CN106540030A - One kind treats migrainous Chinese medicine extract and preparation method and application - Google Patents
One kind treats migrainous Chinese medicine extract and preparation method and application Download PDFInfo
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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- A61K2236/30—Extraction of the material
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Abstract
The invention belongs to natural extract technical field, and in particular to a kind of Chinese medicine extract, and its extracting method and its purposes for preparing treatment migraine remedy are further disclosed.Chinese medicine extract of the present invention, containing at least total polysaccharidess of 15wt% and total polyphenols, extract obtained effective ingredient clearly, and has significant analgesic effect, can effectively alleviate and treat cephalagra, and have the advantages that safe and free of toxic and side effects.Meanwhile, the analgesic drug product of different dosage form is prepared using the clear and definite extract of effective ingredient, not only make patient easy to carry, while therapeutic effect is also more projected.
Description
Technical field
The invention belongs to natural extract technical field, and in particular to one kind treats migrainous Chinese medicine extract, goes forward side by side
One step discloses its preparation method.
Background technology
Seed of the Semen Arecae for babassu Semen Arecae (Areca catechu L.), is the precious tropical plants in Hainan, position
First of 5 great Nan medicines of China (Semen Arecae, Fructus Amomi, Fructus Alpiniae Oxyphyllae, Morinda offcinalis How, Lignum Aquilariae Resinatum).China's Semen Arecae is mainly distributed on Hainan, two province of Taiwan,
Hainan Semen Arecae cultivated area and yield account for the 98% of China mainland at present.Semen Arecae is to be only second to natural rubber in Hainan Province's tropical crops
The second largest pillar industry of glue industry, is described as " emerald " by local farmers.Betel quid chewing is the tradition with more than 2,000 years history
Dietetic custom, Chinese's custom betel quid chewing fresh fruit (Hainan, Taiwan) and dry fruit processed goods (other areas of China), and print
Degree and Southeast Asia are based on Semen Arecae chewing block.Semen Arecae has refreshment, the effect for producing sense of euphoria, improving endurance, is only secondary
In nicotine, ethanol, coffee global the fourth-largest preference, the current whole world there are about 700,000,000 people's edible areca-nuts, it is contemplated that will after 10 years
2,000,000,000 whole world consumption Semen Arecae crowd is formed, annual value of production is expected to break through 2 trillion yuan of RMB.
Fresh areca nuts contain various chemical compositions, have detected 68 kinds of chemical composition, mainly including alkaloid, polyphenol and
Tannin etc..Version in 2015《Chinese Pharmacopoeia》Semen Arecae (dry mature seed) is recorded with parasite killing, removing food stagnancy, circulation of qi promoting, diuretic, preventing the attack (or recurrence) of malaria etc.
Effect, above effect majority and arecoline positive correlation, arecoline is main alkaloid in Semen Arecae, with excited heating, increases stomach
Enterokinesia, shrink bronchus, cause the physiologically actives such as vasodilation.It is anti-tired that scientific research in the recent period finds that the new effect of Semen Arecae includes
Labor, reduction cholesterol, antioxidation, antidepressant, anti-senile dementia effect etc., such effect and effective portion such as Semen Arecae polysaccharide, polyphenol
Position is related, and the constituents mostly are heat sensitive components, understands decomposes or lose activity more than 60 DEG C.
Migraine is that a class is ictal and be often unilateral pulsatile headache, is a kind of commonly encountered diseases, frequently-occurring disease, and most is suffered from
Person has family history.Domestic migrainous sickness rate is about 10%, and the developed country such as America and Europe sickness rate is higher.In the U.S., inclined head
The social economical burden that pain is caused is hundred million dollars of 10-17.A large amount of migraineurs thus have a strong impact on work, studying and living.
When migraine is suddenly shown effect, patient is very painful, it is now recognized that Drug therapy still controls the best approach shown effect, greatly
Medicine of applying has vasoconstrictor, hormone, prostaglandin inhibitor etc., but these medicines have different degrees of side effect.Adopt
Have long-range history with treatment by Chinese herbs migraine, for example the permanent pungent soup of rhizome of chuanxiong in Lee east, using Rhizoma Chuanxiong, Herba Asari, Fructus Viticises, the Radix Angelicae Dahuricae,
The medicines such as Radix Saposhnikoviae, Radix Glycyrrhizae.But being on the one hand directly used as medicine with Chinese medicine crude drug causes processing complex, it is often more important that, medical material
In other non-principal components for containing the performance of drug effect may be affected even to cause unknown side effect, be unfavorable for controlling curative effect
Really.
The content of the invention
For this purpose, the technical problem to be solved is to provide a kind of Chinese medicine extract, and further discloses which and carry
Method is taken, and for preparing the purposes for the treatment of migraine remedy.
To solve above-mentioned technical problem, Chinese medicine extract of the present invention, the extract includes that mass ratio is 10-
70：The total polysaccharidess and total polyphenols of 5-30, and preferably the mass ratio of the total polysaccharidess and total polyphenols is 45-50：8-10.
Preferably, in terms of the total amount of the extract, the mass percent of the total polysaccharidess and total polyphenols is at least
15wt%.
The invention also discloses a kind of method for extracting Chinese medicine extract, comprises the steps：
(1) squeezing is extracted：Fresh Semen Arecae is crushed and carried out physical squeezing, collection fruit juice is separated by filtration, while merging residual
Slag is standby；
(2) residue is extracted：Add water in residue mixing, and adds low-temperature cellulase to carry out biological cracking, subsequently adjusts
Reacting liquid pH value 2-7, filters to obtain extracting solution；
(3) it is dehydrated：Gained fruit juice will merge and carry out processed and obtain solidss in gained extracting solution and step (1), as
Required Chinese medicine extract effective site.
Low-temperature cellulase of the present invention is using commercially available prod in prior art.
In the step (1), the squeezing step is carried out at a temperature of 10-80 DEG C.
In the step (2), the addition of the low-temperature cellulase accounts for the 0.05%-1wt% of the residue weight, institute
The addition for stating water is the 3-10 times of weight amounts of the residue.
The invention also discloses the Chinese medicine extract obtained by the extracting method, the extract includes that mass ratio is
10-70：The total polysaccharidess and total polyphenols of 5-30.
Preferably, in terms of the total amount of the extract, containing at least total polysaccharidess of 15wt% and total polyphenols.
The invention also discloses the Chinese medicine extract is used for the purposes for preparing treatment migraine remedy.
The invention also discloses by the Chinese medicine extract, adding customary adjuvant and/or carrier, according to common process, make
Into clinically-acceptable oral formulations.
Above-mentioned pharmaceutically acceptable carrier refers to the conventional pharmaceutical carrier of pharmaceutical field or adjuvant, for example：Disintegrating agent is such as
It is dried starch, sodium carboxymethyl cellulose, polyvinylpyrrolidone etc., filler such as calcium phosphate, starch, dextrin, sucrose, Fructus Hordei Germinatus
Sugar, Microcrystalline Cellulose etc.；Disintegrating agent such as corn starch；Binding agent such as starch slurry, polyvidone, cellulose derivative, alginate, bright
Glue etc.；Lubricant such as Pulvis Talci, calcium stearate and magnesium, differential silica gel and Polyethylene Glycol, glycerol etc.；Absorption enhancer is for example quaternized
Compound；Surfactant such as hexadecanol, sodium lauryl sulphate；Stabilizer such as methyl parahydroxybenzoate, para hydroxybenzene first
Propyl propionate etc..
Described preparation includes the routine oral preparations such as buccal tablet, chewable tablet, drop pill or chewing gum.
Chinese medicine extract of the present invention is to extract to prepare gained with fresh Semen Arecae as raw material, with low temperature fiber element to extract
Enzyme, further extracts from Semen Arecae residue and obtains total polysaccharidess and total polyphenols, and extract contains total polysaccharidess and total polyphenols composition, gained
The effective ingredient of extract is clear and definite, and more than content 15wt% of effective ingredient, effective site content is higher.Pharmacological evaluation table
Bright, Chinese medicine extract of the present invention has significant analgesic effect, can effectively alleviate and treat cephalagra, and have
The advantages of safe and free of toxic and side effects.Study carefully its pharmacological action, the Chinese medicine extract can effectively facilitate cerebral blood circulation, suppress 5-
HT, pathogenic peptides and Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 isoreactivity, with activating blood circulation to dissipate blood stasis, dredging collateral, alleviate angiospastic effect, and can significantly inhibit
Platelet aggregation, reduction blood viscosity, so as to improve cerebral blood circulation and brain cell energy metabolism, protect brain cell, so as to
Can effectively preventing migraine.
The analgesic drug product of different dosage form can be prepared using the clear and definite Chinese medicine extract of effective ingredient of the present invention, not only made
Patient is easy to carry, while therapeutic effect is also more projected.
Specific embodiment
Authentication method：
First, using total polysaccharidess content in spectrophotometry Chinese medicine extract
Main agents and instrument：Glucose (biochemical reagents, National Institute for Food and Drugs Control)；5% phenol solution；It is dense
Sulfuric acid solution.DUV-2450 type ultraviolet-visible spectrophotometers (Japanese Shimadzu).
1st, the preparation of standard solution
Precision weighs the glucose about 25mg of 105 DEG C of dryings to constant weight, is placed in 250mL volumetric flasks, after being dissolved in water, and uses
Water is settled to scale, shakes up, and in the standard solution being made into, concentration of glucose is about 0.1mg/mL.
2nd, prepared by Chinese medicine extract (test sample) solution
Test sample about 50mg is taken, accurately weighed, the 40mL that adds water dissolvings are quantitatively transferred in 250mL volumetric flasks, dilute
To scale.
3rd, assay method
3.1 standard curve determination
Precision measures reference substance solution 0.2mL, 0.4mL, 0.6mL, 0.8mL, 1.0mL, puts respectively in tool plug test tube, respectively
Add water and mend to 2.0mL；
5% phenol solution 1mL of each accurate addition, shakes up, rapid accurate addition sulphuric acid 5mL, shakes up, places 10min, put 40
15min is incubated in DEG C water-bath, is taken out, is rapidly cooled to room temperature；
Blank solution is prepared simultaneously：Precision measures purified water 2mL, puts in tool plug test tube, prepares according to test sample method blank
Solution；
With blank solution return to zero, in 490nm locate mensuration absorbance, with absorbance as vertical coordinate, concentration is abscissa, drafting
Regression curve, calculates equation of linear regression.
3.2 sample analysis
Precision measures need testing solution 0.5mL, puts in tool plug test tube, the benefit that adds water to 2.0mL.According under standard curve determination item
Method prepare test sample and blank solution, returned to zero with blank solution, the mensuration absorbance at the 490nm.
4th, result is calculated
According to the equation of linear regression of glucose, the total polysaccharidess concentration C in determined need testing solution is calculated2。
In Chinese medicine extract, total polysaccharidess are with mass fraction w2Meter, numerical value are represented with %, are calculated as follows：
The mass fraction of total polysaccharidess component, % in w2- test samples；
C2Total polysaccharidess concentration of component in-need testing solution, unit are mg/mL；
V2The dilution volume of-need testing solution, unit are milliliter (mL)；
m2The sample weighting amount of-test sample, unit are milligram (mg).
2nd, using total polyphenols in spectrophotometry Chinese medicine extract.
Main agents and instrument：Gallic acid (biochemical reagents, National Institute for Food and Drugs Control)；Methanol；7.5% carbon
Acid sodium solution；Forint phenol test solution；DUV-2450 type ultraviolet-visible spectrophotometers (Japanese Shimadzu).
1st, the preparation of standard solution
Gallic acid standard substance about 20mg is taken, it is accurately weighed, it is transferred in 100mL volumetric flasks after being dissolved with methanol, plus first
Alcohol is settled to scale, shakes up, and obtains gallic acid storing solution.Precision measures above-mentioned storing solution 0.5,1,2,4,6,8,10mL, respectively
Put in 10mL volumetric flasks, plus methanol is to scale, shakes up, obtain a series of gallic acid standard solution of variable concentrations.2nd, Chinese medicine is carried
Take the preparation of thing (test sample) solution
Precision weighs test sample about 200-300mg, is transferred in 250mL volumetric flasks, with methanol constant volume extremely after methanol dissolving
Scale, shakes up and both obtained.
3rd, assay method
3.1 standard curve determination
Precision measures the standard solution 0.2mL of above-mentioned each concentration, puts in 10mL nessler colorimetric tubes, plus distilled water 1mL, shakes
It is even；
1.4mL films phenol reagent is added to add 1.8mL 0.9%NaNO immediately after acutely shaking3Aqueous solution acutely shakes again
Swing, shady place is placed 30 minutes；
Blank solution is prepared：Precision measures methanol 0.2mL, puts in 10mL nessler colorimetric tubes, plus distilled water 1mL, shakes up, together
When prepare blank solution according to aforementioned test sample method；
With blank solution return to zero, in 730nm locate mensuration absorbance, with absorbance as vertical coordinate, concentration is abscissa, drafting
Regression curve, calculates equation of linear regression.
3.2 sample analysis
It is accurate to draw 0.2mL need testing solutions, put in 10mL nessler colorimetric tubes, plus distilled water 1mL, shaking up, sighting target is accurate bent
Line determines legal system available test product and blank solution below item, is returned to zero with blank solution, the mensuration absorbance at the 730nm.
4th, result is calculated
According to the equation of linear regression of gallic acid, the polyphenol concentration C in determined need testing solution is calculated1。
In Chinese medicine extract, polyphenol is with mass fraction w1Meter, numerical value are represented with %, are calculated as follows：
w1The mass fraction of weight polyphenol fraction, % in-test sample；
C1Weight polyphenol fraction concentration in-need testing solution, unit are mg/mL；
V1The dilution volume of-need testing solution, unit are milliliter (mL)；
m1The sample weighting amount of-test sample, unit are milligram (mg).
Embodiment 1
Described in the present embodiment, Chinese medicine extract is extracted in accordance with the following steps：
(1) squeezing is extracted：Fresh Semen Arecae is sorted, is cleaned up, crush, at 50 DEG C, squeezing is carried out with physical method and obtained
Fruit juice is obtained, fruit juice obtains clear juice through processing, while it is stand-by to merge residue；
(2) residue is extracted：The water of 5 times of weight amount of residue weight is added to mix in the residue of above-mentioned collection, while add accounting for
The low-temperature cellulase of the residue weight percentage ratio 0.1wt% carries out biological cracking, and adds hydrochloric acid to adjust reacting liquid pH value
5, after standing 8h, 10000rpm centrifugations obtain extracting solution；
(3) it is dehydrated：Gained fruit juice in extracting solution obtained by combining step (2) and step (1), using concentrate under reduced pressure at low temperature mode
It is dehydrated, obtains solidss, and cross 60 mesh and crush, inspection, the Chinese medicine extract needed for obtaining final product.
Detect according to aforementioned detection method, in gained Chinese medicine extract, total polysaccharidess content is 50wt%, and Determination of Polyphenols is
10wt%.
Embodiment 2
Described in the present embodiment, Chinese medicine extract is extracted in accordance with the following steps：
(1) squeezing is extracted：Fresh Semen Arecae is sorted, is cleaned up, crush, at 20 DEG C, squeezing is carried out with physical method and obtained
Fruit juice is obtained, fruit juice obtains clear juice through processing, while it is stand-by to merge residue；
(2) residue is extracted：The water of 3 times of weight amount of residue weight is added to mix in the residue of above-mentioned collection, while add accounting for
The low-temperature cellulase of the residue weight percentage ratio 0.05wt% carries out biological cracking, and adds hydrochloric acid to adjust reacting liquid pH value
2, after standing 12h, 6000rpm centrifugations obtain extracting solution；
(3) it is dehydrated：Gained fruit juice in extracting solution obtained by combining step (2) and step (1), using concentrate under reduced pressure at low temperature mode
It is dehydrated, obtains solidss, and cross 30-120 mesh and crush, inspection, the effective ingredient in Chinese needed for obtaining final product.
Detect according to aforementioned detection method, in gained Chinese medicine extract, total polysaccharidess content is 45wt%, and Determination of Polyphenols is
10wt%.
Embodiment 3
Described in the present embodiment, Chinese medicine extract is extracted in accordance with the following steps：
(1) squeezing is extracted：Fresh Semen Arecae is sorted, is cleaned up, crush, at 80 DEG C, squeezing is carried out with physical method and obtained
Fruit juice is obtained, fruit juice obtains clear juice through processing, while it is stand-by to merge residue；
(2) residue is extracted：The water of 10 times of weight amount of residue weight is added to mix in the residue of above-mentioned collection, while add accounting for
The low-temperature cellulase of the residue weight percentage ratio 1wt% carries out biological cracking, and adds hydrochloric acid to adjust reacting liquid pH value 7,
After standing 1h, 12000rpm centrifugations obtain extracting solution；
(3) it is dehydrated：Gained fruit juice in extracting solution obtained by combining step (2) and step (1), using concentrate under reduced pressure at low temperature mode
It is dehydrated, obtains solidss, and cross 30-120 mesh and crush, inspection, the Chinese medicine extract needed for obtaining final product.
Detect according to aforementioned detection method, in gained Chinese medicine extract, total polysaccharidess content is 50wt%, and Determination of Polyphenols is
8wt%.
The preparation of 4 buccal tablet of embodiment
The Chinese medicine extract 10g for preparing in taking above-described embodiment 1, cane sugar powder 10g, Mannitol powder 5g, sorbitol powder 20g,
It is placed in pulverizer and crushes.It is subsequently adding 50% appropriate ethanol soft material, the wet grain of 20 mesh sieve series, in 50 DEG C of drying under reduced pressure, 16
Mesh sieve granulate, after adding strawberry essence 5g, carboxymethyl starch sodium 3g and 0.5g to mix, tabletting, both.
The preparation of 5 chewable tablet of embodiment
The Chinese medicine extract 10g for preparing in taking above-described embodiment 1, Mannitol 20g, Microcrystalline Cellulose 20g, are placed in pulverizer
Middle crushing, crosses 50 mesh sieves.Magnesium stearate-Pulvis Talci 5g, micropowder silica gel 5g and polyvidone powder 10g are subsequently adding, are stirred
Direct powder compression, both obtained afterwards.
The preparation of 6 drop pill of embodiment
Take 5g Macrogol 4000s, 10g polyethylene glycol 6000s and 90 DEG C are heated in water-bath, after all melting, add
5g Chinese medicine extract, stirs to dissolving, is uniformly dispersed, and in 75 DEG C of sealed thermal insulatings 60 minutes, instills 0-10 DEG C of dimethicone
In, the drip of the drop pill of formation to the greatest extent and is wiped into dimethicone, drying, drop pill is made.
The preparation of 7 chewing gum of embodiment
5g Chinese medicine extract, 10g chewing gum bases (are softened), 5g is sugared, 5g essence, the stirring of 10 polyhydric alcohol heats 60 DEG C,
It is mixed into mixed material.Then the mixed material for obtaining cooling, tabletting, cutting are obtained final product into chewing gum.
Experimental example
First, clinical treatment
1st, Therapeutic Method
Clinical observation treatment is carried out to 300 migraineurs, wherein man 100, female 200, the age 14-70 year it
Between.
Using the buccal tablet prepared in the embodiment of the present invention 4, the morning, noon and afternoon are each 1 time, each 25g, one after each meal.Patients with mild takes
With 30 days or so, severe case took 90 days or so.
2nd, curative effect judging standard is：
Cure：Migraine and related symptoms all disappear, and do not affect activity and work, and follow-up half a year is without recurrence；
It is effective：Migraine and related symptoms all disappear, and after treatment, symptom substantially mitigates, and does not affect activity and work；
Effectively：Related symptoms and sign have improvement, but unstable condition, have rebound phenomenon after drug withdrawal；
It is invalid：Clinical symptoms and sign are unchanged or increase on the contrary.
3rd, clinical effectiveness
300 patients are carried out with therapeutic effect tracking and follow-up according to above-mentioned criterion of therapeutical effect, record clinical therapeutic efficacy is such as
Under：Clinical cure 272 (90.7%), effective 18 (6%), effective 8 (2.7%), invalid 2 (0.6%), total effective rate
For 99.4%.
2nd, model case：
Case 1
XX is opened, male, 50 years old, the migraine course of disease was 2 years, per monthly average attack times at 3 times, the persistent period of showing effect every time is
3 days.Check the patient's condition：Dimly red tongue, white and thin fur.Using Chinese medicine extract buccal tablet of the present invention, continuous experiment 3 months, symptom disappear,
Follow-up half a year has no recurrence.
Case 2
Remaining XX, female, 52 years old, the migraine course of disease 3 years was averagely monthly shown effect 2-3 time, and the outbreak persistent period is 2 days every time.Inspection
Look into the patient's condition：Dimly red tongue, white and thin fur, deep-slow pulse.Using Chinese medicine extract buccal tablet of the present invention, continuous experiment 3 months, symptom disappears
Lose, follow-up half a year has no recurrence.
Case 3
Pay XX, female, 42 years old, overworked burst migraine.Check the patient's condition：Tongue nature is dark violet spottiness or ecchymosis, stringy and hesitant pulse.
Jing takes Chinese medicine extract buccal tablet of the present invention 2 months, and symptom mitigation takes a recovery from illness in month again, and follow-up half a year has no recurrence.
Obviously, above-described embodiment is only intended to clearly illustrate example, and the not restriction to embodiment.It is right
For those of ordinary skill in the art, can also make on the basis of the above description other multi-forms change or
Change.There is no need to be exhaustive to all of embodiment.And thus it is extended obvious change or
Among changing still in the protection domain of the invention.
Claims (10)
1. a kind of Chinese medicine extract, it is characterised in that the extract includes that mass ratio is 10-70：Total polysaccharidess of 5-30 and total
Polyphenol.
2. Chinese medicine extract according to claim 1, it is characterised in that in terms of the total amount of the Chinese medicine extract, described
The mass percent of total polysaccharidess and total polyphenols is at least 15wt%.
3. it is a kind of extract Chinese medicine extract method, it is characterised in that comprise the steps：
(1) squeezing is extracted：Fresh Semen Arecae is crushed and carried out physical squeezing, collection fruit juice is separated by filtration, while it is standby to merge residue
With；
(2) residue is extracted：Add water in residue mixing, and adds low-temperature cellulase to carry out biological cracking, subsequently adjusts reaction
Liquid pH value 2-7, filters to obtain extracting solution；
(3) it is dehydrated：Gained fruit juice will merge and carry out processed and obtain solidss in gained extracting solution and step (1), it is as required
Chinese medicine extract effective site.
4. the method for the Chinese medicine extract described in extraction according to claim 3, it is characterised in that in the step (1),
The squeezing step is carried out at a temperature of 10-80 DEG C.
5. the method for the Chinese medicine extract described in the extraction according to claim 3 or 4, it is characterised in that the step (2)
In, the addition of the low-temperature cellulase accounts for the 0.05%-1wt% of the residue weight, and the addition of the water is described
The 3-10 times of weight amounts of residue.
6. the Chinese medicine extract that the extracting method by described in any one of claim 3-5 is obtained, it is characterised in that the extract bag
Mass ratio is included for 10-70：The total polysaccharidess and total polyphenols of 5-30.
7. Chinese medicine extract according to claim 6, it is characterised in that in terms of the total amount of the extract, containing at least
The total polysaccharidess and total polyphenols of 15wt%.
8. Chinese medicine extract any one of claim 1,2,6,7 is used for the purposes for preparing treatment migraine remedy.
9. the Chinese medicine extract by any one of claim 1,2,6,7, adds customary adjuvant and/or carrier, according to routine
Technique, made by clinically-acceptable oral formulations.
10. preparation according to claim 9, it is characterised in that the preparation includes that buccal tablet, chewable tablet, drop pill or mouth are fragrant
Sugar.
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| CN201710025751.2A CN106540030A (en) | 2017-01-13 | 2017-01-13 | One kind treats migrainous Chinese medicine extract and preparation method and application |
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| CN201710025751.2A CN106540030A (en) | 2017-01-13 | 2017-01-13 | One kind treats migrainous Chinese medicine extract and preparation method and application |
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Citations (2)
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| CN101961059A (en) * | 2009-07-24 | 2011-02-02 | 天津天士力现代中药资源有限公司 | Puer tea extract, preparation method and application |
| CN103478719A (en) * | 2013-09-27 | 2014-01-01 | 许启太 | Method for extracting betel nut biotin form fresh betel nuts |
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2017
- 2017-01-13 CN CN201710025751.2A patent/CN106540030A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961059A (en) * | 2009-07-24 | 2011-02-02 | 天津天士力现代中药资源有限公司 | Puer tea extract, preparation method and application |
| CN103478719A (en) * | 2013-09-27 | 2014-01-01 | 许启太 | Method for extracting betel nut biotin form fresh betel nuts |
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| Title |
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| AMOL BHANDARE等: "Evaluation of anti-migraine potential of Areca catechu to prevent nitro glycerin-induced delayed inflammation in rat meninges:Possible involvemen tof NOS inhibition", 《JOURNAL OF ETHNOPHARMACOLOGY》 * |
| 卢俊等: "《常见病食疗手册》", 30 September 2003, 羊城晚报出版社 * |
| 普义鑫: "槟榔多酚提取、纯化及组分分析", 《中国优秀硕士学位论文全文数据库》 * |
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Application publication date: 20170329 |