr. Karl Thomae Gmbh One-pot mixer/granulator/dryer
CN202778406U (en) * 2012-04-01 2013-03-13 江西天佳实业有限公司 Granulator unit
CN204890605U (en) * 2015-08-18 2015-12-23 常州市海江干燥设备有限公司 Modularization solid preparation equipment
CN105232334A (en) * 2015-11-05 2016-01-13 翰林航宇(天津)实业有限公司 Multifunctional all-in-one machine for medicine preparation laboratory
CN105423704A (en) * 2015-12-26 2016-03-23 宜春万申制药机械有限公司 Dust-free production system for granulating high-viscosity material

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560122A (en) * 1993-06-03 1996-10-01 Dr. Karl Thomae Gmbh One-pot mixer/granulator/dryer
CN202778406U (en) * 2012-04-01 2013-03-13 江西天佳实业有限公司 Granulator unit
CN204890605U (en) * 2015-08-18 2015-12-23 常州市海江干燥设备有限公司 Modularization solid preparation equipment
CN105232334A (en) * 2015-11-05 2016-01-13 翰林航宇(天津)实业有限公司 Multifunctional all-in-one machine for medicine preparation laboratory
CN105423704A (en) * 2015-12-26 2016-03-23 宜春万申制药机械有限公司 Dust-free production system for granulating high-viscosity material

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110975751A (en) * 2019-12-06 2020-04-10 宜春万申制药机械有限公司固体制剂制造装备工业设计中心 Granulating and drying integrated machine

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