CN111184838A - Traditional Chinese medicine composition containing coix seeds and application thereof - Google Patents
Traditional Chinese medicine composition containing coix seeds and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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Abstract
The invention discloses a traditional Chinese medicine composition containing coix seeds and application thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: coix seed: amomum fruit: beautiful millettia root: radix rhodomyrti (3.75-15): (0.75-3): (3.75-15): (3.75-15). The application of the traditional Chinese medicine composition in preparing the medicine for enhancing immunity has the effect of enhancing immunity, adopts Ling nan Tao ground medicinal materials, has easily obtained raw materials, simple and convenient medicine extraction process, is beneficial to large-scale production and has easily controlled product quality.
Description
Technical Field
The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition with an immunity enhancing effect.
Background
In recent years, research on the mechanism of improving immunity of traditional Chinese medicines has made great progress. Many research results show that the traditional Chinese medicine plays a very good role in promoting the development of immune organs and improving the immunity of organisms. Such as Chinese medicine, can promote the development of immune organs, improve the immunocompetence and relieve the immunosuppression.
Therefore, the traditional Chinese medicine compound for enhancing immunity is researched and developed by utilizing the traditional Chinese medicine resources, the modern biotechnology and combining the characteristics of the Lingnan Chinese herbal medicine, has important significance and also has huge market development potential.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition containing coix seeds, which has an obvious curative effect of enhancing immunity and mild medicine property.
The invention also aims to provide the application of the traditional Chinese medicine composition in preparing a medicine for enhancing immunity.
In order to achieve the purpose, the invention adopts the following technical scheme: a traditional Chinese medicine composition containing coix seeds is characterized by comprising the following components in parts by weight: coix seed: amomum fruit: beautiful millettia root: radix rhodomyrti (3.75-15): (0.75-3): (3.75-15): (3.75-15).
More preferably, the composition comprises the following components in percentage by weight: coix seed: amomum fruit: beautiful millettia root: radix rhodomyrti (7.5-15): (1.5-3): (7.5-15): (7.5-15).
Application of the Chinese medicinal composition in preparing medicament for enhancing immunity
The medicine for enhancing immunity is decoction prepared from traditional Chinese medicine decoction pieces of the traditional Chinese medicine composition, or is an oral preparation prepared from an extract of the traditional Chinese medicine composition as an effective component, conventional auxiliary materials and a conventional preparation process of traditional Chinese medicines.
The extract is water extract or alcohol extract.
The water extract is obtained by heating and decocting water; the alcohol extract is obtained by heating, decocting and extracting ethanol.
The ethanol is 70% ethanol.
The concentration of the extract is 0.3-1.2g raw material/ml.
The oral preparation is tablets, capsules, granules, oral liquid or dripping pills.
The traditional Chinese medicine composition has the effect of enhancing immunity, adopts Ling nan Tao ground medicinal materials, has easily obtained raw materials, simple and convenient medicine extraction process, is beneficial to large-scale production and has easily controlled product quality.
Detailed Description
The invention relates to a Chinese medicinal composition containing coix seed fruit and having the effects of enhancing immunity and enriching blood, which comprises the following components in part by weight: coix seed: amomum fruit: beautiful millettia root: radix rhodomyrti (3.75-15): (0.75-3): (3.75-15): (3.75-15). More preferably, the composition comprises the following components in percentage by weight: coix seed: amomum fruit: beautiful millettia root: radix rhodomyrti (7.5-15): (1.5-3): (7.5-15): (7.5-15).
The Lingnan characteristic traditional Chinese medicine used in the invention comprises:
coicis semen, dried mature kernel of Coix lacryma-jobi L.var.ma-yuen (Roman.) Stapf of Gramineae. Harvesting plants when fruits are mature in autumn, drying in the sun, removing fruits, drying in the sun again, removing shells, tawny seed coats and impurities, and collecting kernels. Mainly produced in Fujian, Hebei and Liaoning. Sweet and bland in flavor and cool in nature. Has effects in promoting water penetration, removing dampness, invigorating spleen, relieving diarrhea, relieving arthralgia, expelling pus, removing toxic substance, and resolving hard mass. The Coicis semen contains Coicis semen oil, saccharide, proteins, and oil, and has immunity enhancing effect.
Fructus Amomi, dry ripe fruit of Amomum villosum lour, Var, Xanthioides T.L.Wu et Senjen or Hainan Sand Amomum longiligerere T.L.Wu. Collected in summer and autumn when the fruits are ripe, dried in the sun or at low temperature. Is distributed in Fujian, Guangdong, Guangxi and Yunnan provinces of China. Pungent flavor and warm nature. Has effects of eliminating dampness, promoting appetite, warming spleen, relieving diarrhea, regulating qi-flowing, and preventing miscarriage.
Millettia speciosa Champ of Millettia of Leguminosae is used as root medicine. Collected all the year round, preferably in autumn. Cleaning, slicing, and sun drying or steaming and sun drying. Distributed in Hainan, Fujian, Taiwan, Guangxi, Guangdong, Hubei, Hunan, Guizhou, and Jiangxi. Sweet in flavor and neutral in nature. Has the effects of tonifying deficiency, moistening lung, strengthening tendons and activating collaterals. Millettia speciosa champ contains flavonoids.
Rhodomyrtus tomentosa, a fruit of Rhodomyrtus tomentosa (air.) Hassk. Sweet and astringent taste, mild in nature. Is distributed in Fujian, Taiwan, Hunan, Guangdong, Hainan, Guangxi, Guizhou, Yunnan and other places. Has the effects of nourishing blood, stopping bleeding, astringing intestine and securing meridian. Rhodomyrtus tomentosa contains flavonoids, phenolic components, amino acids and saccharides.
The coix seed is used as a monarch, has sweet and cool nature and taste, enters spleen, stomach and lung channels, tonifies middle-jiao and qi, enhances immunity, is assisted by fructus amomi and beautiful millettia root, assists the coix seed in warming spleen and stimulating appetite, moistening lung and tonifying deficiency, is assisted by rosemyrtle, regulates qi and strengthens channels, enables the medicines to tonify without stagnation, is compatible with each other, tonifies both, tonifies spleen and stomach qi of middle-jiao, and plays a role in enhancing immunity.
The Lingnan characteristic traditional Chinese medicine has the function of enhancing immunity and can be applied to preparing medicines for enhancing immunity. The medicine is decoction prepared from traditional Chinese medicine decoction pieces of the traditional Chinese medicine composition, or comprises effective components and conventional auxiliary materials, and is prepared into any oral preparation according to a conventional traditional Chinese medicine preparation process, such as tablets, capsules, granules, oral liquid, dropping pills and the like. The effective component is extract of the above Chinese medicinal composition. The extract is semen Coicis, fructus Amomi, radix Millettiae Speciosae, and fructus Rhodomyrti extract, preferably water extract or ethanol extract, most preferably water extract. By conventional decocting, heating with water or ethanol as solvent, extracting generally twice, and concentrating to obtain extract with concentration of about 0.3-1.2 g/ml, preferably 0.6-1.2 g/ml, and most preferably 1.2 g/ml. The alcohol extract is obtained by decocting with ethanol, preferably 70% ethanol.
The present invention will be further described with reference to the following examples, but the present invention is not limited to these specific examples.
Example 1
Taking 15g of coix seeds, 3g of fructus amomi, 15g of rhodomyrtus tomentosa and 15g of beautiful millettia root, adding 10 times of distilled water each time, extracting for 1 hour under reflux for 2 times, filtering, combining the two filtrates, and concentrating to 40mL to obtain a water extract with the concentration of 1.2g of raw materials per mL.
Example 2
Taking 7.5g of coix seeds, 1.5g of fructus amomi, 7.5g of rhodomyrtus tomentosa and 7.5g of beautiful millettia root, adding 10 times of distilled water each time, carrying out reflux extraction for 1h, extracting for 2 times, filtering, combining filtrates of the two times, and concentrating to 40mL to obtain a water extract with the concentration of 0.6g of raw material/mL.
Example 3
Taking 3.75g of coix seeds, 0.75g of fructus amomi, 3.75g of rhodomyrtus tomentosa and 3.75g of beautiful millettia root, adding 10 times of distilled water each time, carrying out reflux extraction for 1h, extracting for 2 times, filtering, combining filtrates of the two times, and concentrating to 40mL to obtain a water extract with the concentration of 0.3g of raw material/mL.
Example 4
Taking 15g of coix seeds, 3g of fructus amomi, 15g of rhodomyrtus tomentosa and 15g of beautiful millettia root, adding 70% ethanol in an amount which is 10 times of that of the coix seeds, extracting for 1 hour under reflux for 2 times, filtering, combining the two filtrates, and concentrating to 40mL to obtain 1.2g of raw material/mL of alcohol extract.
Example 5
Taking 7.5g of coix seeds, 1.5g of fructus amomi, 7.5g of rhodomyrtus tomentosa and 7.5g of beautiful millettia root, adding 70 percent ethanol in an amount which is 10 times that of the coix seeds, extracting for 1 hour under reflux for 2 times, filtering, combining filtrates of the two times, and concentrating to 40mL to obtain 0.6g of raw material/mL of alcohol extract.
Example 6
Taking 3.75g of coix seeds, 0.75g of fructus amomi, 3.75g of rhodomyrtus tomentosa and 3.75g of beautiful millettia root, adding 10 times of distilled water each time, carrying out reflux extraction for 1h, extracting for 2 times, filtering, combining filtrates of the two times, and concentrating to 40mL to obtain 0.3g of raw material/mL of alcohol extract.
Example 7
Taking 15g of coix seeds, 3g of fructus amomi, 10g of rhodomyrtus tomentosa and 10g of beautiful millettia root, adding 10 times of distilled water each time, extracting for 1 hour under reflux for 2 times, filtering, combining the two filtrates, and concentrating to 40mL to obtain a water extract with the concentration of 0.95g of raw material/mL.
Example 8
Taking 10g of coix seeds, 2g of fructus amomi, 4g of rhodomyrtus tomentosa and 4g of beautiful millettia root, adding 10 times of distilled water each time, extracting for 1 hour under reflux for 2 times, filtering, combining the two filtrates, and concentrating to 40mL to obtain a water extract with the concentration of 0.5g of raw material/mL.
Example 9
Taking 7.5g of coix seeds, 3g of fructus amomi, 10g of rhodomyrtus tomentosa and 10g of beautiful millettia root, adding 70% ethanol in an amount which is 10 times of that of the coix seeds, reflux-extracting for 1 hour, extracting for 2 times, filtering, combining the two filtrates, and concentrating to 40mL to obtain 0.76g of raw material/mL of alcohol extract.
Examples of the experiments
1 material Kunming mouse, SPF grade, 6-8 weeks, male, experimental animal production license number: SCXK sports 2015-.
2 methods and results
2.1 enhanced immunization experiments
2.1.1 grouping and administration
Dividing Kunming mice into 4 groups at random, namely a negative control group and a group with high, medium and low (1.2 g/mL prepared in example 1, 0.6g/mL prepared in example 2 and 0.3g/mL prepared in example 3) concentration of the medicine water extract, wherein each group contains 8 mice; feeding distilled water to the negative control group, respectively feeding high, medium and low concentration medicinal water extracts to the other three groups, 0.5mL each time once a day, with administration time of 9:00 a.m., continuously administering for 14 days, and fasting for one day before the experiment is finished; killing all mice by a neck breaking method 24 hours after the last administration, weighing the weight of the mice by an electronic balance, dissecting the mice, taking out the spleen and the thymus of the mice, sucking residual blood by filter paper, weighing (mg) on an analytical balance, calculating the spleen index and the thymus index of the mice, comparing a concentration group with a negative control group, and analyzing the immunity enhancing effect of the coix seeds; spleen index ═ spleen weight/mouse body weight × 10, and thymus index ═ thymus weight/mouse body weight × 10.
After the experiment is finished, all experimental data are analyzed by adopting GraphPadprism 5 statistical software, SPSS compares differences among groups, metering data are analyzed by adopting One-Way ANOVA variance analysis, and the results are compared by LSD (standard deviation plus or minus) according to the mean
) Is represented by P<0.05 is a significant difference.
2.1.2 results
The results are shown in Table 1
TABLE 1 Effect of Compound Water extract of Chinese herbs on immune organs of mice: (
n＝8)
Note: p <0.05, P <0.01, compared to negative control group
The experimental analysis result shows that: compared with a negative control group, the thymus index and the spleen index of the high-concentration group and the medium-concentration group containing the coix seed traditional Chinese medicine composition water extract have significant difference (P is less than 0.01 and P is less than 0.05), and the low-concentration group has no significant difference, so that the result shows that the traditional Chinese medicine composition water extract can promote the development of immune organs of mice. The extract can promote the development of immune organs, and the aqueous extract of the traditional Chinese medicine composition containing the coix seeds can enhance the immunity of mice.
Claims (9)
1. A traditional Chinese medicine composition containing coix seeds is characterized by comprising the following components in parts by weight: coix seed: amomum fruit: beautiful millettia root: radix rhodomyrti (3.75-15): (0.75-3): (3.75-15): (3.75-15).
2. The coix seed-containing traditional Chinese medicine composition of claim 1, which is characterized in that: the composition consists of the following components in percentage by weight: coix seed: amomum fruit: beautiful millettia root: radix rhodomyrti (7.5-15): (1.5-3): (7.5-15): (7.5-15).
3. Use of the Chinese medicinal composition of claim 1 or 2 for preparing a medicament for enhancing immunity.
4. Use according to claim 3, characterized in that: the medicine for enhancing immunity is decoction prepared from traditional Chinese medicine decoction pieces of the traditional Chinese medicine composition, or is an oral preparation prepared from an extract of the traditional Chinese medicine composition as an effective component, conventional auxiliary materials and a conventional preparation process of traditional Chinese medicines.
5. Use according to claim 4, characterized in that: the extract is water extract or alcohol extract.
6. Use according to claim 5, characterized in that: the water extract is obtained by heating and decocting water; the alcohol extract is obtained by heating, decocting and extracting ethanol.
7. Use according to claim 6, characterized in that: the ethanol is 70% ethanol.
8. Use according to claim 4, characterized in that: the concentration of the extract is 0.3-1.2g raw material/ml.
9. Use according to claim 4, characterized in that: the oral preparation is tablets, capsules, granules, oral liquid or dripping pills.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010097930.9A CN111184838A (en) | 2020-02-18 | 2020-02-18 | Traditional Chinese medicine composition containing coix seeds and application thereof |
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| CN202010097930.9A CN111184838A (en) | 2020-02-18 | 2020-02-18 | Traditional Chinese medicine composition containing coix seeds and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111778126A (en) * | 2020-06-10 | 2020-10-16 | 李时珍医药集团有限公司 | Health wine for improving immunity and preparation method thereof |
| CN112516227A (en) * | 2020-11-27 | 2021-03-19 | 南方医科大学 | Compound essential oil for enhancing immunity and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771683A (en) * | 2015-03-18 | 2015-07-15 | 苏州普罗达生物科技有限公司 | Nut composition for strengthening immunity |
| CN106336983A (en) * | 2016-08-23 | 2017-01-18 | 常熟市吉健葡萄科技有限公司 | Health grape beverage |
-
2020
- 2020-02-18 CN CN202010097930.9A patent/CN111184838A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771683A (en) * | 2015-03-18 | 2015-07-15 | 苏州普罗达生物科技有限公司 | Nut composition for strengthening immunity |
| CN106336983A (en) * | 2016-08-23 | 2017-01-18 | 常熟市吉健葡萄科技有限公司 | Health grape beverage |
Non-Patent Citations (2)
| Title |
|---|
| 南京中医药大学: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
| 朱春福: ""桃金娘的化学成分及生物活性研究"", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111778126A (en) * | 2020-06-10 | 2020-10-16 | 李时珍医药集团有限公司 | Health wine for improving immunity and preparation method thereof |
| CN111778126B (en) * | 2020-06-10 | 2023-01-17 | 李时珍医药集团有限公司 | Health wine for improving immunity and preparation method thereof |
| CN112516227A (en) * | 2020-11-27 | 2021-03-19 | 南方医科大学 | Compound essential oil for enhancing immunity and application thereof |
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Application publication date: 20200522 |