CN106556709A - The micro flow control chip device comprising hydrophobic substrate of coupling Dual Drive pattern - Google Patents
The micro flow control chip device comprising hydrophobic substrate of coupling Dual Drive pattern Download PDFInfo
- Publication number
- CN106556709A CN106556709A CN201510639145.0A CN201510639145A CN106556709A CN 106556709 A CN106556709 A CN 106556709A CN 201510639145 A CN201510639145 A CN 201510639145A CN 106556709 A CN106556709 A CN 106556709A
- Authority
- CN
- China
- Prior art keywords
- micro
- substrate
- fluidic chip
- terminal
- ultrasound wave
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention relates to a kind of micro flow control chip device comprising hydrophobic substrate of coupling Dual Drive pattern, belongs to analysis field tests.The substrate of micro-fluidic chip is made using polydimethylsiloxane i.e. PDMS that is cheap and easily processing, a physical presence series difficult problem, this case are directed to the serial difficult problem.This case main points are, substrate selectes the PDMS with ecosystem surface, and by the elastic clip that miniature ultrasonic transducer units are attached on its clamping limb with elastic force snap-in location the micro-fluidic chip test liquid stream terminal its neighbor positions, interfacial tension is reduced with ultrasound wave, strong absorbabilities of the PDMS to ultrasound wave is utilized simultaneously, reach ultrasonic intensity rapid decrement in the short distance, so as to form interfacial tension difference at the two ends of the chip, the difference provide it is a kind of drive test liquid stream along strength from hydrophobic capillary channel to terminal direction flowing, the strength and while its mechanicalness pumping strength intercouples with the Micropump that includes in structure, Collaboration.
Description
Technical field
The present invention relates to a kind of micro flow control chip device comprising hydrophobic substrate of coupling Dual Drive pattern, belongs to analysis test neck
Domain.
Background technology
For the microflow control technique overall general picture of itself, may refer to famous micro-fluidic expert Mr. Lin Ping Cheng and go out not long ago
Monograph " diagram Microfluid based Lab on a chip ", the monograph via Science Press publish, the monograph is for microflow control technique
Past, now, and, vision of the future etc. aspect, suffer from detail, be deep into long discussion of detail.
The field that micro-fluidic chip is often applied to includes carrying out various analyses, detection to the sample solution containing biomacromolecule.
The basic framework of micro-fluidic chip, including the substrate for being etched with small fluid course and the cover plate for fitting together therewith,
Small fluid course on the substrate, before assembling upper cover plate, it is apparent on see to be exactly some micro-channel, be when thereon
After covering cover plate, just real closure forms the small fluid course, and the conduit inner surface of the micro-channel is together with surround this
The part cover plate of micro-channel constitutes described small fluid course together；So, it is clear that this after assembling is completed is small
Fluid course, the major part of its inner surface area is the inner surface area of that micro-channel, in other words, in the micro-channel
The state or property on surface substantially determines the integrality or property of the small fluid course；Therefore say, this structure is in base
The inner surface state or inner surface property of the micro-channel on piece is key factor；In principle, it is any to keep or protecting substantially
The material of its solid forms is held, can be used to make substrate and cover plate, such as, the material that can act as substrate and cover plate can be with
It is monocrystalline silicon piece, piezoid, sheet glass, high polymer such as polydimethylsiloxane, polymethyl methacrylate, Merlon etc.
Deng；Certainly, the selection of substrate can be with identical with the selection of cover plate, it is also possible to differs；From material consumption, manufacture difficulty and
Application popularization prospect etc. aspect from the point of view of, there is not little difference between these materials, especially the selection of that substrate, affect compared with
Greatly.
In various substrate making materials, polydimethylsiloxane, i.e. PDMS, comparatively very easy molding, so
Substrate on make that micro-channel is extremely simple, and the lower cost for material makes substrate with the polydimethyl siloxane material,
Suppress or etch micro-channel thereon, and the cover plate made with glass or the cheap material such as polypropylene or other plastic sheets is engaged,
It is a kind of more satisfactory selection seemingly；Certainly, patch material can also be selected using cheap polydimethyl siloxane material：
So, scheme of this substrate selection for polydimethyl siloxane material, material are extremely cheap, make extremely simple, seem and should also be as
It is extremely easy to popularize, promotes.
But, thing is really not so simple.
First, this polydimethyl siloxane material, that is, the material referred to by the letter PDMS that abridges, itself are a kind of strong
Hydrophobic material, builds micro-channel on this material, if not carrying out the modified operation for the micro-channel surface, then,
Integral installation with after completing, that is, after covering cover plate, because of structure in the micro-channel its inner surface occupy most liquid circulation
The inner surface in road, then, the PDMS micro-channel inner surface its strong hydrophobic property is deciding factor, and it can cause class
Be similar to aqueous solution the fine liquid stream of polar liquid by becoming very difficult, its flow resistance is big, or even general Micropump is all
It is difficult to promote, certainly, if cover plate is also selected using the PDMS material, then, problem is substantially identical, similar；
Therefore, among prior art, modification is modified particular for the micro-channel inner surface on the PDMS material, is necessary
Operation；So, this is pretty troublesome for the modified operation of PDMS micro-channel inner surfaciesThat falls nor this problem, structure
Into serious technical puzzlement, it is another problem：PDMS polymer molecules tool inside this PDMS material substrate its body phase
There is the characteristic for diffusing to the surface automatically, migrating, PDMS polymer molecules are diffused to the surface automatically, moved inside this substrate body phase
The characteristic of shifting, by cause that micro-channel its inner surface through surface modifying and decorating it is modified after state can not maintain foot
The enough long time, being held time of the micro-channel after that is surface-modified its inner surface state be substantially only sufficient to, and to complete experiment indoor
The time of portion's test experiments needs；In other words, PDMS micro-channel inner surfacies of or surface modification modified through surface, its
The apparent condition formed after modified or after saying modification can not be lasting, but soon automatically tends to or say become surface again and change
Apparent condition before property, returns to the strong hydrophobic apparent condition of that script in the shorter time, then, just think,
Such micro-fluidic chip can be made in a large number, mass storage, be widely popularized, and answer is it is obvious that is, impossible.
Micro-channel on this PDMS material, if not doing surface modification, cannot pump similar to the fine liquid stream of polar solvent of aqueous solution
Send and pass through, chip also cannot just be used；And if having done surface modification, the state after its modification cannot be persistently kept again, also
Being equally cannot popularization and application.
So, how to accomplish substrate can either be made using cheap PDMS material, and can release table in the micro-channel
Face decorating state cannot persistently, chip cannot make in a large number, deposit and then be widely popularized and such a make this area numerous specially in a large number
The puzzlement that industry personnel are entangled with for a long time, the highly difficult problem that exactly one its obvious technology barrier can not be despised.
Be present many days in the highly difficult problem, so far, not yet properly settled.
Second, the PDMS material of non-surface modification, above it is stated that, its surface is strongly hydrophobic, this strong hydrophobic
Material surface and there is another problem, that is, biomacromolecule can be adsorbed in this strong hydrophobic PDMS surfaces, and
And, the depression that these adsorbed biomacromolecules can also be further further on PDMS surfaces gradually falls into gradually deep, directly
It is trapped within the body phase of PDMS substrates, in fact to heavy, this process is partly also due to inside PDMS material body phase
Polymer molecule have diffuse to the surface, travel motion is caused；Such case, it is also possible to explain from another angle, i.e.
Continuously from inside PDMS body phases to its diffusion into the surface, migration those polymer molecules, its motion result, be by
Gradually those are involved within the body phase of PDMS substrates, briefly by the biomacromolecule of surface adsorption, these are inhaled
Attached biomacromolecule is exactly to be swallowed up by PDMS substrate body phases；So, this PDMS substrates body phase swallows up biomacromolecule
Phenomenon, the impact caused by which, the severe deviations of all kinds of test data of experiment for necessarily causing to be related to biomacromolecule.
As described above, the problem of PDMS substrates is, its not only surface adsorption biomacromolecule, and swallow up biomacromolecule,
So, as experiment test object biomacromolecule its disappear will not because surface saturation adsorb and stop, but, no
It is disconnected adsorbed, also constantly swallowed up.
With regard to PDMS substrates in related experiment test process its body phase constantly swallow up test associated biomolecule macromole phenomenon, separately
A kind of explanation is to say, there are substantial amounts of Minute pores in PDMS body phases, associated biomolecule macromole by after surface adsorption, depression
Into these Minute pores, and then swallowed up；However, inventor thinks, those can allow the air point of miniature scale
Son clamp-ons the Minute pores therebetween, is not equal to them and also can directly allow that the biomacromolecule of relative large scale is entered, and two
Person's difference on yardstick is huge, must not make sweeping generalizations.Explanation is bypassed, and in any case, the biology of object is analyzed as dependence test
Macromole is adsorbed by PDMS substrate micro-channel inner surface, and then is constantly swallowed up by PDMS substrate body phases, and this is known objective
The phenomenon of presence.
In order to prevent this PDMS substrate bodies relative to the effect of swallowing up of biomacromolecule, can be from containment PDMS surfaces opposite
The absorption of thing macromole addressing, method be aiming at the PDMS material surface be chemically modified it is modified, for
For PDMS is for the situation of substrate material, modified, Jing Guohua is chemically modified to the surface of described micro-channel part exactly
The micro-channel inner surface of modification is learned, its absorption to biomacromolecule can be contained, and then avoided biomacromolecule quilt
PDMS substrate body phases are swallowed up；But, or that old problem, that is, the chemical modification on PDMS material surface changes
Apparent condition after property persistently cannot keep, the polymer molecule inside the PDMS substrate body phases its diffuse to the surface automatically,
The process of migration, soon can become that again script strong through the micro-channel inner surface state that surface chemical modification is modified and dredge
The state of water and strong adsorption biomacromolecule, in other words, no matter how professionals in the field turn from side to side, the PDMS
Substrate its micro-channel inner surface is always rapidly to strong hydrophobic surface state evolution.
So, how can either obtain that PDMS material price is extremely cheap, substrate makes extremely easy benefit, can reach again
Growth stage contains the absorption process of the PDMS substrate micro-channel inner surfacies to biomacromolecule, and then prevents PDMS substrate body phases
The effect of swallowing up to biomacromolecule so that related chip manufactured goods are able to maintain that a prolonged enough, rational shelf-life,
It is exactly a very thorny difficult problem.The difficult problem makes the numerous specialties in this area as another difficult problem addressed above, equally
Personnel are entangled with for a long time, perplex, and the difficult problem is equally the highly difficult problem that its obvious technology barrier can not be despised.The hardly possible
Also be present many days in topic, so far, also not yet properly settled.
Third, as described above, the PDMS micro-channel inner surfacies are strongly hydrophobic, and targetedly surface chemical modification or come to the surface
Learn modification to be again difficult to persistently, therefore, actually can only its surface is modified or surface modification after apparent condition still belong to effectively short
It is used within phase；If have passed through that ofer short duration expiry date, and still by force if use, due to surface shape
State already again near hydrophobic state, drives test liquid stream then to certainly exist than larger flow resistance using usual Micropump,
So, test liquid just can only be forced by increasing Micropump pump power and pumping pressure to flow to target direction flowing, as described above,
This PDMS material is soft, pumps test liquid stream with the pumping pressure of too high, machinery, and which enters will to cause the substrate
Sample end includes that the micro-channel of sample introduction end near zone occurs bubbling, expanded, distortion, deformation, also, this high-pressure situations
Under, the micro-channel and its periphery in the sample introduction end and its near zone is also susceptible to the stripping between substrate and cover plate, this feelings
Under shape, the crack of the appearance between the substrate formed into after the stripping and cover plate is flow over by sample solution everywhere, this reality
Border causes the damage of the micro-fluidic chip；Certainly, if the surface is modified or surface modification is not in place if originally, also result in
There is said circumstances within of short duration usual effect duration；It is in the case where liquid stream driving is carried out using additional Micropump merely, above-mentioned
The problem is present all the time.If as described above, do not did that any surface is modified completely or the pre action such as surface modification,
So, the above-mentioned problem will be even more serious, even without occur sample introduction end and its micro-channel bubbling described near zone, it is expanded,
Between distortion, deformation and substrate and cover plate the problems such as peel off, merely because the flow resistance is excessive, using high pressure Micropump also not
Test liquid stream must be driven to march forward towards terminal side.
The content of the invention
The technical problem to be solved is to provide a package solution, while solving three for addressing above
The a series of difficult problem for actually mutually involving together of aspect.
The present invention solves the technical problem by following scheme, and the device that the program is provided is a kind of coupling Dual Drive pattern
Micro flow control chip device comprising hydrophobic substrate, the structure of the device include micro-fluidic chip, and the structure of the micro-fluidic chip includes
The end of the substrate installed together bonded to each other and cover plate, its test liquid stream sample introduction end of the micro-fluidic chip and the sample fluid flow
End is located remotely from each other, the distance between the sample introduction end and the terminal between 3 centimetres and 10 centimetres, it is important that, the substrate its
Material is polydimethylsiloxane material, and its surface of the substrate is the surface of primary form, the surface of the primary form its be meant to
Be not through any surface chemical modification or any surface chemical modification the material primary form surface, the device
Structure also includes elastic clip, the neighbouring described terminal of two opposite clamping limb snap-in locations of the elastic clip in the micro-fluidic chip
Position, on a clamping limb at least in attach fixation is equiped with miniature ultrasonic transducer units, and, high frequency vibrating
Electric signal transmission cable is swung, one end and the miniature ultrasonic transducer units of the higher-order of oscillation electric signal transmission cable link together；
The elastic clip provides a function of facilitating the device to disassemble；The miniature ultrasonic transducer units its major functions is in micro-fluidic core
When the actual sample introduction of piece is tested, the ultrasound wave launched using which is reducing in sample solution and its inner passage of the micro-fluidic chip
Interfacial tension between wall so as to can be compatible, also, changed with the miniature ultrasonic using the sample introduction end and the terminal
Difference that can be on the distance between device installation position difference and its ultrasonic intensity for being experienced, sample introduction end described in induced synthesis
Difference between its interfacial tension and the terminal its interfacial tension, the interfacial tension difference meeting between the micro-fluidic chip two ends
Pressure gap is formed between the two ends of the micro-fluidic chip, the pressure gap can drive sample solution to the end flow；
The miniature ultrasonic transducer units its functions also include with its ultrasound wave launched check biomacromolecule contained in sample its
Absorption on the micro-fluidic chip its inner passage inner surface, and then check substrate its body phase of the polydimethylsiloxane material
The effect of swallowing up to the biomacromolecule；Substrate its function of the polydimethylsiloxane material that is soft and having elasticity is included with which
Property to the strong absorption of ultrasound wave, is absorbed strongly to ultrasound wave, and thereby in the micro-fluidic chip terminal to the sample introduction
The rapid decrement of ultrasonic intensity is realized within limited short distance between end；And, Micropump, the Micropump are connected with the sample introduction end
Connect；The function of the Micropump is that the interfacial tension between the inwall of the sample solution and its inner passage of micro-fluidic chip is received should
Ul-trasonic irradiation and reduce, under the precondition that the alternate compatibility increases, come and the ultrasound with the mechanicalness of Micropump pumping strength
Interfacial tension difference its driving force brought between the two ends of ripple induction is supported mutually, adjusts mutually, is mutually coupled,
One is pooled in the way of Collaboration drives test liquid to flow to the strength of the terminal direction flowing.
One word of Micropump art-recognized meanings of itself are known for the professional in micro-fluidic chip field.
The Micropump can both be the Micropump of external form；The Micropump can also be done into or say inside the embedded micro-fluidic chip
The Micropump of the built in version of its sample introduction end structure position or the sample introduction end Near-neighbor Structure position.
For example miniature piezoelectric pump of the Micropump, miniature peristaltic pump or miniature air driven pump.
One word of elastic clip art-recognized meanings of itself are known.
For one word of the ultrasonic transducer art-recognized meanings of itself of professional only with regard to to(for) ultrasonic technology field, it is public
Know.
Various sizes, variously-shaped ultrasonic transducer are commercially available；Commercially available miniature ultrasonic transducer units its sizes can be with
It is little to only with millimeter calculate magnitude.
Only with regard to miniature ultrasonic transducer units its technique for fixing on general industry application solid body surface itself and
Speech, for the professional in ultrasonic technology field, is known general technology.This case is not to this expansion superfluous words.
Only with regard to naked PDMS substrates itself micro-channel molding or lithographic technique for, be open-and-shut known technology.
The industrial products market of involved its all size of higher-order of oscillation electric signal transmission cable is on sale.
The structure of the device can also include higher-order of oscillation electric signal generator；Which is another for the higher-order of oscillation electric signal transmission cable
One end can be connected with the higher-order of oscillation electric signal generator.
The involved higher-order of oscillation electric signal generator technology of itself, for the professional in ultrasonic technology field, be
It is simple and known；The higher-order of oscillation electric signal generator can be customized to ultrasonic instrument specialized factory.
The preferred scope of the miniature ultrasonic transducer units its specified ultrasonic emitting power be between 2 milliwatts and 9000 milliwatts it
Between；The preferred scope of the frequency of the miniature ultrasonic transducer units its ultrasound wave operationally launched be between 100KHz with
Between 12MHz.
This case device can further include some adnexaes certainly, and the adnexa for example can be used cooperatively with micro-fluidic chip
Electrically or optically testing equipment.The equipment that the electricity, optics etc. are used cooperatively with micro-fluidic chip, may refer to described
Monograph.
The cover plate in chip structure, its material can allow to be any electrical insulating property material, for example：Polypropylene, glass
Glass, polymethyl methacrylate, polydimethylsiloxane, etc., in order to make smaller size of micro-fluidic chip, such as do
Into the micro-fluidic chip of only 2.0 centimetres to 3.0 centimetres of super-small of length, and realize to ultrasound wave in the extremely short distance
Extremely fast decay, it may be preferred to polydimethylsiloxane is used as cover plate.Certainly, select on large-sized micro-fluidic chip
It is used as the cover plate using polydimethylsiloxane, and this case technical scheme is allowed.
The cover plate and substrate its thickness can allow the thickness for being easy to assemble for being any setting, the thickness of recommendation or say preferably
Thickness be between 1.0 millimeters and 5.0 millimeters.Less thickness is conducive to material-saving.
It is an advantage of the invention that in the terminal its elastic clip described in close position snap-in location of the micro-fluidic chip, with
The miniature ultrasonic transducer units of attached installation on the clamping limb of the elastic clip, using the miniature ultrasonic transducer units, which is launched
The ultrasound wave of low-power, high-frequency band so that without strong hydrophobic micro-fluidic chip internal pipeline of surface chemical modification
The compatibility between its tube wall and test object aqueous solution is significantly increased, and this is test liquid stream by possible there is provided a reality
Property；Meanwhile, using its strong absorbability to ultrasound wave of polydimethylsiloxane substrate, in shorter distance, also
Be, from the terminal to the very short distance of the only several centimeters yardstick the sample introduction end in, reach the quick of ultrasonic intensity
Successively decrease, the difference of the interfacial tension is thereby caused at the two ends of the micro-fluidic chip, the interfacial tension between the two ends
Difference can cause a kind of driving force, and because of interfacial tension difference, its function of caused driving force is to drive test liquid stream to exist to this kind
Originally flow to the terminal direction in strong hydrophobic capillary channel；And the simultaneous Micropump in structure, its function
It is that the interfacial tension between the inwall of the sample solution and its inner passage of micro-fluidic chip is received the ul-trasonic irradiation and dropped
Under the precondition that low, the alternate compatibility increases, carry out described two with the ultrasound wave induction with the mechanicalness pumping strength of the Micropump
Interfacial tension difference between end its driving force brought is supported mutually, adjusts mutually, is mutually coupled, with Collaboration
Mode pools one and drives test liquid to flow to the strength of the terminal direction flowing；The presence of the Micropump so that the miniature ultrasonic
Wave transducer its ultrasonic emitting intensity can be allowed to appropriate reduction, this in detection object containing ultrasound wave sensitive composition
Situation is particularly suitable for；And due to the presence of the ultrasonic transducer and its radiated ultrasound wave, it is possible to increase the alternate compatibility, drop
Low interfacial tension, and the two ends interfacial tensions difference special driving force brought by which is provided, then, in this case,
Test liquid stream its flow resistance in the micro-channel is greatly reduced, and correspondingly, the Micropump its running resistance is greatly reduced, so,
The Micropump just can be to carry out the pumping work for the sample solution than relatively low pumping pressure, due to mechanical pumping
Pressure is greatly reduced, therefore, in such a situation, just it is not susceptible to because sample introduction terminal tool pumping pressure is excessive and caused
Between the micro-channel bubbling of the sample introduction end and its near zone, expansion, deformation, distortion and the region substrate and cover plate
The problems such as stripping etc.；The scheme of this case Dual Drive coupling running and increased manipulation for the sample fluid flow action
Property, can allow for coming using the multiple indexs of ultrasonic intensity, ultrasonic frequency, Micropump pump power, Micropump pumping pressure etc.
It is many that flow rate, flowing action for the flowing includes that flow forward or time-out flowing or acceleration flowing etc. flowing action are carried out
Parameter is accurately manipulated；By the scheme of this case Dual Drive coupling running, entirely without must be to the base of the polydimethylsiloxane material
Piece its micro-channel etc. relevant surfaces carry out any surface chemical modification or surface chemical modification, have altogether dispensed with the surface chemistry
Modification or the laborious procedures of surface chemical modification；On the other hand, the ultrasound wave of the low-power, high-frequency band, additionally it is possible to containment examination
Absorption of the biomacromolecule in sample on literalness naked its inner surface of pipeline of polydimethylsiloxane substrate, and then contain
The swallow up effect of its body phase of polydimethylsiloxane substrate to the biomacromolecule；Due to described adsorption and described
Swallow up effect contained, therefore, dependence test result will be better able to objectively reflect practical situation.
Based on this case scheme, repair completely without the surface chemistry carried out for the polydimethylsiloxane substrate its relevant surfaces
Decorations or surface chemical modification operation, therefore, this surface chemical modification layer or surface chemical modification layer not need presence,
So, its body phase interior polymer molecule of the polydimethylsiloxane substrate constantly diffuse to the surface automatically, migrate its institute caused by
The damaging influence of the surface chemical modification layer or surface chemical modification layer is not also just present.
The technical scheme of this case has dissolved its application related one to polydimethylsiloxane substrate addressed above totally
Row technical barrier.Based on this case scheme, the polydimethyl siloxane material of this kind very cheap and easily processing and fabricating just has can
Can in the micro-fluidic chip, which be prepared, production, application etc. field play bigger effect.
The miniature ultrasonic transducer units have been installed in fixation on the elastic clip its clamping limb in this case structure, be this architecture provides
One facilitates the function that the device is disassembled, thus, the elastic clip just can be conveniently together with miniature ultrasonic transducer units appended thereon
Ground is mutually disengaged with the micro-fluidic chip, then, the component that the part freely can depart from just can be reused with circulating benignly and be permitted
Repeatedly；The architectural feature is conducive to the use cost for saving the device.
Description of the drawings
Fig. 1 is its rough outside side view of this case device.
In figure, 1 is elastic clip, and 2,7 is two clamping limbs of elastic clip respectively, and 3 is the terminal of the micro-fluidic chip,
4 is the sample introduction end of the micro-fluidic chip, and 5 is the substrate of polydimethylsiloxane material, and 6 is cover plate, and 8 is miniature super
Acoustic wave transducer, 9 is higher-order of oscillation electric signal transmission cable, and 10 is tension spring, and 11 is infusion tube, and 12 is Micropump；
The spring clamp structure in legend is only the legend structure illustrated, and actual spring clamp structure is not limited to the legend spring clamp structure；Figure
Example in arrow indicate the micro-fluidic chip its in actual motion, by pressure at two ends difference drive, the flowing of its test liquid stream
Direction.
Specific embodiment
In this case that Fig. 1 is shown embodiment, the structure of the device includes micro-fluidic chip, the knot of the micro-fluidic chip
Structure includes the substrate 5 installed together bonded to each other and cover plate 6, its test liquid stream sample introduction end 4 of the micro-fluidic chip and the sample
The terminal 3 of fluid flow is located remotely from each other, the distance between the sample introduction end 4 and the terminal 3 between 3 centimetres and 10 centimetres,
It is important that, the substrate 5 its material is polydimethylsiloxane material, and its surface of substrate 5 is the surface of primary form, the original
The surface of raw form its be intended to refer to not through any surface chemical modification or the original of the material of any surface chemical modification
The surface of raw form, the structure of the device also include elastic clip 1, and two opposite clamping limbs 2,7 of the elastic clip 1 are engaged
The position of the neighbouring described terminal 3 of the micro-fluidic chip is positioned at, fixed dress on a clamping limb at least in, is attached
Miniature ultrasonic transducer units are provided with, in this example, the miniature ultrasonic transducer units 8 are fixed on clamping limb 7 by attaching, and,
Higher-order of oscillation electric signal transmission cable 9, one end of the higher-order of oscillation electric signal transmission cable 9 and the miniature ultrasonic transducer units 8
Link together；All fixed respectively on two clamping limbs 2,7 miniature ultrasonic transducer units can also be installed, but it is general next
Say, miniature ultrasonic transducer units being installed only on a clamping limb and being just enough to deal with using needs, the elastic clip 1 provides one
The function of facilitating the device to disassemble；The miniature ultrasonic transducer units 8 its major functions is sample introduction test actual in micro-fluidic chip
When, the ultrasound wave launched using which is reducing the interface between sample solution and the inwall of its inner passage of micro-fluidic chip
Power so as to can be compatible, also, utilize the sample introduction end 4 and the terminal 3 to install with the miniature ultrasonic transducer units 8
Difference in the distance between position difference and its ultrasonic intensity for being experienced, its interface of sample introduction end 4 described in induced synthesis
Difference between tension force and the terminal 3 its interfacial tension, the interfacial tension difference between the micro-fluidic chip two ends 3,4
Pressure gap can be formed between the two ends 3,4 of the micro-fluidic chip, the pressure gap can drive sample solution to the end
3 directions are held to flow；The miniature ultrasonic transducer units 8 its functions also includes checking with its ultrasound wave launched contained in sample
Biomacromolecule its absorption on the micro-fluidic chip its inner passage inner surface, and then check the polydimethylsiloxane material
Swallow up effect of its body phase of substrate 5 of matter to the biomacromolecule；The base of the polydimethylsiloxane material that is soft and having elasticity
Piece 5 its function includes, with its property to the strong absorption of ultrasound wave, absorbing strongly ultrasound wave, and thereby micro-fluidic at this
The chip terminal 3 realizes the rapid decrement of ultrasonic intensity within the limited short distance between the sample introduction end 4；And, it is micro-
Pump 12, the Micropump 12 are connected with the sample introduction end 4；The function of the Micropump 12 is, in the sample solution and the micro-fluidic chip
Interfacial tension between the inwall of its inner passage receive the ul-trasonic irradiation and reduce, the alternate compatibility increase precondition under,
Come with the mechanicalness of the Micropump 12 pumping strength and the interfacial tension difference between the two ends 3,4 of ultrasound wave induction its
The driving force brought is supported mutually, adjusts mutually, is mutually coupled, and pools one and drive sample in the way of Collaboration
Liquid flows to the strength of 3 direction of terminal flowing.
Arrow in legend indicate the micro-fluidic chip its in actual motion, by two ends 3,4 pressure differentials drive, its examination
The flow direction of sample liquid stream.
Fig. 1 is depicted without the associate members such as the higher-order of oscillation electric signal generator.
The Micropump 12 can be customized to specialized factory.
Involved elastic clip 1 is commercially available.Be available for commercially available alternative spring clamp structure that this case structure uses and moulding and
Size etc., quality are various, and concrete elastic clip pattern can be selected as needed.
Involved miniature ultrasonic transducer units 8 are commercially available；Can also customize to ultrasonic transducer producer.
Involved higher-order of oscillation electric signal transmission cable 9 is commercially available；Can also be to ultrasonic transducer producer or cable special manufacturer
Family's customization.
Involved higher-order of oscillation electric signal generator market has the product for being close to needs commercially available；Can also customize to relevant manufacturers.
Its inner passage of the micro-fluidic chip involved by this case is the pipeline of hydrophobic capillary tube form.
The Micropump can both be the Micropump of external form；The Micropump can also be done into or say inside the embedded micro-fluidic chip
The Micropump of the built in version of its sample introduction end structure position or the sample introduction end Near-neighbor Structure position.Micropump in legend is external form
Micropump；The Micropump can certainly do into or say sample introduction end or its Near-neighbor Structure position inside the embedded microfluidic chip structure
The Micropump of the built in version, its basic structure key element are identical with the Micropump of external form.
Claims (5)
1. the micro flow control chip device comprising hydrophobic substrate of Dual Drive pattern is coupled, and the structure of the device includes micro-fluidic chip,
The structure of the micro-fluidic chip includes installing substrate together bonded to each other and cover plate, the micro-fluidic chip its test liquid stream sample introduction
The terminal with the sample fluid flow is held to be located remotely from each other, the distance between the sample introduction end and the terminal are between 3 centimetres and 10 centimetres
Between, it is characterised in that the substrate its material is polydimethylsiloxane material, and its surface of the substrate is the surface of primary form,
Its material for being intended to refer to not through any surface chemical modification or any surface chemical modification of the surface of the primary form
Primary form surface, the structure of the device also includes elastic clip, and two opposite clamping limb snap-in locations of the elastic clip exist
The position of the neighbouring described terminal of the micro-fluidic chip, attaching fixation on a clamping limb at least in is equiped with miniature
Ultrasonic transducer, and, higher-order of oscillation electric signal transmission cable, one end of the higher-order of oscillation electric signal transmission cable are micro- with this
Type ultrasonic transducer links together；The elastic clip provides a function of facilitating the device to disassemble；The miniature ultrasonic is changed
Can device its major function be when the actual sample introduction of micro-fluidic chip is tested, the ultrasound wave launched using which reduce sample solution and
Interfacial tension between the inwall of its inner passage of micro-fluidic chip so as to can be compatible, also, using the sample introduction end with
And the distance between the terminal and miniature ultrasonic transducer units installation position difference and its ultrasonic intensity for being experienced
On difference, the difference between its interfacial tension of sample introduction end described in induced synthesis and the terminal its interfacial tension, the micro-fluidic core
Interfacial tension difference between the piece two ends can form pressure gap between the two ends of the micro-fluidic chip, the pressure gap meeting
Sample solution is driven to the end flow；The miniature ultrasonic transducer units its functions also includes checking with its ultrasound wave launched
Its absorption on the micro-fluidic chip its inner passage inner surface of contained biomacromolecule in sample, so check this poly- two
Swallow up effect of its body phase of the substrate of methylsiloxane material to the biomacromolecule；The polydimethylsiloxanes that are soft and having elasticity
The substrate of alkane material its function includes, with its property to the strong absorption of ultrasound wave, absorbing strongly ultrasound wave, and thereby existing
The micro-fluidic chip terminal realizes the rapid decrement of ultrasonic intensity within the limited short distance between the sample introduction end；With
And, Micropump, the Micropump are connected with the sample introduction end；The function of the Micropump is, in the sample solution and the micro-fluidic chip inside which
Interfacial tension between the inwall of passage receive the ul-trasonic irradiation and reduce, the alternate compatibility increase precondition under, it is micro- with this
The mechanicalness pumping strength of pump come the interfacial tension difference between the two ends of the ultrasound wave induction driving force brought by which
Amount is supported mutually, adjusts mutually, is mutually coupled, and pools one and drive test liquid to flow to the terminal in the way of Collaboration
The strength of direction flowing.
2. the micro flow control chip device comprising hydrophobic substrate of a kind of coupling Dual Drive pattern according to claim 1, which is special
Levy and be, its material of the cover plate is polydimethylsiloxane material.
3. the micro flow control chip device comprising hydrophobic substrate of a kind of coupling Dual Drive pattern according to claim 1, which is special
Levy and be, the cover plate and substrate its thickness are between 1.0 millimeters and 5.0 millimeters.
4. the micro flow control chip device comprising hydrophobic substrate of a kind of coupling Dual Drive pattern according to claim 1, which is special
Levy and be, the structure of the device also includes higher-order of oscillation electric signal generator, which is another for the higher-order of oscillation electric signal transmission cable
End is connected with the higher-order of oscillation electric signal generator.
5. the micro flow control chip device comprising hydrophobic substrate of a kind of coupling Dual Drive pattern according to claim 1, which is special
Levy and be, between 2 milliwatts and 9000 milliwatts, this is miniature for the miniature ultrasonic transducer units its specified ultrasonic emitting power
The frequency of ultrasonic transducer its ultrasound wave operationally launched is between 100KHz and 12MHz.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510639145.0A CN106556709A (en) | 2015-09-24 | 2015-09-24 | The micro flow control chip device comprising hydrophobic substrate of coupling Dual Drive pattern |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510639145.0A CN106556709A (en) | 2015-09-24 | 2015-09-24 | The micro flow control chip device comprising hydrophobic substrate of coupling Dual Drive pattern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106556709A true CN106556709A (en) | 2017-04-05 |
Family
ID=58417255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510639145.0A Pending CN106556709A (en) | 2015-09-24 | 2015-09-24 | The micro flow control chip device comprising hydrophobic substrate of coupling Dual Drive pattern |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106556709A (en) |
Citations (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080200343A1 (en) * | 2007-02-15 | 2008-08-21 | Clinical Microsensors, Inc, Dba Osmetech Molecular Diagnostics | Fluidics Devices |
| US20090129981A1 (en) * | 2007-11-20 | 2009-05-21 | Canon Kabushiki Kaisha | Microfluidic device |
| CN101620227A (en) * | 2009-07-12 | 2010-01-06 | 宁波大学 | Multi-channel chip for cholera diagnosis based on structural conductive macromolecular material technology |
| CN101629143A (en) * | 2008-12-02 | 2010-01-20 | 中国科学院上海微系统与信息技术研究所 | Microfluidic cell array chip for high-throughput medicament screening, method and use |
| US20100086441A1 (en) * | 2008-10-08 | 2010-04-08 | Samsung Electronics Co., Ltd. | Beam radiating device, bio-chemical analyzer including the beam radiating device, and bio-chemical analyzing system including the bio-chemical analyzer |
| US20100139377A1 (en) * | 2008-12-05 | 2010-06-10 | The Penn State Reserch Foundation | Particle focusing within a microfluidic device using surface acoustic waves |
| CN101881779A (en) * | 2010-05-31 | 2010-11-10 | 武汉大学 | Ultrasonic standing wave type micro-fluidic chip and preparation method thereof |
| US20110014297A1 (en) * | 2008-10-08 | 2011-01-20 | The Regents Of The University Of California | Multimodal therapeutic hybrid particle complex and system |
| CN101966473A (en) * | 2010-10-26 | 2011-02-09 | 武汉大学 | Micro fluid control screening chip based on ultrasonic standing wave and preparation method thereof |
| CN102478582A (en) * | 2011-10-08 | 2012-05-30 | 宁波大学 | Multi-channel microfluidic chip capable of detecting various subtype swine influenza viruses simultaneously |
| CN102527280A (en) * | 2012-01-11 | 2012-07-04 | 华中科技大学 | Micro mixing and micro reaction device |
| CN103058131A (en) * | 2012-12-19 | 2013-04-24 | 中国科学院上海微系统与信息技术研究所 | Manufacture method of reversible bonding micro-fluidic chip with high strength |
| CN103055985A (en) * | 2012-12-31 | 2013-04-24 | 兰州大学 | Polymer micro-fluidic chip batch manufacturing process based on metal wire hot pressing method |
| CN103111337A (en) * | 2013-02-04 | 2013-05-22 | 江苏大学 | Microfluidic experimental device for studying dynamic process of acoustic and electric field filter aid |
| CN103182334A (en) * | 2013-03-14 | 2013-07-03 | 上海交通大学 | Preparation method and application of electrochemical micro-fluidic sensing chip |
| CN106290852A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | Can the AIDS diagnosis device of Dual Drive CGCM of rapid disassembling |
| CN106290929A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | The hypotype swine flue detection device of the Dual Drive CGCM that can disassemble rapidly |
| CN106290526A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | The hypotype swine flue detection device of the Dual Drive CGCM conveniently disassembled |
| CN106268987A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | The controller used in syphilis diagnosis device of Dual Drive CGCM based on easily-disassembled framework |
| CN106290869A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | The controller used in syphilis diagnosis micro fluidic device of the Dual Drive CGCM of easily-disassembled framework |
| CN106290853A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | Take the AIDS diagnosis device of the Dual Drive CGCM of easily-disassembled framework |
| CN106290492A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | Driving component is easily-disassembled and cholera diagnosis device more capable of circulation |
| CN106290851A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | A kind of easily-disassembled cholera diagnosis micro fluidic device of Dual Drive CGCM |
-
2015
- 2015-09-24 CN CN201510639145.0A patent/CN106556709A/en active Pending
Patent Citations (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080200343A1 (en) * | 2007-02-15 | 2008-08-21 | Clinical Microsensors, Inc, Dba Osmetech Molecular Diagnostics | Fluidics Devices |
| US20090129981A1 (en) * | 2007-11-20 | 2009-05-21 | Canon Kabushiki Kaisha | Microfluidic device |
| US20100086441A1 (en) * | 2008-10-08 | 2010-04-08 | Samsung Electronics Co., Ltd. | Beam radiating device, bio-chemical analyzer including the beam radiating device, and bio-chemical analyzing system including the bio-chemical analyzer |
| US20110014297A1 (en) * | 2008-10-08 | 2011-01-20 | The Regents Of The University Of California | Multimodal therapeutic hybrid particle complex and system |
| CN101629143A (en) * | 2008-12-02 | 2010-01-20 | 中国科学院上海微系统与信息技术研究所 | Microfluidic cell array chip for high-throughput medicament screening, method and use |
| US20100139377A1 (en) * | 2008-12-05 | 2010-06-10 | The Penn State Reserch Foundation | Particle focusing within a microfluidic device using surface acoustic waves |
| CN101620227A (en) * | 2009-07-12 | 2010-01-06 | 宁波大学 | Multi-channel chip for cholera diagnosis based on structural conductive macromolecular material technology |
| CN101881779A (en) * | 2010-05-31 | 2010-11-10 | 武汉大学 | Ultrasonic standing wave type micro-fluidic chip and preparation method thereof |
| CN101966473A (en) * | 2010-10-26 | 2011-02-09 | 武汉大学 | Micro fluid control screening chip based on ultrasonic standing wave and preparation method thereof |
| CN102478582A (en) * | 2011-10-08 | 2012-05-30 | 宁波大学 | Multi-channel microfluidic chip capable of detecting various subtype swine influenza viruses simultaneously |
| CN102527280A (en) * | 2012-01-11 | 2012-07-04 | 华中科技大学 | Micro mixing and micro reaction device |
| CN103058131A (en) * | 2012-12-19 | 2013-04-24 | 中国科学院上海微系统与信息技术研究所 | Manufacture method of reversible bonding micro-fluidic chip with high strength |
| CN103055985A (en) * | 2012-12-31 | 2013-04-24 | 兰州大学 | Polymer micro-fluidic chip batch manufacturing process based on metal wire hot pressing method |
| CN103111337A (en) * | 2013-02-04 | 2013-05-22 | 江苏大学 | Microfluidic experimental device for studying dynamic process of acoustic and electric field filter aid |
| CN103182334A (en) * | 2013-03-14 | 2013-07-03 | 上海交通大学 | Preparation method and application of electrochemical micro-fluidic sensing chip |
| CN106290852A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | Can the AIDS diagnosis device of Dual Drive CGCM of rapid disassembling |
| CN106290929A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | The hypotype swine flue detection device of the Dual Drive CGCM that can disassemble rapidly |
| CN106290526A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | The hypotype swine flue detection device of the Dual Drive CGCM conveniently disassembled |
| CN106268987A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | The controller used in syphilis diagnosis device of Dual Drive CGCM based on easily-disassembled framework |
| CN106290869A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | The controller used in syphilis diagnosis micro fluidic device of the Dual Drive CGCM of easily-disassembled framework |
| CN106290853A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | Take the AIDS diagnosis device of the Dual Drive CGCM of easily-disassembled framework |
| CN106290492A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | Driving component is easily-disassembled and cholera diagnosis device more capable of circulation |
| CN106290851A (en) * | 2015-05-11 | 2017-01-04 | 宁波大学 | A kind of easily-disassembled cholera diagnosis micro fluidic device of Dual Drive CGCM |
Non-Patent Citations (9)
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107121545A (en) | Multichannel micro-fluidic chip device is used in the cholera diagnosis of dual drive coupling operating mode | |
| CN106290492A (en) | Driving component is easily-disassembled and cholera diagnosis device more capable of circulation | |
| CN107115902A (en) | The controller used in syphilis diagnosis micro flow control chip device of two kinds of type of drive coupling runnings | |
| CN107138188A (en) | The hypotype swine flu detection means for the dual drive CGCM conveniently disassembled | |
| CN107138186A (en) | It is capable of the AIDS diagnosis device of the dual drive CGCM of rapid disassembling | |
| CN107138185A (en) | The controller used in syphilis diagnosis micro fluidic device of the dual drive CGCM of easily-disassembled framework | |
| CN106290852A (en) | Can the AIDS diagnosis device of Dual Drive CGCM of rapid disassembling | |
| CN106556709A (en) | The micro flow control chip device comprising hydrophobic substrate of coupling Dual Drive pattern | |
| CN106290526A (en) | The hypotype swine flue detection device of the Dual Drive CGCM conveniently disassembled | |
| CN107138187A (en) | Couple the micro flow control chip device for including hydrophobic substrate of dual drive pattern | |
| CN106556708A (en) | The micro flow control chip device containing hydrophobic substrate of two kinds of type of drive coupling runnings | |
| CN107159322A (en) | The micro flow control chip device of the substrate containing PDMS based on dual drive CGCM | |
| CN106556711A (en) | For the micro flow control chip device of the double mode coupling driving of hydrophobic base sheet matter | |
| CN107670711A (en) | For the micro flow control chip device of the double mode coupling driving of hydrophobic base sheet matter | |
| CN107020157A (en) | A kind of micro flow control chip device for taking new fluid type of drive | |
| CN107138190A (en) | The controller used in syphilis diagnosis device of dual drive CGCM based on easily-disassembled framework | |
| CN107159323A (en) | For the controller used in syphilis diagnosis Multichannel device of the dual drive coupling running of hydrophobic substrate | |
| CN107159320A (en) | Multichannel and the cholera diagnosis micro flow control chip device of dual drive coupling running | |
| CN107121477A (en) | The controller used in syphilis diagnosis micro flow control chip device of operation principles is coupled based on dual drive | |
| CN106268987A (en) | The controller used in syphilis diagnosis device of Dual Drive CGCM based on easily-disassembled framework | |
| CN106248938A (en) | A kind of dimethyl siloxane makees the controller used in syphilis diagnosis micro flow control chip device of substrate | |
| CN107138184A (en) | Driving is with the easily-disassembled and recyclable cholera diagnosis device of component | |
| CN106290935A (en) | A kind of hypotype swine flue detection micro flow control chip device using strong hydrophobic substrate | |
| CN106556710A (en) | The micro flow control chip device containing PDMS substrates based on Dual Drive CGCM | |
| CN106290936A (en) | A kind of substrate material is the cholera diagnosis micro flow control chip device of PDMS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170405 |
|
| WD01 | Invention patent application deemed withdrawn after publication |