CN106511805A - Preparation method for traditional Chinese medicine composition and traditional Chinese medicine capsule used for treating diabetes - Google Patents

Preparation method for traditional Chinese medicine composition and traditional Chinese medicine capsule used for treating diabetes Download PDF

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CN106511805A
CN106511805A CN201611123860.XA CN201611123860A CN106511805A CN 106511805 A CN106511805 A CN 106511805A CN 201611123860 A CN201611123860 A CN 201611123860A CN 106511805 A CN106511805 A CN 106511805A
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radix
chinese medicine
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张超英
虞安琴
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Zhang Chaoying
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Abstract

The invention specifically relates to a traditional Chinese medicine composition for treating diabetes, belonging to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition comprises 10 to 50 g of Radix Astragali, 15 to 50 g of Ligusticum wallichii, 10 to 30 g of tuber of dwarf lilyturf, 10 to 40 g of Cornus officinalis, 15 to 40 g of cassia bark, 30 to 60 g of red sage root, 20 to 60 g of anemarrhena rhizome, 10 to 40 g of Radix Codonopsis, 5 to 20 g of asparagus tuber, 15 to 50 g of prepared rehmannia root, 10 to 80 g of Chinese yam, 10 to 30 g of Radix Bupleuri, 15 to 40 g of white peony root, 20 to 40 g of kudzu vine root, 10 to 40 g of Poria cocos, 15 to 30 g of wolfberry, 15 to 30 g of cassia seed, 5 to 20 g of corn silk, 10 to 25 g of Radix Scrophulariae and 15 to 35 g of glossy privet fruit. The traditional Chinese medicine composition can reduce urine sugar; through cooperation of the above Chinese herbal medicines, the traditional Chinese medicine composition is capable of strengthening the middle warmer, tonifying qi, invigorating yin and securing essence, prevents leakage caused by a diet of refined nutritious substances and enables urine sugar to become negative; and the traditional Chinese medicine composition can be directly taken without decoction, effective lipid-lowering components in the Chinese herbal medicines can be absorbed, and good treatment effect is obtained.

Description

A kind of preparation method of the Chinese medicine composition and Chinese medicinal capsule for treating diabetes
Technical field
The present invention relates to technical field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating diabetes.
Background technology
Diabetes are the common frdquently encountered diseases of serious harm human health, be one kind due to defect of insulin secretion or insulin The metabolic disease being characterized with hyperglycemia caused by effect obstacle.The classical symptom of diabetes is three-many-one-little symptom, i.e., many Urine, polydipsia, polyphagia and become thin.Diabetes are one of three big difficult and complicated illness of the world, and complication is more, persistent high blood sugar and long-term metabolic Disorder etc. can cause the infringement of body tissue's organ, particularly eye, kidney, cardiovascular and nervous system and its dysfunction and decline Exhaust, make patient suffer untold misery.
Be used in the market treating the product of diabetes, mainly have insulin and the like, sulfonylurea acyl class promote to secrete agent, Metformin class, alpha-glucosidase inhibitor, tetrahydrothiazole diketone derivatives promote quick dose, benzene fennel acid derivative promote secrete agent, GLP-1 receptor stimulating agents, DDP-4 enzyme inhibitors and the multiple kinds of nine big class of Chinese patent medicine.Its Chinese medicine and western medicine hypoglycemic effect is fast, but secondary work With larger, its common side effect is hypoglycemia, patient be possible to occur feel on an empty stomach, be in a cold sweat strongly, general weakness, the heart Throb with fear, trick is shaken, eyes grow dim, headache, the phenomenon such as stupefied, and stupor can occur when serious.Alpha-glucosidase inhibitor, biguanideses and Euglycemic agent is used alone and will not typically cause hypoglycemia, may still occur when being used in conjunction with other drugs;But alpha-glucosidase Inhibitor increases can gas in abdomen;Injury of the antidiabetic drug of biguanideses to the intestines and stomach is larger, is easily caused dyspepsia, when serious May result in beta-oxybutyria and lactic acidosis;Euglycemic agent can cause water retention, face and trick edema, affect appetite body Weight degradation.TCM Treatment of Diabetes is not only in that reduction blood glucose, it is often more important that focuses on preventing and treating diabetic complication, rises To improving the quality of living and prolong long-life effect, but at present except the curative effect of traditional decoction prescription is ideal, other preparations are imitated Fruit is not general obvious.Therefore research and develop one kind evident in efficacy, gently, side effect is low for drug effect, in the treatment diabetes that need not be decocted Medicine just seems very important.
The content of the invention
In view of this, it is necessary to for above-mentioned problem, there is provided a kind of Chinese medicine composition for treating diabetes.
For achieving the above object, the present invention takes following technical scheme:
The Chinese medicine composition of present invention treatment diabetes, including:10-50 gram of the Radix Astragali, 15-50 gram of Rhizoma Chuanxiong, Radix Ophiopogonis 10-30 Gram, 10-40 gram of Fructus Corni, 15-40 gram of Cortex Cinnamomi, 30-60 gram of Radix Salviae Miltiorrhizae, 20-60 gram of the Rhizoma Anemarrhenae, 10-40 gram of Radix Codonopsis, Radix Asparagi 5-20 Gram, 15-50 gram of Radix Rehmanniae Preparata, 10-80 gram of Rhizoma Dioscoreae, 10-30 gram of Radix Bupleuri, 15-40 gram of the Radix Paeoniae Alba, 20-40 gram of Radix Puerariae, 10-40 gram of Poria, 15-30 gram of Fructus Lycii, 15-30 gram of Semen Cassiae, 5-20 gram of Stigma Maydis, 10-25 gram of Radix Scrophulariae, 15-35 gram of Fructus Ligustri Lucidi.
The preparation method of Chinese medicine composition for the treatment of diabetes is:(1) above-mentioned raw materials medicine is made as according to a conventional method aqueous The aqueous extract for 10% is measured, (2) are made as oral liquid with aqueous extract obtained in step (1) according to a conventional method, (3) are by step (1) aqueous extract for obtaining is dried, crushes, crosses at least 200 mesh sieves, extracting screen underflow, is extract drugs powder, and (4) are routinely square Extract drugs powder obtained in method step (3) is made as tablet, granule, pill, electuary or capsule.Can also using without Extraction is crossed, medicinal water in above-mentioned formula is cleaned up, dried, grind to form mix homogeneously after fine powder respectively, make 10-12 gram of dress Capsule.
As further prioritization scheme, the Chinese medicine composition of the treatment diabetes of the present invention, including:10-40 gram of the Radix Astragali, river 15-40 gram of rhizome of chuanxiong, 15-30 gram of Radix Ophiopogonis, 10-30 gram of Fructus Corni, 15-30 gram of Cortex Cinnamomi, 30-50 gram of Radix Salviae Miltiorrhizae, 20-50 gram of the Rhizoma Anemarrhenae, Radix Codonopsis 10-30 gram, 5-15 gram of Radix Asparagi, 15-40 gram of Radix Rehmanniae Preparata, 10-70 gram of Rhizoma Dioscoreae, 10-25 gram of Radix Bupleuri, 15-30 gram of the Radix Paeoniae Alba, Radix Puerariae 20-30 gram, 10-30 gram of Poria, 15-25 gram of Fructus Lycii, 15-25 gram of Semen Cassiae, 10-20 gram of Stigma Maydis, 15-25 gram of Radix Scrophulariae, female It is loyal sub- 15-25 gram.
As further prioritization scheme, the Chinese medicine composition of the treatment diabetes of the present invention, including:30 grams of the Radix Astragali, Rhizoma Chuanxiong 20 grams, 20 grams of Radix Ophiopogonis, 15 grams of Fructus Corni, 25 grams of Cortex Cinnamomi, 40 grams of Radix Salviae Miltiorrhizae, 30 grams of the Rhizoma Anemarrhenae, 20 grams of Radix Codonopsis, 10 grams of Radix Asparagi, Radix Rehmanniae Preparata Yellow 25 grams, 50 grams of Rhizoma Dioscoreae, 20 grams of Radix Bupleuri, 25 grams of the Radix Paeoniae Alba, 25 grams of Radix Puerariae, 20 grams of Poria, 20 grams of Fructus Lycii, 20 grams of Semen Cassiae are beautiful 15 grams of rice palpus, 20 grams of Radix Scrophulariae, 20 grams of Fructus Ligustri Lucidi.
In order to obtain more preferably curative effect, the Chinese medicine composition of the treatment diabetes of the present invention can be with the basis of said medicine 15-30 gram of Radix Scutellariae, the Radix Astragali is added to be to increase one of Chinese medicine of insulin secretion, the Radix Astragali has promotion beta Cell of islet point to diabetes Secrete the effect of insulin.The Radix Astragali plays the role of two-ways regulation immunologic function, and Radix Astragali Main Function is to expand blood vessel, blood pressure lowering, increase Renal blood flow, reduces platelet adhesion reaction rate, improves microcirculation, anti-hypoxia and regulation immunity, removes the effect such as free radical, strengthen people The remarkable efficacies such as body immunity, increase the composition in compositionss, can reach the effect of Synergistic, and antihypertensive effect is excellent.For More preferable curative effect is reached, 5-20 gram of Herba Epimedii can also be added is combined, kidney invigorating and YANG supporting, expelling wind and removing dampness reduce blood glucose and live Property, promoting insulin secretion and other effects, curative effect is optimal.
The preparation method of the Chinese medicinal capsule of above-mentioned treatment diabetes:
Each starting material with water in claim 1,2,3,4 or 5 is cleaned up, dried, ground to form mixing after fine powder respectively Uniformly, make the capsule of 10-12 gram of dress.
Early, late three warm water of above-mentioned capsule point take, and each take three.
Chinese medicine thinks that the glycosuria disease of diabetess is more because of deficiency of the kidney yin, the bright Tianjin of interior-heat, and the method managed a household using nourishing YIN to lower pathogenic fire is no Then, glucose in urine remains high, patient's polydipsia, polyuria, polyphagia, emaciated physique, dry pharynx dryness of the tongue, Dao Zhi uremias and renal failure. For above-mentioned mechanism, the present invention adopts nourishing YIN to lower pathogenic fire, nourishing saliva and qi, the medicine reasonable compatibility of urine glucose lowering blood glucose, to reach preferably Therapeutic effect.
The medical material property of medicine of the present invention and effect are as follows:
The Radix Astragali has the effect of invigorating the spleen and replenishing QI, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema.Compatibility Rhizoma Dioscoreae, Fructus Lycii, Rhizoma Anemarrhenae blood sugar lowering, glucose in urine It is evident in efficacy.
Rhizoma Chuanxiong enter liver, gallbladder meridian, activating QI to alleviate the depression, method wind-dryness are wet, promoting blood circulation and stopping pain.Control air-cooled headache rotation dizzy, hypochondriac pain abdomen pain, arthralgia due to cold Clonic spasm of the muscle, amenorrhea.
Radix Ophiopogonis sweet in the mouth, slight bitter, cold nature returns stomach, lung, heart channel, has functions that nourishing YIN and moistening the lung, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire, For diseases such as dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed insomnia, dry constipation of intestines.
Fructus Corni liver and kidney tonifying, arresting seminal emission hidroschesis:For deficiency of the liver and kindey the soreness of waist pass out semen, have a dizzy spell, menorrhagia and The diseases such as frequent micturition, spontaneous perspiration.
Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Decline of the fire from the gate of life is controlled, cold weak pulse of limb, YANG-depletion collapse, stomachache are let out Rush down, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is floating more, heat in the upper and cold in the lower.
Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness that clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, abdominal mass accumulation, chest and abdomen thorn Bitterly, hot numbness pain, sore swell and ache curative, dysphoria and insomnia;Hepatosplenomegaly, angina pectoriss.
Rhizoma Anemarrhenae nature and flavor bitter cold, return lung stomach kidney channel, has the work(of nourishing YIN to lower pathogenic fire, moisturize laxation.Control it is scorching, quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, Cough due to lung-heat.
It is Radix Codonopsis sweet in the mouth, nontoxic, can invigorating the spleen and replenishing QI, except cold and heat, qi-restoratives is only tired, promoting the production of body fluid to quench thirst.
Radix Asparagi nourshing Yin and drynsessmoistening prescription, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire.
Radix Rehmanniae Preparata sweet in the mouth, tepor are nontoxic, can nourishing the liver and kidney, beneficial Kidney-Yin, long muscle, promoting generation of vital essence and blood, promoting blood circulation.
Rhizoma Dioscoreae enters spleen and lung kidney channel, does not tremble with fear not dry, with strengthening the spleen and stomach, the work(of nourishing the lung and kidney.Compatibility Fructus Lycii, the Rhizoma Anemarrhenae, can Increase the effect of enriching yin and nourishing kidney;Compatibility Semen Coicis, can cut down one's diet.Suitable for various types of diabetes, especially to weakness of the spleen and stomach, mouth Thirsty polyphagia person is more preferably.
Radix Bupleuri treating SHAO YANG disease by mediation, dispersing the stagnated liver-QI for regulating the stomach, ascending up spleen-Qi and Yang;
Antiperspirant is received in Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, pain relieving in delaying, yin fluid astringing.Control chest and abdomen pain over the hypochondriac region, diarrhea dysentery abdominal pain, spontaneous sweating, the deficiency of YIN Heating.
It is Radix Puerariae sweet in the mouth, pungent, flat, nontoxic, can promoting the production of body fluid to quench thirst, solve all poison, whetting the appetite
Poria sweet in the mouth, it is cold in nature.GUIXIN, liver, kidney channel.
Fructus Lycii mend and it is oiliness, have the work(of enriching yin and nourishing kidney, replenishing vital essence to improve eyesight, promoting the production of body fluid to quench thirst, tonifying both YIN and YANG.
Stigma Maydis nature and flavor are sweet, flat, return all Jing of stomach, gallbladder, kidney, have the effect of diuresis, detumescence, heat clearing away, reducing pressure and sugar.
Semen Cassiae is used for the puckery pain of conjunctival congestion, many tears of photophobia, dizziness of having a headache, poor vision, constipation.
Radix Scrophulariae nature and flavor are bitter salty cool, enter lung kidney channel, have functions that nourishing YIN to lower pathogenic fire, relieving restlessness removing toxic substances, cure mainly the thermophilic drink of xerostomia, frequent micturition food Prosperous, fatigue and weakness person.
Fructus Ligustri Lucidi nourishing the liver and kidney, improving eyesight black hair, sweet in the mouth, slight bitter are puckery, for treating hyperlipidemia, hypertension, optic neuritis.
Beneficial effects of the present invention are:
The present invention recognizes disconnected diabetes system deficiency of both QI and YIN to the theory of the diabetess for causing according to Traditional Chinese Medicine, all from right Nontoxic, harmless, the without any side effects Chinese herbal medicine of human body is raw material, effective urine glucose lowering, and many medicines are with assistant invigorating middle warmer, QI invigorating, Sheng Yin, solid Reason, controlling nocturnal emission with astringent drugs, the leakage for preventing diet precise and tiny rush down, and make glucose in urine switch to feminine gender, while preparation need not be decocted directly taking, preferably can inhale Effective lipid-loweringing composition in Chinese herbal medicine is received, so as to obtain preferable therapeutic effect.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, below in conjunction with the embodiment of the present invention, to this Bright technical scheme is made further clearly and completely to describe.It should be noted that described embodiment is only the present invention one Section Example, rather than the embodiment of whole.Based on the embodiment in the present invention, those of ordinary skill in the art are not doing The every other embodiment obtained under the premise of going out creative work, belongs to the scope of protection of the invention.
Embodiment 1
10 grams of the Radix Astragali, 15 grams of Rhizoma Chuanxiong, 10 grams of Radix Ophiopogonis, 10 grams of Fructus Corni, 15 grams of Cortex Cinnamomi, 30 grams of Radix Salviae Miltiorrhizae, 20 grams of the Rhizoma Anemarrhenae, Radix Codonopsis 10 grams, 5 grams of Radix Asparagi, 15 grams of Radix Rehmanniae Preparata, 10 grams of Rhizoma Dioscoreae, 10 grams of Radix Bupleuri, 15 grams of the Radix Paeoniae Alba, 20 grams of Radix Puerariae, 10 grams of Poria, Fructus Lycii 15 grams, 15 grams of Semen Cassiae, 5 grams of Stigma Maydis, 10 grams of Radix Scrophulariae, 15 grams of Fructus Ligustri Lucidi.
In above-mentioned formula, medicinal water is cleaned up, and is dried, is ground to form mix homogeneously after fine powder respectively, makes the glue of 12 grams of dresses Capsule, point early, late three warm water take, and each take three.
Embodiment 2
20 grams of the Radix Astragali, 30 grams of Rhizoma Chuanxiong, 20 grams of Radix Ophiopogonis, 15 grams of Fructus Corni, 15 grams of Cortex Cinnamomi, 30 grams of Radix Salviae Miltiorrhizae, 22 grams of the Rhizoma Anemarrhenae, Radix Codonopsis 12 grams, 8 grams of Radix Asparagi, 20 grams of Radix Rehmanniae Preparata, 50 grams of Rhizoma Dioscoreae, 15 grams of Radix Bupleuri, 18 grams of the Radix Paeoniae Alba, 25 grams of Radix Puerariae, 10 grams of Poria, Fructus Lycii 15 grams, 16 grams of Semen Cassiae, 15 grams of Stigma Maydis, 20 grams of Radix Scrophulariae, 20 grams of Fructus Ligustri Lucidi.
In above-mentioned formula, medicinal water is cleaned up, and is dried, is ground to form mix homogeneously after fine powder respectively, makes the glue of 11 grams of dresses Capsule, point early, late three warm water take, and each take three.
Embodiment 3
30 grams of the Radix Astragali, 30 grams of Rhizoma Chuanxiong, 30 grams of Radix Ophiopogonis, 20 grams of Fructus Corni, 18 grams of Cortex Cinnamomi, 35 grams of Radix Salviae Miltiorrhizae, 28 grams of the Rhizoma Anemarrhenae, Radix Codonopsis 17 grams, 10 grams of Radix Asparagi, 20 grams of Radix Rehmanniae Preparata, 60 grams of Rhizoma Dioscoreae, 20 grams of Radix Bupleuri, 22 grams of the Radix Paeoniae Alba, 25 grams of Radix Puerariae, 10 grams of Poria, Fructus Lycii 18 grams of son, 18 grams of Semen Cassiae, 14 grams of Stigma Maydis, 23 grams of Radix Scrophulariae, 22 grams of Fructus Ligustri Lucidi.
In above-mentioned formula, medicinal water is cleaned up, and is dried, is ground to form mix homogeneously after fine powder respectively, makes the glue of 10 grams of dresses Capsule, point early, late three warm water take, and each take three.
Embodiment 4
40 grams of the Radix Astragali, 40 grams of Rhizoma Chuanxiong, 30 grams of Radix Ophiopogonis, 10 grams of Fructus Corni, 15 grams of Cortex Cinnamomi, 30 grams of Radix Salviae Miltiorrhizae, 20 grams of the Rhizoma Anemarrhenae, Radix Codonopsis 30 grams, 5 grams of Radix Asparagi, 40 grams of Radix Rehmanniae Preparata, 10 grams of Rhizoma Dioscoreae, 10 grams of Radix Bupleuri, 15 grams of the Radix Paeoniae Alba, 27 grams of Radix Puerariae, 20 grams of Poria, Fructus Lycii 12 grams, 18 grams of Semen Cassiae, 12 grams of Stigma Maydis, 22 grams of Radix Scrophulariae, 25 grams of Fructus Ligustri Lucidi.
In above-mentioned formula, medicinal water is cleaned up, and is dried, is ground to form mix homogeneously after fine powder respectively, makes the glue of 11 grams of dresses Capsule, point early, late three warm water take, and each take three.
Embodiment 5
18 grams of the Radix Astragali, 20 grams of Rhizoma Chuanxiong, 20 grams of Radix Ophiopogonis, 22 grams of Fructus Corni, 22 grams of Cortex Cinnamomi, 38 grams of Radix Salviae Miltiorrhizae, 38 grams of the Rhizoma Anemarrhenae, Radix Codonopsis 18 grams, 10 grams of Radix Asparagi, 17 grams of Radix Rehmanniae Preparata, 66 grams of Rhizoma Dioscoreae, 14 grams of Radix Bupleuri, 28 grams of the Radix Paeoniae Alba, 24 grams of Radix Puerariae, 22 grams of Poria, Fructus Lycii 20 grams of son, 20 grams of Semen Cassiae, 15 grams of Stigma Maydis, 20 grams of Radix Scrophulariae, 25 grams of Fructus Ligustri Lucidi, 18 grams of Radix Scutellariae.
In above-mentioned formula, medicinal water is cleaned up, and is dried, is ground to form mix homogeneously after fine powder respectively, makes the glue of 12 grams of dresses Capsule, point early, late three warm water take, and each take three.
Embodiment 6
22 grams of the Radix Astragali, 24 grams of Rhizoma Chuanxiong, 19 grams of Radix Ophiopogonis, 25 grams of Fructus Corni, 30 grams of Cortex Cinnamomi, 50 grams of Radix Salviae Miltiorrhizae, 45 grams of the Rhizoma Anemarrhenae, Radix Codonopsis 27 grams, 14 grams of Radix Asparagi, 30 grams of Radix Rehmanniae Preparata, 48 grams of Rhizoma Dioscoreae, 20 grams of Radix Bupleuri, 20 grams of the Radix Paeoniae Alba, 22 grams of Radix Puerariae, 15 grams of Poria, Fructus Lycii 20 grams of son, 20 grams of Semen Cassiae, 15 grams of Stigma Maydis, 18 grams of Radix Scrophulariae, 27 grams of Fructus Ligustri Lucidi.
In above-mentioned formula, medicinal water is cleaned up, and is dried, is ground to form mix homogeneously after fine powder respectively, makes the glue of 10 grams of dresses Capsule, point early, late three warm water take, and each take three.
Embodiment 7
30 grams of the Radix Astragali, 20 grams of Rhizoma Chuanxiong, 20 grams of Radix Ophiopogonis, 15 grams of Fructus Corni, 25 grams of Cortex Cinnamomi, 40 grams of Radix Salviae Miltiorrhizae, 30 grams of the Rhizoma Anemarrhenae, Radix Codonopsis 20 grams, 10 grams of Radix Asparagi, 25 grams of Radix Rehmanniae Preparata, 50 grams of Rhizoma Dioscoreae, 20 grams of Radix Bupleuri, 25 grams of the Radix Paeoniae Alba, 25 grams of Radix Puerariae, 20 grams of Poria, Fructus Lycii 20 grams of son, 20 grams of Semen Cassiae, 15 grams of Stigma Maydis, 20 grams of Radix Scrophulariae, 20 grams of Fructus Ligustri Lucidi, 10 grams of Herba Epimedii.
In above-mentioned formula, medicinal water is cleaned up, and is dried, is ground to form mix homogeneously after fine powder respectively, makes the glue of 11 grams of dresses Capsule, point early, late three warm water take, and each take three.
Embodiment 8
30 grams of the Radix Astragali, 20 grams of Rhizoma Chuanxiong, 20 grams of Radix Ophiopogonis, 15 grams of Fructus Corni, 25 grams of Cortex Cinnamomi, 40 grams of Radix Salviae Miltiorrhizae, 30 grams of the Rhizoma Anemarrhenae, Radix Codonopsis 20 grams, 10 grams of Radix Asparagi, 25 grams of Radix Rehmanniae Preparata, 50 grams of Rhizoma Dioscoreae, 20 grams of Radix Bupleuri, 25 grams of the Radix Paeoniae Alba, 25 grams of Radix Puerariae, 20 grams of Poria, Fructus Lycii 20 grams of son, 20 grams of Semen Cassiae, 15 grams of Stigma Maydis, 20 grams of Radix Scrophulariae, 20 grams of Fructus Ligustri Lucidi, 20 grams of Radix Scutellariae.
In above-mentioned formula, medicinal water is cleaned up, and is dried, is ground to form mix homogeneously after fine powder respectively, makes the glue of 10 grams of dresses Capsule, point early, late three warm water take, and each take three.
Embodiment 9
30 grams of the Radix Astragali, 20 grams of Rhizoma Chuanxiong, 20 grams of Radix Ophiopogonis, 15 grams of Fructus Corni, 25 grams of Cortex Cinnamomi, 40 grams of Radix Salviae Miltiorrhizae, 30 grams of the Rhizoma Anemarrhenae, Radix Codonopsis 20 grams, 10 grams of Radix Asparagi, 25 grams of Radix Rehmanniae Preparata, 50 grams of Rhizoma Dioscoreae, 20 grams of Radix Bupleuri, 25 grams of the Radix Paeoniae Alba, 25 grams of Radix Puerariae, 20 grams of Poria, Fructus Lycii 20 grams of son, 20 grams of Semen Cassiae, 15 grams of Stigma Maydis, 20 grams of Radix Scrophulariae, 20 grams of Fructus Ligustri Lucidi, 20 grams of Radix Scutellariae, 10 grams of Herba Epimedii.
In above-mentioned formula, medicinal water is cleaned up, and is dried, is ground to form mix homogeneously after fine powder respectively, makes the glue of 12 grams of dresses Capsule, point early, late three warm water take, and each take three.
Further to verify the Chinese medicine composition drug effect of the present invention, the Chinese medicine composition is tested as follows:
First, zoopery
1.1 laboratory animal
SPF level Balb/C mices, male, week old are 4w~6w, and body weight is 20g~22g.
1.2 experiment packet:
Experiment is divided to two groups:Normal group, model group.
1.3 model cycles
24 weeks
1.4 main agents and compound method
Citric acid, trisodium citrate, streptozotocin mycin (Streptozocin, STZ)
1.41 sodium citrate buffer solution is prepared:2.10g citric acids addition distilled water 100ml is made into into citric acid mother liquor, is claimed For A liquid;2.94g trisodium citrates addition distilled water 100ml is made into into sodium citrate mother liquor, referred to as B liquid;A, B liquid is pressed into 1: 1.32 ratios mix, and pH meter determines pH value, set up pH value of solution=4.0, and the 0.1mol/L sodium citrates that STZ is prepared needed for being delay Rush liquid.
The preparation of 1.42 STZ solution:STZ is dissolved in 0.1mol/L sodium citrate buffer solutions, Fresh is into 10mg/ The STZ solution of mL concentration, and with 0.22 μm of bacteria filter filtration sterilization.Notice that lucifuge is prepared, matching while using.
1.5 modeling method
1.51 preoperative 12h fasting
1.52 model group mices carry out lumbar injection according to the STZ of 120mg/kg dosage, and matched group gives identical dose The sodium citrate buffer solution of amount.
After 1.53 STZ injection 3d, fasting glucose is surveyed, select blood glucose formal experiment to be included higher than 16.7mmol/L.
After 1.54 STZ injections, blood glucose is surveyed weekly, is weighed, observe body weight change of blood sugar, experimental period is 12 weeks.
The change of fasting glucose, triglyceride and total cholesterol level after 1.6 12 weeks:
The fasting glucose of Normal group, triglyceride and total cholesterol level are before and after experiment without significant difference;
The fasting glucose of model group, triglyceride and total cholesterol level are significantly higher than matched group.Show as body weight to lighten, Lethargy, bradykinesia, the perpendicular tarnish of hair, slow movement, hunchbacked scroll, urine volume are dramatically increased.
20 hyperglycemia animal stochastic averaginas of model group are divided into two groups (1 group of experiment, 2 groups of experiments) by 2.1,10 per group Animal, it is desirable to the average level of fasting glucose, triglyceride and T-CHOL difference (the P > that compare that there are no significant after packet 0.05)。
2.2 1 group of experiments are control sample, normal to feed;2 groups of Chinese medicine compositions given in the present invention are tested, the daily morning and evening Jing stomaches are administered 0.3mg/kg.
After 2.3 3 days, 2 groups of Mouse Weights of experiment rise, and the mental status improves, and can be reacted and become sensitive with action, and hair is put down Volt recovers certain gloss;1 group of Mouse Weight and the mental status are tested without significant change.
Test 2 groups of mices after two weeks body weight it is medium, the mental status is good, and blood sugar level recovers normal.And test 1 group of mice and arrive Just recover after 25-30 days normal.
2nd, clinical experiment
Diabetes totally 100 are treated using present invention tracking, wherein, male 60, women 40, send out age 40-80 year 1-20 after being ill.Patients symptomatic, thirst and liking drink, rapid digestion of food and polyorexia, itching over the body have a formication, numb limbs and tense tendons, and acra is sent out cool, limbs pain Or twinge, fatigue and weakness, spontaneous perspiration, dysphoria with feverish sensation in the chest palms and soles, constipation, corpulent tongue is big, purplish tongue or have ecchymosis, and pulse condition is counted accurately or thin puckery. Fasting glucose >=8.0mmol/L, after the meal 2 hours blood glucoses >=12.1mmol/L.Wherein type 1 diabetes patient 11, type 2 diabetes mellitus Patient 89, needs long-term taking Western medicine antidiabetic drug control blood glucose.
Therapeutic Method:The each 10ml of oral liquid, takes 3 day, 3-10 gram every time of granule, powder, capsule, electuary, pill etc., Day takes 3 times.10 days courses for the treatment of.The generally 1-3 course for the treatment of, the serious symptom 4-5 course for the treatment of.The 1-3 course for the treatment of of medication, clinical symptoms disappear substantially Effective patient be 44 people, total effective rate 44%.Clinical symptoms part disappear effective patient be 66 people, total effective rate 66%. Clinical symptoms are without 8 people for improving, total inefficiency 8%.Obvious adverse effect and toxic and side effects are had no over the course for the treatment of, are not had It is found the phenomenon of liver, kidney, lung, spleen, stomach upset.
The Chinese medicine composition of the treatment diabetes of the present invention, can have reduces the blood glucose of type 2 diabetes mellitus patient to a certain extent, Combined from the natural drug of integration of edible and medicinal herbs, have no toxic side effect, directly take, facilitate feasible.
Embodiment described above only expresses the several embodiments of the present invention, and its description is more concrete and detailed, but and Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art For, without departing from the inventive concept of the premise, some deformations and improvement can also be made, these belong to the guarantor of the present invention Shield scope.Therefore, the protection domain of patent of the present invention should be defined by claims.

Claims (6)

1. a kind of Chinese medicine composition for treating diabetes, it is characterised in that including 10-50 gram of the Radix Astragali, 15-50 gram of Rhizoma Chuanxiong, Radix Ophiopogonis 10-30 gram, 10-40 gram of Fructus Corni, 15-40 gram of Cortex Cinnamomi, 30-60 gram of Radix Salviae Miltiorrhizae, 20-60 gram of the Rhizoma Anemarrhenae, 10-40 gram of Radix Codonopsis, Radix Asparagi 5-20 gram, 15-50 gram of Radix Rehmanniae Preparata, 10-80 gram of Rhizoma Dioscoreae, 10-30 gram of Radix Bupleuri, 15-40 gram of the Radix Paeoniae Alba, 20-40 gram of Radix Puerariae, Poria 10- 40 grams, 15-30 gram of Fructus Lycii, 15-30 gram of Semen Cassiae, 5-20 gram of Stigma Maydis, 10-25 gram of Radix Scrophulariae, 15-35 gram of Fructus Ligustri Lucidi.
2. it is according to claim 1 treatment diabetes Chinese medicine composition, it is characterised in that include:10-40 gram of the Radix Astragali, 15-40 gram of Rhizoma Chuanxiong, 15-30 gram of Radix Ophiopogonis, 10-30 gram of Fructus Corni, 15-30 gram of Cortex Cinnamomi, 30-50 gram of Radix Salviae Miltiorrhizae, 20-50 gram of the Rhizoma Anemarrhenae, party 10-30 gram of ginseng, 5-15 gram of Radix Asparagi, 15-40 gram of Radix Rehmanniae Preparata, 10-70 gram of Rhizoma Dioscoreae, 10-25 gram of Radix Bupleuri, 15-30 gram of the Radix Paeoniae Alba, Radix Puerariae 20-30 gram, 10-30 gram of Poria, 15-25 gram of Fructus Lycii, 15-25 gram of Semen Cassiae, 10-20 gram of Stigma Maydis, 15-25 gram of Radix Scrophulariae, female It is loyal sub- 15-25 gram.
3. it is according to claim 1 and 2 treatment diabetes Chinese medicine composition, it is characterised in that include:30 grams of the Radix Astragali, 20 grams of Rhizoma Chuanxiong, 20 grams of Radix Ophiopogonis, 15 grams of Fructus Corni, 25 grams of Cortex Cinnamomi, 40 grams of Radix Salviae Miltiorrhizae, 30 grams of the Rhizoma Anemarrhenae, 20 grams of Radix Codonopsis, 10 grams of Radix Asparagi, 25 grams of Radix Rehmanniae Preparata, 50 grams of Rhizoma Dioscoreae, 20 grams of Radix Bupleuri, 25 grams of the Radix Paeoniae Alba, 25 grams of Radix Puerariae, 20 grams of Poria, 20 grams of Fructus Lycii, Semen Cassiae 20 Gram, 15 grams of Stigma Maydis, 20 grams of Radix Scrophulariae, 20 grams of Fructus Ligustri Lucidi.
4. it is according to claim 1 and 2 treatment diabetes Chinese medicine composition, it is characterised in that also including Radix Scutellariae 15-30 Gram.
5. it is according to claim 4 treatment diabetes Chinese medicine composition, it is characterised in that also including Herba Epimedii 5-20 Gram.
6. a kind of preparation method of the Chinese medicinal capsule for treating diabetes, it is characterised in that by claim 1,2,3,4 or 5 Each starting material with water is cleaned up, and is dried, is ground to form mix homogeneously after fine powder respectively, makes the capsule of 10-12 gram of dress.
CN201611123860.XA 2016-11-04 2016-12-08 Preparation method for traditional Chinese medicine composition and traditional Chinese medicine capsule used for treating diabetes Pending CN106511805A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102266520A (en) * 2011-07-25 2011-12-07 王保江 Traditional Chinese medicine composition for treating diabetes
CN103405658A (en) * 2013-08-28 2013-11-27 安耀苍 Drug for treating diabetes mellitus and preparation method thereof
CN105395842A (en) * 2015-11-09 2016-03-16 长葛市新世纪机电有限公司 Traditional Chinese medicine composition for treating diabetes and oral preparation and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102266520A (en) * 2011-07-25 2011-12-07 王保江 Traditional Chinese medicine composition for treating diabetes
CN103405658A (en) * 2013-08-28 2013-11-27 安耀苍 Drug for treating diabetes mellitus and preparation method thereof
CN105395842A (en) * 2015-11-09 2016-03-16 长葛市新世纪机电有限公司 Traditional Chinese medicine composition for treating diabetes and oral preparation and preparation method thereof

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