CN106581614A - Ginger tea and preparation method thereof - Google Patents
Ginger tea and preparation method thereof Download PDFInfo
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- CN106581614A CN106581614A CN201611053274.2A CN201611053274A CN106581614A CN 106581614 A CN106581614 A CN 106581614A CN 201611053274 A CN201611053274 A CN 201611053274A CN 106581614 A CN106581614 A CN 106581614A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention belongs to the field of health-care products, and particularly relates to ginger tea and a preparation method thereof. The ginger tea is prepared from the following components in parts by weight: 3 to 10 parts of raw ginger, 1 to 3 parts of rhizoma galangae, 2 to 6 parts of folium artemisiae argyi, 3 to 8 parts of red dates, 2 to 6 parts of poria cocos, 1 to 5 parts of white atractylodes rhizome, 3 to 5 parts of pericarpium citri reticulatae, 3 to 8 parts of pearl barley, 4 to 6 parts of brown rice, 1 to 3 parts of brown sugar and 12 to 22 parts of an auxiliary material, wherein the auxiliary material is prepared by mixing dextrin, 0.1 to 3 percent (W/W) PVP alcohol solution and corncobs according to the weight ratio of 1: (0.2 to 0.6): (0.02 to 0.08). The ginger tea disclosed by the invention has the advantages of high formability, difficulty in wet absorption and high stability, has the effects of clearing away heat and toxic materials as well as eliminating swelling and removing dampness, and is low in preparation cost and suitable for great popularization and application.
Description
Technical field
The invention belongs to field of health care products, and in particular to a kind of ginger tea and preparation method thereof.
Background technology
The traditional Chinese medical science thinks that eczema mainly has wind, cold, wet, dry, fiery, worm poison, wound, and natural disposition is intolerant to disharmony between ying and wei and internal organs
Functional disturbance hot and humid ecchymosis inner product, the foreign aggression six external factors which cause diseases, climate change, the change of living environment, internal damage by the excessive seven emotions, overwork, spirit
Anxiety, emotional change, intra focal, dysbolism, endocrinopathy etc. are relevant.With internal heat spleen it is wet based on, because mind it is fidgety, the heart
Product raw in fiery to cause blood-head, can sending out because of intemperance of taking food or overfeeding raw meat again, injure taste, the dysfunction of the spleen in transport, overflow from humorously, wet with hot two
Heresy is mutually fought, and is altered under upper steaming, caused by exuberant skin, its pathology the disease being located in the exterior skin, but root is in blood.Using treatment by Chinese herbs, have no side effect,
Sample can be reached grasp and control, thoroughly cure eczema.
Chinese patent application CN103656243A discloses a kind of Chinese medicine for treating eczema, and the Chinese medicine is by following raw material systems
Into:Spina gleditsiae, tribulus terrestris, the root of Chinese clematis, golden cypress, felwort, plantain seed, honeysuckle, the capsule of weeping forsythia, Radix Angelicae Sinensis, the red sage root, Radix Glycyrrhizae, notopterygium root, wild pepper
It is sub, windproof, earthworm, the root of bidentate achyranthes, balloonflower root, peach kernel, Semen Leonuri, safflower, radix bupleuri, rhizoma Gastrodiae, yncaria stem with hooks, parasitic loranthus, grass-leaved sweetflag, rhizoma alismatis, white
Art, pyrrosia lingua, talcum, fringed pink, the membrane of a chicken's gizzard, stringy stonecrop, Sargent gloryvine, Asian puccoon, rhizome of cyrtomium, the root of kudzu vine, the bark of official magnolia, monkshood, wrinkled giant hyssop.Should Chinese medicine control
Eczema effect is significant is treated, is had no toxic side effect, but the heat-clearing and dampness eliminating herb tea prescription is complicated, is unfavorable for that its large-scale popularization should
With.
Separately, because granule has a taking convenience, the advantages of absorb fast, effective rapid, occur in that on market various
Ginger tea, but, its preparation technology of traditional ginger tea is using decocting by several times, decocting liquid is condensed into the water extracted immersing paste, then adds sweetener
Make particle.There are problems that using this technique, for example 1) yield of extract is low;2) decocting method and circumfluence method are due to behaviour
Make that temperature is higher, the impact to a part of thermal sensitivity active ingredient is larger, starch, polysaccharide, protein and resin etc. in extract
Impurity is more, is unfavorable for separating and purifies;3) extraction process long flow path.Production cost is caused to increase therefrom, long the production cycle,
Stability is bad, and drug effect is easily affected.
Therefore, it is necessary to provide a kind of prescription simply, and low cost of manufacture, have good stability, the obvious ginger tea of drug effect.
The content of the invention
In order to solve technical problem present in prior art, it is an object of the invention to provide a kind of ginger tea, to solve
Disadvantages described above.
The present invention provides a kind of ginger tea, including the component of following parts by weight:3~10 parts of ginger, 1~3 part of galangal, Chinese mugwort
It is 2~6 parts of leaf, 3~8 parts of red date, 2~6 parts of Poria cocos, 1~5 part of the bighead atractylodes rhizome, 3~5 parts of dried orange peel, 3~8 parts of the seed of Job's tears, 4~6 parts of brown rice, red
12~22 parts of 1~3 part of sugar and auxiliary material, the auxiliary material is by dextrin, the PVP alcoholic solutions of 0.1~3% (W/W) and corncob Ultramicro-powder
By 1:(0.2~0.6):The weight of (0.02~0.08) is than composition.
Preferably, the ginger tea includes the component of following parts by weight:3 parts of ginger, 1 part of galangal, 2 parts of tarragon, red date 3
Part, 2 parts of Poria cocos, 1 part of the bighead atractylodes rhizome, 3 parts of dried orange peel, 3 parts of the seed of Job's tears, 4 parts of brown rice, 1 part of brown sugar and 12 parts of auxiliary material, the auxiliary material by dextrin,
The PVP alcoholic solutions and corncob Ultramicro-powder of 1% (W/W) presses 1:0.2:0.02 weight is than composition.
Preferably, the ginger tea includes the component of following parts by weight:6 parts of ginger, 2 parts of galangal, 4 parts of tarragon, red date 5
Part, 3 parts of Poria cocos, 3 parts of the bighead atractylodes rhizome, 4 parts of dried orange peel, 6 parts of the seed of Job's tears, 5 parts of brown rice, 2 parts of brown sugar and 18 parts of auxiliary material, the auxiliary material by dextrin,
The PVP alcoholic solutions and corncob Ultramicro-powder of 1% (W/W) presses 1:0.3:0.06 weight is than composition.
Preferably, the ginger tea includes the component of following parts by weight:10 parts of ginger, 3 parts of galangal, 6 parts of tarragon, red date
22 parts of 8 parts, 6 parts of Poria cocos, 5 parts of the bighead atractylodes rhizome, 5 parts of dried orange peel, 8 parts of the seed of Job's tears, 6 parts of brown rice, 3 parts of brown sugar and auxiliary material, the auxiliary material by dextrin,
The PVP alcoholic solutions and corncob Ultramicro-powder of 1% (W/W) presses 1:0.6:0.08 weight is than composition.
Preferably, the corncob Ultramicro-powder is obtained by following steps:
The corncob after drying is taken, is shredded, Jing micronizers are broken into particle diameter for 30~42 μ after precomminution to 40~60 mesh
The powder of m, obtains final product.
Correspondingly, present invention also offers a kind of method for preparing above-mentioned ginger tea, comprises the following steps:
A ginger, galangal and tarragon) are taken, is cleaned, dried, be ground into meal, add 3~7 times of amounts 60~90% of meal
Ethanol solution impregnates 3~24h, collects maceration extract, stands, and filters, and retains filtrate and filter residue;
B the purified water of 6~10 times of amounts) is added toward above-mentioned filter residue, is decocted 1~3 time, filtered, merge decoction liquor, by decoction liquor
Merge to obtain extract I with above-mentioned filtrate, it is standby;
C) will mix with dried orange peel, the seed of Job's tears and brown rice after extracting red date stone, be ground into the fine powder of 200~400 mesh, it is standby;
D) bighead atractylodes rhizome is cleaned, is dried, be ground into meal, add the 70~90% of 3~5 times of amounts of meal ethanol solution dipping
1~3 time, every time 12~24h, collects maceration extract, stands, and filters, and obtains bighead atractylodes rhizome alcohol extract;
E) Poria cocos is cleaned, is dried, be ground into meal, add the purified water of 3~10 times of amounts of meal, decocted 1~3 time, mistake
Filter, merges decoction liquor, obtains Poria cocos water extract;
F) extract I, bighead atractylodes rhizome alcohol extract and Poria cocos water extract are merged, is mixed, be evaporated to relative density for 1.10
~1.30 medicinal extract, adds brown sugar, step C after medicinal extract is spray-dried) fine powder and auxiliary material, mix, thick piece, powder are pressed in advance
It is broken, sieve, obtain final product.
Preferably, the auxiliary material presses 1 by dextrin, the PVP alcoholic solutions of 0.1~3% (W/W) and corncob Ultramicro-powder:(0.2
~0.6):The weight of (0.02~0.08) is than composition.
Preferably, the auxiliary material presses 1 by dextrin, the PVP alcoholic solutions of 0.1~3% (W/W) and corncob Ultramicro-powder:0.3:
0.06 weight is than composition.
Preferably, step A) it is additionally included in dipping process and is continually fed into high-frequency high-voltage current.
Preferably, the frequency of the high-frequency high-voltage current is 3000~9000 hertz, and voltage is 3000~8000 volts.
Rhizoma zingiberis is the dry rhizome of Zingiber herbaceos perennial ginger, and taste is pungent, property is hot, returns spleen, stomach, the heart, lung channel, and it has
Warming spleen and stomach for dispelling cold, Back to Yang Tongmai, eliminating dampness dissolving phlegm, Wenfei of drink.Tarragon is the dried leaf of feverfew Chinese mugwort;Nature and flavor toil, temperature;Return
Liver,spleen,kidney Jing;Eliminating cold to stop pain, warming channel for arresting bleeding.Galangal, is the dry rhizome of zingiberaceous plant Gao Liang;Nature and flavor are pungent, heat;With temperature
Stomach cold dispelling, the effect for the pain relieving that helps digestion.Red date is the fruit of Rhamnaceae plant jujube;Nature and flavor tepor, it is sweet, it is micro- sweet;With invigorating the spleen and benefiting qi,
Effect of nourishing blood and tranquilization.Dried orange peel, is the ripe pericarp of rutaceae orange and its variety;It is warm in nature, taste is pungent, bitter;Have
Regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, effect of resolving sputum.The seed of Job's tears is sweet, be slightly cold;With main arthritis with fixed pain caused by dampness, sharp stomach, anthydropic effect.It is rough
Rice is that paddy sloughs the caryopsis after outer protection cortex rice husk;The content of calcium is 1.7 times of rice in brown rice, and iron-holder is 2.75
Times, nicotine element is 3.2 times, and Aneurine is up to 12 times.Vitamin E in brown rice is 10 times of rice, and cellulose is up to 14 times,
There is nutrition diversification.The bighead atractylodes rhizome is the rhizome of the feverfew bighead atractylodes rhizome, and nature and flavor are bitter, sweet, temperature;With strengthening the spleen and replenishing qi, eliminating dampness
Li Shui, hidroschesis, antiabortive effect.Poria cocos, also known as beautiful spirit, Fu spirits, Wan Linggui, Fu Tu.Shi Ni shelf funguses section fungi Poria cocos it is dry
Dry sclerotium;Nature and flavor are sweet, light, put down;With sharp water medicine, effect of diuretics with the action of eliminating dampness.Each component complements each other in formula, and cold dispelling is played altogether
With in, the effects such as clearing heat and expelling damp.
Inventor has found to be individually added into grain forming obtained in dextrin typically in process of the test, and easy to stick between particle
Even, easily the moisture absorption is lumpd in later stage storage, and storage life is shorter;PVP has good dissolubility and stability, and inventor attempts
PVP alcoholic solutions, the mouldability of as a result obtained particle is added to be obviously improved on the basis of dextrin is added;But inventor is same
Mono- problem of Shi Faxian, the reappearance of particle is poor, and properties of product are poor between the particle obtained by the PVP alcoholic solutions of variable concentrations
Different larger, inventor finally determines the particle effect obtained by the PVP alcoholic solutions of 0.1~3% (W/W) by substantial amounts of test
It is best.
But, due to the Chinese medical concrete easily moisture absorption itself, add dextrin and particle obtained in PVP alcoholic solutions also have easily suction
Wet, the problem of stability difference is embodied in, and it is only 12 to add dextrin and the granule of PVP alcoholic solutions its most long storage life
Individual month, at 12nd month moisture absorption caking phenomenon was occurred in that.Inventor is had found, above-mentioned finally by a large amount of long-term tests
On the basis of add corncob Ultramicro-powder and can dramatically improve the hygroscopicity of particle, this point is that inventor is unexpected.Together
When inventor, it was also found that the particle diameter and consumption of corncob Ultramicro-powder have large effect to its effect.Finally, inventor is not by
Slack effort draws, by the size controlling of corn Ultramicro-powder at 30~42 μm, and controls it with the proportion of dextrin 1:0.06 it
Between can greatly improve the hygroscopicity of particle.
The present invention can significantly shorten the Soakage extraction time using high-frequency high-voltage current and alcohol dipping, and test is proved, and two
Time can be foreshortened to 3~6h by person with reference to extraction.Trace it to its cause and be, in the presence of electric field force, Chinese traditional medicine biology molecule quilt
Polarization, manifests electric polarity, and intermolecular gravitation is destroyed, and the structure of medicinal material becomes loose, solvent can rapid osmotic to medicinal material
Inside, then the vibration that high-frequency high-voltage current is produced by it is passed through, cell membrane is abolished, finally reach the purpose of extraction.
Compared with prior art, ginger tea of the present invention has the advantage that:
1) ginger tea of the present invention has good moldability, is difficult moisture absorption, and stability is high, while having clearing heat and detoxicating, detumescence dampness removing
Effect.
2) present invention realizes the extraction to medicinal material using high-frequency high-voltage current with reference to ethanol, enables active ingredient molten
Go out, the advantage of low cost short with extraction time, with good application prospect.
Specific embodiment:
Below by way of the description of specific embodiment, the invention will be further described, but this is not the limit to the present invention
System, those skilled in the art's basic thought of the invention, various modifications may be made or improves, but without departing from this
The basic thought of invention, within the scope of the present invention.
The preparation of embodiment 1, corncob Ultramicro-powder
The corncob after drying is taken, is shredded, Jing micronizers are broken into the powder that particle diameter is 38 μm after precomminution to 50 mesh,
Obtain final product.
Embodiment 2, a kind of ginger tea
Ginger tea described in the embodiment of the present invention 2 is by 3 parts of ginger, 1 part of galangal, 2 parts of tarragon, 3 parts of red date, 2 parts of Poria cocos, the bighead atractylodes rhizome
12 parts of 1 part, 3 parts of dried orange peel, 3 parts of the seed of Job's tears, 4 parts of brown rice, 1 part of brown sugar and auxiliary material, the auxiliary material is by dextrin, the PVP alcohol of 1% (W/W)
Solution and corncob Ultramicro-powder described in embodiment 1 press 1:0.2:0.02 weight is than composition.
Preparation method:
A ginger, galangal and tarragon) are taken, is cleaned, dried, be ground into meal, add the ethanol of 6 times of amounts 80% of meal molten
Immersion stain 24h, collects maceration extract, stands, and filters, and retains filtrate and filter residue;
B) toward above-mentioned filter residue add 8 times amount purified waters, decoct 2 times, filter, merge decoction liquor, by decoction liquor with it is above-mentioned
Filtrate merges to obtain extract I, standby;
C) will mix with dried orange peel, the seed of Job's tears and brown rice after extracting red date stone, be ground into the fine powder of 300 mesh, it is standby;
D) bighead atractylodes rhizome is cleaned, is dried, be ground into meal, the ethanol solution for adding the 80% of 4 times of amounts of meal impregnates 2 times, often
Secondary 12h, collects maceration extract, stands, and filters, and obtains bighead atractylodes rhizome alcohol extract;
E) Poria cocos is cleaned, is dried, be ground into meal, add the purified water of 6 times of amounts of meal, decocted 2 times, filtered, merged
Decoction liquor, obtains Poria cocos water extract;
F) extract I, bighead atractylodes rhizome alcohol extract and Poria cocos water extract are merged, is mixed, be evaporated to relative density for 1.20
Medicinal extract, brown sugar, step C are added after medicinal extract is spray-dried) fine powder and auxiliary material, mix, thick piece is pressed in advance, crush, mistake
Sieve, obtains final product.
Embodiment 3, a kind of ginger tea
Ginger tea described in the embodiment of the present invention 3 is by 6 parts of ginger, 2 parts of galangal, 4 parts of tarragon, 5 parts of red date, 3 parts of Poria cocos, the bighead atractylodes rhizome
3 parts, 4 parts of dried orange peel, 6 parts of the seed of Job's tears, 5 parts of brown rice, 2 parts of brown sugar and 18 parts of auxiliary material composition, the auxiliary material is by dextrin, 1% (W/W)
PVP alcoholic solutions and corncob Ultramicro-powder described in embodiment 1 press 1:0.3:0.06 weight is than composition.
Preparation method:
A ginger, galangal and tarragon) are taken, is cleaned, dried, be ground into meal, add the ethanol of 5 times of amounts 85% of meal molten
Immersion stain 5h, while being continually fed into high-frequency high-voltage current, collects maceration extract, stands, and filters, and retains filtrate and filter residue, wherein, it is high
The frequency of frequency high-tension current is 6000 hertz, and voltage is 6000 volts;
B) toward above-mentioned filter residue add 8 times amount purified waters, decoct 2 times, filter, merge decoction liquor, by decoction liquor with it is above-mentioned
Filtrate merges to obtain extract I, standby;
C) will mix with dried orange peel, the seed of Job's tears and brown rice after extracting red date stone, be ground into the fine powder of 200 mesh, it is standby;
D) bighead atractylodes rhizome is cleaned, is dried, be ground into meal, the ethanol solution for adding the 80% of 4 times of amounts of meal impregnates 2 times, often
Secondary 12h, collects maceration extract, stands, and filters, and obtains bighead atractylodes rhizome alcohol extract;
E) Poria cocos is cleaned, is dried, be ground into meal, add the purified water of 6 times of amounts of meal, decocted 2 times, filtered, merged
Decoction liquor, obtains Poria cocos water extract;
F) extract I, bighead atractylodes rhizome alcohol extract and Poria cocos water extract are merged, is mixed, be evaporated to relative density for 1.20
Medicinal extract, brown sugar, step C are added after medicinal extract is spray-dried) fine powder and auxiliary material, mix, thick piece is pressed in advance, crush, mistake
Sieve, obtains final product.
Embodiment 4, a kind of ginger tea
Ginger tea described in the embodiment of the present invention 4 is by 10 parts of ginger, 3 parts of galangal, 6 parts of tarragon, 8 parts of red date, 6 parts of Poria cocos, white
22 parts of 5 parts of art, 5 parts of dried orange peel, 8 parts of the seed of Job's tears, 6 parts of brown rice, 3 parts of brown sugar and auxiliary material composition, the auxiliary material is by dextrin, 1% (W/W)
PVP alcoholic solutions and corncob Ultramicro-powder described in embodiment 1 press 1:0.6:0.08 weight is than composition.
Preparation method:
A ginger, galangal and tarragon) are taken, is cleaned, dried, be ground into meal, add the ethanol of 7 times of amounts 90% of meal molten
Immersion stain 6h, while being continually fed into high-frequency high-voltage current, collects maceration extract, stands, and filters, and retains filtrate and filter residue, wherein, it is high
The frequency of frequency high-tension current is 9000 hertz, and voltage is 9000 volts;
B) toward above-mentioned filter residue add 10 times amount purified waters, decoct 3 times, filter, merge decoction liquor, by decoction liquor with it is above-mentioned
Filtrate merges to obtain extract I, standby;
C) will mix with dried orange peel, the seed of Job's tears and brown rice after extracting red date stone, be ground into the fine powder of 400 mesh, it is standby;
D) bighead atractylodes rhizome is cleaned, is dried, be ground into meal, the ethanol solution for adding the 90% of 5 times of amounts of meal impregnates 3 times, often
Secondary 24h, collects maceration extract, stands, and filters, and obtains bighead atractylodes rhizome alcohol extract;
E) Poria cocos is cleaned, is dried, be ground into meal, add the purified water of 10 times of amounts of meal, decocted 3 times, filtered, merged
Decoction liquor, obtains Poria cocos water extract;
F) extract I, bighead atractylodes rhizome alcohol extract and Poria cocos water extract are merged, is mixed, be evaporated to relative density for 1.30
Medicinal extract, brown sugar, step C are added after medicinal extract is spray-dried) fine powder and auxiliary material, mix, thick piece is pressed in advance, crush, mistake
Sieve, obtains final product.
Comparative example 1, a kind of ginger tea
Comparative example 1 is with the difference of embodiment 3:Dried orange peel is eliminated, remaining parameter and operation are such as embodiment 3.
Comparative example 2, a kind of ginger tea
Comparative example 2 is with the difference of embodiment 3:The mixed accessories are dextrin, remaining parameter and operation such as embodiment
3。
Comparative example 3, a kind of ginger tea
Comparative example 3 is with the difference of embodiment 3:The mixed accessories are pressed by the PVP alcoholic solutions of dextrin and 2% (W/W)
1:0.3 weight is than composition, remaining parameter and operation such as embodiment 3.
A kind of ginger tea of comparative example 4
Comparative example 4 is with the difference of embodiment 3:The mixed accessories are by dextrin, the PVP alcoholic solutions of 2% (W/W) and jade
Rice core Ultramicro-powder presses 1:1:1 weight is than composition, remaining parameter and operation such as embodiment 3.
Test example one, safety testing
Respectively Example 2~4 and granule obtained in comparative example 1~4, carry out acute toxicity test, feed within 30 days
Test and feeding test for 90 days.As a result:The growing state of nutrition purposes, especially for feeding animals is good, and hematology and physico-chemical examination are normal.Therefore, this
The ginger tea of bright offer has edible safety, suitably drinks for a long time.
Test example two, quality evaluation
Take the embodiment of the present invention 2~4 and granule described in comparative example 1~4, according to《Chinese Pharmacopoeia》2010 editions one attached
Record the proterties to each group granule, granularity, moisture, microbial limit, loss on drying and granulating efficiency to evaluate, comment
Valency result is as shown in table 1.
The evaluation result of table 1
Group | Proterties | Granularity | Moisture | Microbial limit | Loss on drying | Granulating efficiency |
Embodiment 2 | It is qualified | 10.4% | 2.3% | It is qualified | It is qualified | Easily pelletize |
Embodiment 3 | It is qualified | 9.8% | 3.2% | It is qualified | It is qualified | Easily pelletize |
Embodiment 4 | It is qualified | 11.5% | 2.5% | It is qualified | It is qualified | Easily pelletize |
Comparative example 1 | It is qualified | 13.5% | 4.6% | It is qualified | It is qualified | Easily granulation |
Comparative example 2 | It is unqualified | 18.8% | 6.9% | It is qualified | It is qualified | Granulation is difficult, shaping is difficult |
Comparative example 3 | It is qualified | 16.5% | 5.5% | It is qualified | It is qualified | Easily granulation |
Comparative example 4 | It is qualified | 15.3% | 5.2% | It is qualified | It is qualified | Easily granulation |
Note:【Proterties】:Brown yellow granule, particle is uniform, and color and luster is unanimously qualified;【Granularity】:Survey according to granulometry
It is fixed, it is impossible to by a sieve and the summations that No. five sieves can be passed through no more than 15%;【Moisture】:Survey according to aquametry
It is fixed, test sample about 1g is taken, put 75 DEG C of drying under reduced pressure 5 hours, cool down 30 minutes, it is accurately weighed, then to be dried 1 in said temperature little
When, cooling is weighed, and to the double difference weighed less than 5mg, water content is qualified not less than 6%;【Microorganism
Limit】:According to microbial decolorization inspection;【Loss on drying】In 80 DEG C of drying under reduced pressure to constant weight, less loss weight is less than
2% is qualified.
From upper table 1:
Granule described in the embodiment of the present invention 2~4 has the characteristics of particle is uniform, and color and luster is consistent, and its granulation is easy.
Compared with granule described in embodiment 3, granule each side index has declined described in comparative example 1~4.
It is to be noted that:Can be seen that from the result of comparative example 2, be individually added into dextrin, be difficult granulation, hardly possible shaping, it is impossible to logical
The summations crossed a sieve and can pass through No. five sieves are each group highest, reach 18.8%;Comparative example 3 adds on the basis of comparative example 2
Enter PVP alcoholic solutions, compared with comparative example 2, granulating efficiency is obviously improved the particle obtained by it;It is auxiliary that comparative example 4 changes mixing
The proportioning of dextrin, PVP alcoholic solutions and corncob Ultramicro-powder in material, the granule obtained by it has declined compared with Example 3, but
It is better than granule described in comparative example 2~3.
Test example two, stability test
2.1 long-term room-temperatures keep sample test
Example 2~4 and the commercial samples of comparative example 2~4, under room temperature condition, kept sample for a long time test.Respectively at
3rd, 6,12 and 18 the end of month samplings, investigate its appearance character, moisture and microbial limit, the results are shown in Table shown in 2.
The long-term room-temperature of table 2 keeps sample result of the test
From upper table 2, the embodiment of the present invention 2~4 keeps sample after test Jing long-term room-temperature, the face shaping of sample, moisture
Content and microbial limit have no significant change, and are valid up to a year and a half, with excellent stability.
It is to be noted that:Compared with sample described in embodiment 3, sample Jing long-term room-temperatures described in comparative example 2~4 keep sample examination
After testing, sample has different degrees of change.Wherein, sample hygroscopicity described in comparative example 2,3 is stronger, and it is respectively at 6th month
Just there is moisture absorption phenomenon with 12nd month, there is caking, mildew phenomena at 12nd month and 18th month, two groups of samples
Less stable, is unfavorable for long-term preservation.
Test example three, effect assessment
1. physical data
Selection has by eczema patients 250, between 20~35 years old age, 250 volunteers is randomly divided into into 5 groups, per group
50 people, are respectively 2~4 groups of embodiment, 1 group of comparative example and control group (Shiduqing Capsule, 0.5g*30 grains, Guangxi Yulin pharmacy
Co., Ltd).
2nd, treatment method
2 groups of embodiment:Ginger tea described in the embodiment of the present invention 2 (5g/ bags), 2 times a day, 1 pouch is taken every time and is taken after mixing it with water with warm water,
7 days is 1 course for the treatment of, continuously takes 4 courses for the treatment of;
3 groups of embodiment:Ginger tea described in the embodiment of the present invention 3 (5g/ bags), 2 times a day, 1 pouch is taken every time and is taken after mixing it with water with warm water,
7 days is 1 course for the treatment of, takes 4 courses for the treatment of;
4 groups of embodiment:Ginger tea described in the embodiment of the present invention 4 (5g/ bags), 2 times a day, 1 pouch is taken every time and is taken after mixing it with water with warm water,
7 days is 1 course for the treatment of, takes 4 courses for the treatment of;
1 group of comparative example:Ginger tea described in comparative example of the present invention 1 (5g/ bags), 2 times a day, 1 pouch is taken every time and is taken after mixing it with water with warm water,
7 days is 1 course for the treatment of, takes 4 courses for the treatment of;
Control group:Shiduqing Capsule, warm water takes, one time 3,3 times a day, continuously takes 28 days.
3rd, observation of curative effect.
3.1 curative effect index
(1) it is effective:Eczema disappears, recovery from illness;
(2) effectively:Symptom substantially mitigates, and most of erythema disappears, and effect is obvious;
(3) it is invalid:Symptom is without alleviation or DeGrain.
3.2 statistical analysis application SPSS13.0 softwares carry out statistical procedures, data to represent, enumeration data x2Inspection
Test, measurement data is checked with t.
3.3 efficacy result
The efficacy result of table 3
Group | Number of cases | Effective (obvious effective rate) | Effectively (efficient) | Invalid (inefficiency) | Total effective rate |
2 groups of embodiment | 50 | 40 (80%) | 7 (14%) | 3 (6%) | 94% |
3 groups of embodiment | 50 | 42 (84%) | 6 (12%) | 2 (4%) | 96% |
4 groups of embodiment | 50 | 38 (76%) | 9 (18%) | 3 (6%) | 94% |
1 group of comparative example | 50 | 25 (50%) | 13 (26%) | 12 (24%) | 76% |
Control group | 50 | 20 (40%) | 15 (30%) | 15 (30%) | 70% |
From upper table 3, granule described in the embodiment of the present invention 2~4 can effectively treatment eczema, its total effective rate exists
More than 90%, the significantly larger than therapeutic effect of comparative example 1 and granule described in control group.
Claims (10)
1. a kind of ginger tea, it is characterised in that including the component of following parts by weight:3~10 parts of ginger, 1~3 part of galangal, Chinese mugwort
It is 2~6 parts of leaf, 3~8 parts of red date, 2~6 parts of Poria cocos, 1~5 part of the bighead atractylodes rhizome, 3~5 parts of dried orange peel, 3~8 parts of the seed of Job's tears, 4~6 parts of brown rice, red
12~22 parts of 1~3 part of sugar and auxiliary material, the auxiliary material is by dextrin, the PVP alcoholic solutions of 0.1~3% (W/W) and corncob Ultramicro-powder
By 1:(0.2~0.6):The weight of (0.02~0.08) is than composition.
2. ginger tea as claimed in claim 1, it is characterised in that including the component of following parts by weight:3 parts of ginger, galangal 1
12 parts of part, 2 parts of tarragon, 3 parts of red date, 2 parts of Poria cocos, 1 part of the bighead atractylodes rhizome, 3 parts of dried orange peel, 3 parts of the seed of Job's tears, 4 parts of brown rice, 1 part of brown sugar and auxiliary material,
The auxiliary material presses 1 by dextrin, the PVP alcoholic solutions of 1% (W/W) and corncob Ultramicro-powder:0.2:0.02 weight is than composition.
3. ginger tea as claimed in claim 1, it is characterised in that including the component of following parts by weight:6 parts of ginger, galangal 2
18 parts of part, 4 parts of tarragon, 5 parts of red date, 3 parts of Poria cocos, 3 parts of the bighead atractylodes rhizome, 4 parts of dried orange peel, 6 parts of the seed of Job's tears, 5 parts of brown rice, 2 parts of brown sugar and auxiliary material,
The auxiliary material presses 1 by dextrin, the PVP alcoholic solutions of 1% (W/W) and corncob Ultramicro-powder:0.3:0.06 weight is than composition.
4. ginger tea as claimed in claim 1, it is characterised in that including the component of following parts by weight:10 parts of ginger, galangal
3 parts, 6 parts of tarragon, 8 parts of red date, 6 parts of Poria cocos, 5 parts of the bighead atractylodes rhizome, 5 parts of dried orange peel, 8 parts of the seed of Job's tears, 6 parts of brown rice, 3 parts of brown sugar and auxiliary material 22
Part, the auxiliary material presses 1 by dextrin, the PVP alcoholic solutions of 1% (W/W) and corncob Ultramicro-powder:0.6:0.08 weight is than composition.
5. the ginger tea as described in claim 1 or 4 is arbitrary, it is characterised in that the corncob Ultramicro-powder is obtained by following steps:
The corncob after drying is taken, is shredded, it is 30~42 μm that Jing micronizers are broken into particle diameter after precomminution to 40~60 mesh
Powder, obtains final product.
6. a kind of method for preparing the ginger tea as described in Claims 1 to 5 is arbitrary, it is characterised in that comprise the following steps:
A ginger, galangal and tarragon) are taken, is cleaned, dried, be ground into meal, add the ethanol of 3~7 times of amounts 60~90% of meal
3~24h of solution impregnation, collects maceration extract, stands, and filters, and retains filtrate and filter residue;
B) toward above-mentioned filter residue add 6~10 times amount purified waters, decoct 1~3 time, filter, merge decoction liquor, by decoction liquor with it is upper
State filtrate and merge to obtain extract I, it is standby;
C) will mix with dried orange peel, the seed of Job's tears and brown rice after extracting red date stone, be ground into the fine powder of 200~400 mesh, it is standby;
D) bighead atractylodes rhizome is cleaned, is dried, be ground into meal, add the 70~90% of 3~5 times of amounts of meal ethanol solution dipping 1~3
Secondary, every time 12~24h, collects maceration extract, stands, and filters, and obtains bighead atractylodes rhizome alcohol extract;
E) Poria cocos is cleaned, is dried, be ground into meal, add the purified water of 3~10 times of amounts of meal, decocted 1~3 time, filtered, closed
And decoction liquor, obtain Poria cocos water extract;
F) extract I, bighead atractylodes rhizome alcohol extract and Poria cocos water extract are merged, are mixed, be evaporated to relative density for 1.10~
1.30 medicinal extract, adds brown sugar, step C after medicinal extract is spray-dried) fine powder and auxiliary material, mix, thick piece, powder are pressed in advance
It is broken, sieve, obtain final product.
7. method as claimed in claim 6, it is characterised in that the auxiliary material is molten by the PVP alcohol of dextrin, 0.1~3% (W/W)
Liquid and corncob Ultramicro-powder press 1:(0.2~0.6):The weight of (0.02~0.08) is than composition.
8. method as claimed in claim 7, it is characterised in that the auxiliary material is molten by the PVP alcohol of dextrin, 0.1~3% (W/W)
Liquid and corncob Ultramicro-powder press 1:0.3:0.06 weight is than composition.
9. method as claimed in claim 6, it is characterised in that step A) it is additionally included in dipping process and is continually fed into height
Frequency high-tension current.
10. method as claimed in claim 9, it is characterised in that the frequency of the high-frequency high-voltage current is 3000~9000 hertz
Hereby, voltage is 3000~8000 volts.
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