CN106440711A - Full-automatic pelleting, drying and neatening integrated machine for integrated-type laboratories - Google Patents

Abstract

This invention discloses an integrated, fully automated laboratory granulation, drying, sizing, and mixing machine that reduces pollution risk, alleviates labor intensity, features highly integrated control, and is mobile. Its production system comprises several subsystems, each consisting of corresponding equipment or devices. These subsystems or their equipment include a dryer and a vacuum feeder. Each subsystem is integrated onto a corresponding platform. The key feature is that all corresponding operating parts of all subsystems are exposed, and the relevant equipment or devices of each subsystem are horizontally and/or vertically mounted on the outer surface of the platform. The power components of all equipment or devices are internally integrated.

Description

Integrated laboratory automatic granulation, drying, granulation and mixing machine

technical field

The present invention relates to a pharmaceutical system. In particular, it relates to an integrated laboratory fully automatic granulation, drying, granulation and mixing machine.

Background technique

Existing pharmaceutical devices or systems are usually distributed in the corresponding factory buildings. On the one hand, it occupies a large area and the construction cost of the factory building is high. At the same time, the decentralized installation brings certain difficulties to packaging production. Especially at the present stage, due to the small amount of raw materials used in laboratory pharmaceutical equipment, they are relatively small compared to the large-scale production models. Because they are relatively small, these devices are placed in a stand-alone model. This stand-alone layout has three shortcomings. : First of all, the experimental material interface between equipment and equipment is not convenient for closed connection of close-distance pipelines. The turnover of materials needs to be handled manually, exposed to the air, and there will be a certain amount of material loss. This is for some drugs that are sensitive to moisture. Generally speaking, the consequences are very serious. The second point is that each device has a separate control system, and each machine must be equipped with a touch screen, etc., which causes repeated waste of external resources and control hardware. There must be a certain interval of space. If there are more stand-alone machines, it will take up more space. The laboratory space is relatively small, and there are too many stand-alone equipment, resulting in a large waste of area. And the reason that some integrated equipments of existing release are in the structural composition structure, its operation effect is unsatisfactory, still needs further improvement and perfect part. For example, blindly pursuing integrated integration, and stacking various devices together in a bundled manner makes the flow of materials difficult during operation and makes maintenance difficult.

Contents of the invention

The purpose of the present invention is to overcome the above-mentioned deficiencies of the prior art, and provide an integrated laboratory fully automatic granulation, drying, granulation and mixing machine with reduced pollution risk, reduced labor intensity, highly integrated control and mobility.

The production system of the integrated laboratory automatic granulation, drying, granulation and mixing machine of the present invention includes several subsystems respectively composed of corresponding equipment or devices. The subsystems or their equipment include dryers, vacuum feeders, The subsystems and their integration are arranged on a corresponding platform, which is characterized in that the corresponding operating parts of all subsystems are all exposed, and the relevant equipment or devices of each subsystem are installed on the outer surface of the platform horizontally or/and vertically, and the equipment Or the power part of the device is all built-in.

The integrated control system includes a PLC controller, and the PLC controller includes a touch screen.

The equipment or device includes a wet mixing granulator, and the wet mixing granulator includes a closed mixing granulation bin and a discharge port.

The advantages of the present invention due to the above-mentioned technical scheme are that all subsystems of the production system, such as wet mixing granulator, dry granulator, dryer, vacuum feeder, dry granulator, hopper mixer, etc. The hardware is connected in an orderly manner through corresponding pipelines, and the entire working process realizes a closed connection, which greatly reduces the pollution risk of materials during production and turnover. Each process is highly integrated and controlled, and the required resources are uniformly supplied.

Description of drawings

Accompanying drawing 1 is the structural schematic diagram of the integrated laboratory automatic granulation, drying, granulation and mixing all-in-one machine. Fig. 2 is a structural schematic diagram of an embodiment of the air exhaust and dust removal system of the dryer of the present invention. Fig. 3 is a schematic structural diagram of a vacuum feeder in an embodiment of the present invention. Fig. 4 is a structural schematic diagram of another embodiment of the drying machine of the present invention.

detailed description

The present invention will be described in detail below in conjunction with the accompanying drawings.

As shown in Figure 1. The on-site production equipment (system) of the integrated laboratory automatic granulation, drying, granulation and mixing machine of the present invention is an integrated mixing production line, which divides the entire production line or system into several subsystems including corresponding equipment, and each subsystem Correspond or connect with each other according to the sequence of the process, each corresponding connection is connected by soft connection, steel wire hose connection and/or clamp closed hard connection to form an integrated mixed production line. Each subsystem is controlled by an integrated control system for fully automatic operation and management of the entire production process. Each subsystem or its corresponding main and/or auxiliary equipment or devices are all set on one platform, which is a mobile platform.

The working and operating parts of all subsystems are exposed, and the related equipment or devices of each subsystem are installed horizontally or/and vertically on the outer surface of the mobile platform, and the power parts of the equipment or devices are all built-in. It not only realizes fully encapsulated production, but also provides possibility and convenience for human intervention.

Its subsystems include wet mixing granule system, wet granulation system, drying subsystem, vacuum feeding subsystem, dry granulation system and hopper mixing subsystem.

Its wet mixing granulation system, wet granulation system, drying subsystem, vacuum feeding subsystem, dry granulation system and hopper mixing subsystem are respectively composed of wet mixing granulator 2, wet granulator 3, The drying machine 5, the vacuum feeder 7, the dry granulator 8 and the hopper mixer 9 are constituted as the main equipment of the on-site production equipment.

The specific structure and production method of this embodiment are shown in Figures 1 and 2. That is: in this embodiment, the integrated mixing production line includes the wet mixing granule system, the wet granulation system, the drying subsystem, the vacuum feeding subsystem, the dry granulation system and the Hopper mixing subsystem. Each of its subsystems is controlled by the local control management layer or its main control computer through the intelligent controller 11 . Its wet mixing granulation system, wet granulation system, drying subsystem, vacuum feeding subsystem, dry granulation system and hopper mixing subsystem are respectively composed of wet mixing granulator 2, wet granulator 3, A dryer 5, a vacuum feeder 7, a dry granulator 8 and a hopper mixer 9 are configured as main equipment.

The wet mixing granulator 2, wet granulator 3, dryer 5, vacuum feeder 7, dry granulator 8, hopper mixer 9 and other related hardware equipment of each subsystem pass through corresponding pipelines etc. in an orderly connection.

The corresponding input ends of the on-site control layer or its intelligent controller 11 communicate with each subsystem through corresponding electrical signal lines, including wet mixing granulator 2, wet granulator 3, dryer 5, and vacuum feeder. 7. Connect the electrical signal detectors (sensors) of all relevant equipment or devices including the dry granulator 8 and the hopper mixer 9. The corresponding output terminals of the on-site control layer or its intelligent controller communicate with the wet mixing granulator 2, wet granulator 3, dryer 5, vacuum feeder 7, The dry granulator 8 is connected with the actuators of all related equipment or devices including the hopper mixer 9 and its corresponding auxiliary equipment. Its actuators include servo amplifiers, automatic control valves, regulating valves, current and voltage regulators, motor speed regulators, frequency conversion regulators, etc.

The wet mixing granulator 2, wet granulator 3, dryer 5, vacuum feeder 7, dry granulator 8, hopper mixer 9 and other related equipment of each subsystem are also controlled by their integrated control system Provide corresponding resources or power in a unified manner, such as water, electricity, gas and other required resources. That is, the required resources or power of each subsystem of the entire production line or production system, such as water, electricity, gas and other required resources (set on the mobile platform) are uniformly supplied by the mobile platform.

The integrated control system implements full automatic monitoring, operation, management and control of the entire production process including various subsystems. Wet mixing granulator 2, wet granulator 3, dryer 5, vacuum feeder 7, dry granulator 8, hopper mixer 9 and on-site control layer 2 or its PLC controller 11 are all integrated and installed on the same mobile platform 1.

The working parts of all subsystems are exposed, installed horizontally or vertically on the outer surface of the mobile platform, and the power parts are all built-in. The material of the wet mixing granulator is discharged under the action of the stirring paddle and its own gravity, and then enters the wet granulator.

The wet mixing granulator 2 and the wet granulator 3 are connected to each other up and down. The clamps are used to seal the hard connection between the wet mixing granulator and the wet granulator, and the vacuum feeder and the dry granulator.

The vacuum feeder 7 is arranged on the top of the dry granulator 8 in a vertical position with each other. The material of the dry granulator 8 enters the dryer through the closed connection line of the steel wire hose under the action of its own gravity.

The dryer 5 and the vacuum feeder 7 are connected to each other through a steel wire hose 11 . The material in the drier 5 enters into the vacuum feeder through the airtight connection of the steel wire hose 11 under the gravity and the negative pressure of the vacuum feeder 7 .

The material in the vacuum feeder enters the dry granulator through the outlet butterfly valve under the action of gravity.

The dry granulator 8 is installed above the hopper mixer 9 in a vertical state. The dry granulator 8 and the hopper mixer 9 are connected to each other through a soft connection 12 . The material of the dry granulator enters the hopper mixer through the soft connection of the lower port under the action of gravity.

The mobile platform integrates all the subsystems of the production line, saving a lot of space. There are mobile casters at the bottom for flexible installation and placement. All production line equipment and its on-site control layer or its PLC controller are integrated on a mobile platform, which avoids the inconvenience of time-consuming and labor-intensive human intervention.

The integrated control system of the present invention includes a PLC controller including a touch screen. The present invention can be applied to the granulation, drying, granulation and mixing processes of solid preparation workshops in the pharmaceutical industry. It integrates functions such as granulation, drying, granulation and mixing. It is controlled by a PLC touch screen and detects the results of each process, and can be continuously connected to production. It can be applied to the laboratory as an experimental system for drug research and production, and it can also be applied to general on-site scale drug production, and it is also suitable for food, chemical, agricultural and other industries.

In Example 2 of the present invention. as shown in picture 2. Its drier includes air inlet system and exhaust air dust removal system, and its exhaust air dust removal system includes exhaust air channel 19, trousers-shaped air duct 15 and induced draft fan 16 etc., and the two entrances of trousers-shaped air duct 15 are connected to exhaust air duct 19 opposite On both sides, the outlet of the trousers-shaped air duct 15 is connected to the inlet of the induced draft fan 16, and the outlet of the induced draft fan 16 is connected to an expansion pipe muffler 17, and the outlet of the trousers-shaped air duct 15 and the exhaust duct 19 of the exhaust and dust removal system 4 Canvas cover with dust filter. The wind conveyed by the air inlet system dries the corresponding materials and reaches the exhaust and dust removal system, and then passes through the canvas cover 8 to filter the dust, and then enters the expansion tube muffler through the trousers-shaped air duct and induced draft fan for noise reduction treatment, after reducing the noise Efflux. The rest of the structure of this example can be similar to the above-mentioned embodiment.

In Example 3 of the present invention. As shown in Figure 3. Its vacuum feeding machine is a lifting vacuum feeding dust collector. It includes a dust removal cover 38, a pulley rotating frame, a hand control device 31, a dust removal bag 34, a pulse dust removal device, and the like. The pulse dedusting device includes a dust removal case 38 and a material guide pipe 39 arranged on the dust removal case. The top of the dust removal case 28 is provided with a suction port 35, and the dust removal case is connected with a corresponding vacuum feeder through the suction port. The lower port of the dust removal cover 38 can be airtightly connected with the feed port of the corresponding upper material bucket (square cone barrel) 37, and its outer diameter is far smaller than that of the corresponding inner diameter guide of the lower port of the dust removal cover 38. One end of the material pipe 39 is inserted from the inner cavity of the dust removal case 38 and extends out of the lower end port of the dust removal case 38 (to the inner cavity of the upper material barrel), and the other end of the material guide pipe 39 as the feeding port is inserted from the dust removal case 38 The corresponding side wall of the pipe extends out of the dust removal casing, and the other end of the material guide pipe 39 is airtightly connected and fixed with the corresponding cover wall of the dust removal casing.

The pulse dust removal device includes several dust removal bags 34 arranged in the dust removal cover 28, and the pulse control device 33 includes a control valve connected to the dust removal bag and its corresponding pulse controller.

The corresponding side of its dedusting case 38 is connected with a safety valve, to control the negative pressure limit in its dedusting case and square cone barrel. Its dust removal cover 38 can be connected to the pulley through the pulley mechanism connected between the dust bag 34 and the pulley rotary frame, and the hand control device 31 connected between the pulley mechanism and the pulley rotary frame. on a rotating rack.

When feeding, the dust removal cover is moved to the feed port of the square cone barrel through the hand control device, and the lower port of the dust removal cover is airtightly connected with the feed port of the square cone barrel, and fixed with a clamp. Connect the other end of the material guide tube as the feed port with the corresponding turnover barrel, so that the opposite cone barrel can be vacuum loaded. During the feeding process, the pulse dust removal time and pulse dust removal interval can be set by the pulse control device. When the material is not being loaded, the rack is rotated and moved away from the square cone barrel by the hand control device, which does not occupy the working space.

In Example 4 of the present invention. As shown in Figure 4. Its dryer includes a shell 41, a cylinder 42 inside the shell, and a speed-regulating motor 43 arranged at the rear end of the cylinder. The speed-regulating motor is controlled by an integrated control system, and the induced draft fan is connected to the cylinder through a solenoid valve. At the rear end, the housing also has a heater, a temperature and humidity sensor, a dust removal system, and a dehumidification system. The side of the housing has an exhaust passage 44 tangential to the outer circle of the cylinder, and the inner wall of the cylinder has two-way spiral distribution. Discontinuous double-layer blades 45; the inside of the housing has an insulating layer, and the bottom of the housing is a porous structure; the cylinder is made up of a conical front section, a cylindrical middle section and a conical rear section, and the front section has an inlet and outlet 46, and the front section inner wall There are also several material lead-out plates 47 on the top, and the rear section is connected to the speed-regulating motor 43 through a connecting shaft, and there are several round holes or long holes on the cylinder;

The double-layer blade is composed of two identical porous helical blades and two triangular pieces. The helical blade is composed of an arc edge, a straight inner edge and two identical straight side edges. The two helical blades The inner edges are connected to each other to form a V-shaped strip, the angle between the two connected spiral blades is at a certain angle (25-40 degrees), and the shape of the two triangular pieces is consistent with the two ends of the V-shaped strip. The shape is the same, the two triangular pieces are isosceles triangles, the two waists of which are respectively welded to the two sides of the end face of the V-shaped bar, the arc sides of the two spiral blades are welded on the inner wall of the middle section parallel to each other, and the two The base of the isosceles triangle is welded to the inner wall of the middle section; the part where the double-layer blades are welded on the cylinder does not have a cylinder wall; the double-layer blades distributed in a bidirectional helix include at least one left-handed double-layer blade and at least one A right-handed double-layer blade, the angle between the double-layer blade and the central axis of the middle section is 60 degrees.

When working, control the temperature of the hot air blown into the cylinder by the electromagnetic valve induced fan at a corresponding temperature, load materials into the cylinder from the inlet, and connect the air outlet of the electromagnetic valve induced fan with the discharge port of the cylinder. The cylinder rotates in the forward direction, and the temperature and humidity sensor inside the cylinder monitors the temperature and humidity changes in the cylinder in real time, and is controlled by an integrated control system (such as a PLC controller), and the drying can be completed automatically, and the cylinder can be dried by reverse rotation. Dry material output.

Claims (3)

1. An integrated laboratory fully automatic granulation, drying, granulation and mixing machine, its production system includes a number of subsystems composed of corresponding equipment or devices, the subsystems or their equipment include dryers, vacuum feeding machine, the subsystems and integration are arranged on a corresponding platform, which is characterized in that the corresponding operating parts of all subsystems are all exposed, and the related equipment or devices of each subsystem are installed horizontally or/and vertically on the outer surface of the platform, The power part of its equipment or device is all built-in. 2. The integrated laboratory fully automatic granulation, drying, granulation and mixing machine according to claim 1, characterized in that the integrated control system includes a PLC controller, and the PLC controller includes a touch screen. 3. According to claim 1, the integrated laboratory automatic granulation, drying, sizing and mixing machine is characterized in that the equipment or device includes a wet mixing granulator, and the wet mixing granulator includes a closed mixing granulator. Granulation bin and outlet.