CN106492199A - A kind of nail hydrogel plaster - Google Patents
A kind of nail hydrogel plaster Download PDFInfo
- Publication number
- CN106492199A CN106492199A CN201611117221.2A CN201611117221A CN106492199A CN 106492199 A CN106492199 A CN 106492199A CN 201611117221 A CN201611117221 A CN 201611117221A CN 106492199 A CN106492199 A CN 106492199A
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- weight portion
- nail
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Abstract
The present invention provides a kind of nail hydrogel plaster, and including gel layer and medicine layer, the gel layer is arranged on the centre position of medicine layer, and the surface of the medicine layer has one layer of pharmaceutical composition, and described pharmaceutical composition is made up of the raw material of following weight portion：8 12 weight portion of collagen, 8 weight portion of keratin 5,10 13 weight portion of avocado oil, 12 15 weight portion of macadamia nut oil, 8 10 weight portion of hyaluronic acid, 68 weight portion of vitamin A, 57 weight portion of evening primrose oil, deionized water surplus；Compared with prior art, the present invention has following beneficial effect：It is specifically designed for the hydrogel plaster that finger nail and toenail are used.Collagen and keratin contribute to repairing nail crack.The antioxidant content of vitamin A, contributes to the robustness for strengthening nail and toenail.Avocado oil, macadamia nut oil and evening primrose oil can moisten the nail outer layer nail of softness and nail plate.
Description
Technical field
The present invention relates to a kind of nail hydrogel plaster, belongs to field of beauty care.
Background technology
Annex one of of the nail as skin.There is its specific function.It has " shield " to act on first, can protect minor details
Finger pulp safeguards its stability from damage, strengthens the sensitiveness of finger touch, assists hand to grab, hold under the arm, pinch, squeeze.Nail matrix blood supply is rich
Richness, plays the role of to adjust peripheral blood confession, body temperature.Secondly, nail is the emphasis of hand beauty again, and beautiful nail increases women's
Glamour.Nail defects or the patient of deformity, even if he（She）Have the finger that One function is good, due to awarded nail he（She）Can
This can be hidden to refer to without it because feeling oneself inferior, so that function is useless moving back.
In prior art, the technology with regard to manicure is still little.
Content of the invention
In view of the shortcomings of the prior art, it is an object of the present invention to provide a kind of nail hydrogel plaster, to solve the above-mentioned back of the body
The problem proposed in scape technology, the present invention are easy to use, are easy to operate, and design is ingenious, improves the market competitiveness.
To achieve these goals, the present invention is by the following technical solutions realizing：A kind of nail hydrogel plaster, bag
Gel layer and medicine layer is included, the gel layer is arranged on the centre position of medicine layer, and the surface of the medicine layer has one layer
Pharmaceutical composition, described pharmaceutical composition are made up of the raw material of following weight portion：Collagen 8-12 weight portions, keratin 5-8
Weight portion, avocado oil 10-13 weight portions, macadamia nut oil 12-15 weight portions, hyaluronic acid 8-10 weight portions, vitamin A 6-8 weight
Part, evening primrose oil 5-7 weight portion, deionized water surplus.
Further, the gel layer is made up of hydrogel plaster.
Further, cockscomb fragment is added in acetone, soaked overnight is hardened to cockscomb dehydration, is subsequently placed in porcelain dish
Be dried, powdering crushed through pulverizer after drying, cockscomb powder is poured in enamel pot, add 6～7 times of distilled water, stirring
Uniformly, more than 24h is soaked, makes cockscomb powder fully swelling, then filter, collect filtrate, filter residue is soaked 3 times again in the same way,
Merge 3 filtered fluids, then filtrate is poured in ceramic cylinder, the solid sodium chloride of the lower addition 10% of stirring, and add isopyknic chlorine
Imitative, after stirring 3h, water phase is separated, 95% ethanol of 2 times of volumes is added in the water phase for separating, is stirred, stand more than 12h,
Hyaluronic acid is settled out, sediment is then filtered dry, crude product after drying, is obtained, crude product is re-dissolved in the 0.1mol/L sodium chloride of 4 times of volumes
In solution, pH=4.5～5 are adjusted with watery hydrochloric acid, add isopyknic chloroform, after stratification, suction out upper strata aqueous phase, water phase
PH=7.5 is adjusted with 8% sodium hydroxide solution, pronase is added, and 24h is incubated at 37 DEG C, then uses isopyknic chloroform extraction
Process 2 times, merge upper strata aqueous phase, lower floor's liquids recovery chloroform adds isopyknic 1% cetylpyridinium chloride molten in water phase
Liquid, stirs, and staticly settles, and filters, and collects precipitation, and precipitation is dissolved with the 0.4mol/L sodium chloride of 2～3 times of volumes again, mistake
Filter, adds 3 times of 95% ethanol of volume, staticly settles, suck upper strata ethanol in filtrate, lower floor is again with 95% ethanol repeated precipitation 2
Secondary, lower sediment thing hangs filter, dries, then is washed with acetone 2 times, is vacuum dried, obtains the hyaluronic acid in raw material.
Further, the fish scale of deep-sea cod, fish-skin and fish-bone are added after water mixing, under thermophilic digestion, plus
Enter enzymolysis agent, carry out enzymolysis and extraction, after the completion of carry out fine filtering, filtrate enters evaporation concentration system thickening, will concentration
Liquid afterwards enters spray drying device, obtains powder, and gained powder is the collagen in raw material.
Further, be condensed with ethyl chloride by β irisones, 2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenal is obtained through hydrolysis, decarboxylation, separately by second
Alkynes sodium and ethylene methacrylic ketone are condensed, and the material for obtaining obtains double bromine magnesium compounds again with ethyl phosphonium bromide reactive magnesium, by double bromine magnesium compounds with
2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenal condensation, hydrolysis, catalytic hydrogenation obtain hydroxy vitamin A, act on obtaining hydroxy vitamin acetic acid esters, then bromine with chloroacetic chloride
Change, debrominate obtains the vitamin A in raw material.
Further, in pharmaceutical composition, contain 12 weight portion of collagen in the raw material of every 100 weight portion, per 100
Contain CK8 weight portion in the raw material of weight portion, contain 13 weight portion of avocado oil in the raw material of every 100 weight portion, per 100 weights
Contain 15 weight portion of macadamia nut oil in the raw material of amount part, contain 10 weight portion of hyaluronic acid in the raw material of every 100 weight portion, per 100
Contain 8 weight portion of vitamin A in the raw material of weight portion, in the raw material of every 100 weight portion, contain 7 weight portion of evening primrose oil, per
Contain 27 weight portion of deionized water in the raw material of 100 weight portions.
Beneficial effects of the present invention：A kind of nail hydrogel plaster of the present invention, is specifically designed for finger nail and toenail is used
Hydrogel plaster.Collagen and keratin contribute to repairing nail crack.The antioxidant content of vitamin A, contributes to strengthening
Nail and the robustness of toenail.Avocado oil, macadamia nut oil and evening primrose oil can moisten the nail outer layer nail of softness and nail plate.
Additionally, the moisturizing effect up to 8 hours can be carried out.The outward appearance by nail is lifted persistently is used, and keeps good nail health
State.It is preferable night care paster, overnight can uses.
Description of the drawings
The detailed description that non-limiting example is made with reference to the following drawings by reading, the further feature of the present invention,
Objects and advantages will become more apparent upon：
Fig. 1 is a kind of structural representation of nail hydrogel plaster of the invention；
In figure：1- gel layers, 2- medicine layers.
Specific embodiment
For being easy to understand technological means, creation characteristic, reached purpose and effect of present invention realization, with reference to
Specific embodiment, is expanded on further the present invention.
Fig. 1 is referred to, the present invention provides a kind of technical scheme：A kind of nail hydrogel plaster, including gel layer 1 and medicine
Layer 2, gel layer 1 are arranged on the centre position of medicine layer 2, and the surface of medicine layer 2 has one layer of pharmaceutical composition, pharmaceutical composition
It is made up of the raw material of following weight portion：Collagen 8-12 weight portions, -8 weight portion of keratin 5, avocado oil 10-13 weight portions,
Macadamia nut oil 12-15 weight portions, hyaluronic acid 8-10 weight portions, vitamin A 6-8 weight portions, evening primrose oil 5-7 weight portion, go from
Sub- water surplus.
Gel layer 1 is made up of hydrogel plaster.
Cockscomb fragment is added in acetone, soaked overnight is hardened to cockscomb dehydration, is subsequently placed in porcelain dish and is dried,
Powdering is crushed through pulverizer after drying, cockscomb powder is poured in enamel pot, added 6～7 times of distilled water, stir, soaked
More than 24h, makes cockscomb powder fully swelling, then filters, and collects filtrate, and filter residue is soaked 3 times again in the same way, merges 3 mistakes
Filtrate, then filtrate is poured in ceramic cylinder, the solid sodium chloride of the lower addition 10% of stirring, and isopyknic chloroform is added, stir 3h
Afterwards, water phase is separated, 95% ethanol of 2 times of volumes is added in the water phase for separating, is stirred, stand more than 12h, be settled out
Bright matter acid, is then filtered dry sediment, obtains crude product after drying, and crude product is re-dissolved in the 0.1mol/L sodium chloride solutions of 4 times of volumes, is used
Watery hydrochloric acid adjusts pH=4.5～5, adds isopyknic chloroform, after stratification, suctions out upper strata aqueous phase, and water mutually uses 8% hydroxide
Sodium solution adjusts pH=7.5, adds pronase, is incubated 24h, then is processed 2 times with isopyknic chloroform extraction, close at 37 DEG C
And upper strata aqueous phase, lower floor's liquids recovery chloroform, isopyknic 1% cetylpyridinium chloride solution is added in water phase, stirring is
Even, staticly settle, filter, collect precipitation, precipitation is dissolved with the 0.4mol/L sodium chloride of 2～3 times of volumes again, is filtered, in filtrate
3 times of 95% ethanol of volume are added, is staticly settled, suck upper strata ethanol, again with 95% ethanol repeated precipitation 2 times, lower floor sinks for lower floor
Starch hangs filter, dries, then is washed with acetone 2 times, is vacuum dried, obtains the hyaluronic acid in raw material.
The fish scale of deep-sea cod, fish-skin and fish-bone are added after water mixing, under thermophilic digestion, enzymolysis agent is added,
Carry out enzymolysis and extraction, after the completion of carry out fine filtering, filtrate enters evaporation concentration system thickening, by concentration after liquid enter
Enter spray drying device, obtain powder, gained powder is the collagen in raw material.
Be condensed with ethyl chloride by β irisones, 2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenal is obtained through hydrolysis, decarboxylation, separately by sodium acetylide and first
Ethyl ketene is condensed, and the material for obtaining obtains double bromine magnesium compounds again with ethyl phosphonium bromide reactive magnesium, by double bromine magnesium compounds and 2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenal
Condensation, hydrolysis, catalytic hydrogenation obtain hydroxy vitamin A, act on obtaining hydroxy vitamin acetic acid esters with chloroacetic chloride, then bromination, debrominate are obtained
Vitamin A in raw material.
As one embodiment of the present of invention：In pharmaceutical composition, in the raw material of every 100 weight portion, contain collagen
12 weight portions, contain CK8 weight portion in the raw material of every 100 weight portion, contain avocado oil 13 in the raw material of every 100 weight portion
Weight portion, containing 15 weight portion of macadamia nut oil in the raw material of every 100 weight portion, contains hyaluronic acid in the raw material of every 100 weight portion
10 weight portions, containing 8 weight portion of vitamin A in the raw material of every 100 weight portion, contain evening primrose in the raw material of every 100 weight portion
Oily 7 weight portions, contain 27 weight portion of deionized water in the raw material of every 100 weight portion.
As one embodiment of the present of invention：Present invention is specifically directed to the hydrogel plaster that finger nail and toenail are used.Glue
Former albumen and keratin contribute to repairing nail crack.The antioxidant content of vitamin A, contributes to strengthening nail and toenail
Robustness.Avocado oil, macadamia nut oil and evening primrose oil can moisten the nail outer layer nail of softness and nail plate.Additionally, can be grown
Up to 8 hours moisturizing effect.The outward appearance by nail is lifted persistently is used, and keeps good nail health status.It is preferable
Night care paster, overnight can use.
The general principle and principal character and advantages of the present invention of the present invention is had been shown and described above, for this area skill
For art personnel, it is clear that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and in the spirit without departing substantially from the present invention or
In the case of essential characteristic, the present invention can be realized in other specific forms.Therefore, no matter from the point of view of which point, all should be by
Embodiment regards exemplary as, and be nonrestrictive, the scope of the present invention by claims rather than on state
Bright restriction, it is intended that all changes in the implication and scope of the equivalency of claim that will fall are included in the present invention
Interior.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Contain an independent technical scheme, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical scheme in each embodiment can also form those skilled in the art through appropriately combined
Understandable other embodiment.
Claims (6)
1. a kind of nail hydrogel plaster, including gel layer and medicine layer, it is characterised in that：The gel layer is arranged on medicine layer
Centre position, the surface of the medicine layer has one layer of pharmaceutical composition, original of the described pharmaceutical composition by following weight portion
Material is constituted：Collagen 8-12 weight portions, -8 weight portion of keratin 5, avocado oil 10-13 weight portions, macadamia nut oil 12-15 weight
Part, hyaluronic acid 8-10 weight portions, vitamin A 6-8 weight portions, evening primrose oil 5-7 weight portion, deionized water surplus.
2. a kind of nail hydrogel plaster according to claim 1, it is characterised in that：The gel layer is by hydrogel plaster structure
Into.
3. a kind of nail hydrogel plaster according to claim 1, it is characterised in that：Cockscomb fragment is added in acetone,
Soaked overnight is hardened to cockscomb dehydration, is subsequently placed in porcelain dish and is dried, and crushes powdering through pulverizer, by cockscomb after drying
Powder is poured in enamel pot, is added 6～7 times of distilled water, is stirred, and is soaked more than 24h, is made cockscomb powder fully swelling, then mistake
Filter, collects filtrate, and filter residue is soaked 3 times again in the same way, merges 3 filtered fluids, then filtrate is poured in ceramic cylinder, under stirring
10% solid sodium chloride being added, and adding isopyknic chloroform, after stirring 3h, separate water phase, 2 are added in the water phase for separating
95% ethanol of times volume, stirs, and stands more than 12h, is settled out hyaluronic acid, is then filtered dry sediment, after drying slightly
Product, crude product are re-dissolved in the 0.1mol/L sodium chloride solutions of 4 times of volumes, are adjusted pH=4.5～5 with watery hydrochloric acid, are added equal-volume
Chloroform, after stratification, suction out upper strata aqueous phase, water mutually with 8% sodium hydroxide solution adjust pH=7.5, addition pronase,
24h is incubated at 37 DEG C, then is processed 2 times with isopyknic chloroform extraction, merge upper strata aqueous phase, lower floor's liquids recovery chloroform, water phase
Middle add isopyknic 1% cetylpyridinium chloride solution, stir, staticly settle, filter, collect precipitation, precipitation is used again
The 0.4mol/L sodium chloride dissolving of 2～3 times of volumes, filters, adds 3 times of 95% ethanol of volume, staticly settle, suck in filtrate
Upper strata ethanol, again with 95% ethanol repeated precipitation 2 times, lower sediment thing hangs filter, dries, then washs 2 times with acetone, vacuum for lower floor
Dry, obtain the hyaluronic acid in raw material.
4. a kind of nail hydrogel plaster according to claim 1, it is characterised in that：By the fish scale of deep-sea cod, fish-skin with
And fish-bone add water mixing after, under thermophilic digestion, add enzymolysis agent, carry out enzymolysis and extraction, after the completion of carry out fine filtering,
Filtrate enter evaporation concentration system thickening, by concentration after liquid enter spray drying device, obtain powder, gained powder
Collagen as in raw material.
5. a kind of nail hydrogel plaster according to claim 1, it is characterised in that：By β irisones and chloroacetic acid second
Ester condensation, obtains 2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenal through hydrolysis, decarboxylation, is separately condensed by sodium acetylide and ethylene methacrylic ketone, the material for obtaining again with ethyl
Bromination reactive magnesium obtains double bromine magnesium compounds, and double bromine magnesium compounds are obtained hydroxy vitamin A with 2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-butenal condensation, hydrolysis, catalytic hydrogenation,
Hydroxy vitamin acetic acid esters is acted on obtaining with chloroacetic chloride, then bromination, debrominate obtain the vitamin A in raw material.
6. a kind of nail hydrogel plaster according to claim 1, it is characterised in that：In pharmaceutical composition, every 100 weight
Contain 12 weight portion of collagen in the raw material of part, in the raw material of every 100 weight portion, contain CK8 weight portion, every 100 weight
Contain 13 weight portion of avocado oil in the raw material of part, in the raw material of every 100 weight portion, contain 15 weight portion of macadamia nut oil, every 100 weight
Contain 10 weight portion of hyaluronic acid in the raw material of part, contain 8 weight portion of vitamin A in the raw material of every 100 weight portion, per 100 weights
Contain 7 weight portion of evening primrose oil in the raw material of amount part, in the raw material of every 100 weight portion, contain 27 weight portion of deionized water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611117221.2A CN106492199A (en) | 2016-12-07 | 2016-12-07 | A kind of nail hydrogel plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611117221.2A CN106492199A (en) | 2016-12-07 | 2016-12-07 | A kind of nail hydrogel plaster |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106492199A true CN106492199A (en) | 2017-03-15 |
Family
ID=58329807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611117221.2A Pending CN106492199A (en) | 2016-12-07 | 2016-12-07 | A kind of nail hydrogel plaster |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106492199A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5667768A (en) * | 1994-04-15 | 1997-09-16 | L'oreal | Care composition to be applied to the nails |
| CN1678277A (en) * | 2002-07-29 | 2005-10-05 | 艾克里麦德公司 | Methods and compositions for treatment of dermal conditions |
| CN101756857A (en) * | 2008-10-20 | 2010-06-30 | 吉蕾 | Nail polish for nourishing nails |
| KR20120048794A (en) * | 2010-11-08 | 2012-05-16 | 오한선 | Manufacture process of nail nutrition and moisturizing of hydrogel nail pack |
| CN103371950A (en) * | 2012-04-16 | 2013-10-30 | 薛晓萌 | Fingernail nutrient solution |
| CN103619415A (en) * | 2010-11-30 | 2014-03-05 | 利普泰股份公司 | Exopolysaccharide for the treatment and/or care of the skin, mucous membranes, hair and/or nails |
| CN203540345U (en) * | 2013-11-15 | 2014-04-16 | 杭州瑞纳膜工程有限公司 | Membrane separation system for extracting collagen |
| CN104173635A (en) * | 2014-09-11 | 2014-12-03 | 成都圣雪贝佳化妆品有限公司 | Drug for treating acnes and preparation method of drug |
| CN105168187A (en) * | 2015-09-07 | 2015-12-23 | 北京东方凯恩医药科技有限公司 | Cutaneous penetration system |
-
2016
- 2016-12-07 CN CN201611117221.2A patent/CN106492199A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5667768A (en) * | 1994-04-15 | 1997-09-16 | L'oreal | Care composition to be applied to the nails |
| CN1678277A (en) * | 2002-07-29 | 2005-10-05 | 艾克里麦德公司 | Methods and compositions for treatment of dermal conditions |
| CN101756857A (en) * | 2008-10-20 | 2010-06-30 | 吉蕾 | Nail polish for nourishing nails |
| KR20120048794A (en) * | 2010-11-08 | 2012-05-16 | 오한선 | Manufacture process of nail nutrition and moisturizing of hydrogel nail pack |
| CN103619415A (en) * | 2010-11-30 | 2014-03-05 | 利普泰股份公司 | Exopolysaccharide for the treatment and/or care of the skin, mucous membranes, hair and/or nails |
| CN103371950A (en) * | 2012-04-16 | 2013-10-30 | 薛晓萌 | Fingernail nutrient solution |
| CN203540345U (en) * | 2013-11-15 | 2014-04-16 | 杭州瑞纳膜工程有限公司 | Membrane separation system for extracting collagen |
| CN104173635A (en) * | 2014-09-11 | 2014-12-03 | 成都圣雪贝佳化妆品有限公司 | Drug for treating acnes and preparation method of drug |
| CN105168187A (en) * | 2015-09-07 | 2015-12-23 | 北京东方凯恩医药科技有限公司 | Cutaneous penetration system |
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| Title |
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