CN106511861A - Chinese and western medicine preparation used for treating allergic rhinitis and preparation method thereof - Google Patents

Chinese and western medicine preparation used for treating allergic rhinitis and preparation method thereof Download PDF

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CN106511861A
CN106511861A CN201610997520.3A CN201610997520A CN106511861A CN 106511861 A CN106511861 A CN 106511861A CN 201610997520 A CN201610997520 A CN 201610997520A CN 106511861 A CN106511861 A CN 106511861A
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parts
vitamin
chinese
western medicine
herba
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陈腊保
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Nanjing Halls Biological Technology Co Ltd
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Nanjing Halls Biological Technology Co Ltd
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

The invention discloses a Chinese and western medicine preparation used for treating allergic rhinitis and a preparation method thereof. The Chinese and western medicine preparation used for treating allergic rhinitis comprises traditional Chinese medicine raw materials including periostracum cicada, flos magnolia, as arum, radix angelicae dahuricae, ligusticum, xanthium strumarium, endothelium corneum gigeriae galli, bighead atractylodes rhizome, limacia sagittata, pericarpium citri reticulatae, polygala tenuifolia, dried hawthorn, clove, alpinia katsumadai, giner processed pinellia, herba houttuyniae and gentian, and western medicine components including vitamin B1, vitamin B2, vitamin B6, vitamin C, oryzanol, metronidazole, cyproheptadine hydrochloride, cinnarizine and dexamethasone acetate. The new simple and reasonable formula is provided, and the Chinese and western medicine preparation not only has the effect of eradicating allergic rhinitis, but also can effectively avoid stimulation to the alimentary canal and side effects to the nervous system from the metronidazole and the cyproheptadine hydrochloride in the western medicine components.

Description

It is a kind of for treating Chinese-western medicine preparation of allergic rhinitises and preparation method thereof
Technical field
The present invention relates to Chinese medicine and western medicine technical field, more particularly to a kind of Chinese-western medicine preparation for treating allergic rhinitises and Its preparation method.
Background technology
Allergic rhinitises are a kind of multi-factor diseases induced by gene and environmental interaction.Its classical symptom is main It is：Paroxysmal sneeze, clear water sample nasal mucus, nasal obstruction and rhinocnesmus, partly with hyposmia.Allergic rhinitises are one global strong Kang Wenti, can cause numerous disease and disability.
At present, there are oral medicine, medicine for external use, injection medicine etc., but great majority recurrence for allergic rhinitises integrative medicine therapy Rate is high.Therefore propose it is a kind of with Periostracum Cicadae, Flos Magnoliae, Herba Asari, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Ligustici, Herba Xanthii, vitamin B1, vitamin B2, During vitamin B6, vitamin C, oryzanol, metronidazole, hydrochloric acid Cyproheptadine, Cinnarizine, dexamethasone acetate are compatibility raw material Western medicine preparation.The Chinese-western medicine preparation can expelling wind and cold, radiate two-ways regulation, and removing dampness and detoxicating, to flu, wind syndrome of head, headache, nose Plug, nasal sinusitis, turbid nasal discharge, especially to allergic rhinitises, sensible, damp eliminating evacuation of pus, effect are rapid, the work(for having radical cure.
However, western medicine composition therein has certain harmful effect, especially first nitre to digestion and nervous system Azoles is irritant to digestive tract, can often cause Nausea and vomiting, inappetence, abdominal colic etc., it is also possible to cause nerveous system The headache of system, dizziness etc.；Cyproheptadine Hydrochloride is likely to cause drowsiness, dizzy, nauseous.
The content of the invention
To solve the above problems, the invention provides a kind of Chinese-western medicine preparation and its preparation for treating allergic rhinitises Method, is prevented effectively from harmful effect of the western medicine composition to digestion and nervous system, so as to get medicament nontoxic secondary make With.
The present invention for overcome prior art exist problem, the technical scheme for being adopted for：
A kind of Chinese-western medicine preparation for treating allergic rhinitises, is counted by weight, and its dispensing includes：
Raw material of Chinese medicine：Periostracum Cicadae 18-28 parts, Flos Magnoliae 18-28 parts, Herba Asari 6-10 parts, Radix Angelicae Dahuricae 9-14 parts, Rhizoma Ligustici 9-14 parts, Herba Xanthii 9- 14 parts, Endothelium Corneum Gigeriae Galli 20-25 parts, Rhizoma Atractylodis Macrocephalae 20-25 parts, Herba Elephantopi scaberis 15-19 parts, Pericarpium Citri Reticulatae 12-15 parts, Radix Polygalae 12-15 part, dry Fructus Crataegi 12-18 parts, Flos Caryophylli 9-12 parts, Semen Alpiniae Katsumadai 9-12 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7-15 parts, Herba Houttuyniae 3-9 parts, bubble ginseng 5-7 parts；
Western medicine composition：Vitamin B1 10-14 parts, vitamin B2 20-24 part, vitamin B6 4-6 parts, vitamin C 4-6 parts, Oryzanol 4-6 parts, metronidazole 4-6 parts, Cyproheptadine Hydrochloride 3-5 part, Cinnarizine 3-5 part, dexamethasone acetate 3-5 parts；
Preferably, the described Chinese-western medicine preparation for treating allergic rhinitises, is counted by weight, and its dispensing includes：
Raw material of Chinese medicine：In 23 parts of Periostracum Cicadae, 23 parts of Flos Magnoliae, 8 parts of Herba Asari, 11.5 parts of the Radix Angelicae Dahuricae, 11.5 parts of Rhizoma Ligustici, 11.5 parts of Herba Xanthii, chicken 22.5 parts of gold, 22.5 parts of the Rhizoma Atractylodis Macrocephalae, 17 parts of Herba Elephantopi scaberis, 13.5 parts of Pericarpium Citri Reticulatae, 13.5 parts of Radix Polygalae, 15 parts of dry Fructus Crataegi Fructus Crataegi, Flos Caryophylli 10.5 Part, 10.5 parts of Semen Alpiniae Katsumadai, 11 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 6 parts of Herba Houttuyniae, 6 parts of bubble ginseng；
Western medicine composition：12 parts of vitamin B1,22 parts of vitamin B2,5 parts of vitamin B6,5 parts of vitamin C, oryzanol 5 parts, 5 parts of metronidazole, 4 parts of Cyproheptadine Hydrochloride, 4 parts of Cinnarizine, 4 parts of dexamethasone acetate.
The described preparation method for treating the Chinese-western medicine preparation of allergic rhinitises, comprises the steps：
Step 1：Periostracum Cicadae, Flos Magnoliae, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Ligustici, Herba Xanthii, Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi, it is respectively washed clean, mixes Close after being dried, crush as powder body, cross 50-80 mesh sieves, then Jing jet mills are ground into superfine powder A；
Step 2：The Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, bubble ginseng are cleaned up, after combination drying, 50-80 mesh sieves were crushed, the Chinese herbal medicine mixed-powder for obtaining was placed in decocting medicine pot, added the distilled water of 5-8 times of weight, boiling water 3-6h is decocted, filtrate I is filtrated to get, filtering residue is added into the distilled water of 3-5 times of weight, boiling water decocts 2-3h, is filtrated to get filter Liquid II.The mass concentration of 3.5-4 times of weight is added after filtrate I and filtrate II are merged for the ethanol of 90-95%, ultrasonic vibration 3- 10min, static 24-48h, isolated ethanol extract, by ethanol extract concentrating under reduced pressure into paste, after being then vacuum dried Powder body is made into, then the powder body is ground into by superfine powder B using jet mill；
Step 3：By vitamin B1, vitamin B2, vitamin B6, vitamin C, oryzanol, metronidazole, Cyproheptadine Hydrochloride, Gui Li Piperazine, dexamethasone acetate are ground into fine powder, after mix homogeneously, are ground into superfine powder C with jet mill；
Step 4：After superfine powder A, superfine powder B and superfine powder C are mixed, adjuvant is added to make the compound mediciness of peroral dosage form Thing preparation.
The compound medicinal formulation of described peroral dosage form is conventional tablet, slow releasing tablet, capsule or drop pill.
Beneficial effects of the present invention：The present invention provides the formula of new advantages of simple, both with elimination allergic rhinitises Effect, can be prevented effectively from the metronidazole and Cyproheptadine Hydrochloride in western medicine composition again to gastral stimulation and to nervous system Side effect.
Specific embodiment
The present invention is described further below in conjunction with embodiment.
Embodiment 1
A kind of Chinese-western medicine preparation for treating allergic rhinitises, is counted by weight, and its dispensing includes：
Raw material of Chinese medicine：28 parts of Periostracum Cicadae, 28 parts of Flos Magnoliae, 10 parts of Herba Asari, 14 parts of the Radix Angelicae Dahuricae, 14 parts of Rhizoma Ligustici, 14 parts of Herba Xanthii, Endothelium Corneum Gigeriae Galli 25 Part, 25 parts of the Rhizoma Atractylodis Macrocephalae, 19 parts of Herba Elephantopi scaberis, 15 parts of Pericarpium Citri Reticulatae, 15 parts of Radix Polygalae, 18 parts of dry Fructus Crataegi, 12 parts of Flos Caryophylli, 12 parts of Semen Alpiniae Katsumadai, Rhizoma Zingiberis Recens half 15 parts of summer, 9 parts of Herba Houttuyniae, 7 parts of bubble ginseng；
Western medicine composition：14 parts of vitamin B1,24 parts of vitamin B2,6 parts of vitamin B6,6 parts of vitamin C, oryzanol 6 parts, 6 parts of metronidazole, 5 parts of Cyproheptadine Hydrochloride, 5 parts of Cinnarizine, 5 parts of dexamethasone acetate.
The described preparation method for treating the Chinese-western medicine preparation of allergic rhinitises, comprises the steps：
Step 1：Periostracum Cicadae, Flos Magnoliae, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Ligustici, Herba Xanthii, Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi, it is respectively washed clean, mixes Close after being dried, crush as powder body, cross 50-80 mesh sieves, then Jing jet mills are ground into superfine powder A；
Step 2：The Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, bubble ginseng are cleaned up, after combination drying, 80 mesh sieves were crushed, the Chinese herbal medicine mixed-powder for obtaining was placed in decocting medicine pot, and added the distilled water of 8 times of weight, boiling water to decoct 6h, is filtrated to get filtrate I, and filtering residue is added the distilled water of 5 times of weight, and boiling water decocts 3h, is filtrated to get filtrate II.By filtrate I and filtrate II add the ethanol that the mass concentration of 4 times of weight is 95% after merging, ultrasonic vibration 10min, static 48h are separated To ethanol extract, by ethanol extract concentrating under reduced pressure into paste, after being then vacuum dried, powder body is made into, then using air-flow powder The powder body is ground into superfine powder B by broken machine；
Step 3：By vitamin B1, vitamin B2, vitamin B6, vitamin C, oryzanol, metronidazole, Cyproheptadine Hydrochloride, Gui Li Piperazine, dexamethasone acetate are ground into fine powder, after mix homogeneously, are ground into superfine powder C with jet mill；
Step 4：After superfine powder A, superfine powder B and superfine powder C are mixed, adjuvant is added to make the ordinary tablet of oral type Agent.
Embodiment 2
A kind of Chinese-western medicine preparation for treating allergic rhinitises, is counted by weight, and its dispensing includes：
Raw material of Chinese medicine：It is 18 parts of Periostracum Cicadae, 18 parts of Flos Magnoliae, 6 parts of Herba Asari, 9 parts of the Radix Angelicae Dahuricae, 9 parts of Rhizoma Ligustici, 9 parts of Herba Xanthii, 20 parts of Endothelium Corneum Gigeriae Galli, white 20 parts of art, 15 parts of Herba Elephantopi scaberis, 12 parts of Pericarpium Citri Reticulatae, 12 parts of Radix Polygalae, 12 parts of dry Fructus Crataegi, 9 parts of Flos Caryophylli, 9 parts of Semen Alpiniae Katsumadai, 7 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), fish 3 parts of raw meat grass, 5 parts of bubble ginseng；
Western medicine composition：10 parts of vitamin B1,20 parts of vitamin B2,4 parts of vitamin B6,4 parts of vitamin C, oryzanol 4 Part, 4 parts of metronidazole, 3 parts of Cyproheptadine Hydrochloride, 3 parts of Cinnarizine, 3 parts of dexamethasone acetate.
The described preparation method for treating the Chinese-western medicine preparation of allergic rhinitises, comprises the steps：
Step 1：Periostracum Cicadae, Flos Magnoliae, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Ligustici, Herba Xanthii, Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi, it is respectively washed clean, mixes Close after being dried, crush as powder body, cross 50 mesh sieves, then Jing jet mills are ground into superfine powder A；
Step 2：The Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, bubble ginseng are cleaned up, after combination drying, 50 mesh sieves were crushed, the Chinese herbal medicine mixed-powder for obtaining was placed in decocting medicine pot, and added the distilled water of 5 times of weight, boiling water to decoct 3h, is filtrated to get filtrate I, and filtering residue is added the distilled water of 3 times of weight, and boiling water decocts 2h, is filtrated to get filtrate II.By filtrate I and filtrate II add the ethanol that the mass concentration of 3.5 times of weight is 90% after merging, ultrasonic vibration 3min, static 24h are separated To ethanol extract, by ethanol extract concentrating under reduced pressure into paste, after being then vacuum dried, powder body is made into, then using air-flow powder The powder body is ground into superfine powder B by broken machine；
Step 3：By vitamin B1, vitamin B2, vitamin B6, vitamin C, oryzanol, metronidazole, Cyproheptadine Hydrochloride, Gui Li Piperazine, dexamethasone acetate are ground into fine powder, after mix homogeneously, are ground into superfine powder C with jet mill；
Step 4：After superfine powder A, superfine powder B and superfine powder C are mixed, adjuvant is added to make the slow releasing tablet of oral type.
Embodiment 3
A kind of Chinese-western medicine preparation for treating allergic rhinitises, is counted by weight, and its dispensing includes：
Raw material of Chinese medicine：In 23 parts of Periostracum Cicadae, 23 parts of Flos Magnoliae, 8 parts of Herba Asari, 11.5 parts of the Radix Angelicae Dahuricae, 11.5 parts of Rhizoma Ligustici, 11.5 parts of Herba Xanthii, chicken 22.5 parts of gold, 22.5 parts of the Rhizoma Atractylodis Macrocephalae, 17 parts of Herba Elephantopi scaberis, 13.5 parts of Pericarpium Citri Reticulatae, 13.5 parts of Radix Polygalae, 15 parts of dry Fructus Crataegi Fructus Crataegi, Flos Caryophylli 10.5 Part, 10.5 parts of Semen Alpiniae Katsumadai, 11 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 6 parts of Herba Houttuyniae, 6 parts of bubble ginseng；
Western medicine composition：12 parts of vitamin B1,22 parts of vitamin B2,5 parts of vitamin B6,5 parts of vitamin C, oryzanol 5 parts, 5 parts of metronidazole, 4 parts of Cyproheptadine Hydrochloride, 4 parts of Cinnarizine, 4 parts of dexamethasone acetate.
The described preparation method for treating the Chinese-western medicine preparation of allergic rhinitises, comprises the steps：
Step 1：Periostracum Cicadae, Flos Magnoliae, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Ligustici, Herba Xanthii, Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi, it is respectively washed clean, mixes Close after being dried, crush as powder body, cross 60 mesh sieves, then Jing jet mills are ground into superfine powder A；
Step 2：The Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, bubble ginseng are cleaned up, after combination drying, 60 mesh sieves were crushed, the Chinese herbal medicine mixed-powder for obtaining was placed in decocting medicine pot, and added the distilled water of 6.5 times of weight, boiling water to decoct 4.5h is boiled, filtrate I is filtrated to get, filtering residue is added into the distilled water of 4 times of weight, boiling water decocts 2.5h, is filtrated to get filtrate II. The mass concentration that 3.8 times of weight are added after filtrate I and filtrate II are merged is 95% ethanol, ultrasonic vibration 6min, static 36h, Isolated ethanol extract, by ethanol extract concentrating under reduced pressure into paste, makes into powder body after being then vacuum dried, then adopts The powder body is ground into superfine powder B by jet mill；
Step 3：By vitamin B1, vitamin B2, vitamin B6, vitamin C, oryzanol, metronidazole, Cyproheptadine Hydrochloride, Gui Li Piperazine, dexamethasone acetate are ground into fine powder, after mix homogeneously, are ground into superfine powder C with jet mill；
Step 4：After superfine powder A, superfine powder B and superfine powder C are mixed, adjuvant is added to make the capsule of peroral dosage form.
Embodiment 4
A kind of Chinese-western medicine preparation for treating allergic rhinitises, is counted by weight, and its dispensing includes：
Raw material of Chinese medicine：It is 18 parts of Periostracum Cicadae, 18 parts of Flos Magnoliae, 6 parts of Herba Asari, 9 parts of the Radix Angelicae Dahuricae, 9 parts of Rhizoma Ligustici, 9 parts of Herba Xanthii, 22 parts of Endothelium Corneum Gigeriae Galli, white 22 parts of art, 17 parts of Herba Elephantopi scaberis, 13 parts of Pericarpium Citri Reticulatae, 13 parts of Radix Polygalae, 15 parts of dry Fructus Crataegi, 10 parts of Flos Caryophylli, 10 parts of Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 11 Part, 6 parts of Herba Houttuyniae, 6 parts of bubble ginseng；
Western medicine composition：14 parts of vitamin B1,24 parts of vitamin B2,6 parts of vitamin B6,6 parts of vitamin C, 6 parts of oryzanol, 6 parts of metronidazole, 5 parts of Cyproheptadine Hydrochloride, 5 parts of Cinnarizine, 5 parts of dexamethasone acetate.
The described preparation method for treating the Chinese-western medicine preparation of allergic rhinitises, comprises the steps：
Step 1：Periostracum Cicadae, Flos Magnoliae, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Ligustici, Herba Xanthii, Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi, it is respectively washed clean, mixes Close after being dried, crush as powder body, cross 50-80 mesh sieves, then Jing jet mills are ground into superfine powder A；
Step 2：The Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, bubble ginseng are cleaned up, after combination drying, 60 mesh sieves were crushed, the Chinese herbal medicine mixed-powder for obtaining was placed in decocting medicine pot, and added the distilled water of 7 times of weight, boiling water to decoct 5h, is filtrated to get filtrate I, and filtering residue is added the distilled water of 4 times of weight, and boiling water decocts 2h, is filtrated to get filtrate II.By filtrate I and filtrate II add the ethanol that the mass concentration of 3.5 times of weight is 90% after merging, ultrasonic vibration 8min, static 30h are separated To ethanol extract, by ethanol extract concentrating under reduced pressure into paste, after being then vacuum dried, powder body is made into, then using air-flow powder The powder body is ground into superfine powder B by broken machine；
Step 3：By vitamin B1, vitamin B2, vitamin B6, vitamin C, oryzanol, metronidazole, Cyproheptadine Hydrochloride, Gui Li Piperazine, dexamethasone acetate are ground into fine powder, after mix homogeneously, are ground into superfine powder C with jet mill；
Step 4：After superfine powder A, superfine powder B and superfine powder C are mixed, adjuvant is added to make the drop pill of peroral dosage form.
Embodiment 5
A kind of Chinese-western medicine preparation for treating allergic rhinitises, is counted by weight, and its dispensing includes：
Raw material of Chinese medicine：28 parts of Periostracum Cicadae, 28 parts of Flos Magnoliae, 10 parts of Herba Asari, 14 parts of the Radix Angelicae Dahuricae, 14 parts of Rhizoma Ligustici, 14 parts of Herba Xanthii, Endothelium Corneum Gigeriae Galli 25 Part, 25 parts of the Rhizoma Atractylodis Macrocephalae, 17 parts of Herba Elephantopi scaberis, 14 parts of Pericarpium Citri Reticulatae, 14 parts of Radix Polygalae, 15 parts of dry Fructus Crataegi, 10 parts of Flos Caryophylli, 10 parts of Semen Alpiniae Katsumadai, Rhizoma Zingiberis Recens half 10 parts of summer, 6 parts of Herba Houttuyniae, 6 parts of bubble ginseng；
Western medicine composition：10 parts of vitamin B1,20 parts of vitamin B2,4 parts of vitamin B6,4 parts of vitamin C, oryzanol 4 Part, 4 parts of metronidazole, 3 parts of Cyproheptadine Hydrochloride, 3 parts of Cinnarizine, 3 parts of dexamethasone acetate.
The described preparation method for treating the Chinese-western medicine preparation of allergic rhinitises, comprises the steps：
Step 1：Periostracum Cicadae, Flos Magnoliae, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Ligustici, Herba Xanthii, Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi, it is respectively washed clean, mixes Close after being dried, crush as powder body, cross 60 mesh sieves, then Jing jet mills are ground into superfine powder A；
Step 2：The Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, bubble ginseng are cleaned up, after combination drying, 60 mesh sieves were crushed, the Chinese herbal medicine mixed-powder for obtaining was placed in decocting medicine pot, and added the distilled water of 6 times of weight, boiling water to decoct 4h, is filtrated to get filtrate I, and filtering residue is added the distilled water of 4 times of weight, and boiling water decocts 3h, is filtrated to get filtrate II.By filtrate I and filtrate II add the ethanol that the mass concentration of 4 times of weight is 95% after merging, ultrasonic vibration 8min, static 40h are isolated Ethanol extract, by ethanol extract concentrating under reduced pressure into paste, makes into powder body after being then vacuum dried, then using comminution by gas stream The powder body is ground into superfine powder B by machine；
Step 3：By vitamin B1, vitamin B2, vitamin B6, vitamin C, oryzanol, metronidazole, Cyproheptadine Hydrochloride, Gui Li Piperazine, dexamethasone acetate are ground into fine powder, after mix homogeneously, are ground into superfine powder C with jet mill；
Step 4：After superfine powder A, superfine powder B and superfine powder C are mixed, adjuvant is added to make the capsule drop of peroral dosage form Ball.
In a word, the present invention provides the formula of new advantages of simple, both has functions that to eradicate allergic rhinitises, can have again Effect avoids the side effect of metronidazole and Cyproheptadine Hydrochloride in western medicine composition to gastral stimulation and to nervous system.

Claims (5)

1. a kind of Chinese-western medicine preparation for treating allergic rhinitises, it is characterised in that count by weight, its dispensing bag Include：
Raw material of Chinese medicine：Periostracum Cicadae 18-28 parts, Flos Magnoliae 18-28 parts, Herba Asari 6-10 parts, Radix Angelicae Dahuricae 9-14 parts, Rhizoma Ligustici 9-14 parts, Herba Xanthii 9- 14 parts, Endothelium Corneum Gigeriae Galli 20-25 parts, Rhizoma Atractylodis Macrocephalae 20-25 parts, Herba Elephantopi scaberis 15-19 parts, Pericarpium Citri Reticulatae 12-15 parts, Radix Polygalae 12-15 part, dry Fructus Crataegi 12-18 parts, Flos Caryophylli 9-12 parts, Semen Alpiniae Katsumadai 9-12 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7-15 parts, Herba Houttuyniae 3-9 parts, bubble ginseng 5-7 parts；
Western medicine composition：Vitamin B1 10-14 parts, vitamin B2 20-24 part, vitamin B6 4-6 parts, vitamin C 4-6 parts, Oryzanol 4-6 parts, metronidazole 4-6 parts, Cyproheptadine Hydrochloride 3-5 part, Cinnarizine 3-5 part, dexamethasone acetate 3-5 parts.
2. it is used for as claimed in claim 1 treating the Chinese-western medicine preparation of allergic rhinitises, it is characterised in that by weight Meter, its dispensing include：
Raw material of Chinese medicine：In 23 parts of Periostracum Cicadae, 23 parts of Flos Magnoliae, 8 parts of Herba Asari, 11.5 parts of the Radix Angelicae Dahuricae, 11.5 parts of Rhizoma Ligustici, 11.5 parts of Herba Xanthii, chicken 22.5 parts of gold, 22.5 parts of the Rhizoma Atractylodis Macrocephalae, 17 parts of Herba Elephantopi scaberis, 13.5 parts of Pericarpium Citri Reticulatae, 13.5 parts of Radix Polygalae, 15 parts of dry Fructus Crataegi, 10.5 parts of Flos Caryophylli, grass 10.5 parts of Fructus Amomi Rotunduss, 11 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 6 parts of Herba Houttuyniae, 6 parts of bubble ginseng；
Western medicine composition：12 parts of vitamin B1,22 parts of vitamin B2,5 parts of vitamin B6,5 parts of vitamin C, oryzanol 5 parts, 5 parts of metronidazole, 4 parts of Cyproheptadine Hydrochloride, 4 parts of Cinnarizine, 4 parts of dexamethasone acetate.
3., as claimed in claim 1 or 2 for treating the preparation method of the Chinese-western medicine preparation of allergic rhinitises, its feature exists In comprising the steps：
Step 1：Periostracum Cicadae, Flos Magnoliae, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Ligustici, Herba Xanthii, Endothelium Corneum Gigeriae Galli, Herba Elephantopi scaberis, dry Fructus Crataegi, it is respectively washed clean, mixes Close after being dried, crush as powder body, cross 50-80 mesh sieves, then Jing jet mills are ground into superfine powder A；
Step 2：The Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Radix Polygalae, Flos Caryophylli, Semen Alpiniae Katsumadai, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Herba Houttuyniae, bubble ginseng are cleaned up, after combination drying, 50-80 mesh sieves were crushed, the Chinese herbal medicine mixed-powder for obtaining was placed in decocting medicine pot, added the distilled water of 5-8 times of weight, boiling water 3-6h is decocted, filtrate I is filtrated to get, filtering residue is added into the distilled water of 3-5 times of weight, boiling water decocts 2-3h, is filtrated to get filter Liquid II.
4. the mass concentration of 3.5-4 times of weight is added for the ethanol of 90-95%, ultrasonic vibration 3- after merging filtrate I and filtrate II 10min, static 24-48h, isolated ethanol extract, by ethanol extract concentrating under reduced pressure into paste, after being then vacuum dried Powder body is made into, then the powder body is ground into by superfine powder B using jet mill；
Step 3：By vitamin B1, vitamin B2, vitamin B6, vitamin C, oryzanol, metronidazole, Cyproheptadine Hydrochloride, Gui Li Piperazine, dexamethasone acetate are ground into fine powder, after mix homogeneously, are ground into superfine powder C with jet mill；
Step 4：After superfine powder A, superfine powder B and superfine powder C are mixed, adjuvant is added to make the compound mediciness of peroral dosage form Thing preparation.
5. the preparation method of the as claimed in claim 3 Chinese-western medicine preparation for being used to treat allergic rhinitises, it is characterised in that institute The compound medicinal formulation of the peroral dosage form stated is conventional tablet, slow releasing tablet, capsule or drop pill.
CN201610997520.3A 2016-11-14 2016-11-14 Chinese and western medicine preparation used for treating allergic rhinitis and preparation method thereof Pending CN106511861A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108421021A (en) * 2018-05-30 2018-08-21 武汉润禾生物医药有限公司 A kind of antibacterial aqua and preparation method thereof for treating rhinitis
CN108524682A (en) * 2018-07-12 2018-09-14 合肥七小俊生物科技有限公司 A kind of children's allergic rhinitis cream and preparation method thereof
CN108542944A (en) * 2018-07-12 2018-09-18 合肥七小俊生物科技有限公司 A kind of adult's allergic rhinitis cream and preparation method thereof
CN111228418A (en) * 2018-11-12 2020-06-05 张洪军 Traditional Chinese medicine and western medicine combined enteritis peaching formula and preparation method

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108421021A (en) * 2018-05-30 2018-08-21 武汉润禾生物医药有限公司 A kind of antibacterial aqua and preparation method thereof for treating rhinitis
CN108524682A (en) * 2018-07-12 2018-09-14 合肥七小俊生物科技有限公司 A kind of children's allergic rhinitis cream and preparation method thereof
CN108542944A (en) * 2018-07-12 2018-09-18 合肥七小俊生物科技有限公司 A kind of adult's allergic rhinitis cream and preparation method thereof
CN111228418A (en) * 2018-11-12 2020-06-05 张洪军 Traditional Chinese medicine and western medicine combined enteritis peaching formula and preparation method

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Application publication date: 20170322