CN106511638A - 一种抗肿瘤中药组合物及其应用 - Google Patents
一种抗肿瘤中药组合物及其应用 Download PDFInfo
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- CN106511638A CN106511638A CN201611257090.8A CN201611257090A CN106511638A CN 106511638 A CN106511638 A CN 106511638A CN 201611257090 A CN201611257090 A CN 201611257090A CN 106511638 A CN106511638 A CN 106511638A
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Abstract
本发明涉及药领域,具涉及一种抗肿瘤中药组合物及其应用,所述中药组合物由以下重量份的原料制成:北豆根20‑50份、赤芍20‑40份、桔梗15‑35份、苦参20‑30份、绵马贯众10‑25份、秦皮8‑15份、蓝莓10‑30份、红旱莲8‑15份、牛蒡子10‑20份、青蒿20‑40份、车前子10‑20份、紫花地丁5‑12份、槲寄生8‑18份、刺五加10‑25份,本发明在中药材的选择和配伍上符合中医辩证理论,通过科学配伍,使各种药材相辅相成,循序渐进,抑制杀灭肿瘤细胞,逐步治疗肿瘤,减少癌症患者痛苦,并延长肿瘤患者的生命,效果显著,无任何副作用,也不会产生药物依赖性,适于广泛推广应用。
Description
技术领域
本发明涉及中药领域,具涉及一种抗肿瘤中药组合物及其应用。
背景技术
肿瘤本质上是一种基因病,各种环境的和遗传的致癌因素以协同或序贯的方式引起DNA损害,从而激活原癌基因或灭活肿瘤抑制基因,加上凋亡调节基因或DNA修复基因的改变,继而引起表达水平的异常,使靶细胞发生转化。被转化的细胞先多呈克隆性的增生,经过一个漫长的多阶段的演进过程,其中一个克隆相对无限制的扩增,通过附加突变,选择性地形成具有不同特点的亚克隆,从而获得浸润和转移的能力,形成恶性肿瘤。
目前,作为恶性肿瘤的治疗方法,一般采取化学疗法、放射线疗法及外壳疗法,放射线疗法副作用大,对正常细胞及癌细胞同时给予损伤,化学疗法一般采用抗生素、代谢、激素类药物等,也是具有很大的副作用。因此,期望安全性高、副作用小的抗肿瘤治疗方法。中医治疗肿瘤从整体进行调理,副作用小,但是,现有的中药治疗肿瘤的方法中,普遍存在见效慢、效果不明显等不足,目前仍然没有真正能值得普遍推广与使用的经验与成果。
发明内容
本发明提供了一种抗肿瘤中药组合物及其应用,所述中药组合物可以抑制杀灭肿瘤细胞、减少癌症患者痛苦,毒副作用小。
为实现以上目的,本发明通过以下技术方案予以实现:
一种抗肿瘤中药组合物,由以下重量份的原料制成:北豆根20-50份、赤芍20-40份、桔梗15-35份、苦参20-30份、绵马贯众10-25份、秦皮8-15份、蓝莓10-30份、红旱莲8-15份、牛蒡子10-20份、青蒿20-40份、车前子10-20份、紫花地丁5-12份、槲寄生8-18份、刺五加10-25份。
优选地,所述抗肿瘤中药组合物由以下重量份的原料制成:北豆根30-40份、赤芍25-35份、桔梗20-30份、苦参22-28份、绵马贯众15-20份、秦皮10-13份、蓝莓15-25份、红旱莲10-13份、牛蒡子12-18份、青蒿25-35份、车前子12-18份、紫花地丁7-10份、槲寄生12-16份、刺五加14-20份。
优选地,所述抗肿瘤中药组合物由以下重量份的原料制成:北豆根35份、赤芍30份、桔梗25份、苦参25份、绵马贯众18份、秦皮12份、蓝莓20份、红旱莲12份、牛蒡子15份、青蒿30份、车前子15份、紫花地丁8份、槲寄生15份、刺五加18份。
本发明的中药组合物可按传统单方抓取,水煎服用;也可制备成各种中成药剂型,方便临床使用。
本发明提供了一种抗肿瘤中药制剂,其是由上述抗肿瘤中药组合物和药学上可接受的载体和/或赋形剂制成临床可接受的剂型。所述临床可接受的剂型可为胶囊剂、片剂、丸剂、颗粒剂或冲剂等。优选胶囊剂。
本发明提供了一种用于制备上述抗肿瘤中药制剂的方法,具体包括以下步骤:
(1)按照配方量称取各中药原料;
(2)将赤芍、桔梗、苦参、牛蒡子、青蒿、紫花地丁和槲寄生七味药材中加7-9倍量的水,蒸馏提取挥发油5-8h,收集挥发油并保留药液和药渣,备用;
(3)将上述提取过挥发油的药渣再加6-8倍量的水煎煮1h,过滤,得煎煮液,将其与上述备用的药液合并,滤过,得提取液一;
(4)将北豆根、绵马贯众、秦皮、蓝莓、红旱莲、车前子、刺五加七味药材中加入10-12倍量的水,煎煮2-3次,每次40-60min,合并滤液,滤过,得提取液二;
(5)将提取液一和提取液二合并,并于70-80℃下减压浓缩成相对密度为1.15-1.25的稠膏,干燥稠膏,粉碎,过60-100目筛,得提取物粉体;
(6)将上述提取物粉体加入药学上可接受的载体和/或赋形剂,再喷入挥发油,制成临床可接受的剂型。
本发明中,各中药原料的药效如下:
赤芍:味苦,性微寒。归肝经。清热凉血,散瘀止痛。用于热人营血,温毒发斑,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,瘾瘕腹痛,跌扑损伤,痈肿疮疡。
桔梗:宣肺,利咽,祛痰,排脓。用于咳嗽痰多,胸闷不畅,咽痛,音哑,肺痈吐脓,疮疡脓成不溃。
苦参:味苦,性寒,归心、肝、胃、大肠、膀胱经。清热燥湿,杀虫,利尿。用于热痢,便血,黄疸尿闭,赤白带下,阴肿阴痒,湿疹,湿疮,皮肤瘙痒,疥癣麻风,外治滴虫性阴道炎。
绵马贯众:苦,微寒;有小毒。归肝、胃经,清热解毒,止血,杀虫。时疫感冒,风热头痛,温毒发斑,疮疡肿毒,崩漏下血,虫积腹痛。
秦皮:味苦、涩,性寒。归肝、胆、大肠经。清热燥湿,收涩止痢,止带,明目。湿热泻痢,赤白带下,目赤肿痛,目生翳膜。
蓝莓:蓝莓能有效降低胆固醇,防止动脉粥样硬化,促进心血管健康;有增强心脏功能、预防癌症和心脏病的功效,能防止脑神经衰老、增强脑力;可以强化视力,减轻眼球疲劳。
红旱莲:味微苦,性寒,无毒。入肝经。全草入药,有平肝、止血、败毒、消肿的作用。
牛蒡子:味辛、苦,性寒。归肺、胃经。疏散风热,清热解毒透疹;宣肺利咽散肿。
青蒿:苦,辛,寒。归肝、胆经、三焦、肾经。清透虚热,凉血除蒸,解暑,截疟。用于暑邪发热,阴虚发热,夜热早凉,骨蒸劳热,疟疾寒热,湿热黄疸。
车前子:甘,寒。入肾、膀胱经。利水,清热,明目,祛痰。治小便不通,淋浊,带下,尿血,暑湿泻痢,咳嗽多痰,湿痹,目赤障翳。
紫花地丁:味苦、辛、寒。归心、肺经。具有清热解毒,凉血消肿,清热利湿的作用,主治疔疮,痈肿,瘰疬,黄疸,痢疾,腹泻,目赤,喉痹,毒蛇咬伤。
北豆根:苦,寒;有小毒。归肺、胃、大肠经。有清热解毒,祛风止痛之功效,常用于咽喉肿痛,热毒泻痢,风湿痹痛等证。
槲寄生:苦,甘,平。归肝、肾经。具有舒筋活络,活血散瘀。用于筋骨疼痛,肢体拘挛,腰背酸痛,跌打损伤。补肝肾,强筋骨,祛风湿,安胎等功效,槲寄生提取物可改善微循环,其总生物碱还具有抗肿瘤作用。
刺五加:辛,苦,微甘;性温。归肝、肾经。祛风湿,补肝肾,强筋骨,活血脉。主风寒湿痹,腰膝疼痛,筋骨痿软,体虚赢弱,跌打损伤,骨折,水肿等症。
本发明的有益效果为:
1、本发明在中药材的选择和配伍上符合中医辩证理论,通过科学配伍,以清热凉血,散瘀止痛、扶正培本为治疗原则,使各种药材相辅相成,循序渐进,抑制杀灭肿瘤细胞,逐步治疗肿瘤,减少癌症患者痛苦,并延长肿瘤患者的生命,效果显著。
2、本发明中药组合物可以单独治疗肿瘤,也可以与手术、放疗、化疗同时使用,无任何副作用,也不会产生药物依赖性,适于广泛推广应用。
3、本发明所用中药药材均为长白山的地道药材,取材集中化,十分方便。
具体实施方式
下面结合具体实施例进一步说明本发明的技术解决方案,实施例不能理解为是对技术解决方案的限制。
实施例1:本发明胶囊剂的制备
(1)称取下述重量配比的原料药:北豆根35份、赤芍30份、桔梗25份、苦参25份、绵马贯众18份、秦皮12份、蓝莓20份、红旱莲12份、牛蒡子15份、青蒿30份、车前子15份、紫花地丁8份、槲寄生15份、刺五加18份。
(2)将赤芍、桔梗、苦参、牛蒡子、青蒿、紫花地丁和槲寄生七味药材中加9倍量的水,蒸馏提取挥发油5h,收集挥发油并保留药液和药渣,备用;
(3)将上述提取过挥发油的药渣再加8倍量的水煎煮1h,过滤,得煎煮液,将其与上述备用的药液合并,滤过,得提取液一;
(4)将北豆根、绵马贯众、秦皮、蓝莓、红旱莲、车前子、刺五加七味药材中加入10倍量的水,煎煮3次,每次40min,合并滤液,滤过,得提取液二;
(5)将提取液一和提取液二合并,并于80℃下减压浓缩成相对密度为1.15的稠膏,干燥稠膏,粉碎,过100目筛,得提取物粉体;
(6)将上述提取物粉体加入淀粉、糊精适量,混匀,用5%PVP溶液制成颗粒,喷入挥发油,加入适量硬脂酸镁,混匀,装胶囊,即得胶囊剂,胶囊剂粒重0.5g。
实施例2:本发明片剂的制备
(1)称取下述重量配比的原料药:北豆根50份、赤芍20份、桔梗35份、苦参30份、绵马贯众10份、秦皮15份、蓝莓30份、红旱莲15份、牛蒡子10份、青蒿20份、车前子20份、紫花地丁5份、槲寄生8份、刺五加25份。
(2)将赤芍、桔梗、苦参、牛蒡子、青蒿、紫花地丁和槲寄生七味药材中加7倍量的水,蒸馏提取挥发油8h,收集挥发油并保留药液和药渣,备用;
(3)将上述提取过挥发油的药渣再加7倍量的水煎煮1h,过滤,得煎煮液,将其与上述备用的药液合并,滤过,得提取液一;
(4)将北豆根、绵马贯众、秦皮、蓝莓、红旱莲、车前子、刺五加七味药材中加入12倍量的水,煎煮2次,每次50min,合并滤液,滤过,得提取液二;
(5)将提取液一和提取液二合并,并于75℃下减压浓缩成相对密度为1.20的稠膏,干燥稠膏,粉碎,过60目筛,得提取物粉体;
(6)将上述提取物粉体加入淀粉、糊精适量,混匀,用5%PVP溶液制成颗粒,喷入挥发油,加入适量羧甲基纤维素钠、硬脂酸镁,混匀,压片,即得。
实施例3:本发明颗粒剂的制备
(1)称取下述重量配比的原料药:北豆根30份、赤芍25份、桔梗30份、苦参22份、绵马贯众15份、秦皮13份、蓝莓25份、红旱莲10份、牛蒡子18份、青蒿25份、车前子18份、紫花地丁10份、槲寄生12份、刺五加20份。
(2)将赤芍、桔梗、苦参、牛蒡子、青蒿、紫花地丁和槲寄生七味药材中加8倍量的水,蒸馏提取挥发油6h,收集挥发油并保留药液和药渣,备用;
(3)将上述提取过挥发油的药渣再加6倍量的水煎煮1h,过滤,得煎煮液,将其与上述备用的药液合并,滤过,得提取液一;
(4)将北豆根、绵马贯众、秦皮、蓝莓、红旱莲、车前子、刺五加七味药材中加入11倍量的水,煎煮3次,每次60min,合并滤液,滤过,得提取液二;
(5)将提取液一和提取液二合并,并于70℃下减压浓缩成相对密度为1.25的稠膏,干燥稠膏,粉碎,过80目筛,得提取物粉体;
(6)取上述提取物粉体加入蔗糖、糊精适量,混匀,用75%乙醇造成软材,过12-14目筛制成颗粒,干燥,喷入挥发油,分装,即得。
实施例4:本发明胶囊剂的制备
除原料药重量配比不同外,其余均与实施例1相同:
原料药重量配比:北豆根20份、赤芍40份、桔梗15份、苦参20份、绵马贯众25份、秦皮8份、蓝莓10份、红旱莲8份、牛蒡子20份、青蒿40份、车前子10份、紫花地丁12份、槲寄生18份、刺五加10份。
实施例5:
除原料药重量配比不同外,其余均与实施例2相同:
原料药重量配比:北豆根40份、赤芍35份、桔梗20份、苦参28份、绵马贯众20份、秦皮10份、蓝莓15份、红旱莲13份、牛蒡子12份、青蒿35份、车前子12份、紫花地丁7份、槲寄生16份、刺五加14份。
临床资料:
1、一般性资料
病人来源:本试验共选取病例160例,男女各半,其中肝癌试验组35例,肝癌对照组35例,胃癌试验组45例,胃癌对照组45例。经与患者以及患者家属的协商并签署知情同意书后,进行临床治疗试验。
2、疗效判定:
(1)显效:肿瘤瘤体缩小10%以上,主要症状消失;
(2)有效:肿瘤瘤体缩小1-10%,临床症状明显改善;
(3)无效:肿瘤瘤体继续增长,临床症状无改善或加重。
3、病例标准
西医诊断为肝癌、胃癌的病人。
4、试验方法
癌症试验组以本发明实施例1的胶囊剂治疗,一日三次,一次4g;对照组采用化疗及放疗治疗。30天为一个疗程,观察3个月。
经临床观察后,结果见表1。
两组综合疗效,见表1
从表中可以看出,两组间综合疗效有显著差异,试验组明显优于对照组。
5、典型病例
病例1:
王某,女,40岁,发现肝癌1年,试过西药化疗疗法,效果不理想,后使用本发明实施例1中的胶囊剂2个疗程后,疼痛减轻。之后坚持服用,疼痛基本缓解,病情基本得到控制,已能正常生活。
病例2:梁某,男,60岁,发现胃癌2年,试过西药化疗疗法,效果不理想,后使用本发明实施例1中的胶囊剂3个疗程后,疼痛减轻,之后坚持服用,病情基本稳定,现状态良好,已能正常生活。
Claims (8)
1.一种抗肿瘤中药组合物,其特征在于,由以下重量份的原料制成:北豆根20-50份、赤芍20-40份、桔梗15-35份、苦参20-30份、绵马贯众10-25份、秦皮8-15份、蓝莓10-30份、红旱莲8-15份、牛蒡子10-20份、青蒿20-40份、车前子10-20份、紫花地丁5-12份、槲寄生8-18份、刺五加10-25份。
2.根据权利要求1所述的抗肿瘤中药组合物,其特征在于,由以下重量份的原料制成:北豆根30-40份、赤芍25-35份、桔梗20-30份、苦参22-28份、绵马贯众15-20份、秦皮10-13份、蓝莓15-25份、红旱莲10-13份、牛蒡子12-18份、青蒿25-35份、车前子12-18份、紫花地丁7-10份、槲寄生12-16份、刺五加14-20份。
3.根据权利要求2所述的抗肿瘤中药组合物,其特征在于,由以下重量份的原料制成:北豆根35份、赤芍30份、桔梗25份、苦参25份、绵马贯众18份、秦皮12份、蓝莓20份、红旱莲12份、牛蒡子15份、青蒿30份、车前子15份、紫花地丁8份、槲寄生15份、刺五加18份。
4.一种抗肿瘤中药制剂,其特征在于,其是由权利要求1-3任一项所述的中药组合物和药学上可接受的载体和/或赋形剂制成的临床可接受的剂型。
5.根据权利要求4所述的抗肿瘤中药制剂,其特征在于,所述临床可接受的剂型为胶囊剂、片剂、颗粒剂、丸剂或冲剂。
6.根据权利要求5所述的抗肿瘤中药制剂,其特征在于,所述临床可接受的剂型为胶囊剂。
7.根据权利要求4所述的抗肿瘤中药制剂的制备方法,其特征在于:包括以下步骤:
(1)按照配方量称取各中药原料;
(2)将赤芍、桔梗、苦参、牛蒡子、青蒿、紫花地丁和槲寄生七味药材中加7-9倍量的水,蒸馏提取挥发油5-8h,收集挥发油并保留药液和药渣,备用;
(3)将上述提取过挥发油的药渣再加6-8倍量的水煎煮1h,过滤,得煎煮液,将其与上述备用的药液合并,滤过,得提取液一;
(4)将北豆根、绵马贯众、秦皮、蓝莓、红旱莲、车前子、刺五加七味药材中加入10-12倍量的水煎煮2-3次,每次40-60min,合并滤液,滤过,得提取液二;
(5)将提取液一和提取液二合并,并于70-80℃下减压浓缩成相对密度为1.15-1.25的稠膏,干燥稠膏,粉碎,过60-100目筛,得提取物粉体;
(6)将上述提取物粉体加入药学上可接受的载体和/或赋形剂,再喷入挥发油,制成临床可接受的剂型。
8.一种如权利要求1-3任一项所述的中药组合物在制备抗肿瘤的药物中的应用。
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