CN106537148B - 癌症干细胞的鉴定及其用于诊断和治疗的用途 - Google Patents

癌症干细胞的鉴定及其用于诊断和治疗的用途 Download PDF

Info

Publication number
CN106537148B
CN106537148B CN201580037960.8A CN201580037960A CN106537148B CN 106537148 B CN106537148 B CN 106537148B CN 201580037960 A CN201580037960 A CN 201580037960A CN 106537148 B CN106537148 B CN 106537148B
Authority
CN
China
Prior art keywords
cells
tumor
population
passaged
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201580037960.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN106537148A (zh
Inventor
本杰明·德克尔
奥里特·哈拉里斯坦伯格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tel Hashemel Medical Research Infrastructure And Services Co Ltd
Original Assignee
Tel Hashemel Medical Research Infrastructure And Services Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tel Hashemel Medical Research Infrastructure And Services Co Ltd filed Critical Tel Hashemel Medical Research Infrastructure And Services Co Ltd
Publication of CN106537148A publication Critical patent/CN106537148A/zh
Application granted granted Critical
Publication of CN106537148B publication Critical patent/CN106537148B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90203—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
CN201580037960.8A 2014-06-25 2015-06-25 癌症干细胞的鉴定及其用于诊断和治疗的用途 Expired - Fee Related CN106537148B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462016773P 2014-06-25 2014-06-25
US62/016,773 2014-06-25
PCT/IL2015/050663 WO2015198334A2 (en) 2014-06-25 2015-06-25 Identification of cancer stem cells and use of same for diagnosis and treatment

Publications (2)

Publication Number Publication Date
CN106537148A CN106537148A (zh) 2017-03-22
CN106537148B true CN106537148B (zh) 2019-10-11

Family

ID=53674236

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580037960.8A Expired - Fee Related CN106537148B (zh) 2014-06-25 2015-06-25 癌症干细胞的鉴定及其用于诊断和治疗的用途

Country Status (11)

Country Link
US (1) US10883994B2 (cg-RX-API-DMAC7.html)
EP (1) EP3161480B1 (cg-RX-API-DMAC7.html)
JP (1) JP6587288B2 (cg-RX-API-DMAC7.html)
KR (1) KR20170041192A (cg-RX-API-DMAC7.html)
CN (1) CN106537148B (cg-RX-API-DMAC7.html)
AU (1) AU2015278659A1 (cg-RX-API-DMAC7.html)
CA (1) CA2953663A1 (cg-RX-API-DMAC7.html)
ES (1) ES2791199T3 (cg-RX-API-DMAC7.html)
IL (1) IL249741B (cg-RX-API-DMAC7.html)
SG (1) SG11201610630RA (cg-RX-API-DMAC7.html)
WO (1) WO2015198334A2 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201610630RA (en) 2014-06-25 2017-01-27 Tel Hashomer Medical Res Infrastructure & Services Ltd Identification of cancer stem cell markers and use of same for diagnosis and treatment
EP3427059A1 (en) * 2016-03-09 2019-01-16 Institut National De La Sante Et De La Recherche Medicale (Inserm) Total cellular iron as a marker of cancer stem cells and uses thereof
CN108967358A (zh) * 2018-05-31 2018-12-11 上海交通大学医学院附属瑞金医院 一种斑马鱼fl肿瘤模型的构建方法及其应用
KR20200109544A (ko) * 2019-03-13 2020-09-23 울산대학교 산학협력단 공통 유전자 추출에 의한 다중 암 분류 방법
KR102400464B1 (ko) * 2020-07-28 2022-05-19 부산대학교 산학협력단 암 줄기세포 검출용 바이오 마커 조성물
CN114624304B (zh) * 2021-12-09 2023-09-19 重庆医科大学国际体外诊断研究院 基于铈银纳米花和分支DNAzyme步行器的miRNA电化学传感器

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101855339A (zh) * 2007-01-22 2010-10-06 雷文生物技术公司 人类癌症干细胞
CN101868534A (zh) * 2007-08-10 2010-10-20 哈布勒支研究所 用于鉴定、扩增和去除成体干细胞和癌干细胞的方法
US20110111434A1 (en) * 2008-07-15 2011-05-12 Huang Emina H Colon stem cells associated with colitisand colorectal cancer and methods of use

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4289747A (en) 1978-12-26 1981-09-15 E-Y Laboratories, Inc. Immunological determination using lectin
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5204096A (en) 1984-03-07 1993-04-20 New York Blood Center, Inc. Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5171578A (en) 1985-06-26 1992-12-15 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US5258499A (en) 1988-05-16 1993-11-02 Vestar, Inc. Liposome targeting using receptor specific ligands
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US6132764A (en) 1994-08-05 2000-10-17 Targesome, Inc. Targeted polymerized liposome diagnostic and treatment agents
US5935850A (en) 1996-09-30 1999-08-10 The Research Foundation Of State University Of New York Model for cell migration and use thereof
US6037137A (en) 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
TW200422749A (en) 2003-04-22 2004-11-01 Adv Lcd Tech Dev Ct Co Ltd Crystallization apparatus, crystallization method, phase modulation element, device and display apparatus
US20070021365A1 (en) * 2005-06-21 2007-01-25 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto
WO2009114809A1 (en) * 2008-03-14 2009-09-17 Retrotope, Inc. Therapies for cancer using isotopically substituted lysine
WO2009120100A1 (en) 2008-03-26 2009-10-01 Veritide Limited An analysis system
EP2401362B1 (en) 2009-02-26 2017-04-12 Tel HaShomer Medical Research Infrastructure and Services Ltd. Isolated populations of renal stem cells and methods of isolating and using same
JPWO2010110346A1 (ja) * 2009-03-24 2012-10-04 独立行政法人理化学研究所 白血病幹細胞マーカー
EP2611463A2 (en) 2010-09-03 2013-07-10 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
WO2013062083A1 (ja) * 2011-10-28 2013-05-02 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞特異的分子
SG11201610630RA (en) 2014-06-25 2017-01-27 Tel Hashomer Medical Res Infrastructure & Services Ltd Identification of cancer stem cell markers and use of same for diagnosis and treatment

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101855339A (zh) * 2007-01-22 2010-10-06 雷文生物技术公司 人类癌症干细胞
CN101868534A (zh) * 2007-08-10 2010-10-20 哈布勒支研究所 用于鉴定、扩增和去除成体干细胞和癌干细胞的方法
US20110111434A1 (en) * 2008-07-15 2011-05-12 Huang Emina H Colon stem cells associated with colitisand colorectal cancer and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
The isolation and characterization of renal cancer initiating cells from human Wilms’ tumour xenografts unveils new therapeutic targets;Naomi Pode-Shakked et al.;《EMBO Molecular Medicine》;20130131;第5卷;摘要，第19-31页"RESULTS"，第33-35页"MATERIALS AND METHODS" *

Also Published As

Publication number Publication date
WO2015198334A3 (en) 2016-02-25
US10883994B2 (en) 2021-01-05
SG11201610630RA (en) 2017-01-27
KR20170041192A (ko) 2017-04-14
CA2953663A1 (en) 2015-12-30
WO2015198334A2 (en) 2015-12-30
ES2791199T3 (es) 2020-11-03
JP2017528114A (ja) 2017-09-28
IL249741B (en) 2019-12-31
AU2015278659A1 (en) 2017-02-02
CN106537148A (zh) 2017-03-22
JP6587288B2 (ja) 2019-10-09
EP3161480B1 (en) 2020-02-12
EP3161480A2 (en) 2017-05-03
IL249741A0 (en) 2017-02-28
US20170199195A1 (en) 2017-07-13

Similar Documents

Publication Publication Date Title
JP6912538B2 (ja) 血中循環腫瘍細胞に関する方法およびアッセイ
CN106537148B (zh) 癌症干细胞的鉴定及其用于诊断和治疗的用途
AU2010222632B2 (en) Methods using Axl as a biomarker of epithelial-to-mesnchymal transition
McCormick Matthews et al. Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma
EP2529223B1 (en) Biomarkers for circulating tumor cells
TW201504438A (zh) 預後分類之方法及套組與以核酸製備治療腺體癌症的醫藥組合物之用途
AU2009291203B2 (en) Peripheral zone tumor cells, methods for their preparation and use
JP2014516551A (ja) メタカリオート（ｍｅｔａｋａｒｙｏｔｉｃ）幹細胞のｄｓＲＮＡ／ＤＮＡハイブリッドゲノム複製中間体
Volpini et al. Use of patient-derived organoids for pleural mesothelioma 3-D modeling
Bellenger et al. High CD44 expression and enhanced E-selectin binding identified as biomarkers of chemoresistant leukemic cells in human T-ALL
US20170192006A1 (en) Biomarkers for human monocyte myeloid0derived suppresor cells
Li Targeting CXCR2+ Neuroendocrine-like Cells for the Treatment of Castration-resistant Prostate Cancer
Norberg The reactive stroma in pancreatic diseases
WO2012110425A1 (en) Methods for monitoring the response to treatment and for treating colorectal cancer
Hurst NF-kappaB function and activation in mouse mammary stem cells and its interplay with the downstream target, cIAP2 in MMTV-ErbB2 induced tumourigenesis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20191011

CF01 Termination of patent right due to non-payment of annual fee