CN106491927A - The uncinariatic Chinese medicine composition of one kind preventing and treating goat and preparation method - Google Patents
The uncinariatic Chinese medicine composition of one kind preventing and treating goat and preparation method Download PDFInfo
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- CN106491927A CN106491927A CN201611117826.1A CN201611117826A CN106491927A CN 106491927 A CN106491927 A CN 106491927A CN 201611117826 A CN201611117826 A CN 201611117826A CN 106491927 A CN106491927 A CN 106491927A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
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- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to technical field of traditional Chinese medicines, especially one kind prevents and treats the uncinariatic Chinese medicine composition of goat and preparation method, chinaberry, Radix Isatidis, garlic, purslane are adopted for raw material, by reasonable compatibility, so that Chinese medicine composition have functions that desinsection removing toxic substances, the heat that disappears scattered blood, anti-inflammation, warming kidney and strengthening spleen, and medicinal material be easy to get, low cost, process is simple.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, the especially a kind of uncinariatic Chinese medicine composition of preventing and treating goat and preparation side
Method.
Background technology
Goat hookworm disease is the disease caused by small intestine in Ancylostomatidae, the nematosis sheep body of Bunostomum.Main propagation
Approach is that female adult passes through to lay eggs in little enteral, excretes through excrement with after, once hatching larva, larva quickly once environment is suitable
There is invasive ability after secondary de- change, sheep body can be invaded from the skin of sheep or alimentary canal, finally parasitize small intestine, cause intestines
Mucosa ulcer, so that sick sheep extreme anaemia and becoming thin, oedema under jaw, long-term diarrhea can cause goat jumpbogroup dead when serious.
At present, for uncinariatic treatment, mainly using chemotherapy and traditional Chinese medicine composition for treating, single due to chemistry
The toxic and side effect of medicine is stronger, and the Immunological Effect of sheep body is increased, and the resistance to the action of a drug strengthens, after causing the secondary outbreak of sheep, its medication
Amount is larger, or even is difficult to cure；And traditional Chinese medicine composition for treating, which has toxic and side effect little, improves journey to the immunity of sheep body
Degree is more excellent, although in prior art, there is the research of the substantial amounts of Chinese medicine composition with regard to bunostomum trigonocephalum disease treatment, such as patent
Number for CN201410246230.6, disclose with Radix Angelicae Sinensis, rhizoma atractylodis macrocephalae, dried orange peel, the bark of official magnolia, radix bupleuri, six songs, kuh-seng, Su Geng, Radix Glycyrrhizae,
The medicine that the fruit of Rangoon creeper, chinaberry and pasta ulmi are made；But the selection of the material composition due to Chinese medicine composition of the prior art
Incorrect, material composition collocation unreasonable, cause to bunostomum trigonocephalum disease treatment effect undesirable, treatment cycle is longer.
Content of the invention
In order to solve above-mentioned technical problem, the researcher of the invention provides a kind of preventing and treating goat uncinariatic Chinese medicine group
Compound, its have nontoxic gentle, treat both principal and secondary aspect of disease, effect is significant effect.
It is achieved particular by technical scheme below：
The uncinariatic Chinese medicine composition of one kind preventing and treating goat, raw material are chinaberry 5-15 part, Radix Isatidis 20- in parts by weight
30 parts, garlic 10-20 parts, purslane 15-30 parts.
More preferably chinaberry 8-12 part, Radix Isatidis 22-26 parts, garlic 14-18 parts, purslane 20-25 parts.
Much further preferably from 10 parts of chinaberry, 25 parts of Radix Isatidis, 16 parts of garlic, 23 parts of purslane.
The present invention also provides a kind of preventing and treating goat uncinariatic Chinese medicine composition preparation method.
Realize especially by the following manner：
The uncinariatic Chinese medicine composition preparation method of one kind preventing and treating goat, comprises the following steps：
(1) by chinaberry, Radix Isatidis, garlic, purslane mixing, impurity is removed, mixture is obtained, using pulverizer powder
Broken, 150～200 mesh sieves are crossed, the water relative to 4～5 times of mixture quality is added, at a temperature of 85 DEG C～100 DEG C, 30 is decocted
Minute～1 and a half hours, decoction liquor is filtered, and obtains the first filtered fluid and filter residue；
(2) filter residue that obtains step (1) adds the water relative to 1～3 times of mixture quality, at 85 DEG C～100 DEG C
At a temperature of, decocting 30 minutes～1 and a half hours, decoction liquor is filtered, and obtains the second filtered fluid；
(3) the first filtrate and the second filtrate are merged, reduced pressure concentration obtains dry cream, dry cream is put in spray dryer
Dry, obtain fine drug powder, add or without medically acceptable auxiliary material, make preparation.
Wherein described formulation is electuary, tablet, granule or powder, but is not limited only to this several formulation.
The present invention adopts chinaberry, Radix Isatidis, garlic, purslane for raw material, wherein：
Dry mature fruit of the chinaberry for Meliaceae plant chinaberry.Qi-regulating, pain relieving, clearing away damp-heat, expelling parasite.There is treatment scabies
The effects such as tinea, pernio, promoting qi circulation and relieving pain, desinsection, gastral cavity abdomen pain over the hypochondriac region, colic, abdominal pain due to enterositosis, favus of the scalp.
Dry root of the Radix Isatidis for cruciferae isatis；Conventional another name：Indigo-blue, indigo root, manyflower glorybower root, bitter, tremble with fear.
The effect of having clearing heat and detoxicating, cool blood profit is swallowed.Poison when being usually used in treating warm epidemic disease, pharyngalgia of generating heat, febrile virulent maculae, mumps, rotten larynx are red
Acute diseases such as cholera and sunstroke, major part pestilence, erysipelas, carbuncle swells etc..
Garlic is called the head of garlic, garlic, giant garlic, calabash, only garlic, single clove garlic, is the general designation of garlic class plant.Semi-annual draft is planted
Thing, Liliaceae allium, is used as medicine with bulb.Nature and flavor temperature, pungent, sweet.There are clearing heat and detoxicating, warming kidney and strengthening spleen and insecticidal and antibacterial effect.
Purslane annual herb, complete stool is without hair.Stem prostration, throw oneself on the ground paving dissipate, branch light green or band kermesinus.Leaf alternate,
Blade is flat, plump, like dent shape, above dirty-green, below light green or with kermesinus；Petiole tubbiness.Flower was contained without stalk, the period of the day from 11 a.m. to 1 p.m
Open；Bract is lobate；Sepal green, helmet shape；Petal yellow, obovate；Stamen flower pesticide yellow；Ovary is without hair.Capsule ovoid；Kind
Careful little, deflection is spherical, and pitchy is glossy.There is desinsection removing toxic substances, the scattered blood of the heat that disappears and bacteriostasis.
Wherein described traditional Chinese medicine composite also includes the bighead atractylodes rhizome and corn stigma.
The wherein described bighead atractylodes rhizome is 15～20 parts of the bighead atractylodes rhizome in parts by weight, and described corn stigma is 15～20 in parts by weight
Part.
After the wherein described bighead atractylodes rhizome adopts temperature for 30～50 DEG C of 1～3min of drying and processing, insert in vapor steam 10～
Use after 20min；Dry and its dry property is relaxed, section becomes simple, and enhances the effect of invigorating the spleen, stomach invigorating；
Rational water steams the time so that the harder bighead atractylodes rhizome of script quality is effectively softened, this and traditional water treating softener mode,
The loss of active ingredient is reduced, while making part carbohydrate hydrolyze easily by the effect of intestinal absorption.
Wherein described corn stigma by with potassium dihydrogen phosphate according to mass ratio be 1:After 0.01～0.07 mixing, in temperature
For 35～46 DEG C of bottom fermentations, process 5～9 days so that the cellulase pectase produced in sweat can destroy corn stigma
Plant cell wall, make active ingredient be come out, after entering in vivo, no longer affect to absorb because of the resistance of cell membrane,
Remove multiple macromolecular substances such as tannin, pectin, mucilaginous substance and floccule simultaneously, improve the utilization rate of effective ingredient.
Compared with prior art, the technique effect of the invention is embodied in：Using chinaberry, Radix Isatidis, garlic, dent
Totally 4 taste pure natural Chinese herbal medicines are raw material to amaranth, by rational collocation mode so that have the function of Synergistic between medicine,
So that the intrusion of hookworm can also be prevented while driving away internal hookworm, it is to avoid the possibility of recurrence, therapeutic effect significantly, also not
Toxic and side effect can be brought to the goat after medication, reduce economic loss.
Specific embodiment
Technical scheme is further limited with reference to specific embodiment, but claimed
Scope is not only limited to description.
Embodiment 1
Fill a prescription and be：15 grams of chinaberry, 30 grams of Radix Isatidis, 20 grams of garlic, 30 grams of purslane；
Preparation method：
(1) by chinaberry, Radix Isatidis, garlic, purslane mixing, impurity is removed, mixture is obtained, using pulverizer powder
Broken, 150～200 mesh sieves are crossed, the water relative to 4～5 times of mixture quality is added, at a temperature of 85 DEG C～100 DEG C, 45 is decocted
Minute, decoction liquor is filtered, and obtains the first filtered fluid and filter residue；
(2) filter residue obtained in step (1) is added the water relative to 2 times of first step mixture quality, 85 DEG C～100
At a temperature of DEG C, decoct 45 minutes, decoction liquor is filtered, obtain the second filtered fluid；
(3) the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration obtains dry cream, dry cream is put into spray drying
Dry in machine, obtain drug powder, be subsequently ground into 300 mesh～400 mesh, make electuary.
Embodiment 2
Fill a prescription and be：5 grams of chinaberry, 20 grams of Radix Isatidis, 10 grams of garlic, 15 grams of purslane；
Preparation method：
(1) by chinaberry, Radix Isatidis, garlic, purslane mixing, impurity is removed, mixture is obtained, using pulverizer powder
Broken, 150～200 mesh sieves are crossed, the water relative to 4～5 times of mixture quality is added, at a temperature of 85 DEG C～100 DEG C, 1 is decocted
Individual hour, decoction liquor are filtered, and obtain the first filtered fluid and filter residue；
(2) filter residue obtained in step (1) is added the water relative to 2 times of first step mixture quality, 85 DEG C～100
At a temperature of DEG C, 1 hour is decocted, decoction liquor is filtered, and obtains the second filtered fluid；
(3) the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration obtains dry cream, dry cream is put into spray drying
Dry in machine, obtain fine drug powder, add sodium carboxymethylcellulose, make tablet.
Embodiment 3
Fill a prescription and be：10 grams of chinaberry, 25 grams of Radix Isatidis, 15 grams of garlic, 25 grams of purslane；
Preparation method：
(1) by chinaberry, Radix Isatidis, garlic, purslane mixing, impurity is removed, mixture is obtained, using pulverizer powder
Broken, 150～200 mesh sieves are crossed, the water relative to 4～5 times of mixture quality is added, at a temperature of 85 DEG C～100 DEG C, 1 is decocted
And a half hours, decoction liquor is filtered, and obtains the first filtered fluid and filter residue；
(2) filter residue obtained in step (1) is added the water relative to 2 times of first step mixture quality, 85 DEG C～100
At a temperature of DEG C, decoct 1 and a half hours, decoction liquor is filtered, obtain the second filtered fluid；
(3) the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration obtains dry cream, dry cream is put into spray drying
Dry in machine, obtain fine drug powder, add starch, make granule.
Embodiment 4
Fill a prescription and be：5 grams of chinaberry, 20 grams of Radix Isatidis, 20 grams of garlic, 30 grams of purslane；
Preparation method：
Chinese medicine drying used is crushed by the first step first, is crossed 150～200 mesh sieves, is made medicinal powder；
Second step, presses 1 with the weight ratio of medicinal powder：1～1.5 ratio gets honey ready；
3rd step, tempers honey, and heating-up temperature is 105 DEG C～115 DEG C, until foam is in light red gloss, hand sth. made by twisting has viscous
Property but long white silk can not be pulled into, that is, make middle honey；
4th step, adjusts medicine, and the honey spoon that tempers is poured in the medicinal powder of basin dress, while using thick bamboo chopsticks in medicinal powder
Stir into circumference, add water before dumpling as face just as doing at ordinary times, medicinal powder is adjusted in the while of falling honey, to be substantially not visible during dry medicinal powder
Stop plus honey, but can not plus too much, a honey how ball not easy-formation；
6th step, rubbing, and ball.Can use a little sesame oil drop in the centre of the palm during with ball, surface compact, the light of honeyed bolus can be made
Clean, color and luster is consistent.
Embodiment 5
Fill a prescription and be：15 grams of chinaberry, 20 grams of Radix Isatidis, 18 grams of garlic, 23 grams of purslane；
Preparation method：
(1) by chinaberry, Radix Isatidis, garlic, purslane mixing, impurity is removed, mixture is obtained, using pulverizer powder
Broken, 150～200 mesh sieves are crossed, the water relative to 4～5 times of mixture quality is added, at a temperature of 85 DEG C～100 DEG C, 50 is decocted
Minute, decoction liquor is filtered, and obtains the first filtered fluid and filter residue；
(2) filter residue obtained in step (1) is added the water relative to 2 times of first step mixture quality, 85 DEG C～100
At a temperature of DEG C, decoct 50 minutes, decoction liquor is filtered, obtain the second filtered fluid；
(3) the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration obtains dry cream, dry cream is put into spray drying
Dry in machine, add lactose, make powder.
Embodiment 6
Fill a prescription and be：5 grams of chinaberry, 30 grams of Radix Isatidis, 20 grams of garlic, 30 grams of purslane；
Preparation method：
(1) by chinaberry, Radix Isatidis, garlic, purslane mixing, impurity is removed, mixture is obtained, using pulverizer powder
Broken, 150～200 mesh sieves are crossed, the water relative to 4～5 times of mixture quality is added, at a temperature of 85 DEG C～100 DEG C, 70 is decocted
Minute, decoction liquor is filtered, and obtains the first filtered fluid and filter residue；
(2) filter residue obtained in step (1) is added the water relative to 2 times of first step mixture quality, 85 DEG C～100
At a temperature of DEG C, decoct 70 minutes, decoction liquor is filtered, obtain the second filtered fluid；
(3) the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration obtains dry cream, dry cream is put into spray drying
Dry in machine, obtain fine drug powder, add sucrose, make decoction.
Embodiment 7
With 1 preparation method of embodiment, filling a prescription is：15 grams of chinaberry, 20 grams of Radix Isatidis, 10 grams of garlic, 30 grams of purslane, white
15 grams of art, 15 grams of corn stigma.
After the wherein described bighead atractylodes rhizome adopts temperature for 30～50 DEG C of 1～3min of drying and processing, insert in vapor steam 10～
Use after 20min；Dry and its dry property is relaxed, section becomes simple, and enhances the effect of invigorating the spleen, stomach invigorating；
Rational water steams the time so that the harder bighead atractylodes rhizome of script quality is effectively softened, this and traditional water treating softener mode,
The loss of active ingredient is reduced, while also have increasing lactone content, the property of medicine is relaxed, part carbohydrate hydrolysis is easily inhaled by human body
The effect of receipts.
Wherein described corn stigma by with potassium dihydrogen phosphate according to mass ratio be 1:After 0.01～0.07 mixing, in temperature
For 35～46 DEG C of bottom fermentations, process 5～9 days so that the cellulase pectase produced in sweat can destroy corn stigma
Plant cell wall, make active ingredient be come out, after entering in vivo, no longer affect to absorb because of the resistance of cell membrane,
Remove multiple macromolecular substances such as tannin, pectin, mucilaginous substance and floccule simultaneously, improve the utilization rate of effective ingredient.
Embodiment 8
With 7 preparation method of embodiment, filling a prescription is：10 grams of chinaberry, 30 grams of Radix Isatidis, 20 grams of garlic, 15 grams of purslane, in vain
Art 20 can, 20 grams of corn stigma.
Test example 1
Toxicity trial of the present invention：
Acute toxicity test：
Body weight is adopted for the small white mouse of 20g or so, male and female half and half, using drug dilution liquid gavage of the present invention, gavage amount is pressed
0.5ml/10g, through the median lethal dose that prerun can not measure Chinese medicine composition of the present invention.Observation two weeks, the test activity of mouse
Normal, none mouse is dead, therefore drug oral toxicity very little of the present invention.
Chronic toxicity test：
Experimental group：Group 1 takes small white mouse 20, and body weight 20g or so, male and female half and half are filled per daily drug dilution liquid of the present invention
Stomach, dosage：200mg/kg；Group 2 takes small white mouse 20, body weight 20g or so, male and female half and half, every daily drug dilution liquid of the present invention
Gavage, dosage：400mg/kg；Group 3 small white mouse 20, body weight 20g or so, male and female half and half, per daily drug dilution liquid of the present invention
Gavage, dosage：600mg/kg；Every group of continuous gavage 25 days, observes after being discontinued 10 days.
Control group：20 small white mouses are taken, the 9g/L physiological saline of daily gavage equivalent, continuous gavage 25 days are discontinued 10 days
After observe.
The mouse of 25 days processes of test, clinical observation test group and control group, the state of mind, diet, drinking-water, urination, defecation
And respond is showed no obvious abnormalities to external world, after being discontinued 10 days, mouse is catched and killed, collection blood separates serum, surveys
Determine the content of serum alt and AST, compared with control group, difference is notable, all in normal range (NR).
After being discontinued 10 days, by cut open inspection, each group small white mouse heart, liver, spleen, lung, the form of kidney, color are normal, without substantially
Naked eyes lesions visible, between each group, the heart of small white mouse, liver, spleen, lungs, Kidney coefficients difference not significantly, are illustrated in this
Drug composition is not result in animal Solid organ injury or ANOMALOUS VARIATIONS.Through above testing and verification, the blood routine of mouse and dirty
Device coefficient illustrates that Chinese medicine composition of the present invention is made to the chronic toxicity that will not produce of small white mouse with control group without significant difference
With.
Test example 2
Goat hookworm disease curative effect diagnostic criteria：
Cure：Goat hookworm disease symptoms are wholly absent, and have no any discomfort, have no recurrence
Effective：Under jaw, oedema disappears substantially, but is not wholly absent, and has no that diarrhea, the change of flock of sheep Body weight loss substantially slow down.
Effectively：Symptom mitigation, under jaw, oedema occasionally has diarrhea than slightly disappearing before medication.
Invalid：Symptom is unchanged.
Clinical observation case totally 240,3 months to 7 months sheep age, wherein ram 123, ewe 117, medical history exists
More than one month；Suffer from sheep by this 240 to be grouped at random, be divided into 8 groups, 30 per group；Of the present invention medicine is taken, every time 20～
30g, three times a day, after taking two weeks, cure rate highest group is embodiment 5, has reached 90%, therefore for most preferably.
Test example 3
Experimental group：The medicine that is made using the formula of embodiment 5.
Control group 1：Using the anthelmintic drug levamisol that commonly uses on market.
Control group 2：Using the anthelmintic drug ivermectin that commonly uses on market.
Control group 3：The medicine made using Patent No. CN201410246230.6.
Clinical observation case totally 120, sheep age, medical history was at one in 3～July, wherein ram 58, ewe 62
More than month, suffer from sheep by this 120 and be randomly divided into 4 groups, experimental group 30, control group 1～3 distinguish 30.Experimental group is taken
It is medicine of the present invention, consumption is 20～30 grams every time, and daily 2～3 times, one week is a course for the treatment of, using 2 courses for the treatment of；Control group 1
Levamisol is taken, specification is 25mg/ pieces, and oral 4 every time, 3 times a day, one week is a course for the treatment of, using 2 courses for the treatment of；Right
Ivermectin is taken according to group 2, by 0.2mg/kg, 3 times every time, one week is a course for the treatment of, using two courses for the treatment of；Control group 3 is taken specially
The medicine that profit number is made for CN201410246230.6, per kilogram feed add 500ml medicines, take two weeks；Its result is real
Test group and gavage medicine of the present invention, cure 20, account for 67%, effective 6, account for 20%, effective 3, account for 10%, invalid 1, account for
3%, total effective rate is up to 97%.Control group 1 takes levamisol, cures 14, accounts for 47%, effective 7, account for 23%, effective 2
Example, accounts for 7%, invalid 7, accounts for 23%, and total effective rate is up to 77%, and easily recurs in therapeutic process, and what healing was more is slight
Suffer from sheep；Control group 2 takes ivermectin, cures 18, accounts for 60%, effective 4, account for 13%, effective 5, account for 17%, invalid 3
Example, accounts for 10%, and total effective rate is up to 90%；Control group 3 takes the medicine of Patent No. CN201410246230.6 making, cures 16
Example, accounts for 53%, effective 5, accounts for 17%, effective 5, accounts for 17%, invalid 4, accounts for 13%, and total effective rate is up to 87%；Experimental group
There is significant difference with control group curative effect.Traditional Chinese medicine composition formula of the invention is unique, with desinsection removing toxic substances, the scattered blood of the heat that disappears, resists
Bacterium anti-inflammatory, warming kidney and strengthening spleen effect.Medicine medicinal material of the present invention is easy to get, and cure rate is high, and recurrence rate is low, and stability is strong, has no toxic side effect,
Treat both principal and secondary aspect of disease, complication do not occur using future trouble sheep.
Test example 4
Control group：Feeding basal diet, does not take any medicine；
Experimental group：Except basal diet of the feeding as control group, the medicine of the making of embodiment 8 is also taken daily, daily
Take 3 times, every time 15～20g；
Clinical testing totally 60, is randomly divided into 2 groups, per group of 30 sheep, and sheep age, experimental group continuously took medicine 30 in 3～September
After it, venous blood collection is carried out, centrifugation prepares serum, and checks；As a result experimental group IL-2, IgA, IgG compared with control group are shown
The equal significant difference of content, shows to add the immunologic function that the bighead atractylodes rhizome and corn stigma can improve goat in medicine of the present invention.
Claims (9)
1. the uncinariatic Chinese medicine composition of a kind of preventing and treating goat, it is characterised in that raw material is in parts by weight：Chinaberry 5-15
Part, Radix Isatidis 20-30 parts, garlic 10-20 parts, purslane 15-30 parts.
2. uncinariatic Chinese medicine composition is prevented and treated as claimed in claim 1, it is characterised in that described raw material is in parts by weight
For：Chinaberry 8-12 part, Radix Isatidis 22-26 parts, garlic 14-18 parts, purslane 20-25 parts.
3. the preventing and treating uncinariatic Chinese medicine composition of goat as claimed in claim 1 or 2, it is characterised in that described raw material is with weight
Amount part is calculated as：10 parts of chinaberry, 25 parts of Radix Isatidis, 16 parts of garlic, 23 parts of purslane.
4. uncinariatic Chinese medicine composition is prevented and treated as claimed in claim 1, it is characterised in that its preparation method includes following step
Suddenly：
(1) by chinaberry, Radix Isatidis, garlic, purslane mixing, impurity is removed, mixture is obtained, is crushed using pulverizer, mistake
150～200 mesh sieves, add the water relative to 4～5 times of mixture quality, at a temperature of 85 DEG C～100 DEG C, decoct 30 minutes
～1 and a half hours, decoction liquor was filtered, and obtains the first filtered fluid and filter residue；
(2) filter residue that obtains step (1) adds the water relative to 1～3 times of mixture quality, in 85 DEG C～100 DEG C of temperature
Under, decocting 30 minutes～1 and a half hours, decoction liquor is filtered, and obtains the second filtered fluid；
(3) the first filtrate and the second filtrate are merged, reduced pressure concentration obtains dry cream, dry cream is put in spray dryer and is dried,
Fine drug powder is obtained, is added or without medically acceptable auxiliary material, is made preparation.
5. the preventing and treating uncinariatic Chinese medicine composition preparation method of goat as claimed in claim 4, it is characterised in that described preparation
For electuary, tablet, granule or powder.
6. the preventing and treating uncinariatic Chinese medicine composition of goat as claimed in claim 1, it is characterised in that the raw material also includes the bighead atractylodes rhizome
And corn stigma.
7. the preventing and treating uncinariatic Chinese medicine composition of goat as claimed in claim 6, it is characterised in that the bighead atractylodes rhizome is in parts by weight
For 15～20 parts of the bighead atractylodes rhizome, described corn stigma is 15～20 parts in parts by weight.
8. the uncinariatic Chinese medicine composition of goat is prevented and treated as claimed in claims 6 or 7, it is characterised in that the bighead atractylodes rhizome is using temperature
After spending for 30～50 DEG C of 1～3min of drying and processing, then insert 10～20min of steaming in vapor, you can.
9. the preventing and treating uncinariatic Chinese medicine composition of goat as claimed in claims 6 or 7, it is characterised in that the corn stigma be with
Potassium dihydrogen phosphate is 1 according to mass ratio:After 0.01-0.07 mixing, it is that 35～46 DEG C of bottom fermentations are processed 5～9 days in temperature.
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| CN108815426A (en) * | 2018-05-29 | 2018-11-16 | 华南农业大学 | A kind of antibacterial agent and its preparation method and application containing natural plant extract |
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