CN106491996A - A kind of treat Chinese medicine composition of manic disorder and preparation method thereof - Google Patents
A kind of treat Chinese medicine composition of manic disorder and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/882—Acoraceae (Calamus family), e.g. sweetflag or Acorus calamus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of treat Chinese medicine composition of manic disorder and preparation method thereof, it is grouped into by the group of following weight portion：10 50 parts of rhizoma Gastrodiae, 30 70 parts of yellow weasel, 10 30 parts of glossy ganoderma, 10 30 parts of grass leaf sweetflag rhizome, 10 30 parts of polygala root.Prescription of the present invention is rigorous, and the few power of medicine specially, have functions that waking up the patient from unconsciousness by clearing away phlegm, tranquilize the mind and promote the intelligence function, has good curative effect to manic disorder.
Description
Technical field
The present invention relates to medicine field, and in particular to a kind of treat Chinese medicine composition of manic disorder and preparation method thereof.
Background technology
Manic disorder is a kind of performance of mental illness, as the popularization of the digital products such as computer, mobile phone is used and modern
People's life, the increase of operating pressure, the manic disorder incidence of disease raised year by year, bad life event and environmental stress thing event
The outbreak of manic disorder can be induced.The easy recurrent exerbation of mania, long-term recurrent exerbation cause patient disease chronicity, personality to change
Become and social function is damaged, the work and life of patient can all be caused to have a strong impact on.
At present, manic disease in drug treatment, mainly based on mood stabilizers treatment, can treat by mood stabilizers
With prevent attacks, its Main Function is that disorderly cerebral nerve chemical process is adjusted, and controls brain excitement, only controls
The symptom of disease processed, does not treat from the cause of disease.Although, Western medicine has rapid-action, effect clear advantage on treatment manic disorder,
But as which is cured the symptoms, not the disease, therefore Most patients easily recur, and western medicine disease easily produces dependence, secondary
Effect is big.
The product that Chinese medicine is the distinctive traditional Chinese medical theory of China with practice, aboundresources are with a long history, are that the mankind earliest should
Natural organic substance.And mental illness is under the jurisdiction of Mental disease category, understanding existing two of the traditional Chinese medicine to emotional disorder
The aspects such as the history in over thousands of year, the cause of disease, the interpretation of the cause, onset and process of an illness, prevention, treatment in emotional disorder define the theoretical system and abundant of uniqueness
Practical experience.The traditional Chinese medical science adopts to nurse one's health mood, consciousness regaining, soothing the liver wash phlegm, recuperating qi-blood, adjust the function of body and flat
The treatment by Chinese herbs mental illness of weighing apparatus negative and positive effect, the problems such as easily produce pharmacological dependence, large side effects when having avoided western medicine,
Reinvigoration, treats both principal and secondary aspect of disease, and reaches the purpose of radical cure.The present invention has to manic disorder good by instruction of Chinese Medicine theory, scientific formula
Good curative effect.Of the invention outer there is not yet the report of rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome and polygala root composition.
(1) rhizoma Gastrodiae, is the dry tuber of orchid rhizoma Gastrodiae Gastrodia elata Bl..Record in Chinese Pharmacopoeia
Version in 2015：【Nature and flavor and return through】Sweet, put down.Return liver warp.【Function with cure mainly】Inflammation Zhijing, suppressing liver-YANG, dispelling wind and removing obstruction in the meridians.For
Child convulsion epilepsy clonus, lockjaw, dizziness of having a headache, hands and feet caused by paralysis, extremity numbness, arthralgia due to wind-dampness.
(2) yellow weasel, is mustelid yellow weasel Mustela sibirica Pallas.【Meridian distribution of property and flavor】Sweet, warm, have little
Poison.Enter lung, kidney two warp【Effect】Desinsection treats sore, warm kidney contracting urine.Control scabies, sore routed disunion, frequent micturition.
(3) glossy ganoderma, is On Polyporaceae red sesame Ganoderma lucidum (Leyss.exFr.) Karst. or purple sesame
Ganoderma sinense Zhao, Xu et Zhang dry fructification.Record in Chinese Pharmacopoeia version in 2015：【Nature and flavor with
Return through】Sweet, put down.The thoughts of returning home, lung, liver and kidney channel.【Function with cure mainly】Invigorating qi for tranquilization, relieving cough and asthma.For having no peace of mind, the heart of having a sleepless night
Throb with fear, deficiency syndrome of the lung cough and asthma, consumptive disease are losed heart, do not feel like eating.
(4) grass leaf sweetflag rhizome, is the dry rhizome of acorus gramineus araceae plant Acorus tatarinowii Schott.【Property
Taste and return through】Pungent, bitter, temperature.The thoughts of returning home, stomach.Record in Chinese Pharmacopoeia version in 2015：【Function with cure mainly】Have one's ideas straightened out slit phlegm, inducing resuscitation
Intelligence development, dampness elimination appetizing.For coma epilepsy, forgetful insomnia, Hiccough and deaf, gastral cavity ruffian is not hungry, a mouthful diarrhea of keeping silent.
(5) polygala root, is the remote Polygala tenuifolia Willd. of milk wort or ovum leaf polygala root Polygala
The dry root of sibirica L..Record in Chinese Pharmacopoeia version in 2015：【Nature and flavor and return through】Bitter, pungent, temperature.The thoughts of returning home, kidney, lung channel.
【Function with cure mainly】Tranquilize the mind and promote the intelligence, restoring normal coordination between heart and kidney, eliminating the phlegm, detumescence.The insomnia and dreamful sleep that causes for breakdown of the normal physiological coordination between the heart and the kidney, forgetful palpitation with fear,
Wandering, expectoration is not well, sore swollen toxin, mastosis.
Content of the invention
It is an object of the invention to provide a kind of treat Chinese medicine composition of manic disorder and preparation method thereof.
The present invention treats the Chinese medicine composition of manic disorder on the basis of traditional Chinese medical science traditional theory, in conjunction with medication experience among the people,
It is formulated with modern scientific theory.Have prescription rigorous, the few power of medicine specially, has good curative effect, effectively can change to manic disorder
The clinical symptoms of kind patient, shorten the course of disease, improve the quality of life of patient.
The technical solution adopted in the present invention is as follows：
A kind of Chinese medicine composition for treating manic disorder, is grouped into by the group of following weight portion：Rhizoma Gastrodiae 10-50 parts, yellow weasel
30-70 parts, glossy ganoderma 10-30 parts, grass leaf sweetflag rhizome 10-30 parts, polygala root 10-30 part.
The Chinese medicine composition of the above treatment manic disorder, is preferably grouped into by the group of following weight portion：Rhizoma Gastrodiae 20-40
Part, yellow weasel 40-60 parts, glossy ganoderma 15-25 parts, grass leaf sweetflag rhizome 15-25 parts, polygala root 15-25 part.
The Chinese medicine composition of the above treatment manic disorder, is most preferably preferably grouped into by the group of following weight portion：Rhizoma Gastrodiae 30
Part, 50 parts of yellow weasel, 20 parts of glossy ganoderma, 20 parts of grass leaf sweetflag rhizome, 20 parts of polygala root.
The Chinese medicine composition of the above treatment manic disorder, can be prepared into oral solid formulation or oral liquid, such as：
Vina, pill, capsule, powder.Preferably, the oral administration solid is pill, the liquid oral system is vina.
The method that the Chinese medicine composition of the above treatment manic disorder is prepared into vina, comprises the following steps：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is net
Choosing, dries；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 10-50 parts, yellow weasel 30-70 parts, glossy ganoderma 10-30 parts, grass leaf sweetflag rhizome 10-
30 parts, polygala root 10-30 part；
(3) above ingredients is taken, cataclasm, put in tank, plus 8-10 times is measured 55 ° of white wine, is sealed, soak 30-50 days
Afterwards, medicinal material is filtered to remove, is obtained final product.
The method that the Chinese medicine composition of the above treatment manic disorder is prepared into pill, comprises the following steps：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is net
Choosing, dries；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 10-50 parts, yellow weasel 30-70 parts, glossy ganoderma 10-30 parts, grass leaf sweetflag rhizome 10-
30 parts, polygala root 10-30 part；
(3) yellow weasel is taken, cataclasm, put in tank, plus 8-10 times is measured 55 ° of white wine, is sealed, steam to wine to the greatest extent, take out, 60 DEG C
After drying, fine powder is ground into, crosses 100 mesh sieves；
(4) rhizoma Gastrodiae, polygala root is taken, after 60 DEG C of dryings, fine powder is ground into, 100 mesh sieves are crossed, standby；
(5) take glossy ganoderma, grass leaf sweetflag rhizome, plus 6-8 times is measured water boiling and extraction 2-3 time, each 1-3 hours merge extract, filter
Cross, filtrate reduced in volume to relative density is the thick paste at 60 DEG C for 1.25-1.28；
(6) combining step (2), the fine powder of (3), mix；
(7) thick paste of above-mentioned fine powder and step (4) is mixed, plus appropriate binder make the concentration water-bindered pill, concentration honeyed bolus or
Concentration water-honeyed pill.
The Chinese medicine composition of the above treatment manic disorder, the purposes in the medicine for preparing treatment manic disorder.
The Chinese medicine composition of present invention treatment manic disorder is on the basis of traditional Chinese medicine traditional theory, passes through in conjunction with medication among the people
Test, be formulated with modern scientific theory.Rhizoma Gastrodiae in side, suppressing liver-YANG is monarch drug in a prescription.Yellow weasel warm kidney moistening lung, is ministerial drug.Spirit
Sesame, invigorating qi for tranquilization；Grass leaf sweetflag rhizome, slit phlegm of having one's ideas straightened out, inducing resuscitation intelligence development, dampness elimination appetizing；Papillary is adjutant.Polygala root, tranquilize the mind and promote the intelligence are handed over
Logical heart kidney, eliminating the phlegm, for making medicine.All medicines share plays the work(of waking up the patient from unconsciousness by clearing away phlegm, tranquilize the mind and promote the intelligence altogether.Prescription of the present invention is rigorous, and the few power of medicine is special,
There is good curative effect to manic disorder.
The invention has the beneficial effects as follows：
(1) prescription is rigorous, and the few power of medicine specially, have functions that waking up the patient from unconsciousness by clearing away phlegm, tranquilize the mind and promote the intelligence function, has to manic disorder good
Curative effect, treats total effective rate up to more than 80%.
(2) component is herbal variety, using safety, treats both principal and secondary aspect of disease, and cures the symptoms, not the disease when overcoming western medicine, disease
Feelings recurrent exerbation and pharmacological dependence is produced easily, the shortcomings of toxic and side effect is big.
Specific embodiment
With reference to specific embodiment, the invention will be further described, but do not limit the scope of the invention and apply
Scope：
First, the preparation of the Chinese medicine composition vina for the treatment of manic disorder
Embodiment 1
A kind of method that Chinese medicine composition for treating manic disorder is prepared into vina, comprises the following steps：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is net
Choosing, dries；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 1kg, yellow weasel 3kg, glossy ganoderma 1kg, grass leaf sweetflag rhizome 1kg, polygala root 1kg；
(3) above ingredients is taken, cataclasm, put in tank, plus 8 times of amounts, 55 ° of white wine, seal, after soaking 50 days, filter
Medicinal material is removed, is obtained final product.
Embodiment 2
A kind of method that Chinese medicine composition for treating manic disorder is prepared into vina, comprises the following steps：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is net
Choosing, dries；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 2kg, yellow weasel 4kg, glossy ganoderma 1.5kg, grass leaf sweetflag rhizome 1.5kg, polygala root
1.5kg；
(3) above ingredients is taken, cataclasm, put in tank, plus 9 times of amounts, 55 ° of white wine, seal, after soaking 30 days, filter
Medicinal material is removed, is obtained final product.
Embodiment 3
A kind of method that Chinese medicine composition for treating manic disorder is prepared into vina, comprises the following steps：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is net
Choosing, dries；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 3kg, yellow weasel 5kg, glossy ganoderma 2kg, grass leaf sweetflag rhizome 2kg, polygala root 2kg；
(3) above ingredients is taken, cataclasm, put in tank, plus 9 times of amounts, 55 ° of white wine, seal, after soaking 40 days, filter
Medicinal material is removed, is obtained final product.
Embodiment 4
A kind of method that Chinese medicine composition for treating manic disorder is prepared into vina, comprises the following steps：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is net
Choosing, dries；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 4kg, yellow weasel 6kg, glossy ganoderma 2.5kg, grass leaf sweetflag rhizome 2.5kg, polygala root
2.5kg；
(3) above ingredients is taken, cataclasm, put in tank, plus 10 times of amounts, 55 ° of white wine, seal, after soaking 40 days, mistake
Medicinal material is filtered, is obtained final product.
Embodiment 5
A kind of method that Chinese medicine composition for treating manic disorder is prepared into vina, comprises the following steps：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is net
Choosing, dries；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 5kg, yellow weasel 7kg, glossy ganoderma 3kg, grass leaf sweetflag rhizome 3kg, polygala root 3kg；
(3) above ingredients is taken, cataclasm, put in tank, plus 10 times of amounts, 55 ° of white wine, seal, after soaking 50 days, mistake
Medicinal material is filtered, is obtained final product.
2nd, the preparation of the Chinese medicine composition pill for the treatment of manic disorder
Embodiment 6
A kind of method that Chinese medicine composition for treating manic disorder is prepared into pill, comprises the following steps：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is net
Choosing, dries；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 3kg, yellow weasel 5kg, glossy ganoderma 2kg, grass leaf sweetflag rhizome 2kg, polygala root 2kg；
(3) yellow weasel is taken, cataclasm, put in tank, plus 9 times of amounts, 55 ° of white wine, seal, steam to wine to the greatest extent, take out, 60 DEG C are done
After dry, fine powder is ground into, crosses 100 mesh sieves；
(4) rhizoma Gastrodiae, polygala root is taken, after 60 DEG C of dryings, fine powder is ground into, 100 mesh sieves are crossed, standby；
(5) glossy ganoderma, grass leaf sweetflag rhizome taken, plus 7 times of amount water boiling and extractions 2 times, 2 hours every time, merge extract, filtration, filtrate
Be evaporated to relative density and be at 60 DEG C be 1.27 thick paste；
(6) combining step (2), the fine powder of (3), mix；
(7) thick paste of above-mentioned fine powder and step (4) is mixed, plus suitable quantity of water and refined honey makes concentration water-honeyed pill.
Embodiment 7
A kind of method that Chinese medicine composition for treating manic disorder is prepared into pill, comprises the following steps：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is net
Choosing, dries；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 1kg, yellow weasel 3kg, glossy ganoderma 1kg, grass leaf sweetflag rhizome 1kg, polygala root 1kg；
(3) yellow weasel is taken, cataclasm, put in tank, plus 8 times of amounts, 55 ° of white wine, seal, steam to wine to the greatest extent, take out, 60 DEG C are done
After dry, fine powder is ground into, crosses 100 mesh sieves；
(4) rhizoma Gastrodiae, polygala root is taken, after 60 DEG C of dryings, fine powder is ground into, 100 mesh sieves are crossed, standby；
(5) glossy ganoderma, grass leaf sweetflag rhizome taken, plus 6 times of amount water boiling and extractions 3 times, 1 hour every time, merge extract, filtration, filtrate
Be evaporated to relative density and be at 60 DEG C be 1.25 thick paste；
(6) combining step (2), the fine powder of (3), mix；
(7) thick paste of above-mentioned fine powder and step (4) is mixed, plus appropriate refined honey makes concentration honeyed bolus.
Embodiment 8
A kind of method that Chinese medicine composition for treating manic disorder is prepared into pill, comprises the following steps：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is net
Choosing, dries；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 5kg, yellow weasel 7kg, glossy ganoderma 3kg, grass leaf sweetflag rhizome 3kg, polygala root 3kg；
(3) yellow weasel is taken, cataclasm, put in tank, plus 10 times of amounts, 55 ° of white wine, seal, steam to wine to the greatest extent, take out, 60 DEG C are done
After dry, fine powder is ground into, crosses 100 mesh sieves；
(4) rhizoma Gastrodiae, polygala root is taken, after 60 DEG C of dryings, fine powder is ground into, 100 mesh sieves are crossed, standby；
(5) glossy ganoderma, grass leaf sweetflag rhizome taken, plus 7 times of amount water boiling and extractions 2 times, 3 hours every time, merge extract, filtration, filtrate
Be evaporated to relative density and be at 60 DEG C be 1.28 thick paste；
(6) combining step (2), the fine powder of (3), mix；
(7) thick paste of above-mentioned fine powder and step (4) is mixed, plus suitable quantity of water makes the concentration water-bindered pill.
3rd, clinical practice test
1st, diagnostic criteria
Meet《Chinese Spirit Obstacles classification scheme and diagnostic criteria》Diagnosis mark of the third edition (CCMD-3) with regard to manic disorder
Standard, symptom standard based in high spirits or irritability, symptoms last more than 2 weeks, and at least following 3 (if being only easily
Excitation, at least needs four)：(1) absent minded or with border shift；(2) language amount increases；(3) flight of ideas (word speed speeds,
Speech is urged), association accelerate or flight of ideas experience；(4) self-assessment is too high or exaggerates；(5) energetic, do not feel tired
Weary, movable increase, be difficult to peace and quiet, or constantly change one's plans and activity；(6) crude and rash behavior (is such as spent freely, irresponsibility or disregards
Behavior of consequence etc.；(7) sleep needs to reduce；(8) sexual hyperesthesia.
2nd, efficacy determination
Recovery from illness：Symptom is wholly absent, and is emotionally stable, and self-assessment is normal；
Effective：Symptom disappears substantially, and mood is basicly stable, and self-assessment is normal；
Effectively：Symptom has mitigated, and partial symptoms disappear substantially, and mood is basicly stable, and self-assessment is normal；
Invalid：Symptom, mood have no to improve, and self-assessment is still too high.
3rd, medication
A treatment groups：The product of oral embodiment 1-14 is given, three times a day, vina 100ml/ time, pill 6g/ time, continuous 1
The Zhou Weiyi courses for the treatment of.
B control groups：Give oral lithium carbonate, initial dose 200mg/ time, 2～4 times/day, add to 600 in two weeks～
2000mg/ days.
4th, result is applied
The Chinese medicine composition of present invention treatment manic disorder, is once used for treating and observing 117 psychiatric patients.Will be above-mentioned
The 8 kinds of embodiment samples for preparing and control sample, are respectively used to manic disorder patient (man 60, female 57, average age 29
Year).The results detailed in following table.
Application result table
| Embodiment | Recovery from illness (%) | Effective (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| Embodiment 1 | 30.8 | 23.1 | 30.8 | 15.4 | 84.6 |
| Embodiment 2 | 30.8 | 38.4 | 15.4 | 15.4 | 84.6 |
| Embodiment 3 | 38.5 | 38.5 | 15.3 | 7.7 | 92.3 |
| Embodiment 4 | 46.1 | 15.4 | 30.8 | 7.7 | 92.3 |
| Embodiment 5 | 46.1 | 30.8 | 15.4 | 7.7 | 92.3 |
| Embodiment 6 | 38.4 | 30.8 | 23.1 | 7.7 | 92.3 |
| Embodiment 7 | 30.8 | 15.4 | 38.4 | 15.4 | 84.6 |
| Embodiment 8 | 46.1 | 23.1 | 23.1 | 7.7 | 92.3 |
| Control | 30.8 | 38.4 | 7.7 | 23.1 | 76.9 |
As a result show：Using the Chinese medicine composition of present invention treatment manic disorder, the total effective rate of manic disease treatment is reached
80% being above control group.Illustrate that Chinese medicine composition of the present invention has good curative effect to treating manic disorder, effectively can change mad
The symptom of hot-tempered disease patient, improves its quality of life, and will not produce dependence, Small side effects.It is below several typical cases.
Typical case 1：Lee's ××, man, 25 years old, suffers from manic disorder half a year, shows as getting excited, language showed increased, self
Overestimate, notice is arbitrarily shifted, energetic, it is difficult to quiet, sleep is reduced, recurrent exerbation.Take the embodiment of the present invention
1, each 100ml, 3 times a day, and after serveing on 7, symptom is substantially improved, and mood tends towards stability, then serve on 7, and symptom all disappears
Lose, mood recovers normal, recovery from illness continues to serve on 42, do not recur after a year and a half.
Typical case 2：What ××, female are 28 years old, ill 5 months, show as getting excited, and language showed increased, word speed are obvious
Accelerate, self-assessment is too high, absent minded, sleep is reduced, but energetic, is not felt tired, with antimigraine, is sent out repeatedly
Make.Take the embodiment of the present invention 6, each 6g, 3 times a day, and after serveing on 14, symptom disappears substantially, mitigation of having a headache, and mood is steady
Fixed, then 42 are serve on, do not recur after 1 year.
Typical case 3：Yellow ××, female 32 years old, are got excited over nearly three months, and energy is excessively vigorous, language showed increased,
Word speed is substantially accelerated, and self-assessment is too high, it is believed that oneself ability superman, but it is having a beginning but no end to do things, absent minded, sleep
Reduce, with antimigraine, recurrent exerbation.Take the embodiment of the present invention 2, each 100ml, 3 times a day, and after serveing on 15, symptom disappears
Lose, recover normal, recovery from illness.It serve on 42 again, does not recur after a year and a half.
Typical case 4：Wei ××, man 22 years old, are got excited half a year more, and behavior is crude and rash, and speech is urged, and notice does not collect
In, self-assessment is exaggerated, and anti-must show effect.Take the embodiment of the present invention 4, each 100ml, 3 times a day, symptom base after serveing on 7
This disappearance, is emotionally stable, then serve on 7, and symptom all disappears, recovery from illness, then serve on 49, does not recur after 1 year.
Typical case 5：Once ××, female, 26 years old, showed as language showed increased, ceaselessly harangued, energetic, slept
Sleep and reduce, self-assessment is exaggerated, had an oar in every man's boat, recurrent exerbation, and with antimigraine, persistently half a year is more.Take enforcement of the present invention
Example 8, each 6g, 3 times a day, and after serveing on 7, symptom disappears substantially, mitigation of having a headache, and is emotionally stable, then serve on 7, and symptom disappears
Lose, recovery from illness continues to serve on 42, do not recur after 2 years.
Claims (10)
1. a kind of Chinese medicine composition for treating manic disorder, it is characterised in that be grouped into by the group of following weight portion：Rhizoma Gastrodiae 10-50
Part, yellow weasel 30-70 parts, glossy ganoderma 10-30 parts, grass leaf sweetflag rhizome 10-30 parts, polygala root 10-30 part.
2. according to claim 1 treatment manic disorder Chinese medicine composition, it is characterised in that by the component of following weight portion
Composition：Rhizoma Gastrodiae 20-40 parts, yellow weasel 40-60 parts, glossy ganoderma 15-25 parts, grass leaf sweetflag rhizome 15-25 parts, polygala root 15-25 part.
3. according to claim 1 treatment manic disorder Chinese medicine composition, it is characterised in that by the component of following weight portion
Composition：30 parts of rhizoma Gastrodiae, 50 parts of yellow weasel, 20 parts of glossy ganoderma, 20 parts of grass leaf sweetflag rhizome, 20 parts of polygala root.
4. according to the Chinese medicine composition of arbitrary described treatment manic disorder in claims 1 to 3, it is characterised in that the Chinese medicine
Composition makes oral solid formulation or oral liquid.
5. the Chinese medicine composition for the treatment of manic disorder according to claim 4, it is characterised in that the oral solid formulation is
Pill, capsule or powder.
6. according to claim 4 treatment manic disorder Chinese medicine composition, it is characterised in that the oral liquid wine
Agent.
7. the Chinese medicine composition for the treatment of manic disorder according to claim 5, it is characterised in that the oral solid formulation is
Pill.
8. a kind of Chinese medicine composition for the treatment of manic disorder as claimed in claim 6 is prepared into the preparation method of vina, including following
Step：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is cleaned,
Dry；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 10-50 parts, yellow weasel 30-70 parts, glossy ganoderma 10-30 parts, grass leaf sweetflag rhizome 10-30
Part, polygala root 10-30 part；
(3) above ingredients is taken, cataclasm, put in tank, plus 8-10 times is measured 55 ° of white wine, is sealed, after soaking 30-50 days, mistake
Medicinal material is filtered, is obtained final product.
9. a kind of Chinese medicine composition for the treatment of manic disorder as claimed in claim 7 is prepared into the preparation method of pill, including following
Step：
(1) rhizoma Gastrodiae, yellow weasel, glossy ganoderma, grass leaf sweetflag rhizome, polygala root are taken respectively, yellow weasel removes fur, internal organ, remaining 4 taste medicinal material is cleaned,
Dry；
(2) weigh according to following weight portion：Rhizoma Gastrodiae 10-50 parts, yellow weasel 30-70 parts, glossy ganoderma 10-30 parts, grass leaf sweetflag rhizome 10-30
Part, polygala root 10-30 part；
(3) yellow weasel is taken, cataclasm, put in tank, plus 8-10 times is measured 55 ° of white wine, is sealed, steam to wine to the greatest extent, take out, 60 DEG C of dryings
Afterwards, fine powder is ground into, 100 mesh sieves are crossed；
(4) rhizoma Gastrodiae, polygala root is taken, after 60 DEG C of dryings, fine powder is ground into, 100 mesh sieves are crossed, standby；
(5) take glossy ganoderma, grass leaf sweetflag rhizome, plus 6-8 times is measured water boiling and extraction 2-3 time, each 1-3 hours merge extract, filtration, filter
It is the thick paste at 60 DEG C for 1.25-1.28 that liquid is evaporated to relative density；
(6) combining step (2), the fine powder of (3), mix；
(7) thick paste of above-mentioned fine powder and step (4) is mixed, plus appropriate binder makes the concentration water-bindered pill, concentration honeyed bolus or concentration
Water-honeyed pill.
10. according to the Chinese medicine composition of arbitrary described treatment manic disorder in claim 1-9, it is characterised in that the Chinese medicine
Purposes of the composition in the medicine for preparing treatment mental illness.
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| CN102908587A (en) * | 2012-10-29 | 2013-02-06 | 钟思冰 | Brain-building intelligence-reinforcing pill for treating brain exhaustion psychosis |
| CN104435775A (en) * | 2014-11-18 | 2015-03-25 | 陈征 | Chinese medicinal health-care spirit and preparation method thereof |
| CN105902963A (en) * | 2016-05-30 | 2016-08-31 | 苏州市天灵中药饮片有限公司 | Chinese medicament for soothing nerves and resolving depression and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2425900A1 (en) * | 2000-10-18 | 2002-04-25 | Tzu-Sheng Wu | Novel medicinal herbal composition for treating liver diseases and hiv |
| EE200400097A (en) * | 2001-12-14 | 2004-10-15 | Council Of Scientific And Industrial Research | A composition for the treatment of neurocerebrovascular disorders and a method for preparing turmeric oil therein |
| CN101507736A (en) * | 2009-03-17 | 2009-08-19 | 候振发 | Traditional Chinese medicine preparation for treating senile dementia, ischium lumbar, swollen glands, get-wind or the other rheumatism |
| CN102908587A (en) * | 2012-10-29 | 2013-02-06 | 钟思冰 | Brain-building intelligence-reinforcing pill for treating brain exhaustion psychosis |
| CN104435775A (en) * | 2014-11-18 | 2015-03-25 | 陈征 | Chinese medicinal health-care spirit and preparation method thereof |
| CN105902963A (en) * | 2016-05-30 | 2016-08-31 | 苏州市天灵中药饮片有限公司 | Chinese medicament for soothing nerves and resolving depression and preparation method thereof |
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Application publication date: 20170315 |