CN106511287A - Vitamin C chewable tablets and preparation method thereof - Google Patents
Vitamin C chewable tablets and preparation method thereof Download PDFInfo
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- CN106511287A CN106511287A CN201610963277.3A CN201610963277A CN106511287A CN 106511287 A CN106511287 A CN 106511287A CN 201610963277 A CN201610963277 A CN 201610963277A CN 106511287 A CN106511287 A CN 106511287A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses vitamin C chewable tablets and a preparation method thereof, and relates to the field of chewable tablets. Every 1,000 vitamin C chewable tablets are prepared from 42-48 g of vitamin C, 1,000 g of sorbitol, 123-127 g of lactose, 23-27 g of citric acid, 33-38 g of orange essence, 2-4 g of cherry fruit powder, 12-16 g of magnesium stearate and 0.2-0.5 g of sunset yellow. The vitamin C chewable tablets can improve the human body immunity and reduce a deficiency disease, have a whitening effect and are slightly sweet in mouthfeel and good in chewing mouthfeel.
Description
Technical field
The present invention relates to chewable tablet direction, and in particular to a kind of Chewable C and preparation method thereof.
Background technology
Vitamin C (Vitamin C, Ascorbic Acid) is called L-AA, is a kind of water soluble vitamins.Food
Vitamin C in thing is absorbed by human small intestine's epimere.Once absorbing, just it is distributed in internal all of water-soluble structure, normally
1500mg vitamin Cs are there are about in the internal vitamin C metabolic activity pond of adult, highest storage peak value is 3000mg vitamin Cs.Just
In the case of often, the most Jing metabolic breakdowns in vivo of vitamin C are combined generation ascorbic acid -2- sulphuric acid into oxalic acid or with sulphuric acid
By urine ejection；Another part can be directly external by urine ejection.Nutritive value：Ascorbic Main Function is enhance immunity, in advance
Anti-cancer, heart disease, apoplexy, take care of one's teeth with gingiva etc..In addition, adhere to that taking vitamin C can also make skin black on time
Plain calm reduction, so as to reduce black speck and freckle, makes whitening skin.Rich in ascorbic food have Herba Astragali Sinici, Radix Rauvolfiae, Fructus Citri junoriss,
Sucus Vitis viniferae, Fructus Lycopersici esculenti etc., it may be said that in all of veterinary antibiotics, Vitamin C content is all many.US Experts think, often
Ascorbic optimum amount should be 200～300 milligrams to people daily, and minimum to be no less than 60 milligrams, the new fresh orange-juice of half cup just can meet
This minimum flow.
There is different degrees of shortage in each crowd according to relevant information report vitamin C.When some indispositions occurs in body
When, just should supplement appropriate vitamin and mineral in time to improve food deficiency disease, especially person in middle and old age more should pay attention to.
Vitamin has preventive effect to numerous disease, and the generation of numerous disease may be more or less relevant with ascorbic shortage
System, vitamin C can also treat some diseases with many other combination therapies in addition.
The content of the invention
According to above the deficiencies in the prior art, the technical problem to be solved is to propose that a kind of vitamin C is chewed
Piece and preparation method thereof, improves body immunity, reduces food deficiency disease, and the effect with whitening, and mouthfeel is slightly sweet,
Chewing mouthfeel is good.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is：A kind of Chewable C, with 1000
Chewable C meter described in piece, comprising following material and its content：Vitamin C 42-48g, Sorbitol 1000g, Lactose
123-127g, citric acid 23-27g, Fructus Citri tangerinae essence 33-38g, Fructus Pruni pseudocerasi fruit powder 2-4g, magnesium stearate 12-16g and sunset yellow
0.2-0.5g。
Preferred version is：In terms of 1000 Chewable Cs, comprising the vitamin C 46g, Sorbitol
1000g, Lactose 125.7g, citric acid 25g, Fructus Citri tangerinae essence 36g, Fructus Pruni pseudocerasi fruit powder 3g, magnesium stearate 14g and sunset yellow 0.3g.
In above-mentioned chewable tablet, in the Fructus Pruni pseudocerasi fruit powder, maltodextrin is added with.Be added with the Fructus Citri tangerinae essence mandarin oil,
Maltodextrin and ethyl n-butyrate..
A kind of preparation method of Chewable C, comprises the steps：Step one, by citric acid crush, cross 80 mesh
Sieve, weighing, mix 10 minutes prepared mixture A with the Fructus Pruni pseudocerasi fruit powder through 40 mesh sieves, after weighing；Step 2, by Lactose crush,
Cross 80 mesh sieves, weigh, with crush, cross 80 mesh sieves, weigh after vitamin C be added in mixture A and mix 20 minutes, be obtained and mix
Compound B；Step 3, will Sorbitol crush, cross 80 mesh sieves, weigh after uniformly mix with mixture B, be obtained mixture C；Step
4th, sunset yellow is weighed, is dissolved in appropriate purified water, add 95% ethanol, 90% ethanol is obtained, 90% ethanol consumption is formula ratio
22%-24%, and mixture C soft material；Step 5, soft material sieve prepared wet granular, and wet granular is through being dried, sieving afterwards
Prepared dry particl；Step 6, Fructus Citri tangerinae essence is crossed 80 mesh sieves, weighing, equal increments mix with dry particl, mixture D is obtained；Step
Rapid seven, total mixture is obtained after mixing with mixture D after weigh magnesium stearate 5 minutes, tablet is obtained through tabletting afterwards.
Soft material in the step 5 sieves from 20 mesh sieves.Wet grain drying temperature in step 5 is 50 degree, is dried
When less than 5% is down to pellet moisture stop drying.
Present invention has the advantages that:The present invention can enhance immunity, reduce food deficiency disease, prevention disease, adhere to by
When take vitamin C and can also make that dermal melanin is calm to be reduced, so as to reduce black speck and freckle, make whitening skin.This product exists
Essence, Sorbitol etc. are mixed with vitamin C, taste are improved, and be with the addition of sunset yellow, change tablet color, outward appearance
More attractive in appearance, it is edible to be adapted to adult, raw material sources fully, with prescription it is simple, technique is unique, product stability, safety
The characteristics of property is high, can produce throughout the year.
Specific embodiment
Below by the description to embodiment, the shape of each component of the specific embodiment of the present invention as involved by, structure
Make, the mutual alignment between each several part and annexation, the effect of each several part and operation principle, manufacturing process and the side of operating with
Method etc., is described in further detail, and has completeer to inventive concept of the invention, technical scheme to help those skilled in the art
Whole, accurate and deep understanding.
Chewable C is in terms of every 1.25g.
Embodiment one,
A kind of Chewable C, in terms of 1000 Chewable Cs, comprising the vitamin C, (L- is anti-bad
Hematic acid) 43g, Sorbitol 1000g, Lactose 126.6g, citric acid 26g, Fructus Citri tangerinae essence 35g, Fructus Pruni pseudocerasi fruit powder 4g, magnesium stearate
15g and sunset yellow 0.4g.
The preparation method of Chewable C：
Step one, by 26g citric acids crush, cross 80 mesh sieves, weigh, with through 40 mesh sieves, weigh after 4g Fructus Pruni pseudocerasi fruit powder
Uniform mixing 10 minutes, is obtained mixture A, and wherein Fructus Pruni pseudocerasi fruit powder is made up of Fructus Pruni pseudocerasi fruit juice and maltodextrin.
Step 2, by 126.6g Lactose crush, cross 80 mesh sieves, weigh, with crush, cross 80 mesh sieves, weigh after vitamin C
43g mixes 20 minutes in being added to mixture A, and mixture B is obtained.
Step 3, by Sorbitol 1000g crush, cross 80 mesh sieves, weigh after uniformly mix with mixture B, be obtained mixing
Thing C.
Step 4, sunset yellow 0.4 is weighed, be dissolved in appropriate purified water, add the ethanol of volume fraction 95%, be obtained 90%
Ethanol, 90% ethanol consumption is the 22%-24% of formula ratio, preferably 23%, and mixture C soft material.
Step 5, soft material are obtained wet granular through 20 mesh sieves, and wet granular is through being dried, prepared dry particl of sieving.It is being dried
In machine, operate according to S.O.P., wet granular is slowly sent in drying machine, process is dried, baking temperature is 50
DEG C, drying stops drying when being down to about less than 5% to pellet moisture, is then obtained dry by 18 mesh sieve granulate with pelletizing machine
Grain.
Step 6, the Fructus Citri tangerinae essence 35g mixed by mandarin oil, maltodextrin and butyl butyrate is crossed 80 mesh sieves, claim
Amount, equal increments are mixed with dry particl, and mixture D is obtained.
Step 7, will magnesium stearate 15g weigh after mix with mixture D after 5 minutes be obtained total mixture, afterwards through pressure
Piece is obtained tablet, the inner packing on tablet counter, chooses the underproof packaging product of outward appearance, inner packing during inner packing in time
Dry particl after (60 piece/bottle) is put in storage Jing after outer package quality inspection.
Embodiment two,
A kind of Chewable C, in terms of 1000 Chewable Cs, comprising the vitamin C 48g, mountain
Pears sugar alcohol 1000g, Lactose 124.5g, citric acid 24g, Fructus Citri tangerinae essence 37g, Fructus Pruni pseudocerasi fruit powder 2g, magnesium stearate 14g and sunset yellow
0.5g。
The preparation method of Chewable C：
Step one, by 24g citric acids crush, cross 80 mesh sieves, weigh, with through 40 mesh sieves, weigh after 2g Fructus Pruni pseudocerasi fruit powder
Uniform mixing 10 minutes, is obtained mixture A.
Step 2, by 124.5g Lactose crush, cross 80 mesh sieves, weigh, with crush, cross 80 mesh sieves, weigh after vitamin C
48g mixes 20 minutes in being added to mixture A, and mixture B is obtained.
Step 3, by Sorbitol 1000g crush, cross 80 mesh sieves, weigh after uniformly mix with mixture B, be obtained mixing
Thing C.
Step 4, sunset yellow 0.5 is weighed, be dissolved in appropriate purified water, add the ethanol of volume fraction 95%, be obtained 90%
Ethanol, 90% ethanol consumption is the 22%-24% of formula ratio, preferably 23%, and mixture C soft material.
Step 5, soft material are obtained wet granular through 20 mesh sieves, and wet granular is through dry, prepared dry particl of sieving afterwards.
In drying machine, operate according to S.O.P., wet granular is slowly sent in drying machine, process, baking temperature is dried
For 50 DEG C, drying stops drying when being down to about less than 5% to pellet moisture, is then obtained by 18 mesh sieve granulate with pelletizing machine dry
Granule.
Step 6, Fructus Citri tangerinae essence 37g is crossed 80 mesh sieves, weighing, equal increments mix with dry particl, mixture D is obtained.
Step 7, will magnesium stearate 14g weigh after mix with mixture D after 5 minutes be obtained total mixture, afterwards through pressure
Piece is obtained tablet, the inner packing on tablet counter, chooses the underproof packaging product of outward appearance, inner packing during inner packing in time
Dry particl after (60 piece/bottle) is put in storage Jing after outer package quality inspection.
Embodiment three
In terms of 1000 Chewable Cs, comprising the vitamin C 46g, Sorbitol 1000g, Lactose 125.7g,
Citric acid 25g, Fructus Citri tangerinae essence 36g, Fructus Pruni pseudocerasi fruit powder 3g, magnesium stearate 14g and sunset yellow 0.3g.
A kind of preparation method of Chewable C：
Step one, by 25g citric acids crush, cross 80 mesh sieves, weigh, with through 40 mesh sieves, weigh after 3g Fructus Pruni pseudocerasi fruit powder
Uniform mixing 10 minutes, is obtained mixture A, and wherein Fructus Pruni pseudocerasi fruit powder is made up of Fructus Pruni pseudocerasi fruit juice and maltodextrin.
Step 2, by 125.7g Lactose crush, cross 80 mesh sieves, weigh, with crush, cross 80 mesh sieves, weigh after vitamin C
46g mixes 20 minutes in being added to mixture A, and mixture B is obtained.Lactose is easily absorbed, while calcium, phosphorus, magnesium can be promoted
Absorb, have facilitation to the probioticss in intestinal, pathogenic bacterium grow in suppressing intestinal.
Step 3, by Sorbitol 1000g crush, cross 80 mesh sieves, weigh after uniformly mix with mixture B, be obtained mixing
Thing C.Sorbitol is added, as sweeting agent, the mouthfeel of chewable tablet is adjusted, is attracted user.
Step 4, sunset yellow 0.3 is weighed, be dissolved in appropriate purified water, add the ethanol of volume fraction 95%, be obtained 90%
Ethanol, 90% ethanol consumption is the 22%-24% of formula ratio, preferably 23%, and mixture C soft material.Addition sunset yellow, changes
Tablet color, outward appearance are more attractive in appearance, and guiding is edible.
Step 5, soft material are obtained wet granular through 20 mesh sieves, and wet granular is through being dried, prepared dry particl of sieving.It is being dried
In machine, operate according to S.O.P., wet granular is slowly sent in drying machine, process is dried, baking temperature is 50
DEG C, drying stops drying when being down to about less than 5% to pellet moisture, is then obtained dry by 18 mesh sieve granulate with pelletizing machine
Grain.
Step 6, the Fructus Citri tangerinae essence 36g mixed by mandarin oil, maltodextrin and butyl butyrate is crossed 80 mesh sieves, claim
Amount, equal increments are mixed with dry particl, and mixture D is obtained.The mouthfeel for being added to a successive step chewable tablet of Fructus Citri tangerinae essence.
Step 7, will magnesium stearate 14g weigh after mix with mixture D after 5 minutes be obtained total mixture, afterwards through pressure
Piece is obtained tablet, the inner packing on tablet counter, chooses the underproof packaging product of outward appearance, inner packing during inner packing in time
Dry particl after (60 piece/bottle) is put in storage Jing after outer package quality inspection.
Above the present invention is exemplarily described, it is clear that the present invention is implemented and is not subject to the restrictions described above,
As long as the improvement of the various unsubstantialities that method of the present invention design and technical scheme are carried out is employed, or it is not improved by this
Bright design and technical scheme directly apply to other occasions, within protection scope of the present invention.The protection of the present invention
The protection domain that scope should be limited by claims is defined.
Claims (7)
1. a kind of Chewable C, it is characterised in that in terms of 1000 Chewable Cs, comprising following material and
Its content：Vitamin C 42-48g, Sorbitol 1000g, Lactose 123-127g, citric acid 23-27g, Fructus Citri tangerinae essence 33-38g,
Fructus Pruni pseudocerasi fruit powder 2-4g, magnesium stearate 12-16g and sunset yellow 0.2-0.5g.
2. Chewable C according to claim 1, it is characterised in that with 1000 Chewable Cs
Meter, comprising the vitamin C 46g, Sorbitol 1000g, Lactose 125.7g, citric acid 25g, Fructus Citri tangerinae essence 36g, Fructus Pruni pseudocerasi
Powder 3g, magnesium stearate 14g and sunset yellow 0.3g.
3. Chewable C according to claim 1, it is characterised in that Fructus Hordei Germinatus paste is added with the Fructus Pruni pseudocerasi fruit powder
Essence.
4. Chewable C according to claim 1, it is characterised in that be added with the Fructus Citri tangerinae essence mandarin oil,
Maltodextrin and ethyl n-butyrate..
5. the preparation method of Chewable C according to claim 1, it is characterised in that the preparation method includes
Following steps：
Step one, by citric acid crush, cross 80 mesh sieves, weigh, with through 40 mesh sieves, weigh after Fructus Pruni pseudocerasi fruit powder mix 10 minutes
Prepared mixture A；
Step 2, Lactose is crushed, 80 mesh sieves is crossed, is weighed, with crush, cross 80 mesh sieves, weigh after vitamin C be added to and mix
Mix 20 minutes in thing A, mixture B is obtained；
Step 3, will Sorbitol crush, cross 80 mesh sieves, weigh after uniformly mix with mixture B, be obtained mixture C；
Step 4, sunset yellow is weighed, be dissolved in appropriate purified water, add 95% ethanol, 90% ethanol, 90% ethanol consumption is obtained
It is the 22%-24% of formula ratio, and mixture C soft material；
Step 5, soft material sieve prepared wet granular, afterwards wet granular through being dried, prepared dry particl of sieving；
Step 6, Fructus Citri tangerinae essence is crossed 80 mesh sieves, weighing, equal increments mix with dry particl, mixture D is obtained；
Step 7, magnesium stearate is weighed after mix with mixture D 5 minutes after be obtained total mixture, afterwards through tabletting be obtained
Tablet.
6. the preparation method of Chewable C according to claim 5, it is characterised in that soft in the step 5
Material sieves from 20 mesh sieves.
7. the preparation method of Chewable C according to claim 5, it is characterised in that wet in the step 5
Particle drying temperature is 50 degree, and drying stops drying when being down to less than 5% to pellet moisture.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610963277.3A CN106511287A (en) | 2016-10-28 | 2016-10-28 | Vitamin C chewable tablets and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610963277.3A CN106511287A (en) | 2016-10-28 | 2016-10-28 | Vitamin C chewable tablets and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175104A (en) * | 2018-01-18 | 2018-06-19 | 广东健林生物科技有限公司 | A kind of homovitamin C content chewable tablets and preparation method thereof |
| CN114601002A (en) * | 2022-04-07 | 2022-06-10 | 佳格食品(中国)有限公司 | Ingot slice and preparation method thereof |
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| CN103462916A (en) * | 2013-09-12 | 2013-12-25 | 山东天力药业有限公司 | Vitamin C chewable tablet and preparation method thereof |
| CN104522679A (en) * | 2014-12-03 | 2015-04-22 | 安徽哈博药业有限公司 | A vitamin c chewable tablet |
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|---|---|---|---|---|
| US3857939A (en) * | 1971-08-18 | 1974-12-31 | Hoffmann La Roche | Chewable sodium-free vitamin c tablets |
| CN1785179A (en) * | 2004-12-10 | 2006-06-14 | 北京昭衍博纳新药研究有限公司 | Compounding chewable vitamin tablets and its prepn. method |
| CN103462916A (en) * | 2013-09-12 | 2013-12-25 | 山东天力药业有限公司 | Vitamin C chewable tablet and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175104A (en) * | 2018-01-18 | 2018-06-19 | 广东健林生物科技有限公司 | A kind of homovitamin C content chewable tablets and preparation method thereof |
| CN114601002A (en) * | 2022-04-07 | 2022-06-10 | 佳格食品(中国)有限公司 | Ingot slice and preparation method thereof |
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Application publication date: 20170322 |