CN106580917A - American ginseng wall-breaking pellet and preparation method thereof - Google Patents
American ginseng wall-breaking pellet and preparation method thereof Download PDFInfo
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- CN106580917A CN106580917A CN201611158300.8A CN201611158300A CN106580917A CN 106580917 A CN106580917 A CN 106580917A CN 201611158300 A CN201611158300 A CN 201611158300A CN 106580917 A CN106580917 A CN 106580917A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
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Abstract
The invention discloses an American ginseng wall-breaking pellet. The American ginseng wall-breaking pellet is prepared from American ginseng wall-breaking powder, carbomer, ethyecellulose, stearic acid, and microcrystalline cellulose. The invention further discloses a preparation method of the American ginseng wall-breaking pellet. The preparation improves the dissolving speed of effective components of the drug and the absorbing effect in the body, largely improves the bioavailability, obtains the ideal drug release rate and prospective blood concentration, avoids peak-valley phenomenon, and maintains a long acting time.
Description
Technical field
The invention belongs to a kind of micropill, specially a kind of Radix Panacis Quinquefolii breaking cellular wall micropill and preparation method thereof.
Background technology
Radix Panacis Quinquefolii has YIN nourishing and QI supplementing, the mind calming and mentality promoting and clearing away heat and promoting production of body fluid, the double effects that pathogenic fire reducing is relieved summer heat.Archaism cloud：" the West
Ginseng is cool in nature and mends, all be intended to Radix Ginseng and do not receive the temperature person of Radix Ginseng all can be with it ".Therefore mend and it is not dry be Radix Panacis Quinquefolii special feature.
Radix Panacis Quinquefolii has multiple efficacies：
1st, strengthen cardiac muscle and strengthen the mobility of heart.
2nd, strong nervus centraliss, stable body and mind simultaneously set up, and have calmness and antialcoholism action, hypermnesis ability, to old
People's dementia has remarkable efficacy.
3rd, there is Accommodation to blood pressure, make temporary or persistency blood pressure drops. suppress arteriosclerosis and promote erythrocyte
Growth, increases the deal of hematochrome.
4th, the secretion of islets of langerhans can be adjusted, thus it is powerful to diabetes.
5th, there are the secretion for adjusting toxin, the effect for enhancing metabolism to liver.
6th, can physical strength reinforcing and to athlete tool greatly benefit.
7th, anticancer growth, increases immunologic function.
8th, digestion is encouraged, it is weak to chronic gastropathy and the intestines and stomach to help effect.
Traditional instructions of taking is boiled, is stewed, steamed wheaten foods, section containing changing, being ground into fine powder and take after mixing it with water, although such method energy
Drug effect is excited, but drug effect is excited not thoroughly, caused medical material waste, and peak valley phenomenon easily occur, affect actual effect.
The content of the invention
The purpose of the present invention is for problem above, there is provided a kind of Radix Panacis Quinquefolii breaking cellular wall micropill, improves medicament effective component
Dissolution rate and internal assimilation effect, bioavailability greatly improved, preferable rate of releasing drug can be obtained and obtain pre-
The blood drug level of phase, it is to avoid peak valley phenomenon, and longer action time can be maintained.
Another object of the present invention is to provide a kind of preparation method of Radix Panacis Quinquefolii breaking cellular wall micropill, and the method is simply easy
Operation, effectively realizes the breaking cellular wall of cell so as to which sporoderm-broken rate has saved medical material more than 95%, plays medical value and more shows
Write, so as to significantly improve the medical value of preparation.
In order to realize object above, the technical solution used in the present invention is：A kind of Radix Panacis Quinquefolii breaking cellular wall micropill, its feature exist
In：Raw material includes internal component and coating, and the internal component includes Radix Panacis Quinquefolii wall cell disruption powder, carbomer, ethyl cellulose, Hard Fat
Acid, Microcrystalline Cellulose, above each component are respectively Radix Panacis Quinquefolii wall cell disruption powder 5-8 parts, 6～8 parts of carbomer, ethyl in terms of mass fraction
5～7 parts of cellulose, stearic acid 3-5 parts, 30～90 parts of Microcrystalline Cellulose；The coating constituents include Pulvis Talci 10-20 parts, increase
Modeling agent 20-30 parts, 1000 parts of purified water, coating weight gain is 10%.
Preferably, each component is respectively in terms of mass fraction：5 parts of Radix Panacis Quinquefolii wall cell disruption powder, 6 parts of carbomer, ethyl are fine
5 parts of dimension element, 3 parts of stearic acid, 30 parts of Microcrystalline Cellulose.
Preferably, the Radix Panacis Quinquefolii wall cell disruption powder is to carry out coarse pulverization through powder machine, is dried, and is then electrified to process 10-
40min；Again Jing after ultra-fine pulverizer disintegrating, the alternate immersion 2-24 hours in dilute alkaline soln and weak acid repeat 1-2 time；Jing again
After cold drying, freezing, 800-1000 mesh powder obtained in low-temperature airflow pulverizer is added.
Preferably, the particle diameter of the micropill is 60-120 μm.
A kind of preparation method of Radix Panacis Quinquefolii breaking cellular wall micropill, comprises the following steps：
Step 1, Feedstock treating：Radix Panacis Quinquefolii 5-8 parts are taken, is cleaned, decontamination, it is standby after being dried；Take 6～8 parts of carbomer, ethyl fine
After 5～7 parts of dimension element, stearic acid 3-5 parts, 30～90 parts of Microcrystalline Cellulose are crushed, mistake 300-400 mesh sieves are standby；
Step 2, prepare suspension：Taking 1000 parts of purified water adds Pulvis Talci 10-20 parts, plasticizer 20-30 parts to be sufficiently stirred for making
Coating suspensions；
Step 3, breaking cellular wall powder：In taking step 1, Radix Panacis Quinquefolii makes Radix Panacis Quinquefolii wall cell disruption powder using low-temperature airflow comminuting method；
Step 4, pill：By Radix Panacis Quinquefolii wall cell disruption powder 5-8 parts, 6～8 parts of carbomer, 5～7 parts of ethyl cellulose, stearic acid 3-5 parts,
30～90 parts of Microcrystalline Cellulose is thrown circule method using extrusion and micropill is obtained；
Step 5, coating：Coating suspensions in step 2 are added into seed-coating machine, coating solution mode is sprayed by step 3 bottom of using
Micropill is coated using micropill, and dry in the air ball 10h.
Preferably, the low-temperature airflow comminuting method in the step 2 is concretely comprised the following steps：
A. draw materials：Medical material is chosen, decontamination is cleaned, is filtered dry；
B. coarse pulverization：Material is put into powder beater carries out coarse pulverization, obtains 80-100 mesh coarse grain；
C. pretreatment：Coarse grain is dried, is then electrified to process 10-40min；
D. it is finely divided：Pretreated coarse grain is added into ultrafine crusher, 300-500 mesh particulates after crushing, are obtained；
E. reprocess：Particulate is placed in dilute alkaline soln and soaks 1-12h, added weak acid that pH value is adjusted to less than 7, soak 1-12h,
Then particulate is filtrated to get, is repeated 1-2 time；
F. comminution by gas stream：To be filtrated to get particulate cold drying, freezing after, add low-temperature airflow pulverizer, obtain 800-1000
Purpose powder, collects finished powder and is medical material wall cell disruption powder；
Pretreatment described in step c is to carry out at -5 DEG C -0 DEG C in temperature；
Energization described in step c is processed as coarse grain being immersed in galvanization 10-45min, power supply in 9%-11% carbon acid solutions
Voltage 5-7V；
Carried out in step e at low ambient temperatures, ambient temperature is 0 DEG C -4 DEG C；Described dilute alkaline soln is the hydrogen that PH is 8.2-8.8
One or more in sodium hydroxide solution, aqua calcises, iron hydroxide solution；
Weak acid described in step e is carbonic acid or acetic acid；
After step e adds weak acid, pH value is adjusted to 6-6.5；
Step f comminution by gas stream is carried out under vacuum environment or oxygen free condition, and it is -0.073MPa that the vacuum environment is vacuum
～-0.08MPa；In 0.8-3MPa, operating temperature is -3 DEG C -7 DEG C to the air pressure of comminution by gas stream.
Preferably, in the step 3, extrusion throwing circule method is concretely comprised the following steps：Material powder mix homogeneously, Jing are extruded into
Fine strip shape, is extruded with scraper plate granulation, the pill of high proper sphere degree is then rolled onto with centrifugal turntable.
Preferably, the operating temperature of coating is at 60 DEG C ± 5 DEG C, 20 h of duration, and coating weight gain is 10%.
Beneficial effects of the present invention：
1st, the present invention provides a kind of Radix Panacis Quinquefolii breaking cellular wall micropill, improve medicament effective component dissolution rate and internal absorption
Effect, greatly improved bioavailability, accordingly save limited rare medical material；Preferable rate of releasing drug can be obtained and obtain pre-
The blood drug level of phase, it is to avoid peak valley phenomenon, and longer action time can be maintained；
2nd, the present invention also provides a kind of preparation method of Radix Panacis Quinquefolii breaking cellular wall micropill, and the method is simple to operation, effectively realizes cell
Breaking cellular wall so as to sporoderm-broken rate more than 95%, make medical value play it is more significantly, so as to significantly improve the medical value of preparation；
3rd, the stability of medicine can be improved, bad smell is covered；And conveniently take.
Specific embodiment
In order that those skilled in the art more fully understand technical scheme, below the present invention is retouched in detail
State, the description of this part is only exemplary and explanatory, there should not be any restriction effect to protection scope of the present invention.
Embodiment 1
Step 1, Feedstock treating：5 parts of Radix Panacis Quinquefolii is taken, is cleaned, decontamination, it is standby after being dried；Take 6 parts of carbomer, ethyl cellulose 5
Part, 3 parts of stearic acid, 30 parts of Microcrystalline Cellulose add the prepared powder of nanoscale grinder standby after crushing；
Step 2, prepare suspension：Take 1000 parts of purified water and add 10 parts of Pulvis Talci, 20 parts of plasticizer is sufficiently stirred for making coating and mixes
Suspension；
Step 3, breaking cellular wall powder：In taking step 1, Radix Panacis Quinquefolii makes Radix Panacis Quinquefolii wall cell disruption powder using low-temperature airflow comminuting method, and material is put
Entering powder beater carries out coarse pulverization, obtains 80 mesh coarse grain；Coarse grain is dried at 0 DEG C, coarse grain is immersed in into 9% carbon acid solution then
Middle energization processes 40min, supply voltage 5V；Then will be dried at -5 DEG C of coarse grain again, add ultrafine crusher, after crushing 300
Mesh particulate, particulate is placed in the hydrated ferric oxide. weak solution that PH is 8.2 and soaks 1h, adds acetic acid that pH value is adjusted to 6.5, immersion
6h, is then filtrated to get particulate, repeats alternate immersion 2 times in alkali acid；After particulate cold drying will be filtrated to get, vacuum is added
The low-temperature airflow pulverizer for -0.073MPa is spent, in the powder of operating temperature to be 7 DEG C obtain 800 mesh.
Step 4, pill：By 5 parts of Radix Panacis Quinquefolii wall cell disruption powder in step 3, with after in step 1, obtained powder is mixed homogeneously, Jing
Be extruded into fine strip shape, be extruded with scraper plate granulation, then high 60-120 μm of proper sphere degree be rolled onto with centrifugal turntable
Pill.
Step 5, coating：Coating suspensions in step 2 are added into seed-coating machine, coating solution mode is sprayed by step 3 bottom of using
In pill be coated using micropill, the operating temperature of coating at 60 DEG C ± 5 DEG C, 18 h of duration, coating weight gain is 10%, so
After dry in the air ball 8h.
Embodiment 2
Step 1, Feedstock treating：6 parts of Radix Panacis Quinquefolii is taken, is cleaned, decontamination, it is standby after being dried；Take 7 parts of polyvidone, ethyl cellulose 5
Part, 4 parts of stearic acid, 60 parts of Microcrystalline Cellulose add the prepared powder of nanoscale grinder standby after crushing；
Step 2, prepare suspension：Take 1000 parts of purified water and add 20 parts of Pulvis Talci, 30 parts of plasticizer is sufficiently stirred for making coating and mixes
Suspension；
Step 3, breaking cellular wall powder：In taking step 1, Radix Panacis Quinquefolii makes Radix Panacis Quinquefolii wall cell disruption powder using low-temperature airflow comminuting method, and material is put
Entering powder beater carries out coarse pulverization, obtains 80 mesh coarse grain；Coarse grain is dried at 0 DEG C, coarse grain is immersed in into 10% carbon acid solution then
Middle energization processes 20min, supply voltage 6V；Then will be dried at -3 DEG C of coarse grain again, add ultrafine crusher, after crushing 400
Mesh particulate, particulate is placed in the calcium hydroxide weak solution that PH is 8.8 and soaks 6h, adds acetic acid that pH value is adjusted to 6.5, immersion
6h, is then filtrated to get particulate, repeats alternate immersion 2 times in alkali acid；After particulate cold drying will be filtrated to get, vacuum is added
The low-temperature airflow pulverizer for -0.073MPa is spent, in the powder of operating temperature to be -3 DEG C obtain 800 mesh.
Step 4, pill：After obtained powder in 6 parts of Radix Panacis Quinquefolii wall cell disruption powder in step 3 and step 1 uniform, Jing extruding is squeezed
Into fine strip shape, scraper plate granulation is extruded with, then 60-120 μm of high pill of proper sphere degree is rolled onto with centrifugal turntable.
Step 5, coating：Coating suspensions in step 2 are added into seed-coating machine, coating solution mode is sprayed by step 3 bottom of using
In pill be coated using micropill, the operating temperature of coating at 60 DEG C ± 5 DEG C, 20 h of duration, coating weight gain is 10%, so
After dry in the air ball 10h.
Embodiment 3
Step 1, Feedstock treating：8 parts of Radix Panacis Quinquefolii is taken, is cleaned, decontamination, it is standby after being dried；Take 6 parts of carbomer, ethyl cellulose 6
Part, 5 parts of stearic acid, 90 parts of Microcrystalline Cellulose add the prepared powder of nanoscale grinder standby after crushing；
Step 2, prepare suspension：Take 1000 parts of purified water and add 10 parts of Pulvis Talci, 25 parts of plasticizer is sufficiently stirred for making coating and mixes
Suspension；
Step 3, breaking cellular wall powder：In taking step 1, Radix Panacis Quinquefolii makes Radix Panacis Quinquefolii wall cell disruption powder using low-temperature airflow comminuting method, and material is put
Entering powder beater carries out coarse pulverization, obtains 80 mesh coarse grain；Coarse grain is dried at -5 DEG C, coarse grain 11% carbonic acid is immersed in into then molten
It is powered in liquid and processes 10min, supply voltage 7V；Then will be dried at 0 DEG C of coarse grain again, add ultrafine crusher, after crushing 400
Mesh particulate, particulate is placed in the mixed solution of sodium hydroxide that PH is 8.2 with hydrated ferric oxide. and soaks 12h, adds acetic acid by pH
Value is adjusted to 6.8, soaks 12h, is then filtrated to get particulate, repeats alternate immersion 1 time in alkali acid；Particulate low temperature will be filtrated to get
After drying, the low-temperature airflow pulverizer that vacuum is -0.08MPa is added, in the powder of operating temperature to be 0 DEG C obtain 800 mesh.
Step 4, pill：By 6 parts of Radix Panacis Quinquefolii wall cell disruption powder in step 3, with after in step 1, obtained powder is mixed homogeneously, Jing
Be extruded into fine strip shape, be extruded with scraper plate granulation, then high 60-120 μm of proper sphere degree be rolled onto with centrifugal turntable
Pill.
Step 5, coating：Coating suspensions in step 2 are added into seed-coating machine, coating solution mode is sprayed by step 3 bottom of using
In pill be coated using micropill, the operating temperature of coating at 60 DEG C ± 5 DEG C, 20 h of duration, coating weight gain is 10%, so
After dry in the air ball 10h.
It should be noted that herein, term " including ", "comprising" or its any other variant are intended to non-row
His property is included, so that a series of process, method, article or equipment including key elements not only include those key elements, and
And also include other key elements being not expressly set out, or also include for this process, method, article or equipment institute inherently
Key element.
Specific case used herein is set forth to the principle and embodiment of the present invention, the explanation of above example
It is only intended to help and understands the method for the present invention and its core concept.The above is only the preferred embodiment of the present invention, should
When pointing out due to the finiteness of literal expression, and objectively there is unlimited concrete structure, for the common skill of the art
For art personnel, under the premise without departing from the principles of the invention, some improvement, retouching or change can also be made, it is also possible to will
Above-mentioned technical characteristic is combined by rights；These improve retouching, change or combine, or the not improved structure by invention
Think and technical scheme directly applies to other occasions, be regarded as protection scope of the present invention.
Claims (8)
1. a kind of Radix Panacis Quinquefolii breaking cellular wall micropill, it is characterised in that：Raw material includes internal component and coating, and the internal component includes west
Radix Panacis Quinquefolii wall cell disruption powder, carbomer, ethyl cellulose, stearic acid, Microcrystalline Cellulose, above each component are respectively west in terms of mass fraction
Radix Panacis Quinquefolii wall cell disruption powder 5-8 parts, 6～8 parts of carbomer, 5～7 parts of ethyl cellulose, stearic acid 3-5 parts, 30～90 parts of Microcrystalline Cellulose；
The coating constituents include Pulvis Talci 10-20 parts, plasticizer 20-30 parts, 1000 parts of purified water, and coating weight gain is 10%.
2. a kind of Radix Panacis Quinquefolii breaking cellular wall micropill according to claim 1, it is characterised in that the internal component each component quality
Number is：5 parts of Radix Panacis Quinquefolii wall cell disruption powder, 6 parts of carbomer, 5 parts of ethyl cellulose, 3 parts of stearic acid, 30 parts of Microcrystalline Cellulose, coating
Composition each component mass fraction be Pulvis Talci 10-20 parts, plasticizer 20-30 parts, 1000 parts of purified water, coating weight gain is 10%.
3. a kind of Radix Panacis Quinquefolii breaking cellular wall micropill according to claim 1 or 2 any one, it is characterised in that the Radix Panacis Quinquefolii breaks
Wall powder is to carry out coarse pulverization through powder machine, is dried, and is then electrified to process 10-40min；Again Jing after ultra-fine pulverizer disintegrating, dilute
Alternate immersion 2-24 hours in aqueous slkali and weak acid, repeat 1-2 time；Again Jing after cold drying, freezing, low-temperature airflow is added to crush
800-1000 mesh powder obtained in machine.
4. a kind of Radix Panacis Quinquefolii breaking cellular wall micropill according to any one of claim 3, it is characterised in that the particle diameter of the micropill is
60-120μm。
5. the preparation method of any one the Radix Panacis Quinquefolii breaking cellular wall micropill as described in claim 1-4, it is characterised in that including following
Step：
Step 1, Feedstock treating：Radix Panacis Quinquefolii 5-8 parts are taken, is cleaned, decontamination, it is standby after being dried；Take 6～8 parts of carbomer, ethyl fine
After 5～7 parts of dimension element, stearic acid 3-5 parts, 30～90 parts of Microcrystalline Cellulose are crushed, add nanoscale grinder that powder is obtained standby；
Step 2, prepare suspension：Taking 1000 parts of purified water adds Pulvis Talci 10-20 parts, plasticizer 20-30 parts to be sufficiently stirred for making
Coating suspensions；
Step 3, breaking cellular wall powder：In taking step 1, Radix Panacis Quinquefolii makes Radix Panacis Quinquefolii wall cell disruption powder using low-temperature airflow comminuting method；
Step 4, pill：By obtained Radix Panacis Quinquefolii wall cell disruption powder 5-8 parts in step 3 with after in step 1, obtained powder mixes, employing
Extrusion is thrown circule method and micropill is obtained；
Step 5, coating：Coating suspensions in step 2 are added into seed-coating machine, coating solution mode is sprayed by step 3 bottom of using
Micropill is coated using micropill, and dry in the air ball 10h.
6. the preparation method of a kind of Radix Panacis Quinquefolii breaking cellular wall micropill according to claim 5, it is characterised in that in the step 2
Low-temperature airflow comminuting method concretely comprise the following steps：
A. draw materials：Medical material is chosen, decontamination is cleaned, is filtered dry；
B. coarse pulverization：Material is put into powder beater carries out coarse pulverization, obtains 80-100 mesh coarse grain；
C. pretreatment：Coarse grain is dried, is then electrified to process 10-40min；
D. it is finely divided：Pretreated coarse grain is added into ultrafine crusher, 300-500 mesh particulates after crushing, are obtained；
E. reprocess：Particulate is placed in dilute alkaline soln and soaks 1-12h, added weak acid that pH value is adjusted to less than 7, soak 1-12h,
Then particulate is filtrated to get, is repeated 1-2 time；
F. comminution by gas stream：To be filtrated to get particulate cold drying, freezing after, add low-temperature airflow pulverizer, obtain 800-1000
Purpose powder, collects finished powder and is medical material wall cell disruption powder；
Pretreatment described in step c is to carry out at -5 DEG C -0 DEG C in temperature；
Energization described in step c is processed as coarse grain being immersed in galvanization 10-45min, power supply in 9%-11% carbon acid solutions
Voltage 5-7V；
Carried out in step e at low ambient temperatures, ambient temperature is 0 DEG C -4 DEG C；Described dilute alkaline soln is the hydrogen that PH is 8.2-8.8
One or more in sodium hydroxide solution, aqua calcises, iron hydroxide solution；
Weak acid described in step e is carbonic acid or acetic acid；
After step e adds weak acid, pH value is adjusted to 6-6.5；
Step f comminution by gas stream is carried out under vacuum environment or oxygen free condition, and it is -0.073MPa that the vacuum environment is vacuum
～-0.08MPa；In 0.8-3MPa, operating temperature is -3 DEG C -7 DEG C to the air pressure of comminution by gas stream.
7. the preparation method of a kind of Radix Panacis Quinquefolii breaking cellular wall micropill according to claim 5, it is characterised in that in the step 3
Extrusion is thrown circule method and is concretely comprised the following steps：By material powder mix homogeneously, Jing is extruded into fine strip shape, granulation, then uses centrifugal turntable
It is rolled onto the pill of high proper sphere degree.
8. a kind of preparation method of Radix Panacis Quinquefolii breaking cellular wall micropill according to claim 5, it is characterised in that the work temperature of coating
Degree at 60 DEG C ± 5 DEG C, 20 h of duration, coating weight gain is 10%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611158300.8A CN106580917A (en) | 2016-12-15 | 2016-12-15 | American ginseng wall-breaking pellet and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611158300.8A CN106580917A (en) | 2016-12-15 | 2016-12-15 | American ginseng wall-breaking pellet and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107998290A (en) * | 2017-12-29 | 2018-05-08 | 贺州市星辉科技有限公司 | A kind of dendrobium candidum compound buccal lozenge and its preparation process |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462717A (en) * | 2010-11-19 | 2012-05-23 | 天津尖峰弗兰德医药科技发展有限公司 | American ginseng extract pellet and preparation method thereof |
| CN106074450A (en) * | 2016-06-27 | 2016-11-09 | 嘉兴杰顺工业设计有限公司 | The bioactivity protective technique prepared for medical material superfine powder |
-
2016
- 2016-12-15 CN CN201611158300.8A patent/CN106580917A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462717A (en) * | 2010-11-19 | 2012-05-23 | 天津尖峰弗兰德医药科技发展有限公司 | American ginseng extract pellet and preparation method thereof |
| CN106074450A (en) * | 2016-06-27 | 2016-11-09 | 嘉兴杰顺工业设计有限公司 | The bioactivity protective technique prepared for medical material superfine powder |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107998290A (en) * | 2017-12-29 | 2018-05-08 | 贺州市星辉科技有限公司 | A kind of dendrobium candidum compound buccal lozenge and its preparation process |
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Application publication date: 20170426 |