CN106543107A - 一种1‑boc‑哌嗪的合成方法 - Google Patents
一种1‑boc‑哌嗪的合成方法 Download PDFInfo
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- CN106543107A CN106543107A CN201610962065.3A CN201610962065A CN106543107A CN 106543107 A CN106543107 A CN 106543107A CN 201610962065 A CN201610962065 A CN 201610962065A CN 106543107 A CN106543107 A CN 106543107A
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- CN
- China
- Prior art keywords
- boc
- piperazines
- reaction
- morpholones
- synthetic method
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201610962065.3A CN106543107B (zh) | 2016-11-04 | 2016-11-04 | 一种1-boc-哌嗪的合成方法 |
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CN201610962065.3A CN106543107B (zh) | 2016-11-04 | 2016-11-04 | 一种1-boc-哌嗪的合成方法 |
Publications (2)
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CN106543107A true CN106543107A (zh) | 2017-03-29 |
CN106543107B CN106543107B (zh) | 2019-02-01 |
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CN201610962065.3A Active CN106543107B (zh) | 2016-11-04 | 2016-11-04 | 一种1-boc-哌嗪的合成方法 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4327095A (en) * | 1979-03-15 | 1982-04-27 | Rhone-Poulenc Industries | Methoxy derivatives of 1,4-dithiepino-[2,3-c]-pyrrole |
US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
CN1266431A (zh) * | 1997-06-17 | 2000-09-13 | 藤泽药品工业株式会社 | 芳基-哌嗪衍生物、及其制备和作为速激肽拮抗剂的应用 |
CN1270584A (zh) * | 1997-09-17 | 2000-10-18 | 西巴特殊化学品控股有限公司 | 作为光稳定剂的吗啉酮化合物 |
-
2016
- 2016-11-04 CN CN201610962065.3A patent/CN106543107B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4327095A (en) * | 1979-03-15 | 1982-04-27 | Rhone-Poulenc Industries | Methoxy derivatives of 1,4-dithiepino-[2,3-c]-pyrrole |
US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
CN1266431A (zh) * | 1997-06-17 | 2000-09-13 | 藤泽药品工业株式会社 | 芳基-哌嗪衍生物、及其制备和作为速激肽拮抗剂的应用 |
CN1270584A (zh) * | 1997-09-17 | 2000-10-18 | 西巴特殊化学品控股有限公司 | 作为光稳定剂的吗啉酮化合物 |
Non-Patent Citations (3)
Title |
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JAROSLAV ROH ET AL: "Large-Scale Synthesis of Piperazine-2,6-dione and Its Use in the Synthesis of Dexrazoxane Analogues", 《SYNTHESIS》 * |
LEO A. PAQUETTE ET AL: "An Enantioselective Ring Expansion Route Leading to Furanose and Pyranose Nucleosides Featuring Spirodiketopiperazines at the Anomeric Position", 《J. ORG. CHEM》 * |
S.M.MCELVAIN ET AL: "1,4-Diazabicyclo[2.2.2]octanes and 1,5-Diazabicyclo[3.2.2]nonanes from Piperazines and Homopiperazines", 《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》 * |
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Publication number | Publication date |
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CN106543107B (zh) | 2019-02-01 |
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Address after: 251400 No. 12, Taixing East Street, Jibei Economic Development Zone, Jiyang District, Jinan City, Shandong Province Patentee after: Shandong Baoyuan Pharmaceutical Co.,Ltd. Address before: Strong in Jiyang County of Ji'nan City, 251400 North Street, Shandong Province Economic Development Zone Patentee before: SHANDONG BOYUAN PHARMACEUTICAL Co.,Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A Synthesis Method of 1-BOC Piperazine Effective date of registration: 20221130 Granted publication date: 20190201 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan science and technology innovation center sub branch Pledgor: Shandong Baoyuan Pharmaceutical Co.,Ltd. Registration number: Y2022980023658 |