CN106491909A - A kind of Chinese medicine for treating Childhood Nephrotic Syndrome - Google Patents
A kind of Chinese medicine for treating Childhood Nephrotic Syndrome Download PDFInfo
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- CN106491909A CN106491909A CN201710020941.5A CN201710020941A CN106491909A CN 106491909 A CN106491909 A CN 106491909A CN 201710020941 A CN201710020941 A CN 201710020941A CN 106491909 A CN106491909 A CN 106491909A
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Abstract
The present invention provides a kind of Chinese medicine for treating Childhood Nephrotic Syndrome, it is related to the field of Chinese medicines, the raw material of the Chinese medicine is by 15 30 parts of Herba Epimedii, 5 15 parts of the Cortex Eucommiae, 10 25 parts of the Radix Astragali, 8 15 parts of Fructus Ligustri Lucidi, 6 12 parts of the Rhizoma Atractylodis Macrocephalae, 5 12 parts of Endothelium Corneum Gigeriae Galli, 5 15 parts of Formica fusca, 10 15 parts of Rhizoma Dioscoreae, 10 15 parts of Fructus Crataegi, 5 10 parts of Radix Glycyrrhizae, 8 12 parts of Fructus Lycii, 5 10 parts of Radix Codonopsis, 38 parts of Fructus Jujubae ratio composition by weight, by the treatment of the Chinese medicine, kidney and spleen invigorating can be played, vigorate qi and replenish the blood, effect of strengthening the tendons and bones, and the immunity of child can be strengthened, preventing and treating recurrence and delay, the side effect for avoiding Western medicine from producing.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine for treating Childhood Nephrotic Syndrome.
Background technology
Childhood Nephrotic Syndrome is a kind of chronic disease, is one group of clinical syndrome in renal glomerular disease, and typical performance is a large amount of eggs
Albiduria, hypoproteinemia, edema or with hyperlipidemia, treatment is got up relatively difficult, easily recurrence and delays, the course of disease during treatment
Long.
At present, the clinical Therapeutic Method to Childhood Nephrotic Syndrome is mainly hormonal medicaments and immunosuppressant therapeutic alliance, but
The side effect that hormone is produced is very big, and due to Long-term Hormone, easy secondary infection common are skin infection, respiratory tract sense
Dye, primary peritonitis etc., what harm was maximum is viral infection, especially during hormone or immunosuppressant treatment, concurrently
Often serious than normal children when measles, chickenpox, herpes zoster.Up to the present, the herbal treatment of Childhood Nephrotic Syndrome is studied also very
Few, Chinese medicine can be prevented effectively from the side effect produced by Western medicine, being reduced to minimum to the actual bodily harm of child.
Content of the invention
(1) technical problem for solving
For the deficiencies in the prior art, the invention provides a kind of Chinese medicine for treating Childhood Nephrotic Syndrome, its Small side effects.
(2) technical scheme
For realizing that object above, the present invention are achieved by the following technical programs:
A kind of Chinese medicine for treating Childhood Nephrotic Syndrome, the Chinese medicine are made up of following raw materials by weight portion ratio:Herba Epimedii 15-
30 parts, Cortex Eucommiae 5-15 part, Radix Astragali 10-25 parts, Fructus Ligustri Lucidi 8-15 parts, Rhizoma Atractylodis Macrocephalae 6-12 parts, Endothelium Corneum Gigeriae Galli 5-12 parts, Formica fusca 5-15 parts,
Rhizoma Dioscoreae 10-15 parts, Fructus Crataegi 10-15 parts, Radix Glycyrrhizae 5-10 parts, Fructus Lycii 8-12 parts, Radix Codonopsis 5-10 parts, Fructus Jujubae 3-8 parts.
Preferably, the Chinese medicine is made up of following raw materials by weight portion ratio:20 parts of Herba Epimedii, 8 parts of the Cortex Eucommiae, the Radix Astragali 15
Part, 10 parts of Fructus Ligustri Lucidi, 8 parts of the Rhizoma Atractylodis Macrocephalae, 8 parts of Endothelium Corneum Gigeriae Galli, 7 parts of Formica fusca, 12 parts of Rhizoma Dioscoreae, 13 parts of Fructus Crataegi, 8 parts of Radix Glycyrrhizae, 10 parts of Fructus Lycii, party
7 parts of ginseng, 4 parts of Fructus Jujubae.
Preferably, the Chinese medicine is made up of following raw materials by weight portion ratio:25 parts of Herba Epimedii, 12 parts of the Cortex Eucommiae, the Radix Astragali
18 parts, 9 parts of Fructus Ligustri Lucidi, 10 parts of the Rhizoma Atractylodis Macrocephalae, 8 parts of Endothelium Corneum Gigeriae Galli, 9 parts of Formica fusca, 14 parts of Rhizoma Dioscoreae, 12 parts of Fructus Crataegi, 7 parts of Radix Glycyrrhizae, 8 parts of Fructus Lycii,
6 parts of Radix Codonopsis, 7 parts of Fructus Jujubae.
Preferably, the Chinese medicine is made up of following raw materials by weight portion ratio:15 parts of Herba Epimedii, 5 parts of the Cortex Eucommiae, the Radix Astragali 25
Part, 8 parts of Fructus Ligustri Lucidi, 6 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Formica fusca, 10 parts of Rhizoma Dioscoreae, 10 parts of Fructus Crataegi, 5 parts of Radix Glycyrrhizae, 9 parts of Fructus Lycii, party
5 parts of ginseng, 8 parts of Fructus Jujubae.
Preferably, the Chinese medicine is made up of following raw materials by weight portion ratio:30 parts of Herba Epimedii, 15 parts of the Cortex Eucommiae, the Radix Astragali
10 parts, 15 parts of Fructus Ligustri Lucidi, 12 parts of the Rhizoma Atractylodis Macrocephalae, 5 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Formica fusca, 15 parts of Rhizoma Dioscoreae, 15 parts of Fructus Crataegi, 10 parts of Radix Glycyrrhizae, Fructus Lycii 12
Part, 10 parts of Radix Codonopsis, 3 parts of Fructus Jujubae.
Preferably, the Chinese medicine is described preparation on any pharmaceuticss.
Preferably, the preparation method of the Chinese medicine is comprised the following steps:(1) taken out, sieve to faint yellow with wheat bran Rhizoma Atractylodis Macrocephalae (parched)
Wheat bran is removed, is cooled;(2) take Fructus Ligustri Lucidi and Endothelium Corneum Gigeriae Galli is added in vinegar, stirring, heating during vinegar to be painted, is taken out, dried;(3) will step
The water of raw material 12 times of the dosing material gross weight together with other described raw materials after (1) and (2) is processed suddenly, decocts 3 hours;(4) mistake
Filter filtrate, the water that medicinal residues are added 8 times of medical material gross weight decoct 2 hours;(5) filter, merge filtrate twice, filtrate is concentrated
Extractum of the relative density for 1.15-1.25 to room temperature;(6) sucrose, dextrin mixing, plus ethanol is added to moisten the extractum
Agent, granulation, dry, granulate are obtained granule, or tabletting is obtained tablet agent;Or add Lactose, Mel to be obtained the extractum
Pill.
(3) beneficial effect
In this prescription, raw materials used major function is as follows:
Herba Epimedii acrid in the mouth, sweet, warm in nature, liver kidney two warp is walked, is the medicine of beneficial vital essence, bone and muscle strengthening, can be with blood pressure lowering blood sugar lowering, increase
Cardiovascular and cerebrovascular vessel blood flow, promotion immunologic function.
Cortex Eucommiae acrid in the mouth, puts down,《Compendium of Materia Medica》Described in:Cortex Eucommiae color is purple and moisten, sweet in the mouth micro-pungent, its temperature is flat, and sweet temperature can be mended,
Micro-pungent can be moistened, therefore can enter liver and the kidney invigorating.
Radix Astragali sweet in the mouth, tepor, return lung, spleen, liver and kidney channel, air making-up and spleen enlivening can treat acute nephritis edema, chronic nephritiss
Edema, spleen kidney deficiency, the deficiency of vital energy are weak.
Fructus Ligustri Lucidi is bitter, cool, returns liver and kidney channel, and tonification liver and gall, improving eyesight, clearind deficient heat, the invigorating the liver and kidney efficacy of a drug are gentle.
Rhizoma Atractylodis Macrocephalae sweet in the mouth, such as slight bitter, stomach of foot Yang Ming, spleen meridian.Invigorating middle warmer dampness, slakes thirst and help produce saliva, and most strengthening the spleen is passed through, big nourishing the stomach
Gas.
Endothelium Corneum Gigeriae Galli sweet taste, does not disappear for food stagnation, vomiting dysentery, infantile malnutrition.
Formica fusca the kidney invigorating and essence nourishing, dredge the meridian passage, removing toxic substances and promoting subsidence of swelling.
Rhizoma Dioscoreae contains the materials such as mucoprotein, amylase, saponin, free amino acid, polyphenol oxidase, and content is more rich
Richness, with tonic effect, is the good merchantable brand of rehabilitation tonic after being ill, plays the role of strong body, kidney nourishing and replenishing vital essence.
Fructus Crataegi nature and flavor acid is sweet, tepor, has aid digestion, blood fat reducing, resists myocardial ischemia, strengthens myocardial contraction, antioxidative
Effect.
Radix Glycyrrhizae has antiinflammatory, anti-allergic effects, and can coordinating the actions of various ingredients in a prescription in side.
Fructus Lycii nourishing the liver, nourishing kidney, lung moistening.
Radix Codonopsis invigorating the spleen and replenishing QI, clearing heat and detoxicating, expelling phlegm for arresting cough.
Fructus Jujubae sweet in the mouth is warm in nature, returns spleen stomach, has invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, the function of relaxing the property of medicine.
The Chinese medicine of the treatment Childhood Nephrotic Syndrome that the present invention is provided, can play a part of kidney and spleen invigorating, and can strengthen
Virgin immunity, strengthening the tendons and bones reduce side effect.
Specific embodiment
Purpose, technical scheme and advantage for making the embodiment of the present invention is clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is the present invention one
Divide embodiment, rather than whole embodiments.Embodiment in based on the present invention, those of ordinary skill in the art are not being made
The every other embodiment obtained under the premise of creative work, belongs to the scope of protection of the invention.
Embodiment 1:
A kind of Chinese medicine for treating Childhood Nephrotic Syndrome, the Chinese medicine are made up of following raw materials by weight portion ratio:Herba Epimedii 20
Part, 8 parts of the Cortex Eucommiae, 15 parts of the Radix Astragali, 10 parts of Fructus Ligustri Lucidi, 8 parts of the Rhizoma Atractylodis Macrocephalae, 8 parts of Endothelium Corneum Gigeriae Galli, 7 parts of Formica fusca, 12 parts of Rhizoma Dioscoreae, 13 parts of Fructus Crataegi are sweet
8 parts of grass, 10 parts of Fructus Lycii, 7 parts of Radix Codonopsis, 4 parts of Fructus Jujubae.Its preparation method is comprised the following steps:
(1) taken out, weed out wheat bran, cool to faint yellow with wheat bran Rhizoma Atractylodis Macrocephalae (parched);(2) take Fructus Ligustri Lucidi and Endothelium Corneum Gigeriae Galli adds vinegar
In, stirring, heating during vinegar to be painted, are taken out, are dried;(3) raw material and other described raw materials one after processing step (1) and (2)
The water of 12 times of dosing material gross weight is played, is decocted 3 hours;(4) filter liquor, the water that medicinal residues are added 8 times of medical material gross weight are decocted
2 hours;(5) filter, merge filtrate twice, concentrate the filtrate to extractum of the relative density for 1.15-1.25 under room temperature;(6) will
The extractum adds sucrose, dextrin mixing, plus ethanol to make wetting agent, and granulation, dry, granulate are obtained granule.
Embodiment 2:
A kind of Chinese medicine for treating Childhood Nephrotic Syndrome, the Chinese medicine are made up of following raw materials by weight portion ratio:Herba Epimedii 25
Part, 12 parts of the Cortex Eucommiae, 18 parts of the Radix Astragali, 9 parts of Fructus Ligustri Lucidi, 10 parts of the Rhizoma Atractylodis Macrocephalae, 8 parts of Endothelium Corneum Gigeriae Galli, 9 parts of Formica fusca, 14 parts of Rhizoma Dioscoreae, 12 parts of Fructus Crataegi,
7 parts of Radix Glycyrrhizae, 8 parts of Fructus Lycii, 6 parts of Radix Codonopsis, 7 parts of Fructus Jujubae.Its preparation method is comprised the following steps:
(1) taken out, weed out wheat bran, cool to faint yellow with wheat bran Rhizoma Atractylodis Macrocephalae (parched);(2) take Fructus Ligustri Lucidi and Endothelium Corneum Gigeriae Galli adds vinegar
In, stirring, heating during vinegar to be painted, are taken out, are dried;(3) raw material and other described raw materials one after processing step (1) and (2)
The water of 12 times of dosing material gross weight is played, is decocted 3 hours;(4) filter liquor, the water that medicinal residues are added 8 times of medical material gross weight are decocted
2 hours;(5) filter, merge filtrate twice, concentrate the filtrate to extractum of the relative density for 1.15-1.25 under room temperature;(6) will
The extractum adds sucrose, dextrin mixing, plus ethanol to make wetting agent, and granulation, dry, granulate, tabletting are obtained tablet.
Embodiment 3:
A kind of Chinese medicine for treating Childhood Nephrotic Syndrome, the Chinese medicine are made up of following raw materials by weight portion ratio:Herba Epimedii 15
Part, 5 parts of the Cortex Eucommiae, 25 parts of the Radix Astragali, 8 parts of Fructus Ligustri Lucidi, 6 parts of the Rhizoma Atractylodis Macrocephalae, 12 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Formica fusca, 10 parts of Rhizoma Dioscoreae, 10 parts of Fructus Crataegi are sweet
5 parts of grass, 9 parts of Fructus Lycii, 5 parts of Radix Codonopsis, 8 parts of Fructus Jujubae.Its preparation method is comprised the following steps:
(1) taken out, weed out wheat bran, cool to faint yellow with wheat bran Rhizoma Atractylodis Macrocephalae (parched);(2) take Fructus Ligustri Lucidi and Endothelium Corneum Gigeriae Galli adds vinegar
In, stirring, heating during vinegar to be painted, are taken out, are dried;(3) raw material and other described raw materials one after processing step (1) and (2)
The water of 12 times of dosing material gross weight is played, is decocted 3 hours;(4) filter liquor, the water that medicinal residues are added 8 times of medical material gross weight are decocted
2 hours;(5) filter, merge filtrate twice, concentrate the filtrate to extractum of the relative density for 1.15-1.25 under room temperature;(6) will
The extractum adds Lactose, Mel mixing, plus ethanol to make wetting agent, and honey pill agent is obtained with modeling preparation method.
Embodiment 4:
A kind of Chinese medicine for treating Childhood Nephrotic Syndrome, the Chinese medicine are made up of following raw materials by weight portion ratio:Herba Epimedii 30
Part, 15 parts of the Cortex Eucommiae, 10 parts of the Radix Astragali, 15 parts of Fructus Ligustri Lucidi, 12 parts of the Rhizoma Atractylodis Macrocephalae, 5 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Formica fusca, 15 parts of Rhizoma Dioscoreae, Fructus Crataegi 15
Part, 10 parts of Radix Glycyrrhizae, 12 parts of Fructus Lycii, 10 parts of Radix Codonopsis, 3 parts of Fructus Jujubae.Its preparation method is comprised the following steps:
(1) taken out, weed out wheat bran, cool to faint yellow with wheat bran Rhizoma Atractylodis Macrocephalae (parched);(2) take Fructus Ligustri Lucidi and Endothelium Corneum Gigeriae Galli adds vinegar
In, stirring, heating during vinegar to be painted, are taken out, are dried;(3) raw material and other described raw materials one after processing step (1) and (2)
The water of 12 times of dosing material gross weight is played, is decocted 3 hours;(4) filter liquor, the water that medicinal residues are added 8 times of medical material gross weight are decocted
2 hours;(5) filter, merge filtrate twice, concentrate the filtrate to extractum of the relative density for 1.15-1.25 under room temperature;(6) will
The extractum adds sucrose, dextrin, granulation to dry, granulate, loads capsule and capsule is obtained.
The acute toxicity test of the present invention:
Take the male and female white mice that body weight is 15-20g each 20, feeding wants one week its body indices Pass Test
Ask, after fasting 12 hours, Chinese medicine obtained in embodiment 1 is given according to 0.5mg/10g gavages, press 0.5mg/10g agent after 2 hours again
Amount administration, Continuous Observation 10 days, none are only dead, observe the organs such as its heart, liver, spleen, lung, kidney and have no significant change after dissection.
It is indicated above that acute toxicity test has no obvious toxic-side effects.
Clinical trial:
The age Childhood Nephrotic Syndrome patient between 2-14 year 80 is chosen, is divided into matched group and experimental group, per group each 40,
Every group of sex covers men and women, and age differencess do not have statistical significance.
Matched group adopts glucocorticoid therapy, experimental group using obtained granule in the embodiment of the present invention 1,10 years old with
Upper child each takes 2g, and three times a day, 5-10 year child each takes 1g, and three times a day, 2-5 year child takes 0.5g daily,
Three times a day, course for the treatment of one week, takes 4 courses for the treatment of.
After treatment, statistical analysiss, P is carried out with SPSS 13.0<0.05 represents that there is significant.Matched group effective percentage
It is 72.5%, treatment group's effective percentage is 92.5%, and the two is compared, the therapeutic effect for the treatment of group is substantially better than matched group.
Typical case:
1st, certain man, 6 years old, nephropathy symptom showed as edema, fatigue and weakness, lethargy, loss of appetite, took of the invention real
Chinese medicine obtained in example 1 is applied after 2 weeks, edema has mitigated, appetite increases, and after taking 4 weeks, edema disappears substantially, diet just recovers
Often, weak sense is eliminated, in high spirits.
2nd, certain female, 10 years old, nephropathy symptom showed as hypertension, nausea, dizziness, vomiting, hematuria, loss of appetite, took this
After 4 weeks, blood pressure is decreased obviously Chinese medicine obtained in inventive embodiments 2, and the symptom such as Nausea and vomiting, hematuria disappears, and appetite increases.
3rd, certain female, 3 years old, nephropathy symptom showed as low grade fever, dizzy faintness, upper eyelid edema, hypoevolutism, dysphoria,
Chinese medicine obtained in the embodiment of the present invention 3 is taken after 5 weeks, low grade fever is disappeared, do not have dizzy faintness phenomenon, upper eyelid edema to disappear, no
Irritated again.
4th, certain man, 10 years old, nephropathy symptom showed as skin and purple striae occurs, and frequent micturition, albuminuria, the withered Huang of hair are withered, anemia,
Inappetence, took Chinese medicine obtained in the embodiment of the present invention 4 after 5 weeks, and urine protein is significantly reduced, and skin purple striae disappears, routine blood test
Check that indices are normal.
To sum up, the embodiment of the present invention has the advantages that:
The Chinese medicine has a significant effect to the nephropathy for treating child, and can avoid the side effect that Western medicine produces, preferably
Prevent disease recurrence and delay.
It should be noted that herein, such as first and second or the like relational terms are used merely to a reality
Body or operation are made a distinction with another entity or operation, and are not necessarily required or implied these entities or deposit between operating
In any this actual relation or order.And, term " including ", "comprising" or its any other variant are intended to
Nonexcludability includes, so that a series of process, method, article or equipment including key elements not only includes that those will
Element, but also other key elements including being not expressly set out, or also include for this process, method, article or equipment
Intrinsic key element.In the absence of more restrictions, the key element for being limited by sentence "including a ...", it is not excluded that
Also there is other identical element in process, method, article or equipment including the key element.
Above example only in order to technical scheme to be described, rather than a limitation;Although with reference to the foregoing embodiments
The present invention has been described in detail, it will be understood by those within the art that:Which still can be to aforementioned each enforcement
Technical scheme described in example is modified, or carries out equivalent to which part technical characteristic;And these modification or
Replace, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (5)
1. a kind of Chinese medicine for treating Childhood Nephrotic Syndrome, it is characterised in that the Chinese medicine is made up of following raw materials by weight portion ratio:
Herba Epimedii 15-30 parts, Cortex Eucommiae 5-15 part, Radix Astragali 10-25 parts, Fructus Ligustri Lucidi 8-15 parts, Rhizoma Atractylodis Macrocephalae 6-12 parts, Endothelium Corneum Gigeriae Galli 5-12 parts, ant
Ant 5-15 parts, Rhizoma Dioscoreae 10-15 parts, Fructus Crataegi 10-15 parts, Radix Glycyrrhizae 5-10 parts, Fructus Lycii 8-12 parts, Radix Codonopsis 5-10 parts, Fructus Jujubae 3-8 parts.
2. a kind of Chinese medicine for treating Childhood Nephrotic Syndrome, it is characterised in that the Chinese medicine is made up of following raw materials by weight portion ratio:
20 parts of Herba Epimedii, 8 parts of the Cortex Eucommiae, 15 parts of the Radix Astragali, 10 parts of Fructus Ligustri Lucidi, 8 parts of the Rhizoma Atractylodis Macrocephalae, 8 parts of Endothelium Corneum Gigeriae Galli, 7 parts of Formica fusca, 12 parts of Rhizoma Dioscoreae, mountain
13 parts of short, bristly hair or beard, 8 parts of Radix Glycyrrhizae, 10 parts of Fructus Lycii, 7 parts of Radix Codonopsis, 4 parts of Fructus Jujubae.
3. a kind of Chinese medicine for treating Childhood Nephrotic Syndrome, it is characterised in that the Chinese medicine is made up of following raw materials by weight portion ratio:
25 parts of Herba Epimedii, 12 parts of the Cortex Eucommiae, 18 parts of the Radix Astragali, 9 parts of Fructus Ligustri Lucidi, 10 parts of the Rhizoma Atractylodis Macrocephalae, 8 parts of Endothelium Corneum Gigeriae Galli, 9 parts of Formica fusca, 14 parts of Rhizoma Dioscoreae, mountain
12 parts of slag, 7 parts of Radix Glycyrrhizae, 8 parts of Fructus Lycii, 6 parts of Radix Codonopsis, 7 parts of Fructus Jujubae.
4. as described in claim 1 treatment Childhood Nephrotic Syndrome Chinese medicine, it is characterised in that the Chinese medicine is any medicament
Described preparation on.
5. the Chinese medicine for the treatment of Childhood Nephrotic Syndrome as claimed in claim 1, its preparation method comprises the following steps:(1) fried with wheat bran
The Rhizoma Atractylodis Macrocephalae is taken out, weeds out wheat bran, cool to faint yellow;(2) take Fructus Ligustri Lucidi and Endothelium Corneum Gigeriae Galli is added in vinegar, stirring, heating, vinegar to be painted
When, take out, dry;(3) 12 times of the dosing material gross weight together with other described raw materials of the raw material after processing step (1) and (2)
Water, decoct 3 hours;(4) filter liquor, the water that medicinal residues are added 8 times of medical material gross weight are decocted 2 hours;(5) filter, merge
Filtrate, concentrates the filtrate to extractum of the relative density for 1.15-1.25 under room temperature twice;(6) extractum is added sucrose, paste
Essence mixes, plus ethanol makees wetting agent, and granulation, dry, granulate are obtained granule, or tabletting is obtained tablet agent;Or by the leaching
Cream adds Lactose, Mel that pill is obtained.
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CN110064016A (en) * | 2019-06-14 | 2019-07-30 | 陕西中医药大学 | A kind of Chinese medicine composition and preparation method thereof adjusting chronic kidney disease immune state |
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CN107582983A (en) * | 2017-10-01 | 2018-01-16 | 河南科技大学第附属医院 | A kind of Chinese medicine for treating Childhood Nephrotic Syndrome and preparation method thereof |
CN110064016A (en) * | 2019-06-14 | 2019-07-30 | 陕西中医药大学 | A kind of Chinese medicine composition and preparation method thereof adjusting chronic kidney disease immune state |
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