CN106581599A - Drug for treating rheumatism and preparation method thereof - Google Patents
Drug for treating rheumatism and preparation method thereof Download PDFInfo
- Publication number
- CN106581599A CN106581599A CN201510670672.8A CN201510670672A CN106581599A CN 106581599 A CN106581599 A CN 106581599A CN 201510670672 A CN201510670672 A CN 201510670672A CN 106581599 A CN106581599 A CN 106581599A
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- parts
- radix
- rhizoma
- medicine
- extractum
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Abstract
The invention discloses a drug for treating rheumatism and a preparation method thereof. The drug is prepared from radix aconiti kusenzoffii, radix aconiti, arisaema, morinda officinalis, rhizoma corydalis, drynaria rhizome, dried rehamnnia root, radix paeoniae rubra, saffron crocus, ligusticum wallichii, eucommia ulmoides, cassia twigs, platycodon grandiflorum, Chinese angelica, peach kernel, radix achyranthis bidentatae, rhizoma sparganii, radix clematidis, Lindera aggregata, fresh ginger, pericarpium citri reticulatae, Astragalus membranaceus, cimicifugae foetidae, radix ophiopogonis and schisandra chinensis. The drug has the effects of regulating qi and blood, balancing yin and yang, dispelling wind-cold and removing damp arthralgia, can relieve various pains significantly, and is used for treatment of rheumatoid arthritis, rheumatoid, scapulohumeral periarthritis, gout, puerperal fever and traumatic injury, remarkable in curative effect, safe and free of side effects.
Description
Technical field
The present invention relates to a kind of treat medicine of rheumatism and preparation method thereof, belong to the field of medicine technology.
Technical background
Rheumatism is medically the chronic pain of articulations digitorum manus and its surrounding soft tissue's unknown cause.Rheumatism then refers to big class disease
Because different but common ground is to involve joint and surrounding soft tissue, including the disease of flesh, ligament, synovial bursa, fascia.Arthrosiss
Change still with swelling and moving obstacle, in the alternate chronic course of disease of outbreak and alleviation, some patientss and may occur in which pass in addition to having pain
Section is disabled and viscera function exhaustion.Rheumatism is a kind of anaphylactic reaction that Hemolytic streptococcuss cause.It is many suffered from otitis media,
What the disease 1-4 anniversaries such as tonsillitiss, pharyngitis, scarlet fever occurred.Teenager is weaker because of resistance, and be easy to get this kind of disease.Body constitution is poor
People be also susceptible to allergy, chance of falling ill is also more.
For rheumatism, though current Western medicine oral medicine is with the rapid-action and strong effect of analgesic activities, side effect can cause gastrointestinal
, all there is different degrees of infringement to heart, liver, kidney in dysfunction.Slowly effect for oral administration.Medicine for external use directly acts on affected part,
Sometimes illing skin allergy is caused even to damage in various degree because drug level is too high.Therefore, a good effect, side effect is less,
Will be well received for rheumatism, traumatic injury and arthritic medicine.
The content of the invention：
It is an object of the present invention to provide a kind of treat medicine of rheumatism and preparation method thereof.The medicine have adjust QI and blood,
Yin Yang balancing, cold-dispelling, except effect of arthralgia chiefly caused by damp pathogen, can significantly alleviate various pain, for treat rheumatic arthritis, rheumatoid,
Scapulohumeral periarthritis, gout, puerperal fever and traumatic injury；It is evident in efficacy, have no side effect safely.
To solve above-mentioned technical problem, the present invention employs the following technical solutions realization：A kind of medicine for treating rheumatism, by weight
Calculate, mainly by Radix Aconiti 15-30 parts, Radix Aconiti Kusnezoffii 10-40 parts, Rhizoma Arisaematis 10-40 parts, Radix Morindae Officinaliss 5-15 parts, Rhizoma Corydalis
25-35 parts, Rhizoma Drynariae 5-15 parts, Radix Rehmanniae 5-15 parts, Radix Paeoniae Rubra 6-18 parts, Stigma Croci 5-15 parts, Rhizoma Chuanxiong 30-40 parts,
Cortex Eucommiae 25-35 part, Ramulus Cinnamomi 5-15 parts, Radix Platycodoniss 5-15 parts, Radix Angelicae Sinensis 5-15 parts, Semen Persicae 5-15 parts, Radix Achyranthis Bidentatae 5-15 parts, three
Rib 5-15 parts, Radix Clematidis 6-18 parts, Radix Linderae 5-15 parts, Rhizoma Zingiberis Recenss 5-15 parts, Pericarpium Citri Reticulatae 10-20 parts, Radix Astragali 20-30 parts,
Rhizoma Cimicifugae 15-30,30-40 Radix Ophiopogonis and Fructus Schisandrae Chinensis 10-20 are made.
In the medicine of aforesaid treatment rheumatism, calculate by weight, mainly by 22 parts of Radix Aconiti, 25 parts of Radix Aconiti Kusnezoffii, Rhizoma Arisaematis
25 parts, 10 parts of Radix Morindae Officinaliss, 30 parts of Rhizoma Corydalis, 10 parts of Rhizoma Drynariae, 10 parts of Radix Rehmanniae, 11 parts of Radix Paeoniae Rubra, Stigma Croci 10
Part, 35 parts of Rhizoma Chuanxiong, 30 parts of the Cortex Eucommiae, 10 parts of Ramulus Cinnamomi, 10 parts of Radix Platycodoniss, 10 parts of Radix Angelicae Sinensis, 10 parts of Semen Persicae, 10 parts of Radix Achyranthis Bidentatae,
10 parts of Rhizoma Sparganii, 11 parts of Radix Clematidis, 10 parts of the Radix Linderae, 10 parts of Rhizoma Zingiberis Recenss, 15 parts of Pericarpium Citri Reticulatae, 25 parts of the Radix Astragali, 23 parts of Rhizoma Cimicifugae, wheat
Winter 35 and Fructus Schisandrae Chinensis 15 are made.
A kind of manufacture method of the medicine of aforesaid treatment rheumatism, takes said medicine, can add adjuvant, it is also possible to be not added with adjuvant,
Make oral formulations.
It is aforesaid treatment rheumatism medicine manufacture method in, the oral formulations be granule, capsule, tablet, pill,
Powder or cream.
In the manufacture method of the medicine of aforesaid treatment rheumatism, the granule so makes：Take said medicine, plus 10 times of amount water
Decoct 3 times, each 1.5h, filter, merge decoction liquor, relative density is the extractum of 1.15-1.20 when being condensed into 50-60 DEG C,
Extractum and the starch and 20% dextrine powder mixing granulation of extractum amount 20%, are dried, and obtain final product.
In the manufacture method of the medicine of aforesaid treatment rheumatism, the manufacture method of the capsule is：Said medicine is taken, with 6 times
The alcohol reflux of amount 70% 2 times, 1 hour every time, extracting solution was filtered, and filtrate recycling ethanol is simultaneously condensed into 50-60 DEG C of phase
It is the extractum of 1.20-1.25 to density, separately takes starch and 0.7% magnesium stearate and the extractum mixing of extractum amount 30%, uses 60%
Alcohol granulation, dry, pulverize, fill capsule, obtain final product.
In the manufacture method of the medicine of aforesaid treatment rheumatism, the manufacture method of the tablet is：Take said medicine, plus 10 times of amounts
Decocting is boiled 3 times, each 1.5h, is filtered, and merges decoction liquor, and relative density is the leaching of 1.15-1.20 when being condensed into 50-60 DEG C
Cream, extractum is mixed with the starch of above-mentioned mixed powder and extractum amount 20%, and tabletting, film coating is obtained final product.
Compared with prior art, medicine of the present invention mainly by Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Arisaematis, Radix Morindae Officinaliss, Rhizoma Corydalis,
Rhizoma Drynariae, Radix Rehmanniae, Radix Paeoniae Rubra, Stigma Croci, Rhizoma Chuanxiong, the Cortex Eucommiae, Ramulus Cinnamomi, Radix Platycodoniss, Radix Angelicae Sinensis, Semen Persicae, Radix Achyranthis Bidentatae, Rhizoma Sparganii, prestige
Radix Clematidis, the Radix Linderae, Rhizoma Zingiberis Recenss, Pericarpium Citri Reticulatae, the Radix Astragali, Rhizoma Cimicifugae, Radix Ophiopogonis and Fructus Schisandrae Chinensis are made, and each raw material has good in prescription
Synergism, play altogether have functions that adjust QI and blood, Yin Yang balancing, cold-dispelling, except arthralgia chiefly caused by damp pathogen, can significantly alleviate various pain,
For treating rheumatic arthritis, rheumatoid, scapulohumeral periarthritis, gout, puerperal fever and traumatic injury；Evident in efficacy, safety is without secondary work
With.
Applicant carried out following experiments, the provable present invention is with effective effect；
Experimental example expelling wind and removing dampness the effects
1 clinical data
1.1 case selections with reference to American society of rheumatism RA diagnostic criterias in 1987, it is all meet following 7 in 5：(1)
Morning stiffness continues daily at least 1h, the course of disease >=6 week；(2) arthralgia number >=3；(3) symmetrical swelling >=6 week；(4) rheumatoid
Positive (the drop number of sex factor (RF)>1：20)；(5) ESR,>30mm/h；(6) there is rheumatic subcutaneous nodule；(7) affected joints x
Line takes the photograph piece and changes (at least matter is sparse and joint space narrow) in RA, and the person of medicine more than 1 for improving the state of an illness in deactivation selects
To observe case.
1.2 physical data examine case totally 104, and 104 rheumatoid arthritis people are randomly divided into into two groups：Medicine of the present invention
Thing group be treatment group 54, matched group 50.Man 20 in treatment group, female 34,18～62 years old age, average 40
Year, course of disease person 27 within 1 year, 2-4 person 17,4 years with person 10；In matched group, man 19, female 31,
Age 17-62 year, average 37.4 years old, course of disease person 28 within 1 year, 2-4 years persons 14, more than 4 years persons 8.
There is comparability between two groups.
2 Therapeutic Method
2.1 treatment groups are treated with medicine of the present invention (method according to embodiment 1 is prepared), every time oral 10g, daily
3 times.
2.2 matched group ibuprofen, each 300m, 3 times a day, takes in meal.
Two groups of courses for the treatment of are 6 weeks, and other medicines are no longer used during treatment, observe the pain of affected joints, swelling and moving obstacle,
By heavy, medium and light, it is difficult 3,2,1,0 and scores, and record untoward reaction, the morning stiffness time is detected before and after treatment, both hands is held
Power, ESR, RF, both hands foot normotopia x line take the photograph piece control.
3 therapeutic outcomes
3.1 criterions of therapeutical effect are cured in the recent period：Morning stiffness<15rain, arthralgia and swelling disappear, and moving obstacle and hand-grip strength recover
Extremely normal, ESR is normal, and RF is negative；It is effective：Morning stiffness<30rain, the disease of affected joints 3 is always scored decline>80%；Have
Effect：Patient's self evaluation has an improvement, and affected joints are always scored decline>40%；It is invalid：Affected joints are always scored decline<40%,
Symptom is unchanged before and after treatment.
3.2 therapeutic outcome
3.2.1 Liang Zu comparitive studies treatment group cures in the recent period 24 (44.44%), effective 2l examples (38.89%)；Effective 7
Example (12.96%)；Invalid 2 (3.7%)；Total effective rate is 96.30%.Matched group cures in the recent period 13 (26%)；
Effective 17 (34%)；Effective 11 (22%)；No effect 9 (18%)；Total effective rate is 82%.
3.2.2 score to compare before and after two groups of affected joints treatments and be shown in Table 1, table 2 and table 3.
Arthralgia is scored and is compared (x ± s) before and after 1 two groups of affected joints treatments of table
Compare * P with before treatment<0.05；
Arthroncuss before and after 2 two groups of affected joints treatments of table are scored and are compared (x ± s)
Compare * P with before treatment<0.05；
Joint movement disorder is scored and is compared (x ± s) before and after 3 two groups of affected joints treatments of table
Compare * P with before treatment<0.05；
Conclusion：The present invention has expelling wind and removing dampness, lenitive effect.
Invention is further described with reference to embodiment, but is not intended as the foundation limited the present invention.
Specific embodiment：
Embodiment 1.
Formula：Radix Aconiti 22g, Radix Aconiti Kusnezoffii 25g, Rhizoma Arisaematis 25g, Radix Morindae Officinaliss 10g, Rhizoma Corydalis 30g, Rhizoma Drynariae 10g,
Radix Rehmanniae 10g, Radix Paeoniae Rubra 11g, Stigma Croci 10g, Rhizoma Chuanxiong 35g, Cortex Eucommiae 30g, Ramulus Cinnamomi 10g, Radix Platycodoniss 10g, Radix Angelicae Sinensis 10g,
Semen Persicae 10g, Radix Achyranthis Bidentatae 10g, Rhizoma Sparganii 10g, Radix Clematidis 11g, Radix Linderae 10g, Rhizoma Zingiberis Recenss 10g, Pericarpium Citri Reticulatae 15g, Radix Astragali 25g, liter
Numb 23g, Radix Ophiopogonis 35 and Fructus Schisandrae Chinensis 15g.
Technique：Said medicine is taken, plus 10 times of amount decoctings are boiled 3 times, each 1.5h is filtered, and merges decoction liquor, is condensed into 50-60 DEG C
When relative density for 1.15-1.20 extractum, the starch and 20% dextrine powder mixing granulation of extractum and extractum amount 20% is dried,
Obtain final product granule.
Specification：0.5g/ grains.
Usage and dosage：Every time 2-3 grains, daily 2-3 time.
Embodiment 2.
Formula：Radix Aconiti 15g, Radix Aconiti Kusnezoffii 10g, Rhizoma Arisaematis 10g, Radix Morindae Officinaliss 5g, Rhizoma Corydalis 25g, Rhizoma Drynariae 5g, the Radix Rehmanniae
Yellow 5g, Radix Paeoniae Rubra 6g, Stigma Croci 5g, Rhizoma Chuanxiong 30g, Cortex Eucommiae 25g, Ramulus Cinnamomi 5g, Radix Platycodoniss 5g, Radix Angelicae Sinensis 5g, Semen Persicae 5g, cattle
Knee joint 5g, Rhizoma Sparganii 5g, Radix Clematidis 6g, Radix Linderae 5g, Rhizoma Zingiberis Recenss 5g, Pericarpium Citri Reticulatae 10g, Radix Astragali 20g, Rhizoma Cimicifugae 15g, 30g Radix Ophiopogonis
And Fructus Schisandrae Chinensis 10g.
Technique：Said medicine is taken, with the alcohol reflux 2 times of 6 times of amounts 70%, 1 hour every time, extracting solution was filtered, filter
Relative density is the extractum of 1.20-1.25 when liquid reclaims ethanol and is condensed into 50-60 DEG C, separately takes the starch and 0.7% of extractum amount 30%
Magnesium stearate and extractum mix, with 60% alcohol granulation, dry, pulverize, fill capsule, obtain final product capsule.
Specification：0.5g/ grains.
Usage and dosage：Every time 2-3 grains, daily 2-3 time.
Embodiment 3.
Formula：Radix Aconiti 30g, Radix Aconiti Kusnezoffii 40g, Rhizoma Arisaematis 40g, Radix Morindae Officinaliss 15g, Rhizoma Corydalis 35g, Rhizoma Drynariae 15g,
Radix Rehmanniae 15g, Radix Paeoniae Rubra 18g, Stigma Croci 15g, Rhizoma Chuanxiong 40g, Cortex Eucommiae 35g, Ramulus Cinnamomi 15g, Radix Platycodoniss 15g, Radix Angelicae Sinensis 15g,
Semen Persicae 15g, Radix Achyranthis Bidentatae 15g, Rhizoma Sparganii 15g, Radix Clematidis 18g, Radix Linderae 15g, Rhizoma Zingiberis Recenss 15g, Pericarpium Citri Reticulatae 20g, Radix Astragali 30g, liter
Numb 30g, 40g Radix Ophiopogonis and Fructus Schisandrae Chinensis 20g.
Technique：Said medicine is taken, plus 10 times of amount decoctings are boiled 3 times, each 1.5h is filtered, and merges decoction liquor, is condensed into 50-60 DEG C
When relative density for 1.15-1.20 extractum, the starch and 20% dextrine powder mixing granulation of extractum and extractum amount 20% is dried,
Obtain final product granule.
Specification：0.5g/ grains.
Usage and dosage：Every time 2-3 grains, daily 2-3 time.
Claims (7)
1. a kind of medicine for treating rheumatism, it is characterised in that：Calculate by weight, mainly by Radix Aconiti 15-30 parts, Radix Aconiti Kusnezoffii 10-40
Part, Rhizoma Arisaematis 10-40 parts, Radix Morindae Officinaliss 5-15 parts, Rhizoma Corydalis 25-35 parts, Rhizoma Drynariae 5-15 parts, Radix Rehmanniae 5-15 parts,
Radix Paeoniae Rubra 6-18 parts, Stigma Croci 5-15 parts, Rhizoma Chuanxiong 30-40 parts, Cortex Eucommiae 25-35 part, Ramulus Cinnamomi 5-15 parts, Radix Platycodoniss 5-15 parts,
Radix Angelicae Sinensis 5-15 parts, Semen Persicae 5-15 parts, Radix Achyranthis Bidentatae 5-15 parts, Rhizoma Sparganii 5-15 parts, Radix Clematidis 6-18 parts, Radix Linderae 5-15 parts,
Rhizoma Zingiberis Recenss 5-15 parts, Pericarpium Citri Reticulatae 10-20 parts, Radix Astragali 20-30 parts, Rhizoma Cimicifugae 15-30 parts, 30-40 parts Radix Ophiopogonis and Fructus Schisandrae Chinensis 10-20
Part is made.
2. the medicine of rheumatism is treated as claimed in claim 1, it is characterised in that：Calculate by weight, mainly by 22 parts of Radix Aconiti,
It is 25 parts of Radix Aconiti Kusnezoffii, 25 parts of Rhizoma Arisaematis, 10 parts of Radix Morindae Officinaliss, 30 parts of Rhizoma Corydalis, 10 parts of Rhizoma Drynariae, 10 parts of Radix Rehmanniae, red
11 parts of Chinese herbaceous peony, 10 parts of Stigma Croci, 35 parts of Rhizoma Chuanxiong, 30 parts of the Cortex Eucommiae, 10 parts of Ramulus Cinnamomi, 10 parts of Radix Platycodoniss, 10 parts of Radix Angelicae Sinensis, Semen Persicae
10 parts, 10 parts of Radix Achyranthis Bidentatae, 10 parts of Rhizoma Sparganii, 11 parts of Radix Clematidis, 10 parts of the Radix Linderae, 10 parts of Rhizoma Zingiberis Recenss, 15 parts of Pericarpium Citri Reticulatae, the Radix Astragali 25
15 parts of part, 23 parts of Rhizoma Cimicifugae, 35 parts of Radix Ophiopogonis and Fructus Schisandrae Chinensis are made.
3. it is a kind of it is as claimed in claim 1 or 2 treatment rheumatism medicine manufacture method, it is characterised in that：Said medicine is taken, can
To add adjuvant, it is also possible to be not added with adjuvant, make oral formulations.
4. the manufacture method for treating the medicine of rheumatism as claimed in claim 3, it is characterised in that：The oral formulations be granule,
Capsule, tablet, pill, powder or cream.
5. the manufacture method for treating the medicine of rheumatism as claimed in claim 4, it is characterised in that：The granule so makes：Take
Said medicine, plus 10 times amount decoctings boil 3 times, each 1.5h, filter, merge decoction liquor, be condensed into relatively close when 50-60 DEG C
The extractum for 1.15-1.20, extractum and the starch and 20% dextrine powder mixing granulation of extractum amount 20% are spent, is dried, obtained final product.
6. the manufacture method for treating the medicine of rheumatism as claimed in claim 4, it is characterised in that：The manufacture method of the capsule is：
Said medicine is taken, with the alcohol reflux 2 times of 6 times of amounts 70%, 1 hour every time, extracting solution was filtered, filtrate recycling ethanol
And relative density is the extractum of 1.20-1.25 when being condensed into 50-60 DEG C, separately takes the starch of extractum amount 30% and 0.7% stearic acid
Magnesium is mixed with extractum, with 60% alcohol granulation, be dry, pulverize, and fills capsule, is obtained final product.
7. the manufacture method for treating the medicine of rheumatism as claimed in claim 4, it is characterised in that：The manufacture method of the tablet is：
Said medicine is taken, plus 10 times of amount decoctings are boiled 3 times, each 1.5h is filtered, and merges decoction liquor, is condensed into relative when 50-60 DEG C
Density is the extractum of 1.15-1.20, and extractum is mixed with the starch of above-mentioned mixed powder and extractum amount 20%, tabletting, film coating,
Obtain final product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434283A (en) * | 2018-06-20 | 2018-08-24 | 李�瑞 | A kind of Chinese medicine composition for treating rheumatism bone disease |
| CN116211934A (en) * | 2023-04-14 | 2023-06-06 | 孙银明 | Traditional Chinese medicine composition and preparation for treating gout and preparation method thereof |
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2015
- 2015-10-15 CN CN201510670672.8A patent/CN106581599A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434283A (en) * | 2018-06-20 | 2018-08-24 | 李�瑞 | A kind of Chinese medicine composition for treating rheumatism bone disease |
| CN116211934A (en) * | 2023-04-14 | 2023-06-06 | 孙银明 | Traditional Chinese medicine composition and preparation for treating gout and preparation method thereof |
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