CN106552181A - A kind of Traditional Chinese medicine collagen protein silk and preparation method thereof - Google Patents
A kind of Traditional Chinese medicine collagen protein silk and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Traditional Chinese medicine collagen protein silk and preparation method thereof, to contain herb powder, shitosan, collagen, glacial acetic acid aqueous solution as spinning solution, the spinning solution is directly entered into solidified forming in coagulating bath from after spinning nozzle extrusion, collection obtains spun filament, short time cleaning is carried out as cleaning fluid using ethanol water to spun filament and 24～48 hours is incubated at 60～80 DEG C, obtain final product Traditional Chinese medicine collagen protein silk.The present invention is obtained Traditional Chinese medicine collagen protein silk using wet spinning, the slow release of Chinese medicine is realized, action time of the Chinese medicine in human body is extended, and effective components of Chinese medicinal is reduced for the pressure of the old human digestive system of body void, good absorption is realized, the purpose nourished is reached.
Description
Technical field
The invention belongs to drug preparation technique field, more particularly, to a kind of Traditional Chinese medicine collagen protein silk and preparation method thereof.
Background technology
The all one's life of people needs several stages such as experience growth, development, growth, maturation, aging.With advancing age, decline
The gradually arrival of old phase, the body of people also Lock-in each several part degradation phenomena.It is tinnitus, dim eyesight, alopecia, weak and feeble, spiritual
It is the elderly's problem encountered that depressed, resistance is poor, have a delicate constitution etc..The traditional Chinese medical science thinks, suitably carries out nourishing for Chinese medicine, can rise
To strengthening vital QI to eliminate pathogenic factors, physical fitness, the effect promoted longevity.How to nourish still need to it is dialectical treat, needs vary with each individual, because disease and
It is different, vary in different localities, because when and it is different, if it is improper to nourish, then run counter to desire, be harmful to body.Nourish for daily, adopt people more
With traditional Chinese medicinal material raw materials of directly taking food, but the elderly's taste are weaker, and the digestion of stomach is poor with the transportation capabilities of spleen, and tonic is more
To grow greasy product, so after taking, moment improves the concentration of the effective components of Chinese medicinal in body, not only can not be disappeared well
Change and absorb, stomach and intestine burden can be increased on the contrary, make digestive system be difficult to tackle body change in short-term, indigestion, mouth occur
Tongue life sore, lie awake all night, abdominal distension is discharged and the symptom such as rushes down.It is generally believed that it is many using flat tonic thing for nourishing for the elderly, for tool
There is the Chinese medicine of potent property（Such as ginseng, pilose antler etc.）Then adopt and repeatedly nourish on a small quantity, it is notable that though repeatedly nourish to delay
Solution gastrointestinal stress, but this step mode of nourishing can also be such that the digestive systems such as stomach and intestine are tested by step pressure, medicine
Effect also is gone soon soon, and overall efficacy is also had a greatly reduced quality.It follows that how the elderly of body void is gently nourished,
Absorption of the human body to effective components of Chinese medicinal is improved, extends Chinese medicine in the action time of human body, this is an important research direction.
The content of the invention
The gastrointestinal stress nourished for the elderly's Chinese medicine is big, drug effect is poor and Chinese medicine short was asked in the action time of human body
Topic, the invention provides a kind of Traditional Chinese medicine collagen protein silk and preparation method thereof.Gained Traditional Chinese medicine collagen protein silk can realize Chinese medicine
Gently discharge in human body, improve absorption of the elderly to effective components of Chinese medicinal, extend the action time of Chinese medicine.
The present invention is realized by following technology：
A kind of Traditional Chinese medicine collagen protein silk, the Traditional Chinese medicine collagen protein silk include the following raw material：Herb powder, shitosan, collagen egg
In vain, glacial acetic acid aqueous solution.
Preferably, the weight proportion of the Traditional Chinese medicine collagen protein silk is as follows：2～5 weight portion of herb powder, shitosan 10～
25 weight portions, 20～40 weight portion of collagen, 250～500 weight portion of glacial acetic acid aqueous solution.
Preferably, the glacial acetic acid aqueous solution is 0.1wt%～0.3wt% glacial acetic acid aqueous solutions.
Preferably, the herb powder is the dried rhizome of rehmannia, the tuber of dwarf lilyturf, radix polygonati officinalis, white fungus, Cordyceps sinensis, the stem of noble dendrobium, donkey-hide gelatin, Radix Angelicae Sinensis, people
One or more in ginseng, pilose antler, American Ginseng, sanchi flower, the fleece-flower root, radix pseudostellariae, glossy ganoderma is size-reduced and prepared.
In the present invention, inventor is to the physique in the selection of nourishing Chinese medicine material according to the elderly, the difference of symptom
Come carry out.Wherein the dried rhizome of rehmannia, the tuber of dwarf lilyturf, radix polygonati officinalis, white fungus, Cordyceps sinensis, the stem of noble dendrobium be adapted to To Be Protected from Heat, irritability, cheek are fired, dry pharyngalgia,
Be hard and dry, scanty drak urine or Huang, dysphoria in chestpalms-soles, night sweat, have a pain in the back, thin emission, red tongue body, tongue or light stripping, arteries and veins it is thin
The elderly of the symptoms such as number；Donkey-hide gelatin, Radix Angelicae Sinensis are adapted to have no peace of mind, palpitaition hardly possible dormancy, dispirited mind, lusterless complexion, nail are pale
The elderly；The suitable asthma of ginseng, American Ginseng, radix pseudostellariae is weak, few speech lazyness language, soft refreshing tired limb, do not feel like eating, memory loss are good for
Forget, rich in nutrition, the elderly for having a dizzy spell, having a sleepless night；Pilose antler is adapted to cold chilly, weakness of limbs, soreness and weakness of waist and knees, big loose stool
The elderly of thin, frequent urination；Sanchi flower be adapted to high blood pressure, blood fat height, decrease of memory, high liver fire, headache and dizzy it is old
Year people；The fleece-flower root is adapted to Light-headedness, palpitaition, insomnia, the elderly of the soreness and weakness of waist and knees of the deficiency of liver-yin and kidney-yin；Glossy ganoderma is adapted to dizziness not
Dormancy, palpitation, neurasthenia, the elderly of consumptive disease cough and asthma.
A kind of preparation method of Traditional Chinese medicine collagen protein silk, the preparation process of the Traditional Chinese medicine collagen protein silk is：
1）Collagen and shitosan are weighed and mix, with glacial acetic acid aqueous solution as solvent, with prepared at a temperature of 40～60 DEG C
Collagen-chitosan solution；
2）Herb powder is added in collagen-chitosan solution, homogeneous 30～60 minutes, obtain final product spinning just liquid；
3）Solidified forming in coagulating bath is directly entered after gained spinning solution is extruded from spinning nozzle under stress, collection is come into being
Silk, after cleaning to spun filament using ethanol water as cleaning fluid, is incubated 24～48 hours, i.e., under the conditions of 60～80 DEG C
Obtain Traditional Chinese medicine collagen protein silk.
Preferably, ethanol water of the ethanol water for 30wt%～50wt%.
Preferably, the time of the cleaning is 15～25 seconds.
Preferably, the aperture of the spinning nozzle is 0.01～0.05mm, and the pressure is 0.1～0.3MPa.
Preferably, metabisulfite solution of the coagulating bath for 15wt%～25wt%.
Preferably, a diameter of 0.04～0.08mm of the Traditional Chinese medicine collagen protein silk.
Traditionally, using directly crush using and solvent extraction realizing the reprocessing and use of Chinese medicine, its product form
For solution or powder.In this manual, the herb powder after crushing is mixed by inventor with collagen, shitosan, is led to
Cross the prepared Traditional Chinese medicine collagen protein silk of method of spinning.In the collagenous shreds, herb powder is evenly distributed in filament.
The release of herb powder is gradually realized in the swelling of human body stomach, digestion process in collagenous shreds and is absorbed by human body.
Secure ph is that 3 solution carries out swelling, dissolving to collagenous shreds, and the release for measuring herb powder is similar to Gaussian Profile song
Line chart, complete release time are 5～6 hours, according to the thickness of fiber difference.Thereby it is assumed that, the elderly for
The absorption of herb powder effective ingredient in the collagenous shreds is a process for gradually increasing and subsequently reducing, and this is individual gentle
Process, can reduce effective components of Chinese medicinal as far as possible for the pressure of the old human digestive system of body void, realize good absorption, reach
To the purpose nourished.Additionally, base material collagen itself of the present invention has higher nourishing health function, there is acceleration
Hemoglobin and erythropoietic effect, play the role of to improve circulation, to coronary heart disease, ischemic cerebral disease, and shitosan is in drop blood
Fat, hypoglycemic and control cholesterol also great effect.
For being processed further for product, collagenous shreds can be cut into the product form of 0.5～1mm chopped fibers,
And mix with other auxiliary materials, make the commodity such as capsule, tablet or oral liquid and sold and used.
A kind of Traditional Chinese medicine collagen protein silk disclosed by the invention and preparation method thereof, its advantage is：Using wet spinning
Prepared Traditional Chinese medicine collagen protein silk, realizes the slow release of Chinese medicine, extends the action time of Chinese medicine, reduces effective components of Chinese medicinal pair
In the pressure of the old human digestive system of body void, good absorption is realized, reach the purpose nourished.
Specific embodiment
With reference to specific embodiment, to a kind of Traditional Chinese medicine collagen protein silk described in the present patent application and its preparation side
Method.It should be appreciated that specific embodiment described herein is not intended to limit the present invention only to explain the present invention.
Embodiment 1
A kind of Traditional Chinese medicine collagen protein silk of the present invention is prepared from by herb powder, shitosan, collagen and glacial acetic acid aqueous solution,
The weight of each raw material is as follows：Herb powder 2Kg, shitosan 10Kg, collagen 20Kg, glacial acetic acid aqueous solution 250Kg, wherein,
Glacial acetic acid aqueous solution is 0.1wt% glacial acetic acid aqueous solutions；Herb powder is that Jing is crushed to after Cordyceps sinensis 1Kg, stem of noble dendrobium 1Kg mix
300 mesh and obtain.
The preparation process of Traditional Chinese medicine collagen protein silk is：
1）Collagen and shitosan are weighed and mix, with glacial acetic acid aqueous solution as solvent, with prepared collagen egg at a temperature of 40 DEG C
In vain-chitosan solution；
2）Herb powder is added in collagen-chitosan solution, homogeneous 30 minutes, obtain final product spinning just liquid；
3）Gained spinning solution is extruded from spinning nozzle under the pressure of 0.1MPa, the aperture of the spinning nozzle is 0.05mm, by spinneret
The spinning solution of mouth extrusion is directly entered solidified forming in 15wt% metabisulfite solutions, and collection obtains spun filament, with the ethanol of 30wt%
After the aqueous solution carries out cleaning 15 seconds as cleaning fluid to spun filament, 24 hours are incubated under the conditions of 60 DEG C, obtain final product Chinese medicine collagen egg
White silk, a diameter of 0.08mm of the Traditional Chinese medicine collagen protein silk.
Traditional Chinese medicine collagen protein silk obtained by the present embodiment is adapted to that To Be Protected from Heat, irritability, cheek are fired, dry pharyngalgia, stool are dry
It is dry, scanty drak urine or Huang, dysphoria in chestpalms-soles, night sweat, have a pain in the back, emission, red tongue body, tongue be thin or the disease such as light stripping, thready rapid pulse
The elderly of shape uses.
Embodiment 2
A kind of Traditional Chinese medicine collagen protein silk of the present invention is prepared from by herb powder, shitosan, collagen and glacial acetic acid aqueous solution,
The weight of each raw material is as follows：Herb powder 5Kg, shitosan 25Kg, collagen 40Kg, glacial acetic acid aqueous solution 500Kg, wherein,
Glacial acetic acid aqueous solution is 0.3wt% glacial acetic acid aqueous solutions；Herb powder is that Jing is crushed to 400 mesh after donkey-hide gelatin 2Kg, Radix Angelicae Sinensis 3Kg mix
And obtain.
The preparation process of Traditional Chinese medicine collagen protein silk is：
1）Collagen and shitosan are weighed and mix, with glacial acetic acid aqueous solution as solvent, with prepared collagen egg at a temperature of 60 DEG C
In vain-chitosan solution；
2）Herb powder is added in collagen-chitosan solution, homogeneous 60 minutes, obtain final product spinning just liquid；
3）Gained spinning solution is extruded from spinning nozzle under the pressure of 0.3MPa, the aperture of the spinning nozzle is 0.01mm, by spinneret
The spinning solution of mouth extrusion is directly entered solidified forming in 25wt% metabisulfite solutions, and collection obtains spun filament, with the ethanol of 50wt%
After the aqueous solution carries out cleaning 25 seconds as cleaning fluid to spun filament, 48 hours are incubated under the conditions of 80 DEG C, obtain final product Chinese medicine collagen egg
White silk, a diameter of 0.04mm of the Traditional Chinese medicine collagen protein silk.
Traditional Chinese medicine collagen protein silk obtained by the present embodiment is adapted to have no peace of mind, palpitaition it is difficult sleep, mind is dispirited, complexion without
China, the elderly of the symptom such as nail is pale use.
Embodiment 3
A kind of Traditional Chinese medicine collagen protein silk of the present invention is prepared from by herb powder, shitosan, collagen and glacial acetic acid aqueous solution,
The weight of each raw material is as follows：Herb powder 4Kg, shitosan 15Kg, collagen 30Kg, glacial acetic acid aqueous solution 350Kg, wherein,
Glacial acetic acid aqueous solution is 0.2wt% glacial acetic acid aqueous solutions；Herb powder is obtained to 350 mesh for ginseng 4Kg is size-reduced.
The preparation process of Traditional Chinese medicine collagen protein silk is：
1）Collagen and shitosan are weighed and mix, with glacial acetic acid aqueous solution as solvent, with prepared collagen egg at a temperature of 50 DEG C
In vain-chitosan solution；
2）Herb powder is added in collagen-chitosan solution, homogeneous 45 minutes, obtain final product spinning just liquid；
3）Gained spinning solution is extruded from spinning nozzle under the pressure of 0.2MPa, the aperture of the spinning nozzle is 0.03mm, by spinneret
The spinning solution of mouth extrusion is directly entered solidified forming in 20wt% metabisulfite solutions, and collection obtains spun filament, with the ethanol of 40wt%
After the aqueous solution carries out cleaning 20 seconds as cleaning fluid to spun filament, 36 hours are incubated under the conditions of 70 DEG C, obtain final product Chinese medicine collagen egg
White silk, a diameter of 0.06mm of the Traditional Chinese medicine collagen protein silk.
Traditional Chinese medicine collagen protein silk obtained by the present embodiment is adapted to weak asthma, few speech lazyness language, refreshing tired limb is soft, do not think drink
Food, forgetful memory loss, rich in nutrition, the elderly of the symptom such as have a dizzy spell, have a sleepless night use.
Embodiment 4
A kind of Traditional Chinese medicine collagen protein silk of the present invention is prepared from by herb powder, shitosan, collagen and glacial acetic acid aqueous solution,
The weight of each raw material is as follows：Herb powder 3Kg, shitosan 20Kg, collagen 25Kg, glacial acetic acid aqueous solution 400Kg, wherein,
Glacial acetic acid aqueous solution is 0.25wt% glacial acetic acid aqueous solutions；Herb powder is obtained to 300 mesh for pilose antler 3Kg is size-reduced.
The preparation process of Traditional Chinese medicine collagen protein silk is：
1）Collagen and shitosan are weighed and mix, with glacial acetic acid aqueous solution as solvent, with prepared collagen egg at a temperature of 55 DEG C
In vain-chitosan solution；
2）Herb powder is added in collagen-chitosan solution, homogeneous 50 minutes, obtain final product spinning just liquid；
3）Gained spinning solution is extruded from spinning nozzle under the pressure of 0.25MPa, the aperture of the spinning nozzle is 0.04mm, by spinneret
The spinning solution of mouth extrusion is directly entered solidified forming in 18wt% metabisulfite solutions, and collection obtains spun filament, with the ethanol of 45wt%
After the aqueous solution carries out cleaning 25 seconds as cleaning fluid to spun filament, 40 hours are incubated under the conditions of 75 DEG C, obtain final product Chinese medicine collagen egg
White silk, a diameter of 0.07mm of the Traditional Chinese medicine collagen protein silk.
Traditional Chinese medicine collagen protein silk obtained by the present embodiment is adapted to cold chilly, weakness of limbs, soreness and weakness of waist and knees, big loose stool
The elderly of thin, frequent urination uses.
Claims (10)
1. a kind of Traditional Chinese medicine collagen protein silk, is characterized in that, the Traditional Chinese medicine collagen protein silk includes the following raw material：Herb powder, shell
Glycan, collagen, glacial acetic acid aqueous solution.
2. a kind of Traditional Chinese medicine collagen protein silk according to claim 1, is characterized in that, the weight of the Traditional Chinese medicine collagen protein silk
Proportioning is as follows：2～5 weight portion of herb powder, 10～25 weight portion of shitosan, 20～40 weight portion of collagen, glacial acetic acid water
250～500 weight portion of solution.
3. a kind of Traditional Chinese medicine collagen protein silk according to claim 1, is characterized in that, the glacial acetic acid aqueous solution is 0.1wt%
～0.3wt% glacial acetic acid aqueous solutions.
4. a kind of Traditional Chinese medicine collagen protein silk according to claim 1, is characterized in that, the herb powder be the dried rhizome of rehmannia, the tuber of dwarf lilyturf,
Radix polygonati officinalis, white fungus, Cordyceps sinensis, the stem of noble dendrobium, donkey-hide gelatin, Radix Angelicae Sinensis, ginseng, pilose antler, American Ginseng, sanchi flower, the fleece-flower root, radix pseudostellariae, glossy ganoderma
In size-reduced obtain to 300～400 mesh for one or more.
5. a kind of preparation method of the Traditional Chinese medicine collagen protein silk described in claim 1, is characterized in that, the Traditional Chinese medicine collagen protein silk
Preparation process be：
1）Collagen and shitosan are weighed and mix, with glacial acetic acid aqueous solution as solvent, with prepared at a temperature of 40～60 DEG C
Collagen-chitosan solution；
2）Herb powder is added in collagen-chitosan solution, homogeneous 30～60 minutes, obtain final product spinning just liquid；
3）Solidified forming in coagulating bath is directly entered after gained spinning solution is extruded from spinning nozzle under stress, collection is come into being
Silk, after cleaning to spun filament using ethanol water as cleaning fluid, is incubated 24～48 hours, i.e., under the conditions of 60～80 DEG C
Obtain Traditional Chinese medicine collagen protein silk.
6. a kind of preparation method of the Traditional Chinese medicine collagen protein silk described in claim 5, is characterized in that, the ethanol water is
The ethanol water of 30wt%～50wt%.
7. a kind of preparation method of the Traditional Chinese medicine collagen protein silk described in claim 5, is characterized in that, the time of the cleaning is 15
～25 seconds.
8. a kind of preparation method of the Traditional Chinese medicine collagen protein silk described in claim 5, is characterized in that, the aperture of the spinning nozzle is
0.01～0.05mm, the pressure are 0.1～0.3MPa.
9. a kind of preparation method of the Traditional Chinese medicine collagen protein silk described in claim 5, is characterized in that, the coagulating bath is 15wt%
The metabisulfite solution of～25wt%.
10. a kind of preparation method of the Traditional Chinese medicine collagen protein silk described in claim 5, is characterized in that, the Traditional Chinese medicine collagen protein
A diameter of 0.04～0.08mm of silk.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201611124568.XA CN106552181A (en) | 2016-12-08 | 2016-12-08 | A kind of Traditional Chinese medicine collagen protein silk and preparation method thereof |
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| CN201611124568.XA CN106552181A (en) | 2016-12-08 | 2016-12-08 | A kind of Traditional Chinese medicine collagen protein silk and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108642945A (en) * | 2018-05-22 | 2018-10-12 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of superfine notoginseng powder cellulose |
| CN109646706A (en) * | 2018-12-28 | 2019-04-19 | 上海纳米技术及应用国家工程研究中心有限公司 | Method for preparing anti-scar overlay film using method of electrostatic spinning and products thereof and application |
-
2016
- 2016-12-08 CN CN201611124568.XA patent/CN106552181A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 任春华等: ""在静电纺丝技术中的溶剂进展"", 《泸天化科技》 * |
| 华坚等: ""胶原蛋白-壳聚糖的溶液纺丝"", 《皮革科学与工程》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108642945A (en) * | 2018-05-22 | 2018-10-12 | 天马（安徽）国药科技股份有限公司 | A kind of preparation method of superfine notoginseng powder cellulose |
| CN109646706A (en) * | 2018-12-28 | 2019-04-19 | 上海纳米技术及应用国家工程研究中心有限公司 | Method for preparing anti-scar overlay film using method of electrostatic spinning and products thereof and application |
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Application publication date: 20170405 |