CN106540097A - A kind of Chinese medicine composition for treating atherosclerosiss hypertension and its application - Google Patents
A kind of Chinese medicine composition for treating atherosclerosiss hypertension and its application Download PDFInfo
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Abstract
The invention belongs to a kind of Chinese medicine composition for treating atherosclerosiss hypertension and its application；It is formulated according to parts by weight comprising following raw materials according：60～300 parts of Radix Salviae Miltiorrhizae, 50～280 parts of Folium Eucommiae, 50～260 parts of Ramulus Uncariae Cum Uncis, 10～100 parts of Rhizoma Coptidis, 50～240 parts of Folium Apocyni Veneti, 50～200 parts of Rhizoma Gastrodiae, 50～200 parts of Pheretima, 6～20 parts of Monas cuspurpureus Went, 20～300 parts of Semen Plantaginiss；There is to realize multipath, multi-level, Mutiple Targets synthetically reducing blood pressure, anti peroxidation of lipid, blood fat reducing, adjust blood glucose, anticoagulant, antiinflammatory, reverse and mitigate atherosclerosiss, have no toxic side effect and being capable of long-term taking.
Description
Technical field
The invention belongs to technical field of Chinese medicine, and in particular to a kind of Chinese medicine group for treating atherosclerosiss hypertension
Compound and its application.
Background technology
Blood circulation is the red life supply line of human body, mainly by the nutrient substance digested and assimilated and the oxygen of breathing suction
Gas is transported to the histiocyte of whole body, and histiocytic metabolite is transported, and maintains the normal new old of body tissue's cell
Metabolism, life are not stopped, and exchange more than.Heart is sanguimotor power, and blood is injected tremulous pulse by heart contraction, and tremulous pulse gradually divides
Trickle vasoganglion being propped up into, allowing blood mass exchange to be carried out with histiocyte, in blood, nutrient substance and oxygen enter histiocyte, group
The metabolic waste for knitting cell enters blood, converges heart step by step by vein, then heart by metabolic waste in blood be transported to lung,
Kidney, liver etc. excrete, and thus move in endless cycles, and maintain the interior environment of body relatively stable.
Blood pressure is lateral pressure of the blood flow to blood vessel wall.Including arteriotony and venous pressure, the blood pressure generally talked is to survey the upper arm
The blood pressure of tremulous pulse, its systolic pressure are that heart contraction projects lateral pressure of the blood to blood vessel wall, blood when diastolic pressure is diastole
Lateral pressure to blood vessel wall, normal contraction pressure ＜ 130mmHg, diastolic pressure ＜ 85mmHg, and be higher than 140mmHg/90mmHg for height
Blood pressure.
Essential hypertension is the hypertension that atherosclerosiss (AS) cause.Hypertension characteristics of lesion is blood vessel pipe
Wall is reconstructed, speckle hypertrophy, luminal stenosis, and tissue blood supply is reduced, and metabolite is piled up, and the acting of reflexive heart strengthens, and causes blood
Pressure is raised, and to ensure tissue blood supply, early stage is more without clinical symptoms, and blood pressure is fluctuated, the referred to as compensatory phase.Elapse over time,
AS persistently increases, and patient's blood pressure keeps high-level state, blood supply insufficiency clinical symptoms, referred to as Decompensated stage still occurs, i.e., former
Essential hypertension disease.Hypertension is the topmost risk factor of cardiovascular and cerebrovascular disease, is important public health problem.According to《In
State resident nourishment and chronic disease status report (2015)》Show, in existing 200,000,000 hyperpietic of China, the whole nation is every year because of high blood
Early death toll up to 2,000,000 is pressed through, direct medical cost is sure to occupy first of China's Residents death cause every year up to 36,600,000,000 yuan.
The pathogeny of atherosclerosiss (AS)：Applicant is considered that lipid peroxidation is how caused because assisting.That is lipid
Caused by peroxidating causes the silent as the grave hematocele tube wall of the unlimited phagocytosis of macrophage, relevant hyperlipidemia, hyperglycemia, high blood viscosity, smoking, height
Blood pressure etc. is then the important accomplice of AS formation and developments.
At present, the preventing and treating of hypertension, doctor trained in Western medicine to hypertension treatment target is：Blood pressure is down to perfect condition, is prevented
Complication, reduces disability rate and mortality rate, improves the quality of living.Therefore, doctor trained in Western medicine is not just carried on Therapeutic Principle and being effected a permanent cure.Chinese medicine
Can reverse or mitigate AS (effecting a permanent cure), but on market, existing Chinese medicine preparation, contain toxic herb more, or curative effect is still needed raising.
The content of the invention
It is an object of the invention to overcome defect of the prior art, and provide one kind can realize multipath, it is multi-level,
Mutiple Targets synthetically reducing blood pressure, anti peroxidation of lipid, blood fat reducing, tune blood glucose, anticoagulant, antiinflammatory, reverse mitigate atherosclerosiss, nothing
Toxic and side effects and a kind of Chinese medicine composition for treating atherosclerosiss hypertension and its application of being capable of long-term taking.
The object of the present invention is achieved like this：It is formulated according to parts by weight comprising following raw materials according：Radix Salviae Miltiorrhizae 60～300
Part, 50～280 parts of Folium Eucommiae, 50～260 parts of Ramulus Uncariae Cum Uncis, 10～100 parts of Rhizoma Coptidis, 50～240 parts of Folium Apocyni Veneti, Rhizoma Gastrodiae 50～200
Part, 50～200 parts of Pheretima, 6～20 parts of Monas cuspurpureus Went, 20～300 parts of Semen Plantaginiss.
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：280 parts of Radix Salviae Miltiorrhizae, 246 parts of Folium Eucommiae, 230 parts of Ramulus Uncariae Cum Uncis, 80 parts of Rhizoma Coptidis, 240 parts of Folium Apocyni Veneti, 180 parts of Rhizoma Gastrodiae, Pheretima 190
Part, 8 parts of Monas cuspurpureus Went, 200 parts of Semen Plantaginiss.
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：It is 80 parts of Radix Salviae Miltiorrhizae, 100 parts of Folium Eucommiae, 60 parts of Ramulus Uncariae Cum Uncis, 10 parts of Rhizoma Coptidis, 60 parts of Folium Apocyni Veneti, 60 parts of Rhizoma Gastrodiae, 60 parts of Pheretima, red
Bent 12 parts, 50 parts of Semen Plantaginiss.
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：240 parts of Radix Salviae Miltiorrhizae, 220 parts of Folium Eucommiae, 220 parts of Ramulus Uncariae Cum Uncis, 50 parts of Rhizoma Coptidis, 100 parts of Folium Apocyni Veneti, 160 parts of Rhizoma Gastrodiae, Pheretima 160
Part, 15 parts of Monas cuspurpureus Went, 150 parts of Semen Plantaginiss.
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：180 parts of Radix Salviae Miltiorrhizae, 150 parts of Folium Eucommiae, 80 parts of Ramulus Uncariae Cum Uncis, 60 parts of Rhizoma Coptidis, 80 parts of Folium Apocyni Veneti, 80 parts of Rhizoma Gastrodiae, 80 parts of Pheretima,
8 parts of Monas cuspurpureus Went, 60 parts of Semen Plantaginiss.
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：220 parts of Radix Salviae Miltiorrhizae, 200 parts of Folium Eucommiae, 260 parts of Ramulus Uncariae Cum Uncis, 50 parts of Rhizoma Coptidis, 80 parts of Folium Apocyni Veneti, 80 parts of Rhizoma Gastrodiae, Pheretima 100
Part, 10 parts of Monas cuspurpureus Went, 120 parts of Semen Plantaginiss.
Present invention also offers above-mentioned Chinese medicine composition answering in treatment atherosclerosiss hypertension disease medicament is prepared
With.
The present invention can be processed into different dosage forms according to the difference of the market demand and processing technology, it is possible to according to its dosage form
Needs addition meet the corresponding adjuvant of national regulation, including flavoring agent, slow releasing agent etc..
The present invention is cured mainly：Atherosclerosiss hypertension.
The present invention contains 9 taste Chinese medicines, and the effect played according to monarch is as follows：
1st, Radix Salviae Miltiorrhizae：Radix Salviae Miltiorrhizae is monarch drug, and its character is：Bitter in the mouth micro-pungent, cold nature；GUIXIN, Liver Channel.【Indication】Promoting blood circulation is dispelled
The stasis of blood, inducing menstruation to relieve menalgia, relieving restlessness that clears away heart-fire.It is the conventional Chinese medicine for treating cardiovascular and cerebrovascular disease.【Pharmacological action】1. there is significantly prevention and resist
Atherosclerosiss cardiac-cerebral ischemia damaging action, this final purpose exactly of the invention, therefore with Radix Salviae Miltiorrhizae as monarch drug.Radix Salviae Miltiorrhizae can show
Work improves cardiac and cerebral blood-supply, improve the hypoxia-bearing capability of body, significantly inhibits lactic acid dehydrogenase (LDH), creatine kinase (CK) and releases
Put, improve cardiac-cerebral ischemia, infarction and cardio cerebral function.2. there is anticoagulant, promote fibrinolytic, suppress platelet aggregation, inhibition thrombosis；
Effect for reducing blood fat；3. synthesis of the Radix Salviae Miltiorrhizae in cell and gene level regulation and control ET (a kind of active polypeptide of vascular endothelial cell secretion)
With release, reduce the Endothelin (ET) in ischemia-reperfusion and raise extremely, block the blood vessel strong contraction that ET causes etc. a series of
Harmful effect.4. there is the relatively mild estrogen activity worked by ovary, reduce blood glucose, strengthen immunity, fibrosis etc.
Effect.
2nd, the Cortex Eucommiae：The Cortex Eucommiae is ministerial drug, and its character is：Sweet in the mouth, it is warm in nature.【Indication】Liver and kidney tonifying, bone and muscle strengthening, solid Jing
Antiabortive effect.【Pharmacological action】1. Cortex Eucommiae extract significantly reduces acute and chronic hypertension.The Cortex Eucommiae contains 4 class antihypertensive compositions：Wooden fat
Plain class, such as pinoresinol diglucoside (PDG), Phenylpropanoid Glycosides class (chlorogenic acid, caffeic acid), iridoidses (Geniposidic acid, capital Buddhist nun
Flat glycosides, aucubin) and flavonoid (Quercetin, rutin).In the Cortex Eucommiae, various antihypertensive compositions are with geniposide and geniposide
Diastole effect of the acid to blood vessel is the most notable.A lignins may make vascular smooth by the inhibitory action to phosphodiesterase
In flesh, the concentration of cAMP is raised, and so as to activated protein kinase A, suppresses the interior stream of calcium ion, it is also possible to by affecting K+Passage is lived
Property, arterial smooth muscle cell film potential depolarising or hyperpolarization are made, vasodilator hypotensive activity is played；The coffee of b Phenylpropanoid Glycosides classes
Acid can promote the synthesis of NO to increase, vasodilator by nitricoxide synthase in inducing endothelial cell；C iridoid apoplexy due to endogenous wind
Geniposidic acid, genipin may raise cAMP concentration and carry out vasodilator, reduce blood pressure；In d flavonoids, Quercetin is by blood
The double inhibition effect of pipe smooth muscle cell voltage dependent channel and receptor operated calcium channel, reduces intracellular free calcium
Level, vasodilator reduce blood pressure.Comprehensive function is by promoting NO releases, suppressing Ca2+Interior stream, angiotensin (Ang
II generation), the activity of phosphodiesterase, and directly the approach such as vasodilator produces hypotensive effect.The blood pressure lowering of Cortex Eucommiae (parched) leaf is made
Tincture is better than with the effect more than Cortex Eucommiae leaf, water decoction.Pinoresinol diglucoside (PDG) and Quercetin are 1: 1 group in ratio
During conjunction, preferably, it is 98% that Quercetin maximum diastole effect is 74.2%, PDG maximum diastole effects to vasodilator effect, Folium Eucommiae
Extractum maximum diastole effect be 95.6%, PDG and Quercetin combination after maximum diastole effect up to 192.5%.The drop of Folium Eucommiae
It is pressed with 3 kinds of mechanism：CNS inhibition, act on peripheral nervouss, directly act on vascular smooth muscle.2. Folium Eucommiae skin, leaf decoction pair
Nervus centraliss have significant sedative-hypnotic effect, can be obviously prolonged the length of one's sleep of mice, its analgesic activity and aspirin
Effect quite, can clinically improve the symptoms such as dizzy insomnia.3. stronger blood fat reducing, regulation blood glucose, antioxidation, antiinflammatory,
Protection cardiovascular and cerebrovascular vessel, recover the pharmacological actions such as blood vessel elasticity, diuresis heat-clearing.Its blood pressure lowering for projecting and dependent interaction are decided to be this
First ministerial drug of invention, leads ministerial drug blood pressure lowering, collaboration monarch drug to ensure cardiac and cerebral blood-supply.
3rd, Ramulus Uncariae Cum Uncis：Ramulus Uncariae Cum Uncis is ministerial drug, and its character is：Sweet-bitter flavor, is slightly cold, and master enters Liver Channel.【Indication】Relieving spasm by subduing liver-wind, clearly
Hot suppressing the hyperactive liver；Liver Channel intenseness of heat, liver-wind stirring up internally.【Pharmacological action】1. 4 kinds of compositions, its blood pressure lowering and the different hook of negative chronotropic property are contained in Ramulus Uncariae Cum Uncis
Rattan alkali (mean arterial pressure reduces by 42.0%) ＞ Ramulus Uncariae cum Uncis alkali (32.1%) ＞ Rhomotoxines (21.3%) ＞ Ramulus Uncariae Cum Uncis non-alkaloids
(12.4%).Mechanism：A energy is directly or reflexive suppresses vasomotor center, retardance sympathetic nerve, strengthens acetylcholine effect,
Suppress L-type calcium channel, promote potassium-channel to open, diastole peripheral blood vessel, reduction Peripheral resistance, relatively lasting significant drop blood
Pressure, for a long time with without drug resistance phenomenon；B substantially suppresses heart rate and Atrioventricular Conduction, decreased heart rate to reduce cardiac output, reduce blood pressure；c
Boosting caused by antagonism Angiotensin II；D suppresses the vascular smooth muscle cell proliferation of Angiotensin II induction, suppresses dynamic
Arteries and veins collagen deposition, arteriosclerosis.2. antioxidation：Ramulus Uncariae Cum Uncis ligroin extraction (PE), chloroform extract (CE), ethyl acetate are carried
Thing (AE) and ethanol extraction (EE) are taken, antioxidant activity order is：E ＞ Vc ＞ AE ＞ CE ＞ Alk ＞ PE.3. antiinflammatory：A Ramulus Uncariae Cum Uncis
Alkali (Rhy) effectively suppress inflammatory cytokine discharge lipopolysaccharide, concentration dependent ground suppress LPS induction inflammatory cell because
The generation of son.B isorhynchophyllines dose-dependently suppress neurogliocyte by the proinflammatory cytokine of lipopolysaccharide-induced generation
The generation of tumor necrosis factor, NO.C Ramulus Uncariae Cum Uncis decocting liquids significantly increase mice pain threshold, reduce capillary permeability, suppress by
Inflammatory reaction caused by dimethylbenzene, significantly mitigates the swelling of Mice Auricle.4. tranquillizing the mind by relieving convulsion, arrhythmia, anticoagulant, drop blood
Fat, regulation blood glucose, reduction serum insulin levels, increase heart and brain blood flow, anti-cardiac-cerebral ischemia damage, cardioprotection and brain.
Its blood pressure lowering for projecting and dependent interaction are decided to be second ministerial drug of the present invention, and collaboration plays atherosclerosiss blood pressure lowering and makees
With.
4th, Rhizoma Coptidis：Rhizoma Coptidis are ministerial drug, and its character is：Bitter in the mouth, trembles with fear.【Indication】Heat clearing and damp drying, eliminating fire and detoxication.For wet
Fullness-oppression in the epigastrium caused by heat is full, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia.Modern study Rhizoma Coptidis (berberine, BBR) containing berberine【Molecular formula and phase
To molecular weight】C20H18NO4, is soluble in boiling water.【Pharmacological action】1. the effect to blood circulation：1. blood pressure lowering：A berberine
(berberine, BBR, Ber), adopted name berberine.Ber is to the competitive blocking effect of a receptors.Ber has stronger to a1 receptors
Affinity, the effect that Ber blocking a1 receptors are produced is block effect produced by a2 receptors 2 times～3 times. has been reported that as 7.1 times
～10 times.BBer is m receptor agonist, can suppress horse serum cholinesterase activity, piles up Ach, acts on the M on blood vessel endothelium
Receptor, expansion of blood vessels blood pressure lowering；C release NOBer are to synthesize and discharge NO to produce arterial relaxation effect by intact endothelium.D lives
Change K+ passages.Ber high concentrations can activate K+ passages, make vascular smooth muscle cell transmembrane potential hyperpolarization, generation be independent of endothelium
Vasodilation and blood pressure lowering；E suppresses intracellular Ca2+Release.Ber interior reservoirs Ca capable of inhibiting cell2+Release, reduces the contraction of blood vessel
, play hypotensive effect.2. blood fat reducing：Berberine is different from Statins and suppresses fat to synthesize and lipid-loweringing, and BBR is：A. pass through cell
The outer activation for adjusting kinases (ERK) signal path promotes low density lipoprotein receptor mRNA (LDLRmRNA) transcriptions to increase, and raises
The expression of LDLR albumen, accelerates LDL to utilize and degrade, significantly reduces TC, TG, LDL-C, respectively 21.41%, 26.4%,
28.22%, improve liver function, raise HDL-C unobvious；B. adenosine phosphate activated protein kinase (AMPK) approach and JNK ways are passed through
Footpath, raises LDLR, suppresses the synthesis of hepatocyte inner lipid；C. the endothelium work(for suppressing the oxidative modification and OX-LDL of LDL-C to cause
Can be disorderly；D. serum Lp-PLA2, MMP-9, OxLDI and MCP-1 level, increasing serum TIMP-1 levels, effect effect are significantly reduced
Fruit is similar to simvastatin；E.BBR plays the role of similar with cholesterol decrease uptake agent Ezetimibe, suppresses intestinal cholesterol
Absorb；F.BBR plays the effect of good reduction triglyceride by PPARct, and PPARct is also the non-promise of triglyceride reducing medicine
The target spot of shellfish medicine；G.BBR can improve intestinal microbial population to improve the metabolism disorder of Induced by High Fat Diet in Rats.H.BBR is by strengthening
PPARct, PPARB, reduce the expression of PPAR (peroxisome proliferation-activated receptors), improve glycolipid metabolism, control
The differentiation of 3T3.L1 adipose cells and National People's Congress's retinulae, suppresses the expression of macrophage inflammatory factor, and reduce inflammation reaction, surely
Determine speckle.3. blood sugar lowering, BBR can improve hyperinsulinemia, adjust blood-fat and blood sugar, redistribute body fat, lose weight, be
Treat insulin resistant, Type 2 Diabetic and hyperlipidemia safely and effectively medicine.Mechanism of action：The albumen of activation AMP activation
Kinases (AMPK, " energy regulator ") approach：A. suppress mitochondrion aerobic oxidation, promote the zymolysis of glucose, make AMP/ATP ratios
Value is raised, and activates AMPK；Promote glycolysiss and strengthen carbohydrate metabolism after b.BBR activation AMPK, strengthen GLUT4
(GLUT-4) expression；C. promote glucose transport.It is metformin and rosiglitazone in treatment of type 2 diabetes mellitus, fat important
Target spot；E.BBR suppresses the activity of enteric epithelium glucose transport a- glycosidase as Acarbose etc., effectively suppresses glucose
Absorb；F. promote the secretion of intestinal diabetic mice GLP-1, stimulate insulin secretion, improve islet function；G. PPART ways are activated
Footpath, strengthens endothelium eNOS expression, improves blood supply of cardiac muscle, suppresses the myocardial hypertrophy of hyperglycemia induction, and PPART is treatment II type glycosurias
The target spot that sick new drug thiazolidinedioneses (TZDs) act on, can increase weight, and BBR in contrast, can subtract to the effect of PPARl
Light weight, suppresses lipid aggregation, improves insulin resistant, have higher antiobesity action.4. antioxidation, 4 kinds of Rhizoma Coptidis polysaccharide
(CCP) there is preferable hypoglycemic activity and remove free radical.A.4 organize the different CCP of carried charge cloudy to hydroxy radical, super oxygen
Ion radical, DPPH free radicals have scavenging action, and wherein CCP-II is stronger to Scavenging action to hydroxyl free radical.Hydroxy radical is new
Produce in old metabolic process, it is big to organism strong toxicity, harm, cell membrane oxidative damage and destruction can be caused, cause cell
The diseases such as necrosis or mutation, aging, tumor；Ultra-oxygen anion free radical activity is strong, can cause intracellular DNA damage, and
The precursor of many reactive radical species；DPPH is a kind of more stable free radical with unpaired electronics, has one on its N atom
Individual free electron.The antioxidant activity of CCP strengthens as carried charge increases.B. Picroside II Amphicoside 6-Vanilloylcatalpol can improve body and remove oxygen certainly
By base ability, hence it is evident that mitigate carbon tetrachloride (Ccl), D-Gal (D-Gal-N), to the liver caused by second phthalein amino phenols (AP)
Cell injury, protects mitochondrion normal configuration, and adjustment energy metabolism is disorderly, and its effect is better than positive control drug bifendate；Together
When reduce mda content, superoxide dismutase activity improving, the oxidative damage caused by anti-cerebral ischemia Reperfu- sion suppress thin
Born of the same parents' apoptosis.5. expand blood vessel, heart tonifying, decreased heart rate protect the effect such as brain, antiinflammatory, anticoagulant, anti-AS.Its blood pressure lowering for projecting and correlation
Effect is decided to be the 3rd ministerial drug of the present invention, and collaboration plays atherosclerosiss hypotensive activity.
5th, Folium Apocyni Veneti：Folium Apocyni Veneti is ministerial drug, and its character is：Sweet-bitter flavor, cool in nature, return liver warp.【Indication】Suppressing the hyperactive liver
Calm the nerves, clearing away heat and promoting diuresiss.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria；Hypertension, neurasthenia, nephritis edema.Modern times grind
Study carefully Herba Apocyni veneti and contain the chemical compositions such as total flavonoid, organic acid, amino acidses and trace element.【Pharmacological action】：1. blood drop
Pressure：Hypertension is referred to as " not dead cancer ".Though Western medicine antihypertensive effect is good, long-term taking large side effects, because not effecting a permanent cure, more control more
Weight.Folium Apocyni Veneti antihypertensive effect is progressive firm, is preferable blood pressure lowering Chinese herbal medicine.Contained hyperin and isoquercitin can stimulate dynamic
Arteries and veins blood vessel produces nitric oxide, causes vasodilation, also can effectively reduce the rising of autonomic nervous dysfunction blood pressure.Its hypotensive effect
10min starts, and the maximum reducing time is 30～40min of dosage, gentle drawdown curve occurs, and heavy dose of then hypotensive effect increases
Plus, the material containing relaxes blood vessels, on heart rate without impact.2. heart tonifying diuresis.Increase can heart contraction amplitude, heart rate is slack-off,
There is cardiotonic glycoside sample to act on, the ECG Change of atherosclerotic rabbit can be made to recover normal, notable coronary artery dilating increases heart
Glycogen resynthesis.Renal hemodynamic can be increased in a small amount, diuresis are stronger, but then reduce urine volume in a large number.3. blood fat reducing, antioxidation are soft
Change blood vessel, atherosclerosiss, resisting myocardial fibrillation, antidepressant, anti-cardiac-cerebral ischemia are damaged, protect heart and brain, slow down aging, drop
Tobacco poisoning, Antialcoholic liver-protecting, loosening bowel to relieve constipation, relieving mental strain and helping sleep, enhance immunity etc. are acted on.Its good blood pressure lowering and heart tonifying diuresis are made
With the 4th ministerial drug for being decided to be the present invention, collaboration performance atherosclerosiss hypotensive activity.
6th, Rhizoma Gastrodiae：Rhizoma Gastrodiae is adjuvant drug, and its character is：Sweet in the mouth is mild-natured, return liver warp, nontoxic.【Indication】Dispelling wind and relieving convulsion.Control
Dizziness pupil, head wind headache, numb limbs and tense tendons, hemiplegia, aphasia.Modern study, Rhizoma Gastrodiae are rich in gastrodine (Gas), day
Numb glycoside unit, gastrodia elata polysaccharide etc..【Pharmacological action】1. blood pressure lowering：Gastrodia elata polysaccharide can substantially reduce by one oxygen of Hypertensive Rats serum
Change nitrogen (NO) content, endothelin level (ET) content to decline, the content of Angiotensin II (Ang II) is in dosage range
Dose dependent reduces systolic pressure and diastolic pressure, does not have obvious effect to rat heart rate and urine volume；Rhizoma Gastrodiae extracting solution and Gastrodine
Arteria coronaria and cerebral vascular resistance can be reduced, have a slight and lasting hypotensive activity, and can be lifted Ramulus Uncariae cum Uncis alkali bioavailability and
Blood pressure lowering effect.2. antioxidation：Gastrodia elata polysaccharide is remarkably improved model mice serum, liver, brain, the super oxygen disproportionation in heart tissue
Enzyme (SOD), catalase (CAT), glutathion peroxidase (GSH-Px) activity, hence it is evident that suppress malonaldehyde (MDA) to contain
Amount.Gastrodia elata polysaccharide reduces the content of MDA, improves the ability of learning and memory of mouse aging by eliminating excessive free radical, promotes
The recovery of cranial nerve, delaying cell aging.3. anti-diabetic gastrodine can increase cystathionine synthetase in insulin resistant model
(CBS) express, regulate and control the transcription and translation level of CBS, the content of homocysteine is reduced by playing antioxidation.
Gastrodine induces the experimental animal model of pain diabetic neuropathy (PDN) to STZ, can be in dose-dependently to reverse glycosuria
Transient state sodium current (INaT) caused by disease strengthens and potassium current weakens, and especially slowly inactivates potassium current (IAS), prevents periphery chronic
Pain.4. protect brain, antidepressant to prevent and treat Alzheimer, improve the health care of sleep, strengthen immunity, antiinflammatory, anticoagulation, antithrombotic are controlled
Treat myocarditiss, myocardial hypertrophy, myocardial fibrosiies etc..Above-mentioned effect is decided to be first adjuvant drug of the present invention, cooperates with above-mentioned all medicine drops
Low hypertension, the symptom of alleviating hypertension patient.
7th, Pheretima：Pheretima is adjuvant drug, and its character is：It is cold in nature, salty in the mouth.【Indication】Heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, profit
Urine；For unconsciousness due to high fever, hemiplegia, oliguria edema, vascular hypertension.【Pharmacological action】1. novel thrombolytic agent, Pheretima extract
Fibrin and activities of endothelial tissue plasminogen can be activated, direct thrombus have substantially drop fibre, thrombolytic, anticoagulation to the crowd of health
Deng effect, toxic and side effects are low, Orally-administrable.2. blood pressure lowering, Pheretima polypeptide and class platelet activating factor, slowly can hold
Blood pressure is effectively reduced long.3. Pheretima extracting solution can improve the activity of body antioxidase, remove the peroxidating of internal body
Product.Separately there is calmness, relieving asthma, diuresis, anticancer, strengthen the effect such as immunity.Above-mentioned effect is decided to be second adjuvant drug of the present invention, association
Reverse with above-mentioned all medicines and mitigate atherosclerosiss hypertension.
8th, Monas cuspurpureus Went：Monas cuspurpureus Went is adjuvant drug, and its character is：Sweet in the mouth, temperature, Return liver, spleen, large intestine channel.【Indication】Blood circulation promoting and blood stasis dispelling,
Strengthening the spleen to promote digestion.【Pharmacological action】Monas cuspurpureus Went contains natural Mo Nakelin classes or lovastatin class material, to internal cholesterol biosynthesis speed limit
Enzyme has efficient inhibitory action, can effectively block cholesterol biosynthesis (70% cholesterol of human body by synthesize in vivo), significantly reduce serum
Triglyceride (TG), cholesterol (TC), low density lipoprotein, LDL (LDL-C), high density lipoprotein increasing (HDL-C), is generally acknowledged
Hypolipidemic.Because atherosclerosiss hypertension is more because assistance causes mainly by lipid peroxidation, it is controlling for this hypertension
Necessary blood fat reducing and antioxidation are treated, is terminated and is mitigated atherosclerosiss and could gradually effect a radical cure hypertension, so increase Monas cuspurpureus Went being
It is necessary.2. Monas cuspurpureus Went has preventing and treating AS and preferable hypotensive activity, can protect vascular endothelial cell, suppresses lipid heavy in liver
Product, reduces platelet aggregation and whole blood viscosity.Above-mentioned effect especially effect for reducing blood fat is decided to be the 3rd adjuvant drug of the present invention, assists
The continuation development that above-mentioned all medicine prevention of arterial are atherosis.
9th, Semen Plantaginiss：To make medicine, its character is Semen Plantaginiss：Sweet-salty, feeble QI are trembled with fear, nontoxic.Enter bladder, spleen, three Jing of kidney.
【Indication】Diuretic relieving constipation, clearing away heat to improve acuity of vision.Treatment arthralgia chiefly caused by damp pathogen, conjunctival congestion are hidden from view, sphincter disturbance.【Pharmacological action】1. blood pressure lowering, profit
Urine, relieving constipation.Herba Plantaginiss water extract-alcohol precipitation liquid energy suppresses Na+-K+- atpase activity, promotes the excretion of water, Sodium Chloride, carbamide and uric acid,
Dramatically increase urine volume.Plantago asiatica linne polyoses contain many hydrophilic groups, and energy imbibition makes the soft easy row of feces, in advance to tens times
It is anti-because constipation induction acute complicationses.2. antioxidation, defying age, Herba Plantaginis flavone have scavenging action to hydroxy radical, its antioxygen
Change ability is similar to vitamin c；Plantago asiatica linne polyoses (PSP) can stable endotheliocyte membrane structure, reduction free radical damage and lipid
The generation of Peroxidation Product MDA, improves the vigor of cell SOD；PSP can strengthen the proliferation activity of cell, suppress the work of OX.LDL
Property；The release and NOS expression of balance endotheliocyte NO, when resisting OX.LDL cause endothelial cell damages, ICAM.1 expression increases；
Lower the mRNA level in-site of endothelial cell damage apoptosis-related genes c-myc, P53 of OX.LDL inductions.3. lipid-loweringing, blood sugar lowering, fat-reducing
Deng effect.
The monarch drug Radix Salviae Miltiorrhizae of the present invention mainly plays preventing and treating cardiac-cerebral ischemia damaging action；The ministerial drug Cortex Eucommiae, Rhizoma Coptidis, Ramulus Uncariae Cum Uncis, sieve
The main performance of cloth fiber crops expands blood vessel hypotensive activity, simultaneous to prevent and treat atherosclerosiss；Adjuvant drug is mainly played and prevents and treats atherosclerosiss
Effect, and assist blood pressure lowering；Make medicine mainly play antihypertensive diuretic relieving constipation, prevent because of the acute complicationses of constipation induction.
The present invention has the advantage that：
One be the present invention from entirety determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs：Multipath, the collaboration of multi-level, Mutiple Targets prevent and treat atherosclerosiss
Hypertension；
Two is principle of the present invention using scientific composition treating both the principal and secondary aspects of a disease：Tens of kinds of Chinese medicine for lowering blood pressure are carried out the property of medicine, drug effect,
Pharmacology, medicine generation, poison of drug screening, realize that synthetically reducing blood pressure, anti peroxidation of lipid, blood fat reducing, tune blood glucose, anticoagulant, antiinflammatory, reverse subtract
Light atherosclerotic effect；
Three is that natural safety has no side effect：Toxic herb is not contained according to pharmacopeia inventive formulation, is adapted to atherosclerosiss
Hyperpietic's long-term taking.
What deserves to be explained is：(1) 9 taste Chinese medicines in the present invention can use the extract of its equivalent functional component to substitute；(2)
The ministerial drug Cortex Eucommiae can be substituted with Folium Eucommiae, and it is 2: 3 than Folium Eucommiae that substitution ratio is the Cortex Eucommiae.(3) present invention can increase as needed
Meet promotion absorbent, slow releasing agent of national regulation etc..
Specific embodiment
The present invention is a kind of Chinese medicine composition for treating atherosclerosiss hypertension and its application, the Chinese medicine composition
It is formulated according to parts by weight comprising following raw materials according：60～300 parts of Radix Salviae Miltiorrhizae, 50～280 parts of Folium Eucommiae, 50～260 parts of Ramulus Uncariae Cum Uncis,
10～100 parts of Rhizoma Coptidis, 50～240 parts of Folium Apocyni Veneti, 50～200 parts of Rhizoma Gastrodiae, 50～200 parts of Pheretima, 6～20 parts of Monas cuspurpureus Went, Herba Plantaginis
20～300 parts of son.
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：280 parts of Radix Salviae Miltiorrhizae, 246 parts of Folium Eucommiae, 230 parts of Ramulus Uncariae Cum Uncis, 80 parts of Rhizoma Coptidis, 240 parts of Folium Apocyni Veneti, 180 parts of Rhizoma Gastrodiae, Pheretima 190
Part, 8 parts of Monas cuspurpureus Went, 200 parts of Semen Plantaginiss.
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：It is 80 parts of Radix Salviae Miltiorrhizae, 100 parts of Folium Eucommiae, 60 parts of Ramulus Uncariae Cum Uncis, 10 parts of Rhizoma Coptidis, 60 parts of Folium Apocyni Veneti, 60 parts of Rhizoma Gastrodiae, 60 parts of Pheretima, red
Bent 12 parts, 50 parts of Semen Plantaginiss.
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：240 parts of Radix Salviae Miltiorrhizae, 220 parts of Folium Eucommiae, 220 parts of Ramulus Uncariae Cum Uncis, 50 parts of Rhizoma Coptidis, 100 parts of Folium Apocyni Veneti, 160 parts of Rhizoma Gastrodiae, Pheretima 160
Part, 15 parts of Monas cuspurpureus Went, 150 parts of Semen Plantaginiss.
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：180 parts of Radix Salviae Miltiorrhizae, 150 parts of Folium Eucommiae, 80 parts of Ramulus Uncariae Cum Uncis, 60 parts of Rhizoma Coptidis, 80 parts of Folium Apocyni Veneti, 80 parts of Rhizoma Gastrodiae, 80 parts of Pheretima,
8 parts of Monas cuspurpureus Went, 60 parts of Semen Plantaginiss.
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：220 parts of Radix Salviae Miltiorrhizae, 200 parts of Folium Eucommiae, 260 parts of Ramulus Uncariae Cum Uncis, 50 parts of Rhizoma Coptidis, 80 parts of Folium Apocyni Veneti, 80 parts of Rhizoma Gastrodiae, Pheretima 100
Part, 10 parts of Monas cuspurpureus Went, 120 parts of Semen Plantaginiss.
Present invention also offers above-mentioned Chinese medicine composition answering in treatment atherosclerosiss hypertension disease medicament is prepared
With.
For the more detailed explanation present invention, the present invention is further elaborated in conjunction with embodiment.Specific embodiment
It is as follows：
Embodiment one
A kind of Chinese medicine composition for treating atherosclerosiss hypertension and its application, the Chinese medicine composition is comprising following
Raw material is formulated according to parts by weight：60 parts of Radix Salviae Miltiorrhizae, 50 parts of Folium Eucommiae, 50 parts of Ramulus Uncariae Cum Uncis, 10 parts of Rhizoma Coptidis, 50 parts of Folium Apocyni Veneti,
50 parts of Rhizoma Gastrodiae, 50 parts of Pheretima, 6 parts of Monas cuspurpureus Went, 20 parts of Semen Plantaginiss.
Embodiment two
A kind of Chinese medicine composition for treating atherosclerosiss hypertension and its application, the Chinese medicine composition is comprising following
Raw material is formulated according to parts by weight：300 parts of Radix Salviae Miltiorrhizae, 280 parts of Folium Eucommiae, 260 parts of Ramulus Uncariae Cum Uncis, 100 parts of Rhizoma Coptidis, Folium Apocyni Veneti
240 parts, 200 parts of Rhizoma Gastrodiae, 200 parts of Pheretima, 20 parts of Monas cuspurpureus Went, 300 parts of Semen Plantaginiss.
Embodiment three
A kind of Chinese medicine composition for treating atherosclerosiss hypertension and its application, the Chinese medicine composition is comprising following
Raw material is formulated according to parts by weight：180 parts of Radix Salviae Miltiorrhizae, 165 parts of Folium Eucommiae, 155 parts of Ramulus Uncariae Cum Uncis, 55 parts of Rhizoma Coptidis, Folium Apocyni Veneti 145
Part, 125 parts of Rhizoma Gastrodiae, 125 parts of Pheretima, 13 parts of Monas cuspurpureus Went, 160 parts of Semen Plantaginiss.
Example IV
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：280 parts of Radix Salviae Miltiorrhizae, 246 parts of Folium Eucommiae, 230 parts of Ramulus Uncariae Cum Uncis, 80 parts of Rhizoma Coptidis, 240 parts of Folium Apocyni Veneti, 180 parts of Rhizoma Gastrodiae, Pheretima 190
Part, 8 parts of Monas cuspurpureus Went, 200 parts of Semen Plantaginiss.
Embodiment five
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：It is 80 parts of Radix Salviae Miltiorrhizae, 100 parts of Folium Eucommiae, 60 parts of Ramulus Uncariae Cum Uncis, 10 parts of Rhizoma Coptidis, 60 parts of Folium Apocyni Veneti, 60 parts of Rhizoma Gastrodiae, 60 parts of Pheretima, red
Bent 12 parts, 50 parts of Semen Plantaginiss.
Embodiment six
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：240 parts of Radix Salviae Miltiorrhizae, 220 parts of Folium Eucommiae, 220 parts of Ramulus Uncariae Cum Uncis, 50 parts of Rhizoma Coptidis, 100 parts of Folium Apocyni Veneti, 160 parts of Rhizoma Gastrodiae, Pheretima 160
Part, 15 parts of Monas cuspurpureus Went, 150 parts of Semen Plantaginiss.
Embodiment seven
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：180 parts of Radix Salviae Miltiorrhizae, 150 parts of Folium Eucommiae, 80 parts of Ramulus Uncariae Cum Uncis, 60 parts of Rhizoma Coptidis, 80 parts of Folium Apocyni Veneti, 80 parts of Rhizoma Gastrodiae, 80 parts of Pheretima,
8 parts of Monas cuspurpureus Went, 60 parts of Semen Plantaginiss.
Embodiment eight
A kind of Chinese medicine composition for treating atherosclerosiss hypertension, prepares according to parts by weight comprising following raw materials according
Form：220 parts of Radix Salviae Miltiorrhizae, 200 parts of Folium Eucommiae, 260 parts of Ramulus Uncariae Cum Uncis, 50 parts of Rhizoma Coptidis, 80 parts of Folium Apocyni Veneti, 80 parts of Rhizoma Gastrodiae, Pheretima 100
Part, 10 parts of Monas cuspurpureus Went, 120 parts of Semen Plantaginiss.
Above-described embodiment is only intended to clearly illustrate example, and the not restriction to embodiment.For institute
For the general technical staff in category field, the change or change of other multi-forms can also be made on the basis of the above description
It is dynamic.There is no need to be exhaustive to all of embodiment, and thus it is amplified obvious change or change
Among moving still in the invention scope of the claims.
Experimental example
Experimental example one：Rat blood pressure lowering is tested
Using the logical SHR (spontaneous hypertensive rat) 24 of Beijing dimension, four groups are randomly divided into, respectively SHR model group, clothes
Of the present invention group, take Nifedipine group, clothes promoting blood circulation YANG hyperactivity suppressing particle group, with the medication of Shanghai noinvasive arteria caudalis instrument for measuring blood pressure dynamic detection
1 week afterwards, 2 weeks, the systolic pressure of 4 weeks SHR.As a result show：Of the present invention group of clothes are pressed with significance and reduce making to SHR systolic pressures and diastole
With its hypotensive effect is slightly less than SHR and takes Nifedipine group, hence it is evident that better than clothes promoting blood circulation YANG hyperactivity suppressing particle group, three groups with SHR model group ratio
Compared with p ＜ 0.05.
Experimental example two：Isolated rat vascular ring Ach blood vessels maximum diastolic rate experiment (being shown in Table 1)
Table 1：The maximum diastolic rate experiment of isolated rat vascular ring Ach blood vessels
| Sequence number | Packet | n | AChEmax (%) | AChEC50(μM) |
| 1 | Blank control group | 8 | 95.43±12.61# | 0.28±0.04# |
| 2 | Model group | 8 | 52.32±14.63* | 2.48±0.15* |
| 3 | Tongxinluo group | 8 | 71.34±17.65*# | 1.89±0.24*# |
| 4 | Of the present invention group | 8 | 74.49±16.09*# | 1.46±0.22*# |
Note：* compare with blank control group, P ＜ 0.05；# model group compares, P ＜ 0.05.
Experimental result is pointed out：Tongxinluo group, of the present invention group have significant difference compared with model group, wherein with the present invention
Group isolated rat vascular ring Ach blood vessel maximum diastolic rate experiment effects are optimal.
Experimental example three
Human trial：Clinical blood pressure lowering test：August part chooses hypertensive patient 29, and matched group takes Nifedipine sustained-release
Piece 5～10mg every time, daily 2 times；Present invention group clothes capsule preparations of the present invention, 3～4 every time, three times a day；Test group is right
Capsule preparations of the present invention are added according to group.Before medication and blood pressure is detected after 8 weeks, as a result of the present invention group has significant blood pressure lowering effect,
It is close to matched group --- Nifedipine sustained release tablets group；Capsule preparations of the present invention and Nifedipine sustained release tablets use in conjunction, and substantially
Better than matched group and application capsule preparations group of the present invention (referring to table 2) merely.
2 three groups of hyperpietic's therapeutic effect of table to contrast (mmHg)
Note：Before each group treatment, between systolic pressure and diastolic pressure, there was no significant difference；* be treatment 8 weeks after with treatment before contrast,
P ＜ 0.05；# is that test group is contrasted with matched group, present invention group respectively, p ＜ 0.05.
Prompting：(1) present invention has preferable hypotensive activity, and its effect is close to Western medicine nifedipine, but without nifedipine
Side effect；(2) present invention can lift therapeutic effect with nifedipine combination, and long-term treatment can cut down the agent of nifedipine
Amount, reduces the side effect of nifedipine.
Case：
Case 1：Gold certain, man, 44 years old, hypertension 6 years, for a long time with western medicine, blood pressure is controlled higher and higher, headache, dizziness,
Work is affected, is felt panic, is started to take capsule preparations of the present invention in August, 2016,4 every time, three times a day, blood after three days
Pressure gradually tends towards stability and declines, and headache, dizziness disappear, and do not affect work, still adhere to so far taking, and feels head and complete
Body is easily a lot.
Case 2：Lv, man, 65 years old, more than 10 years of hypertension, three generation cerebrovasculars of in December, 2015～2016 year May
Spasm hospitalization, all can not very control blood pressure with blood pressure lowerings such as DAIWEN, and the normal dizzy, feeling of fullness in the heads of patient Jing, psychological burden are very heavy,
In June, 2016 starts to add capsule preparations of the present invention, 4 every time, and three times a day, couple of days just feels brains easily, hemiplegia body
Levy and also make moderate progress, now continue to take.
Case 3：It is former so-and-so, female 76 years old, has nearly 30 years hypertension histories, and long-term taking Altace Ramipril makes blood pressure basic
Remain normal.In April, 2016, prominent sense was dizzy, dizzy, and blood pressure is increased to 176mmHg/110mmHg, starts to add capsule of the present invention
Preparation, three times a day, makes blood pressure stabilization by 4 every time, and slightly above normally, patient feels brains and whole body easily, and the mental status is good
It is good, continue to so far take.
Case 4：Zhao, man, 39 years old, height 173cm, body weight 97kg suffered from hypertension 2 years, diabetes 1 year, because without substantially
Malaise symptoms, are treated, and dizziness, headache, tinnitus occurs suddenly in late September, 2016, measure blood pressure 172mmHg/
94mmHg, starts to take capsule preparations of the present invention, and 4 every time, three times a day, blood pressure slowly declines, now slightly above normal, blood glucose
Take a turn for the better, without significant discomfort symptom, continued to take the present invention, and keep on a diet.
Claims (7)
1. a kind of Chinese medicine composition for treating atherosclerosiss hypertension, it is characterised in that：The Chinese medicine composition is included down
Row raw material is formulated according to parts by weight：60～300 parts of Radix Salviae Miltiorrhizae, 50～280 parts of Folium Eucommiae, 50～260 parts of Ramulus Uncariae Cum Uncis, Rhizoma Coptidis 10
～100 parts, 50～240 parts of Folium Apocyni Veneti, 50～200 parts of Rhizoma Gastrodiae, 50～200 parts of Pheretima, 6～20 parts of Monas cuspurpureus Went, Semen Plantaginiss 20～
300 parts.
2. a kind of Chinese medicine composition for treating atherosclerosiss hypertension, it is characterised in that：The Chinese medicine composition is included down
Row raw material is formulated according to parts by weight：280 parts of Radix Salviae Miltiorrhizae, 246 parts of Folium Eucommiae, 230 parts of Ramulus Uncariae Cum Uncis, 80 parts of Rhizoma Coptidis, Folium Apocyni Veneti
240 parts, 180 parts of Rhizoma Gastrodiae, 190 parts of Pheretima, 8 parts of Monas cuspurpureus Went, 200 parts of Semen Plantaginiss.
3. a kind of Chinese medicine composition for treating atherosclerosiss hypertension, it is characterised in that：The Chinese medicine composition is included down
Row raw material is formulated according to parts by weight：80 parts of Radix Salviae Miltiorrhizae, 100 parts of Folium Eucommiae, 60 parts of Ramulus Uncariae Cum Uncis, 10 parts of Rhizoma Coptidis, Folium Apocyni Veneti 60
Part, 60 parts of Rhizoma Gastrodiae, 60 parts of Pheretima, 12 parts of Monas cuspurpureus Went, 50 parts of Semen Plantaginiss.
4. a kind of Chinese medicine composition for treating atherosclerosiss hypertension, it is characterised in that：The Chinese medicine composition is included down
Row raw material is formulated according to parts by weight：240 parts of Radix Salviae Miltiorrhizae, 220 parts of Folium Eucommiae, 220 parts of Ramulus Uncariae Cum Uncis, 50 parts of Rhizoma Coptidis, Folium Apocyni Veneti
100 parts, 160 parts of Rhizoma Gastrodiae, 160 parts of Pheretima, 15 parts of Monas cuspurpureus Went, 150 parts of Semen Plantaginiss.
5. a kind of Chinese medicine composition for treating atherosclerosiss hypertension, it is characterised in that：The Chinese medicine composition is included down
Row raw material is formulated according to parts by weight：180 parts of Radix Salviae Miltiorrhizae, 150 parts of Folium Eucommiae, 80 parts of Ramulus Uncariae Cum Uncis, 60 parts of Rhizoma Coptidis, Folium Apocyni Veneti 80
Part, 80 parts of Rhizoma Gastrodiae, 80 parts of Pheretima, 8 parts of Monas cuspurpureus Went, 60 parts of Semen Plantaginiss.
6. a kind of Chinese medicine composition for treating atherosclerosiss hypertension, it is characterised in that：The Chinese medicine composition is included down
Row raw material is formulated according to parts by weight：220 parts of Radix Salviae Miltiorrhizae, 200 parts of Folium Eucommiae, 260 parts of Ramulus Uncariae Cum Uncis, 50 parts of Rhizoma Coptidis, Folium Apocyni Veneti
80 parts, 80 parts of Rhizoma Gastrodiae, 100 parts of Pheretima, 10 parts of Monas cuspurpureus Went, 120 parts of Semen Plantaginiss.
7. any one Chinese medicine composition according to claim 1-6 is preparing treatment atherosclerosiss hypertension disease medicament
In application.
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| WO2018099216A1 (en) * | 2016-11-29 | 2018-06-07 | 新乡医学院 | Traditional chinese medicine composition for treating atherosclerosis-caused hypertension and application thereof |
| CN110314213A (en) * | 2019-08-12 | 2019-10-11 | 南京依美生物科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating fibroid |
| CN115006455A (en) * | 2022-05-19 | 2022-09-06 | 新乡医学院 | Application of traditional Chinese medicine compound Xinmaijia in preparation of medicines for treating or preventing atherosclerosis diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2018099216A1 (en) * | 2016-11-29 | 2018-06-07 | 新乡医学院 | Traditional chinese medicine composition for treating atherosclerosis-caused hypertension and application thereof |
| CN106924712A (en) * | 2017-04-20 | 2017-07-07 | 上药东英（江苏）药业有限公司 | A kind of compound sustained-released tablet of new anti-hypertension and production technology |
| CN110314213A (en) * | 2019-08-12 | 2019-10-11 | 南京依美生物科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating fibroid |
| CN115006455A (en) * | 2022-05-19 | 2022-09-06 | 新乡医学院 | Application of traditional Chinese medicine compound Xinmaijia in preparation of medicines for treating or preventing atherosclerosis diseases |
Also Published As
| Publication number | Publication date |
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| WO2018099216A1 (en) | 2018-06-07 |
| RU2019102150A (en) | 2020-07-27 |
| RU2736357C2 (en) | 2020-11-16 |
| RU2019102150A3 (en) | 2020-07-27 |
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