CN106492137A - A kind of treat Chinese medicine composition of depression and preparation method thereof - Google Patents
A kind of treat Chinese medicine composition of depression and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of treat Chinese medicine composition of depression and preparation method thereof, it is grouped into by the group of following weight portion：10 50 parts of Ganoderma, 30 80 parts of Hypodematium crenatum (Forsk.) Kuhn, 5 30 parts of Rhizoma Gastrodiae, 10 30 parts of Flos Albiziae, 10 30 parts of Radix Curcumae.Prescription of the present invention is rigorous, and the few power of medicine specially, has resolving stagnation for tranquilization, nourishes the work(of heart kidney, have good curative effect to depression.
Description
Technical field
The present invention relates to medicine field, and in particular to a kind of treat Chinese medicine composition of depression and preparation method thereof.
Background technology
With the quickening pace of modern life, the increase of the various pressure such as working and learning, the complication of inter personal contact, depression
Sickness rate rise year by year, be referred to as " STOP Emotion Cold ", it just as common cold prevailing in world community, social each rank
Layer and various people.Count according to the study, the current patients with depression of China is up to 90,000,000.Depression seriously perplexs the life of patient
Living and work, brings white elephant, about 15% patients with depression to die from suicide to family and society, has become society one
Hang-up.One joint study of World Health Organization (WHO), the World Bank and Harvard University shows that depression has become Chinese disease
The second largest disease of disease burden.Therefore, attention is very urgent to the research of depression and its medicine, updates to finding
The Therapeutic Method of type is effecting a radical cure depression.Depression has caused the attention of related numerous scholars and doctor both at home and abroad at present, to suppression
The research of strongly fragrant disease also becomes study hotspot instantly.
At present, antidepressants have become the first-selected treatment meanss of depressed patient, while combining psychotherapy can increase curative effect.
Antidepressants are big class of numerous psychotropic drugs, are mainly used in treating depression and various depressive states, conventional at present
It is tricyclic antidepressant, its main pharmacological is：Retardance monoamine neurotransmitter (predominantly epinephrine and 5-HT) reuptake, makes
Synaptic space list is raised by content and produces antidepressant effect, while also blocking multiple neurotransmitter receptors, causes many untoward reaction.
Although the advantages of antidepressants have rapid-action, effect is obvious when depression is treated, easily produces dependency and
The side effect of series, causes the discomfort of human body, or even allows people to be difficult to stand.
The product that Chinese medicine is the distinctive Chinese medical theory of China with practice, aboundresources are with a long history, are that the mankind earliest should
Natural organic substance.Chinese traditional treatment depression is to nurse one's health the inherent balance for recovering internal organs QI and blood, and dispelling causes to have a sleepless night
The pathology base of the internal organs QI and blood functional imbalance that pathological product and these pathological products such as the strongly fragrant stasis of blood of the depressed QI and blood phlegm-fire for producing are produced
Plinth, easily produces drug dependence when having avoided western medicine, and the problems such as toxic and side effects are big, vital base and primordial QI consolidating, treating both the principal and secondary aspects of a disease reach root
The purpose that controls, is therefore becoming increasingly popular.The present invention has good treatment by instruction of Chinese Medicine theory, scientific formula to depression
Effect.Of the invention outer there is not yet the report of Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae and Radix Curcumae compositionss.
(1) Ganoderma, is On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganoderma lucidum (Leyss.exFr.) Karst. or Ganoderma
Ganoderma sinense Zhao, Xu et Zhang dry sporophore.Record in Chinese Pharmacopoeia version in 2015：【Nature and flavor with
Return through】Sweet, put down.GUIXIN, lung, liver and kidney channel.【Function with cure mainly】Invigorating QI and tranquilization, relieving cough and asthma.For malaise, the heart of having a sleepless night
Throb with fear, cough and asthma due to lung deficiency, asthenia are losed heart, anorexia.
(2) Hypodematium crenatum (Forsk.) Kuhn, is mustelid Carnis Mustela Mustela sibirica Pallas.【Meridian distribution of property and flavor】Sweet, warm, have little
Poison.Enter lung, kidney two warp【Effect】Parasite killing treats skin ulcer, the kidney warming reducing urination.Control scabies, skin ulcer routed disunion, frequent micturition.
(3) Rhizoma Gastrodiae, is the dry tuber of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Record in Chinese Pharmacopoeia
Version in 2015：【Nature and flavor and return through】Sweet, put down.Return liver warp.【Function with cure mainly】Inflammation Zhijing, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral.For
Infantile convulsion epilepsy clonus, tetanus, dizziness of having a headache, hands and feet caused by paralysis, numb limbs and tense tendons, rheumatic arthralgia.
(4) Flos Albiziae, is that leguminous plant Herba Albiziae Albizia julibrissin Durazz. dry inflorescence or alabastrum.
Record in Chinese Pharmacopoeia version in 2015：【Nature and flavor and return through】Sweet, put down.GUIXIN, Liver Channel.【Function with cure mainly】Resolving stagnation for tranquilization.For
Irritability, melancholy insomnia.
(5) Radix Curcumae, is zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y.H.Chenet C.Ling, Rhizoma Curcumae Longae
Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S.G.Lee et C.F.Liang or Rhizoma Curcumae
The dried root of Curcuma phaeocauLis V al..Record in Chinese Pharmacopoeia version in 2015：【Nature and flavor and return through】It is pungent, bitter,
Cold.Return liver, the heart, lung meridian.【Function with cure mainly】Promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice.For chest side of body shouting pain,
Obstruction of qi in the chest and cardialgia, closed dysmenorrhea, distending pain of the breast, calentura coma, epilepsy are gone mad, blood-head tells nosebleed, jaundice urine is red.
Content of the invention
It is an object of the invention to provide a kind of treat Chinese medicine composition of depression and preparation method thereof.
The present invention treats the Chinese medicine composition of depression on the basis of traditional Chinese medical science traditional theory, in conjunction with medication experience among the people,
It is formulated with modern scientific theory.Have prescription rigorous, the few power of medicine specially, has good curative effect, effectively can change to depression
The clinical symptoms of kind patient, shorten the course of disease, improve the quality of life of patient.
The technical solution adopted in the present invention is as follows：
A kind of Chinese medicine composition for treating depression, is grouped into by the group of following weight portion：Ganoderma 10-50 parts, Hypodematium crenatum (Forsk.) Kuhn
30-80 parts, Rhizoma Gastrodiae 5-30 parts, Flos Albiziae 10-30 parts, Radix Curcumae 10-30 parts.
The Chinese medicine composition of the above treatment depression, is preferably grouped into by the group of following weight portion：Ganoderma 20-40
Part, Hypodematium crenatum (Forsk.) Kuhn 40-60 parts, Rhizoma Gastrodiae 10-20 parts, Flos Albiziae 15-25 parts, Radix Curcumae 15-25 parts.
The Chinese medicine composition of the above treatment depression, is most preferably preferably grouped into by the group of following weight portion：Ganoderma 30
Part, 50 parts of Hypodematium crenatum (Forsk.) Kuhn, 15 parts of Rhizoma Gastrodiae, 20 parts of Flos Albiziae, 20 parts of Radix Curcumae.
The Chinese medicine composition of the above treatment depression, can be prepared into oral solid formulation or oral liquid, such as：
Medicated wine, pill, capsule, powder.Preferably, the oral administration solid is pill, the liquid oral system is medicated wine.
The method that the Chinese medicine composition of the above treatment depression is prepared into medicated wine, comprises the following steps：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is net
Choosing, dries；
(2) weigh according to following weight portion：Ganoderma 10-50 parts, Hypodematium crenatum (Forsk.) Kuhn 30-80 parts, Rhizoma Gastrodiae 5-30 parts, Flos Albiziae 10-
30 parts, Radix Curcumae 10-30 parts；
(3) above ingredients is taken, cataclasm, put in tank, plus 8-10 times is measured 55 ° of Chinese liquor, is sealed, soak 30-50 days
Afterwards, medical material is filtered to remove, is obtained final product.
The method that the Chinese medicine composition of the above treatment depression is prepared into pill, comprises the following steps：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is net
Choosing, dries；
(2) weigh according to following weight portion：Ganoderma 10-50 parts, Hypodematium crenatum (Forsk.) Kuhn 30-80 parts, Rhizoma Gastrodiae 5-30 parts, Flos Albiziae 10-
30 parts, Radix Curcumae 10-30 parts；
(3) Hypodematium crenatum (Forsk.) Kuhn is taken, cataclasm, put in tank, plus 8-10 times is measured 55 ° of Chinese liquor, is sealed, steam to wine to the greatest extent, take out, 60 DEG C
After drying, fine powder is ground into, crosses 100 mesh sieves；
(4) Rhizoma Gastrodiae, Radix Curcumae is taken, after 60 DEG C of dryings, fine powder is ground into, 100 mesh sieves are crossed, standby；
(5) take Ganoderma, Flos Albiziae, plus 6-8 times is measured water boiling and extraction 2-3 time, each 1-3 hours, united extraction liquid, filter
Cross, filtrate reduced in volume to relative density is the thick paste at 60 DEG C for 1.25-1.28；
(6) combining step (2), the fine powder of (3), mix；
(7) thick paste of above-mentioned fine powder and step (4) is mixed, plus appropriate adhesive make concentrated watered pill, concentration honeyed pill or
Concentration water-honeyed pill.
The Chinese medicine composition of the above treatment depression, the purposes in the medicine for preparing treatment depression.
The Chinese medicine composition of present invention treatment depression is on the basis of Chinese medicine traditional theory, passes through in conjunction with medication among the people
Test, be formulated with modern scientific theory.Ganoderma in side, invigorating QI and tranquilization is monarch drug.Hypodematium crenatum (Forsk.) Kuhn the kidney warming lung moistening, is ministerial drug.My god
Numb suppressing liver-YANG；Flos Albiziae resolving stagnation for tranquilization；Papillary is adjuvant drug.Radix Curcumae promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, for making medicine.All medicines are closed
With the work(that plays resolving stagnation for tranquilization altogether, nourish heart kidney.Prescription of the present invention is rigorous, and the few power of medicine specially, has good curative effect to depression.
The invention has the beneficial effects as follows：
(1) prescription is rigorous, and the few power of medicine specially, have functions that resolving stagnation for tranquilization, is nourished heart kidney, has good treatment to depression
Effect, treats total effective rate up to more than 85%.
(2) component is herbal variety, using safety, treating both the principal and secondary aspects of a disease, cures the symptoms, not the disease when overcoming western medicine, disease
The big shortcomings of toxic and side effects such as feelings recurrent exerbation and easily generation drug dependence, infringement cognition.
Specific embodiment
With reference to specific embodiment, the invention will be further described, but do not limit the scope of the invention and apply
Scope：
First, the preparation of the Chinese medicine composition medicated wine for the treatment of depression
Embodiment 1
A kind of method that Chinese medicine composition for treating depression is prepared into medicated wine, comprises the following steps：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is net
Choosing, dries；
(2) weigh according to following weight portion：Ganoderma 1kg, Hypodematium crenatum (Forsk.) Kuhn 3kg, Rhizoma Gastrodiae 0.5kg, Flos Albiziae 1kg, Radix Curcumae 1kg；
(3) above ingredients is taken, cataclasm, put in tank, plus 8 times of amounts, 55 ° of Chinese liquor, seal, after soaking 30 days, filter
Medical material is removed, is obtained final product.
Embodiment 2
A kind of method that Chinese medicine composition for treating depression is prepared into medicated wine, comprises the following steps：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is net
Choosing, dries；
(2) weigh according to following weight portion：Ganoderma 5kg, Hypodematium crenatum (Forsk.) Kuhn 8kg, Rhizoma Gastrodiae 3kg, Flos Albiziae 3kg, Radix Curcumae 3kg；
(3) above ingredients is taken, cataclasm, put in tank, plus 10 times of amounts, 55 ° of Chinese liquor, seal, after soaking 50 days, mistake
Medical material is filtered, is obtained final product.
Embodiment 3
A kind of method that Chinese medicine composition for treating depression is prepared into medicated wine, comprises the following steps：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is net
Choosing, dries；
(2) weigh according to following weight portion：Ganoderma 2kg, Hypodematium crenatum (Forsk.) Kuhn 4kg, Rhizoma Gastrodiae 1kg, Flos Albiziae 1.5kg, Radix Curcumae
1.5kg；
(3) above ingredients is taken, cataclasm, put in tank, plus 9 times of amounts, 55 ° of Chinese liquor, seal, after soaking 50 days, filter
Medical material is removed, is obtained final product.
Embodiment 4
A kind of method that Chinese medicine composition for treating depression is prepared into medicated wine, comprises the following steps：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is net
Choosing, dries；
(2) weigh according to following weight portion：Ganoderma 4kg, Hypodematium crenatum (Forsk.) Kuhn 6kg, Rhizoma Gastrodiae 2kg, Flos Albiziae 2.5kg, Radix Curcumae
2.5kg；
(3) above ingredients is taken, cataclasm, put in tank, plus 10 times of amounts, 55 ° of Chinese liquor, seal, after soaking 40 days, mistake
Medical material is filtered, is obtained final product.
Embodiment 5
A kind of method that Chinese medicine composition for treating depression is prepared into medicated wine, comprises the following steps：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is net
Choosing, dries；
(2) weigh according to following weight portion：Ganoderma 3kg, Hypodematium crenatum (Forsk.) Kuhn 5kg, Rhizoma Gastrodiae 1.5kg, Flos Albiziae 2kg, Radix Curcumae 2kg；
(3) above ingredients is taken, cataclasm, put in tank, plus 9 times of amounts, 55 ° of Chinese liquor, seal, after soaking 40 days, filter
Medical material is removed, is obtained final product.
2nd, the preparation of the Chinese medicine composition pill for the treatment of depression
Embodiment 6
A kind of method that Chinese medicine composition for treating depression is prepared into pill, comprises the following steps：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is net
Choosing, dries；
(2) weigh according to following weight portion：Ganoderma 5kg, Hypodematium crenatum (Forsk.) Kuhn 8kg, Rhizoma Gastrodiae 3kg, Flos Albiziae 3kg, Radix Curcumae 3kg；
(3) Hypodematium crenatum (Forsk.) Kuhn is taken, cataclasm, put in tank, plus 10 times of amounts, 55 ° of Chinese liquor, seal, steam to wine to the greatest extent, take out, 60 DEG C are done
After dry, fine powder is ground into, crosses 100 mesh sieves；
(4) Rhizoma Gastrodiae, Radix Curcumae is taken, after 60 DEG C of dryings, fine powder is ground into, 100 mesh sieves are crossed, standby；
(5) Ganoderma, Flos Albiziae taken, plus 8 times of amount water boiling and extractions 2 times, 3 hours every time, united extraction liquid, filtration, filtrate
Be evaporated to relative density and be at 60 DEG C be 1.28 thick paste；
(6) combining step (2), the fine powder of (3), mix；
(7) thick paste of above-mentioned fine powder and step (4) is mixed, plus suitable quantity of water makes concentrated watered pill.
Embodiment 7
A kind of method that Chinese medicine composition for treating depression is prepared into pill, comprises the following steps：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is net
Choosing, dries；
(2) weigh according to following weight portion：Ganoderma 3kg, Hypodematium crenatum (Forsk.) Kuhn 5kg, Rhizoma Gastrodiae 1.5kg, Flos Albiziae 2kg, Radix Curcumae 2kg；
(3) Hypodematium crenatum (Forsk.) Kuhn is taken, cataclasm, put in tank, plus 9 times of amounts, 55 ° of Chinese liquor, seal, steam to wine to the greatest extent, take out, 60 DEG C are done
After dry, fine powder is ground into, crosses 100 mesh sieves；
(4) Rhizoma Gastrodiae, Radix Curcumae is taken, after 60 DEG C of dryings, fine powder is ground into, 100 mesh sieves are crossed, standby；
(5) Ganoderma, Flos Albiziae taken, plus 7 times of amount water boiling and extractions 2 times, 2 hours every time, united extraction liquid, filtration, filtrate
Be evaporated to relative density and be at 60 DEG C be 1.27 thick paste；
(6) combining step (2), the fine powder of (3), mix；
(7) thick paste of above-mentioned fine powder and step (4) is mixed, plus appropriate refined honey makes concentration honeyed pill.
Embodiment 8
A kind of method that Chinese medicine composition for treating depression is prepared into pill, comprises the following steps：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is net
Choosing, dries；
(2) weigh according to following weight portion：Ganoderma 1kg, Hypodematium crenatum (Forsk.) Kuhn 3kg, Rhizoma Gastrodiae 0.5kg, Flos Albiziae 1kg, Radix Curcumae 1kg；
(3) Hypodematium crenatum (Forsk.) Kuhn is taken, cataclasm, put in tank, plus 8 times of amounts, 55 ° of Chinese liquor, seal, steam to wine to the greatest extent, take out, 60 DEG C are done
After dry, fine powder is ground into, crosses 100 mesh sieves；
(4) Rhizoma Gastrodiae, Radix Curcumae is taken, after 60 DEG C of dryings, fine powder is ground into, 100 mesh sieves are crossed, standby；
(5) Ganoderma, Flos Albiziae taken, plus 8 times of amount water boiling and extractions 3 times, 1 hour every time, united extraction liquid, filtration, filtrate
Be evaporated to relative density and be at 60 DEG C be 1.25 thick paste；
(6) combining step (2), the fine powder of (3), mix；
(7) thick paste of above-mentioned fine powder and step (4) is mixed, plus suitable quantity of water refined honey makes concentration water-honeyed pill.
3rd, clinical practice test
1st, diagnostic criteria
Meet《Chinese Spirit Obstacles classification scheme and diagnostic criteria》Diagnosis mark of the third edition (CCMD-3) with regard to depression
Accurate.Symptom standard with mental state low based on, symptoms last more than 2 weeks, and at least following 4：(1) hebetude, without pleased
Pleasant sensation；(2) decreased energy or tired sense；(3) psychomotor activity is sluggish or intense；(4) self evaluation is too low, self-accusation, or in having
Remorse sense；(5) associate difficult or conscious elaborative faculty to decline；(6) there is repeatedly the thought wanted to die or have suicide, autolesionism；(7)
Sleep disorder, such as insomnia, early awakening, or hypersomnia；(8) appetite reduces or body weight substantially mitigates；(9) hyposexuality.
2nd, efficacy determination
Recovery from illness：Symptom is wholly absent, and emotion is normal；
Effective：Symptom disappears substantially, and emotion is basicly stable；
Effectively：Symptom has mitigated, and partial symptoms disappear substantially, and emotion is basicly stable；
Invalid：Symptom, emotion are without improvement.
3rd, medication
A treatment groups：The product of oral embodiment 1-8 is given, three times a day, medicated wine 100ml/ time, pill 6g/ time, continuous 1 week
For a course for the treatment of.
B matched groups：Give oral hydrochloride imipramine, initial dose 30mg/ time, 2～4 times/day, add to 100 in two weeks～
300mg/ days.
4th, result is applied
The Chinese medicine composition of present invention treatment depression, is once used for treating and observing 126 psychiatric patients.Will be above-mentioned
The 8 kinds of embodiment samples for preparing and control sample, are respectively used to patients with depression (man 56, female 70, mean age 26
Year).The results detailed in following table.
Application result table
| Embodiment | Recovery from illness (%) | Effective (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| Embodiment 1 | 28.6 | 28.5 | 28.6 | 14.3 | 85.7 |
| Embodiment 2 | 42.9 | 35.7 | 14.3 | 7.1 | 92.9 |
| Embodiment 3 | 28.6 | 35.7 | 21.4 | 14.3 | 85.7 |
| Embodiment 4 | 42.9 | 14.3 | 35.7 | 7.1 | 92.9 |
| Embodiment 5 | 35.7 | 40.0 | 7.2 | 7.1 | 92.9 |
| Embodiment 6 | 42.9 | 28.6 | 21.4 | 7.1 | 92.9 |
| Embodiment 7 | 35.7 | 42.9 | 14.3 | 7.1 | 92.9 |
| Embodiment 8 | 28.6 | 21.4 | 35.7 | 14.3 | 85.7 |
| Control | 28.6 | 35.7 | 14.3 | 21.4 | 78.6 |
As a result show：Using the Chinese medicine composition of present invention treatment depression, the total effective rate for the treatment of depression is reached
More than 85%, it is above matched group.Illustrate that Chinese medicine composition of the present invention has good curative effect to treating depression, effectively can change
The symptom of kind patients with depression, improves its quality of life.It is below several typical cases.
Typical case 1：Liu's ××, man, 21 years old, show as hypothymergasia, retardation of thinking and speech action reduce, slow,
Interest is all unable to lift to anything, pessimistic desperate, with insomnia, headache, persistently more than half a year.Take the embodiment of the present invention
1, each 100ml, 3 times a day, and after serveing on 7, symptom is substantially improved, and emotion is basicly stable, and insomnia, headache mitigate, then serve on 7
Day, symptom disappears substantially, and emotion recovers normal, continues to serve on 42, does not recur after 1 year.
Typical case 2：×× is opened, female 27 years old, shows as feeling out of one's plate, upsets, anything is all lost interest,
Inferiority complex is strong, pessimistic desperate, feels that prospects are dim is unglazed, hypersomnia, lasting a year and a half, once has suicidal thought.Take
The embodiment of the present invention 7, each 6g, 3 times a day, and after serveing on 14, symptom disappears substantially, and emotion recovers normal.Continue to serve on 42
Day, do not recur after a year and a half.
Typical case 3：All ××s, female 23 years old, show as lasting sad mood, indifferent to anything, lack fast
Sense, it is difficult to think deeply, spirit cannot be concentrated, thought ability decline, have serious suicidal attempt, with insomnia, dizzy, powerless,
Continue, more than 2 years, once to take antidepressants three months, seek treatment by Chinese herbs because being impatient at its side effect.Take of the invention real
Apply example 4, each 100ml, 3 times a day, and after serveing on 7, symptom mitigates significantly, and emotion is basicly stable.7 are serve on again, and symptom is basic
Disappear, emotion recovers normal.Continue to serve on 42, do not recur after 2 years.
Typical case 4：Song's ××, man, 19 years old, because learning anxiety, mental state occur low the year before, occasionally has susceptible to lose temper due to restlessness, to both
Interest is lost toward Cup of tea feelings, felt tired, with insomnia, dizzy, appetite reduction, continued more than a year.Take the present invention
Embodiment 3, each 100ml, 3 times a day, and after serveing on 14, symptom disappears substantially, and emotion is basicly stable, and appetite recovers normal.Again
42 are serve on, symptom disappears, emotion recovers normal, recovery from illness was not recurred after 2 years.
Typical case 5：Liao's ××, female 30 years old, show as depressed, upset, and irritability, inferiority complex are strong, feel future
Intensely dark, pessimistic desperate, with insomnia, dizzy, lose weight, lasting two-and-a-half years, once had suicide.Take this
Bright embodiment 6, each 6g, 3 times a day, and after serveing on 14, symptom disappears substantially, and emotion is basicly stable.49 day, one year are serve on again
Do not recur after half.
Claims (10)
1. a kind of Chinese medicine composition for treating depression, it is characterised in that be grouped into by the group of following weight portion：Ganoderma 10-50
Part, Hypodematium crenatum (Forsk.) Kuhn 30-80 parts, Rhizoma Gastrodiae 5-30 parts, Flos Albiziae 10-30 parts, Radix Curcumae 10-30 parts.
2. according to claim 1 treatment depression Chinese medicine composition, it is characterised in that by the component of following weight portion
Composition：Ganoderma 20-40 parts, Hypodematium crenatum (Forsk.) Kuhn 40-60 parts, Rhizoma Gastrodiae 10-20 parts, Flos Albiziae 15-25 parts, Radix Curcumae 15-25 parts.
3. according to claim 1 treatment depression Chinese medicine composition, it is characterised in that by the component of following weight portion
Composition：30 parts of Ganoderma, 50 parts of Hypodematium crenatum (Forsk.) Kuhn, 15 parts of Rhizoma Gastrodiae, 20 parts of Flos Albiziae, 20 parts of Radix Curcumae.
4. according to the Chinese medicine composition of arbitrary described treatment depression in claims 1 to 3, it is characterised in that the Chinese medicine
Compositionss make oral solid formulation or oral liquid.
5. the Chinese medicine composition for the treatment of depression according to claim 4, it is characterised in that the oral solid formulation is
Pill, capsule or powder.
6. according to claim 4 treatment depression Chinese medicine composition, it is characterised in that the oral liquid wine
Agent.
7. the Chinese medicine composition for the treatment of depression according to claim 5, it is characterised in that the oral solid formulation is
Pill.
8. a kind of Chinese medicine composition for the treatment of depression as claimed in claim 6 is prepared into the preparation method of medicated wine, including following
Step：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is cleaned,
Dry；
(2) weigh according to following weight portion：Ganoderma 10-50 parts, Hypodematium crenatum (Forsk.) Kuhn 30-80 parts, Rhizoma Gastrodiae 5-30 parts, Flos Albiziae 10-30 parts,
Radix Curcumae 10-30 parts；
(3) above ingredients is taken, cataclasm, put in tank, plus 8-10 times is measured 55 ° of Chinese liquor, is sealed, after soaking 30-50 days, mistake
Medical material is filtered, is obtained final product.
9. a kind of Chinese medicine composition for the treatment of depression as claimed in claim 7 is prepared into the preparation method of pill, including following
Step：
(1) Ganoderma, Hypodematium crenatum (Forsk.) Kuhn, Rhizoma Gastrodiae, Flos Albiziae, Radix Curcumae are taken respectively, Hypodematium crenatum (Forsk.) Kuhn removes fur, internal organs, remaining 4 taste medical material is cleaned,
Dry；
(2) weigh according to following weight portion：Ganoderma 10-50 parts, Hypodematium crenatum (Forsk.) Kuhn 30-80 parts, Rhizoma Gastrodiae 5-30 parts, Flos Albiziae 10-30 parts,
Radix Curcumae 10-30 parts；
(3) Hypodematium crenatum (Forsk.) Kuhn is taken, cataclasm, put in tank, plus 8-10 times is measured 55 ° of Chinese liquor, is sealed, steam to wine to the greatest extent, take out, 60 DEG C of dryings
Afterwards, fine powder is ground into, 100 mesh sieves are crossed；
(4) Rhizoma Gastrodiae, Radix Curcumae is taken, after 60 DEG C of dryings, fine powder is ground into, 100 mesh sieves are crossed, standby；
(5) take Ganoderma, Flos Albiziae, plus 6-8 times is measured water boiling and extraction 2-3 time, each 1-3 hours, united extraction liquid, filtration, filter
It is the thick paste at 60 DEG C for 1.25-1.28 that liquid is evaporated to relative density；
(6) combining step (2), the fine powder of (3), mix；
(7) thick paste of above-mentioned fine powder and step (4) is mixed, plus appropriate adhesive makes concentrated watered pill, concentration honeyed pill or concentration
Water-honeyed pill.
10. according to the Chinese medicine composition of arbitrary described treatment depression in claim 1-9, it is characterised in that the Chinese medicine
Purposes of the compositionss in the medicine for preparing treatment depression.
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