CN1065206A - Natural Chinese medicinal herb is prevented and treated premature ejaculation, gonorrhea economic benefits and social benefits medicinal liquid method for making - Google Patents
Natural Chinese medicinal herb is prevented and treated premature ejaculation, gonorrhea economic benefits and social benefits medicinal liquid method for making Download PDFInfo
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- CN1065206A CN1065206A CN 91102143 CN91102143A CN1065206A CN 1065206 A CN1065206 A CN 1065206A CN 91102143 CN91102143 CN 91102143 CN 91102143 A CN91102143 A CN 91102143A CN 1065206 A CN1065206 A CN 1065206A
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- gonorrhea
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- premature ejaculation
- shuangxiaoxionglu
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Abstract
The present invention is a kind of Qingkunbao Shuangxiaoxionglu method for making of preventing and treating premature ejaculation and gonorrhea.It adopts several Chinese herbal medicine such as Herba Epimedii, Folium Et Cacumen Murrayae, Radix Scutellariae is primary raw material, forms by scientific method is refining.
Description
The invention belongs to the method for making of the health care product of control prospermia of males and gonorrhea, particularly adopt several Chinese herbal medicine be primary raw material refining form prevent and treat premature ejaculation, gonorrhea economic benefits and social benefits medicinal liquid (claims again: the Qingkunbao Shuangxiaoxionglu method for making).
At present, the male sexual disorder patient mostly is sexual impotence in various degree in the world, shows according to the clinical statistics data, and the impotence patient is because premature ejaculation causes more than 55%." practical spermology " (the 195th page of Tianjin science and technology publishing house) is described: the reason of premature ejaculation mostly is psychogenic greatly, nervous by as sexual intercourse, the environment discomfort, fear the sexuality deficiency, factors such as property sensitivity, make sexual activity overhaste, anxiety, form bad trained reflex, cause too anxiety and make ejaculation out of control; Sex medicine is thought: penis inserts vagina and twitches number of times less than 15 times, and the deficiency of time from the insertion vagina to ejaculation 3 minutes is premature ejaculation.Therefore, male sexual disorder disease be improved, cure, premature ejaculation will be cured earlier.Known, the foreign treatment premature ejaculation is used hormonal medicaments and chemical synthetic drug more, and side effect is bigger, and domestic " the ZL89214882.9 Medicine for treating prospermia wet tissue " made with Chinese herbal medicine is that premature ejaculation is controlled in sexual organ's local anesthesia, and can not prevents and treats gonorrhea.
According to another the statistics at domestic prevention and treatment of venereal diseases center, since nineteen eighty-two, China's sexually transmitted disease (STD) sickness rate number, annual speed increase with 3.12 times, and in the various sexually transmitted disease (STD), the gonorrhea that sickness rate is the highest accounts for more than 70%.The gonococcus of gonorrhea can seriously endanger the healthy of people by small stores and the propagation of public service place such as unclean sexual intercourse, underwear, chamber pot, bathing pool, bedding.At present, utilize the Chinese herbal treatment gonorrhea not see as yet precedent is arranged.
Task of the present invention aims to provide and had had a kind ofly not only prevented and treated premature ejaculation, but also prevents and treats the Qingkunbao Shuangxiaoxionglu method for making of gonorrhea.It is to be made with extra care through scientific method by several Chinese herbal medicine to form, be used for the prospermia of males patient, can control the sexual excitation conduction at glans penis position, make and desensitized by the ejaculation response system of sympathetic nerve control, increase the number of times that penis enters the tolerance continued stimulus of vagina, eliminate premature ejaculation patient's anxiety, rebuild the normal ejaculation time, reach the purpose of treatment; Medicinal liquid with the present invention makes dilutes 10 times, embrocates, cleans penis or vagina, can kill gonococcus in 10 minutes, is mixed with ointment with medicinal liquid of the present invention, smears in the penis urethral orifice, can block gonococcal propagation and infect passage, and kill gonococcus effectively.
Under preparation method of the present invention and the practicality for example:
One, Qingkunbao Shuangxiaoxionglu method for making:
1, prevent and treat the preparation of premature ejaculation medicinal liquid:
Adopt Chinese herbal medicine Herba Epimedii 10%, Folium Et Cacumen Murrayae 10%, Rhizoma Chuanxiong 10%, Cortex Cinnamomi 2%, Radix Aconiti 3%, pulverize the back and mix, the amount of the medicinal alcohol 65% with 70% is collected percolate with above-mentioned medicine percolation, filter, in the total amount of percolate, add Oleum Ocimi Gratissimi 4%, hydrogen-oxygen lanonol 5%, antioxidant BHA 0.1%, to stir evenly rearmounted sealed container standby with percolate;
2, prevent and treat the preparation of gonorrhea medicinal liquid:
With Radix Scutellariae section, add the water boil 1 hour of 8 times of amounts, filter, 3 filtrate merges, and transfers pH value to 4 with concentrated hydrochloric acid, is heated to 95 ℃ and be incubated more than half an hour, the baicalin crude product folds, leaching precipitate, the water of 6 times of amounts of adding precipitate, stir evenly, the baicalin crude product is mixed in water, and it is 8 that the caustic lye of soda with 60% is transferred pH value, and the ethanol that adds equivalent 75% again stirs, make the baicalin dissolving, filter, filtrate is transferred pH value to 4 with hydrochloric acid, fully stirs evenly, and be heated to 75 ℃, kept 1 hour, baicalin is folded, filter, washing with alcohol precipitate with 75% to pH value is 4, dry the baicalin elaboration.With baicalin elaboration 1 gram, 50 milliliters of 35% ethanol, 49 milliliters of distilled water, spice is an amount of, and mixed together, stirring, fully dissolving promptly get and prevent and treat the gonorrhea medicinal liquid.As get baicalin elaboration 2 gram, with 10 milliliters of dissolvings of 75% ethanol, restrain with vaseline 88 then and stir evenly, prevent and treat the ointment of gonorrhea.
3, will prevent and treat premature ejaculation medicinal liquid and prevent and treat the gonorrhea medicinal liquid, by amount preparation in 1: 1, prevent and treat the Qingkunbao Shuangxiaoxionglu of premature ejaculation and gonorrhea.This medicinal liquid can be embrocated, spray and lotion are used.
Two, practical function:
1, the made Qingkunbao Shuangxiaoxionglu of the present invention through the clinical verification of the Guangxi hospitals of ethnic minority medicine, is treated 55 routine prospermia of males patients at random, the oldest 60 years old, minimum 22 years old; The course of disease is the longest 8 years, the shortest to be half a year; Occupation: workman's 16 examples, cadre's 25 examples, teacher's 2 examples, reporter's 1 example, resident's 4 examples, soldier's 6 examples, peasant's 1 example; Case is selected: health does not have serious organic disease or the genitals system does not have organic disease, and libido is arranged, and non-living in separate places meets the premature ejaculation diagnosis, and this product is not had the use contraindication.With Qingkunbao Shuangxiaoxionglu treatment, preceding 5～7 minutes of each sexual life is evenly embrocated glans penis and coronary sulcus position to moistening get final product with this product, is for three times one to observe the course of treatment, criterion of therapeutical effect: produce effects, and the sex time prolongation is above more than 3 minutes; Take a turn for the better, sex time prolongs, and does not reach 3 minutes; Invalid, the premature ejaculation symptom does not have improvement, and curative effect and statistical analysis see the following form 1,2,3,4,
Table 1: sex time prolongs statistical table:
| Project | Time expand | Add up to | ||||
| ＜1 minute | ＞1 minute | ＞3 minutes | ＞10 minutes | ＞20 minutes | ||
| The example number | 2 | 3 | 21 | 23 | 6 | 55 |
| Percentage rate | 3.6％ | 5.5％ | 38.2％ | 41.8％ | 10.9％ | 100％ |
Table 2: increase the pleasant sensation information slip
| Project | Pleasant sensation increases situation | ||||||
| Have | Wherein sex time prolongs situation | Do not have | Wherein sex time prolongs situation | ||||
| ＞1 minute | ＞3 minutes | ＜1 minute | ＞1 minute | ＞3 minutes | |||
| The example number | 50 | 2 | 48 | 5 | 2 | 1 | 2 |
| Percentage rate | 91％ | 3.6％ | 87.3％ | 9％ | 3.6％ | 1.8％ | 3.6％ |
Sex time average product score value comparison sheet before and after table 3. treatment
| The average product score value | Contrast | ||
| Before the treatment | After the treatment | The t value | The P value |
| 1.73±0.45 | 12.84±1.00 | 11.11 | ＜0.01 |
Table 4: total effects information slip
| Project | Effectively | Invalid | Add up to | ||
| Add up to | Wherein | ||||
| Produce effects | Take a turn for the better | ||||
| The example number | 53 | 50 | 3 | 2 | 55 |
| Percentage rate | 96.4％ | 91.0％ | 5.4％ | 3.6％ | 100％ |
Untoward reaction is observed: 55 none example of example have untoward reaction, all are satisfied with to the Qingkunbao Shuangxiaoxionglu using method is easy.
From table 1,2,3,4 statistical results show:
1., 55 routine patients use Qingkunbao Shuangxiaoxionglu, 53 examples prolong sex times, total effective rate reaches 96.4%;
2., the treatment obvious effective rate be 91%, wherein prolong sex time greater than person's 29 examples more than 10 minutes, account for 52.7% of total routine number;
3., increase pleasant sensation totally 50 examples, account for 94% of total routine number;
4., sex time contrast before and after the treatment, learning by statistics to handle has tangible significance difference, therapeutic effect is tangible;
5., side effect appears in 55 none example of routine user.
Conclusion: use the clinical verification of Qingkunbao Shuangxiaoxionglu according to 55 routine premature ejaculation patients, it is remarkable to improve premature ejaculation symptom effect, and total effective rate reaches 96.4%, increase pleasant sensation person and account for 94%, easy to use, have no side effect, think that Qingkunbao Shuangxiaoxionglu is an ideal health care product of preventing and treating the premature ejaculation symptom.
2, Qingkunbao Shuangxiaoxionglu is killed speed and strength test to 30 routine gonorrhea patients as gonococcus through the skin disease prevention and treatment institute, Guangxi and at Nanning City's hospital-based outpatient obstetrical clinic:
1), kills the strain test
1., the Qingkunbao Shuangxiaoxionglu sample is diluted variable concentrations with normal saline, 2 milliliters of every pipes, other adds normal saline 1 pipe (control tube) 2 milliliters;
2., every pipe adds 0.2 milliliter of 10 gram gonococcus liquid, shakes up and places after 10 minutes, colludes respectively to get and respectively manages test solution and be seeded on the sensitive culture medium of osmanthus, repeated once again in 20 minutes.Put incubator and cultivate after 24 hours, observation has or not the gonococcus growth, growth note (+), and do not grow note (-), following table as a result:
| The sample dilution factor | 1：1000 | 1：1200 | 1：1400 | 1：1600 | 1：1800 | Control tube |
| Act on 10 minutes | － | － | － | － | ＋＋＋ | ＋＋＋＋ |
| Act on 20 minutes | － | － | － | － | ＋ | ＋＋＋＋ |
2) to the bactericidal assay of male's acute gonorrhea urethral secretions,
1., get 0.5 milliliter of purulent secretion, after adding 1.5 ml physiological salines and being diluted to suspension, be divided into two pipes, 1 milliliter of every pipe.First pipe (developmental tube) adds Qingkunbao Shuangxiaoxionglu and shakes up for 0.1 milliliter, and it is control tube that second pipe does not add Qingkunbao Shuangxiaoxionglu, act on after 10 minutes, gets respectively 0.1 milliliter of the suspension of a pipe and two pipes, is seeded in respectively and does the gonococcus cultivation on the sensitive culture medium of osmanthus;
2., result: the no gonococcus of first pipe (developmental tube) grows, and second pipe (control tube) has the gonococcus growth;
3), at Nanning City's hospital-based outpatient obstetrical clinic, 30 routine gonorrheas (gonococcus cultivate positive) patient's vagina is coated with Qingkunbao Shuangxiaoxionglu, kill gonococcus and zest clinical trial:
1., get secretions in the deep intravaginal before the test and do the gonococcus cultivation once;
2., get 1 milliliter of Qingkunbao Shuangxiaoxionglu, evenly be coated with vagina, act on after 10 minutes, get specimen with 1. method again and do the gonococcus cultivation once with the cotton swab of growing up is sticking,
3., result: cultivate positive 27 people of gonococcus before the medication, negative 3 people.After the medication, gonococcus is cultivated and all is negative, and patient has no adverse reaction;
Estimate: institute is tested by Qingkunbao Shuangxiaoxionglu through me, 1600 times of this medicinal liquid dilutions can be killed gonococcus in 10 minutes; The male gonorrhoea purulent secretion is added 1/10 medicine amount liquid, and after 30 routine clinical trials are coated with 1 milliliter of medicinal liquid, can kill gonococcus in 10 minutes, do not find that patient has untoward reaction, test shows: Qingkunbao Shuangxiaoxionglu has the stronger gonococcus effect of killing.
3, Qingkunbao Shuangxiaoxionglu is done cosmetics toxicological experiment and chemical examination by Guangxi health and epidemic prevention station:
1), toxicological experiment is pressed standard GB 7919-87 " safety evaluation of cosmetics program and method " result:
1., acute toxicity test, the LD50 that white mice is irritated on an empty stomach stomach is greater than 5000 mg/kg body weight, in the actual nontoxic rank of this experiment condition subordinate;
2., acute skin irritation, smear test through a skin, be subjected to examination district's skin skin irritation such as erythema edema not occur and react, its irritant reaction integration is zero, according to the skin irritation intensity evaluation, under this experiment condition to the skin nonirritant;
3., acute mucous membrane irritation, through an eye irritant test, acute eye irritation score index (I, A, O, I) is that average eye irritation after 10,48 hours (M, I, O, I) is less than 5, according to the eye irritation evaluation criterion, to the mucosa nonirritant;
4., chronic skin irritation, through 14 days continued stimuluses, do not find the reaction of skin irritation such as erythema edema, skin irritation index and pathological tissue check that integration is zero, according to the skin irritation intensity evaluation: under this experiment skin is not had chronic stimulation.
2), Qingkunbao Shuangxiaoxionglu (microorganism, chemical index) result of laboratory test:
Total number of bacteria (individual/milliliter)＜10
Excrement colibacillus group does not detect
Bacillus pyocyaneus does not detect
Staphylococcus aureus does not detect
Hydrargyrum (PPM)＜0.01
Plumbous (PPM) 4.0
Arsenic (PPM)＜0.5
Methanol (%)＜0.01
Claims (2)
1, a kind of is the Qingkunbao Shuangxiaoxionglu of preventing and treating premature ejaculation and gonorrhea that primary raw material is made with the Chinese herbal medicine, it is characterized in that:
1), the assembly that prevents and treats the premature ejaculation medicinal liquid is with Herba Epimedii 10%, Folium Et Cacumen Murrayae 10%, Rhizoma Chuanxiong 10%, Cortex Cinnamomi 2%, Radix Aconiti 3%, pulverizes the back and mixes, the amount of the medicinal alcohol 65% with 70% is collected percolate with above-mentioned medicine percolation, filtration.In the percolate total amount, add Oleum Ocimi Gratissimi 4%, hydrogen-oxygen lanonol 5%, BHA 0.1%, after stirring evenly with percolate;
2), the preparation that prevents and treats the gonorrhea medicinal liquid is with Radix Scutellariae section, adds the water boil 1 hour of 8 times of amounts, filters, get the merging of 3 filtrates, transfer pH value to 4, be heated to 95 ℃ and be incubated more than half an hour with concentrated hydrochloric acid, getting the baicalin crude product folds, the leaching precipitate, the water of 6 times of amounts of adding precipitate stirs evenly, the baicalin crude product is mixed in water, transferring pH value with 60% caustic lye of soda is 8, and 75% the ethanol that adds equivalent again stirs, and makes the baicalin dissolving, filter, filtrate is transferred pH value to 4 with hydrochloric acid, fully stirs evenly, and is heated to 75 ℃ of maintenances 1 hour, baicalin is folded, filter, the washing with alcohol precipitate pH value to 4 with 75%, dry the baicalin elaboration.Get 50 milliliters of baicalin elaboration 1 gram, 35% ethanol, 49 milliliters of distilled water, spice is an amount of, and mixed together, stirring, fully dissolving is promptly;
3), will prevent and treat premature ejaculation medicinal liquid 1) and prevent and treat gonorrhea medicinal liquid 2), by the preparation of 1: 1 amount Qingkunbao Shuangxiaoxionglu.
2, Qingkunbao Shuangxiaoxionglu method for making as claimed in claim 1 is characterized in that preventing and treating gonorrhea medicinal liquid preparation 2) the baicalin elaboration of gained, get 2 grams with after 10 milliliters of dissolvings of ethanol of 75%, with vaseline 88 restrain stir evenly prevent and treat the gonorrhea ointment.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91102143 CN1065206A (en) | 1991-04-01 | 1991-04-01 | Natural Chinese medicinal herb is prevented and treated premature ejaculation, gonorrhea economic benefits and social benefits medicinal liquid method for making |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91102143 CN1065206A (en) | 1991-04-01 | 1991-04-01 | Natural Chinese medicinal herb is prevented and treated premature ejaculation, gonorrhea economic benefits and social benefits medicinal liquid method for making |
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| CN1065206A true CN1065206A (en) | 1992-10-14 |
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| CN 91102143 Pending CN1065206A (en) | 1991-04-01 | 1991-04-01 | Natural Chinese medicinal herb is prevented and treated premature ejaculation, gonorrhea economic benefits and social benefits medicinal liquid method for making |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5587167A (en) * | 1993-09-14 | 1996-12-24 | Choi; Hyung K. | Pharmaceutical composition for prophylaxis and treatment of premature ejaculation |
| EP0643058B1 (en) * | 1993-09-10 | 1999-06-09 | Daiichi Pharmaceutical Co., Ltd. | Crystals of an antimicrobial compound |
| CN105362877A (en) * | 2015-10-17 | 2016-03-02 | 薛学明 | Medicine for prolonging coitus time and preparation method thereof |
| CN112641774A (en) * | 2020-12-22 | 2021-04-13 | 浙江大学 | Application of chalcone and flavonoid compound in preparation of antibacterial drugs |
-
1991
- 1991-04-01 CN CN 91102143 patent/CN1065206A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0643058B1 (en) * | 1993-09-10 | 1999-06-09 | Daiichi Pharmaceutical Co., Ltd. | Crystals of an antimicrobial compound |
| US5587167A (en) * | 1993-09-14 | 1996-12-24 | Choi; Hyung K. | Pharmaceutical composition for prophylaxis and treatment of premature ejaculation |
| CN105362877A (en) * | 2015-10-17 | 2016-03-02 | 薛学明 | Medicine for prolonging coitus time and preparation method thereof |
| CN112641774A (en) * | 2020-12-22 | 2021-04-13 | 浙江大学 | Application of chalcone and flavonoid compound in preparation of antibacterial drugs |
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| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |