CN106491854A - For treating Chinese medicine composition of skin and soft tissue infection and preparation method thereof - Google Patents

For treating Chinese medicine composition of skin and soft tissue infection and preparation method thereof Download PDF

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Publication number
CN106491854A
CN106491854A CN201611007795.4A CN201611007795A CN106491854A CN 106491854 A CN106491854 A CN 106491854A CN 201611007795 A CN201611007795 A CN 201611007795A CN 106491854 A CN106491854 A CN 106491854A
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China
Prior art keywords
chinese medicine
medicine composition
herba
soft tissue
skin
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CN201611007795.4A
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Chinese (zh)
Inventor
朱元方
黎红平
陈旭
李瑶
高燕玲
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SHENZHEN BAOAN WOMEN AND CHILDREN HEALTHCARE HOSPITAL
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SHENZHEN BAOAN WOMEN AND CHILDREN HEALTHCARE HOSPITAL
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Priority to CN201611007795.4A priority Critical patent/CN106491854A/en
Publication of CN106491854A publication Critical patent/CN106491854A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/86Violaceae (Violet family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
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  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is disclosed for treating Chinese medicine composition of skin and soft tissue infection and preparation method thereof, wherein, is counted by weight, mainly composed of the following components:25 35 parts of Herba Centellae;25 35 parts of Herba Hydrocotyleses;15 25 parts of Herba potentillae kleinianae Herba Potentillae Chinensis;5 15 parts of Herba Violae japonicae;5 15 parts of Hemerocallis citrina Baroni Herba Oxalidis Corniculatae;10 15 parts of glycerol;10 30 parts of starch;45 55 parts of distilled water;0.3 0.7 parts of sodium benzoate.Effect of the Chinese medicine composition be anti-inflammatory analgetic, dial the pus, eliminating stagnation, anti-virus sterilizing, infection, have prevention trauma infection contamination effect, without using any antibiotic.

Description

For treating Chinese medicine composition of skin and soft tissue infection and preparation method thereof
Technical field
The present invention relates to drug world, more particularly to a kind of Chinese medicine composition for treating skin and soft tissue infection and Its preparation method.
Background technology
Skin and soft tissue infection, also known as skin and skin structure infection, is that pathogenic bacterium invade epidermis, corium and subcutaneous group Knit the diseases associated with inflammation for causing.Skin and soft tissue infection is clinically commonly encountered diseases and frequently-occurring disease, with sending out for society and economy Undesirable substance (such as pollutant, chemicals etc.) more and more, diabetes, the wound contacted in exhibition, people's daily life and work Constantly rise etc. incidence rate, the sickness rate of such disease is also continuously increased, the only a few severe patient of the disease can concurrent deep group Infection or pyemia is knitted, can threat to life.Major part show as gently-medium-sized, do not jeopardize patient's major organs and life, but with Sample produces harmful effect to life, work.Wherein, neck, the infection of face can affect the image attractive in appearance of people, directly affect people's Orthobiosiss and work, meanwhile, cause larger mental pressure.And surgical incision and drainage, antibiosis used in conventional Therapeutic Method Extract for treating etc., surgical incision and drainage wound are big, easily produce larger cicatrix;The a large amount of frequent use of antibiotic, not only gives people Liver, the vitals such as kidney cause larger infringement, while stronger dependency and drug resistance can be produced.Therefore, study Invention one kind treats such disease, and reduces the natural drug of skin scar formation, be clinicing aspect in the urgent need to.
Content of the invention
In view of above-mentioned the deficiencies in the prior art, it is an object of the invention to provide a kind of be used for treating skin and soft tissue sense Chinese medicine composition of dye and preparation method thereof, for the acute and chronic infectious diseases of skin soft tissue, such as folliculitises, furuncle, carbuncle, pouring Hand shaft inflammation, acute cellulitis, Burn Infection, postoperative infection and decubital ulcer infection etc..
Technical scheme is as follows:
A kind of Chinese medicine composition for treating skin and soft tissue infection, wherein, is counted, by weight mainly by following Group is grouped into:
The described Chinese medicine composition for treating skin and soft tissue infection, wherein, is counted by weight, also include with The following group is grouped into;
Sodium benzoate 0.3-0.7 parts.
The described Chinese medicine composition for treating skin and soft tissue infection, wherein, is counted by weight, mainly by with The following group is grouped into:
The described Chinese medicine composition for treating skin and soft tissue infection, wherein, is counted by weight, also include with The following group is grouped into;
0.5 part of sodium benzoate.
The described Chinese medicine composition for treating skin and soft tissue infection, wherein, described for treating skin and soft The Chinese medicine composition of tissue infection is paste.
A kind of preparation method of the Chinese medicine composition for being used for treating skin and soft tissue infection as above, wherein, bag Include following steps:
Herba Centellae, Herba Hydrocotyleses, Herba potentillae kleinianae Herba Potentillae Chinensis, Herba Violae japonicae, Hemerocallis citrina Baroni Herba Oxalidis Corniculatae decocting are boiled 2-3 time, filtered while hot, are merged Filtrate, is concentrated into 1: 4-5, obtains concentrated solution;
Concentrated solution is dried, is crushed, is sieved, obtain dry extract;
Glycerol is added in extract powder, is ground well, is added starch and stir evenly, obtain mixture;
Distilled water is boiled, sodium benzoate is added;
Distilled water is poured in mixture, is stirred continuously, water-bath is to gelatinizing;
Stir to cooling.
The described preparation method for treating the Chinese medicine composition of skin and soft tissue infection, wherein, the temperature of drying For 60 DEG C;The size that sieves is 100 mesh.
Beneficial effect:The present invention is suitable for for treating Chinese medicine composition of skin and soft tissue infection and preparation method thereof In the acute and chronic infectious diseases of skin soft tissue, the such as skin such as folliculitises, furuncle, carbuncle, acute cellulitises, abscess, erysipelas Local treatment;The malunited auxiliary treatment of postoperative wound.Effect of the Chinese medicine composition be antiinflammatory, pain relieving, dial the pus, eliminating stagnation, Anti-virus sterilizing, have prevention trauma infection contamination effect, can replace topical antibiotic use.Herba Hydrocotyleses, Herba Centellae, Herba potentillae kleinianae Herba Potentillae Chinensis, Herba Violae japonicae, Hemerocallis citrina Baroni Herba Oxalidis Corniculatae belong to Common Chinese Herbs, and edible is nontoxic.Remove during life-time service and slight prurituss occur individually Uncomfortable outer, other untoward reaction are had no, safe.
Specific embodiment
Present invention offer is a kind of for treating Chinese medicine composition of skin and soft tissue infection and preparation method thereof, for making this The purpose of invention, technical scheme and effect are clearer, clear and definite, and the present invention is described in more detail below.It should be appreciated that this The described specific embodiment in place is not intended to limit the present invention only in order to explain the present invention.
Chinese medicine composition for treating skin and soft tissue infection provided by the present invention, is counted, mainly by weight Composed of the following components:
The Chinese medicine composition directed toward bacteria property skin and soft tissue infection, mainly takes heat clearing away, the antiinflammatory of Herba Hydrocotyleses, and accumulated snow The eliminating inflammation and expelling toxin of grass, the pharmacological action for suppressing proliferation of fibrous tissue, coordinate Hemerocallis citrina Baroni Herba Oxalidis Corniculatae eliminating stasis to stop pain, the solution of Herba potentillae kleinianae Herba Potentillae Chinensis Poison promoting blood circulation, effect of Herba Violae japonicae detumescence and drawing out poison, the four big symptoms for eliminating scytitiss are red, swollen, hot, bitterly, so as to reach treatment skin The effect of skin furuncle carbuncle poison.
Wherein, Herba Hydrocotyleses have heat clearing away, detumescence, Detoxication, play main antiinflammatory action.Herba Centellae has heat-clearing and toxic substances removing, Inducing diuresis and reducing edema effect.Proliferation of fibrous tissue can be suppressed and stimulate the replacement of deep skin cell.Play in said composition and promote Wound healing, reduces cicatrization effect, and plays auxiliary antiinflammatory action.Hemerocallis citrina Baroni Herba Oxalidis Corniculatae has clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain Effect, plays in the composition and reduces local pain effect.Herba potentillae kleinianae Herba Potentillae Chinensis have heat clearing away, removing toxic substances, promoting blood circulation effect, in the combination Removing toxic substances promoting blood circulation effect is played in thing, is promoted inflammation to remove, is helped out.Herba Violae japonicae has heat-clearing and toxic substances removing, cool blood detumescence, external to have The effect that antiinflammatory is drawn out pus by applying a plaster to the affected part, plays detumescence, the effect of evacuation of pus in the composition.Glycerol is substrate, belongs to secondary solvent.Starch is powder Last composition, can absorb the purulent secretion that discharges, beneficial to medicine molding, convenient use.Distilled water be used for make powder starch into Pasty state.Sodium benzoate is preservative, prevents mouldy and fermentation.
Herba Hydrocotyleses, Herba Centellae, Herba potentillae kleinianae Herba Potentillae Chinensis, Herba Violae japonicae, Hemerocallis citrina Baroni Herba Oxalidis Corniculatae belong to Common Chinese Herbs, and edible is nontoxic. During life-time service in addition to there is individually slight prurituss discomfort, other untoward reaction are had no, safe.
Most preferred embodiment scheme is also provided in the present invention, the compositionss drug effect prepared using following proposal is optimal, tool Count by weight, mainly by following components group in body ground, the Chinese medicine composition for treating skin and soft tissue infection Into:
Provided by the present invention for treating the Chinese medicine composition of skin and soft tissue infection through clinical verification for many years, Safe and reliable, determined curative effect, in combination with the Chinese drug preparation technique of modernization, has produced Chinese medicine easy to use, eutherapeutic Paste, is applied directly to affected part.The preparation method of the Chinese medicine composition is also provided in the present invention, following step is specifically included Suddenly:
Herba Hydrocotyleses, Herba Centellae, Herba potentillae kleinianae Herba Potentillae Chinensis, Herba Violae japonicae, Hemerocallis citrina Baroni Herba Oxalidis Corniculatae decocting are boiled 2-3 time, filtered while hot, are merged Filtrate, is concentrated into 1: 4-5, obtains concentrated solution;
Concentrated solution is positioned over 60 DEG C of drying of baking box, is crushed, is crossed 100 mesh sieves, obtain dry extract;
Glycerol is added in extract powder, is ground well, is added starch and stir evenly, obtain mixture;
Distilled water is boiled, sodium benzoate is added;
Distilled water is poured in mixture, is stirred continuously, water-bath is to gelatinizing;
Stir to cooling.
Below by way of specific embodiment, the invention will be further described
Embodiment 1
Preparation technology:Herba Centellae, Herba Hydrocotyleses, Herba potentillae kleinianae Herba Potentillae Chinensis, Herba Violae japonicae, Hemerocallis citrina Baroni Herba Oxalidis Corniculatae decocting are boiled 2-3 time, while hot Filter, merging filtrate is concentrated into 1: 4-5, obtain concentrated solution.Concentrated solution is put 60 DEG C of drying of baking box, is crushed, is crossed 100 mesh sieves, obtain Dry extract.In extract powder, add glycerol 10ml to grind well, add 10-30 gram of starch and stir evenly, obtain mixture;By distilled water 50ml boils 0.5 gram of sodium benzoate of addition.The distilled water for being added with sodium benzoate is poured in mixture, is stirred continuously, water-bath To gelatinizing.Finally stir to cooling, both obtained external application paste.
The Chinese medicine composition for treating skin carbuncle furuncle described in being made using this proportioning, used in clinic, external application, Daily two~tri- times.External reaches red and swollen range shorter after 1-2 days, local skin tight feeling disappears, and pain relief, pus point go out Existing, 3-5 days, red and swollen basic regression, puss were discharged, 7-10 days wound healings.Diabeticss concurrent lower limb infection etc. is such as treated Chronic skin infectious disease needs the extended treatment time to be healed to wound completely, about needs 20-30 days.
Case 1:Xx, female, 10 years old, because " right lateral thigh lateral cutaneous pain 2 days " was examined in 201x July 10.Suffer from Person goes to a doctor first 2 days and thigh lateral cutaneous pain occurs without obvious inducement, without heating, does not give treatment, pain to increase in progressive, then To examine.Have a medical check-up:36.5 DEG C of body temperature, psychoreaction is good, and the heart, lung, abdomen are had a medical check-up without exception, and extremity acra is warm, capillary filling 2 seconds time.The red knot property enclosed mass of the visible 5*5cm sizes of the outer middle side part of right lateral thigh, with surrounding skin unclear, the no pus of boundary Point, local Pi Wengao, skin tension are high, and pressing pain is obvious.Diagnosis:Skin furuncle and phyma.1 gained paste of embodiment is spread on trouble Place, changes, pain relief in second day, local skin Wen Bugao sooner or later, and skin tension is alleviated;After treatment 3 days, see pus point, puncture Pus point, the more pus and blood of outflow, continual cure, the 5th day, non-goodbye pus flowed out, without pain, the red range shorter of skin to 1*1cm Size, is further continued for treating 2 days, heals completely, have no obvious cicatrix at present, has slight pigmentation, pigmentation area about 1* 1cm sizes.
Case 2:Multitude xx, man, 47 years old, because " wound protracted course of disease 20 days after the instep wound of right side " comes in 201x Augusts on the 2nd Examine.Because surprisingly being damaged by irony agriculture device during farming before 20 days, there is the irregular wound of a 3cm length to patient assessment in right crus of diaphragm instep, from Row gives and cleaning a wound, and does not go regular debridement and suturing and sterilizing bandaging is processed, and after 3 days, oozing out occurs in wound, transudate be septic, To local clinic, local clinic gives Mupirocin Ointment to smear affected part, and hands over holding wound clean, it is to avoid touch water;Patient medication Five days, period did not followed the doctor's advice, and continued to be engaged in farm work, and wound is without improvement, and has and increase trend, then examining.Have a medical check-up:Body weight 36.5 DEG C, psychoreaction is good, and the heart, lung, abdomen are had a medical check-up without exception.Instep visible 3*2cm sizes in right side are festered, and periphery skin is slightly red, office Portion's skin temperature is slightly higher, the visible purulent secretion in injury.Diagnosis:Skin ulceration.1 gained paste of embodiment is spread on affected part, sooner or later more Plastic sheeting parcel protection, other times is given to keep ventilation when changing, and handing over farming.After treatment 3 days, secretions are reduced, locally Dry clean, wound circumference is not red, continuously uses paste 15 days, wound healing.Current patient's freedom of movement, partially visible cicatrix, scar Trace area about 2*2cm sizes.
It should be appreciated that the application of the present invention is not limited to above-mentioned citing, and for those of ordinary skills, can To be improved according to the above description or be converted, all these modifications and variations should all belong to the guarantor of claims of the present invention Shield scope.

Claims (7)

1. a kind of Chinese medicine composition for treating skin and soft tissue infection, it is characterised in that count by weight, mainly by Following components is constituted:
2. the Chinese medicine composition for treating skin and soft tissue infection according to claim 1, it is characterised in that by weight Amount number meter, also includes that following components is constituted;
Sodium benzoate 0.3-0.7 parts.
3. the Chinese medicine composition for treating skin and soft tissue infection according to claim 1, it is characterised in that by weight Amount number meter, mainly composed of the following components:
4. the Chinese medicine composition for treating skin and soft tissue infection according to claim 3, it is characterised in that by weight Amount number meter, also includes that following components is constituted;
0.5 part of sodium benzoate.
5., according to the arbitrary described Chinese medicine composition for treating skin and soft tissue infection of Claims 1 to 4, its feature exists In the Chinese medicine composition for treating skin and soft tissue infection is paste.
6. a kind of as claimed in claim 2 for treating the preparation method of the Chinese medicine composition of skin and soft tissue infection, its It is characterised by, comprises the following steps:
Herba Centellae, Herba Hydrocotyleses, Herba potentillae kleinianae Herba Potentillae Chinensis, Herba Violae japonicae, Hemerocallis citrina Baroni Herba Oxalidis Corniculatae decocting are boiled 2-3 time, filtered while hot, merge filter Liquid, is concentrated into 1: 4-5, obtains concentrated solution;
Concentrated solution is dried, is crushed, is sieved, obtain dry extract;
Glycerol is added in extract powder, is ground well, is added starch and stir evenly, obtain mixture;
Distilled water is boiled, sodium benzoate is added;
Distilled water is poured in mixture, is stirred continuously, water-bath is to gelatinizing;
Stir to cooling.
7. the preparation method for treating the Chinese medicine composition of skin and soft tissue infection according to claim 6, its are special Levy and be, the temperature of drying is 60 DEG C;The size that sieves is 100 mesh.
CN201611007795.4A 2016-11-16 2016-11-16 For treating Chinese medicine composition of skin and soft tissue infection and preparation method thereof Pending CN106491854A (en)

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Application Number Priority Date Filing Date Title
CN201611007795.4A CN106491854A (en) 2016-11-16 2016-11-16 For treating Chinese medicine composition of skin and soft tissue infection and preparation method thereof

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Country Status (1)

Country Link
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Application publication date: 20170315

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