CN106491853A - A kind of Chinese medicine and western medicine combination for treating bronchiectasiss and preparation method thereof - Google Patents
A kind of Chinese medicine and western medicine combination for treating bronchiectasiss and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
Abstract
The invention discloses a kind of Chinese medicine and western medicine combination for treating bronchiectasiss, the Chinese medicine and western medicine combination of the treatment bronchiectasiss, according to the primary raw material of weight portion are：β, 5 11 parts of β dimethylacrylshikonins, 23 28 parts of ethoxychelerythrine, 6 15 parts of Herba Gentianae Algidae, 5 12 parts of Folium Isatidiss, 17 26 parts of Herba Canscorae, 8 12 parts of Herba Canscorae, 24 parts of dalbergin, 36 parts of 7,8 dihydroxy, 4 phenyl coumarin, 78 parts of 3 β D glucosides of pungent shellfish A prime.Medicine of the present invention is strictly selected to material composition according to the understanding mechanism of bronchiectasiss, so as to reach the purpose of comprehensive rehabilitation, with rapid-action, effect stable, carry taking convenience, long-term taking and have no toxic side effect the characteristics of.
Description
Technical field
The present invention relates to a kind of field of medicine preparation, specifically a kind of Chinese medicine and western medicine combination for treating bronchiectasiss.
Background technology
Bronchiectasis are due to bronchus and its surrounding lung tissue chronic suppurative inflammation and fibrosiss, make bronchial wall
Muscle and Elastic tissue destruction, cause bronchus deformation and persistently expand.Main pathogenic be bronchial infection, obstruction and
Drawing, partly has congenital heredity factor.In chronic process more than the bronchiectasis course of disease, typical clinical manifestations are chronic cough, cough
A large amount of purulent sputums and spit blood repeatedly.90% patient often has spitting of blood, varying degree.Some patients, spitting of blood are probably which is starting and only
Main suit, be clinically referred to as " dry bronchiectasis ", be common in tuberculous bronchiectasiss, pathological changes are more in superior lobar branchess trachea.
If secondary infection repeatedly, there are heating, night sweat during patient, weak, loss of appetite, become thin.When the concurrent compensatory of bronchiectasis
Or during obstructive emphysema, patient can have dyspnea, an out of breath or cyanosis, late period may occur in which pulmonary heart disease and cardiorespiratory failure
Performance.
Primary disease any age can all fall ill, but common with teenager, and many childhood are with pneumonia after measles, pertussis or influenza
Medical history, or have the medical histories such as pulmonary tuberculosis, endobronchial tuberculosises, pulmonary fibrosiss.Primary disease Later development has multiple complications, may lead
Cause lung collapse.
The bronchiectasiss cause of disease includes infection, heredity, cilium exception, immunodeficiency, foreign-body aspiration etc., and pathogeny is
The infection of Bronchi-pulmonary tissue and bronchial obstruction infection cause hyperemia, the edema of tube chamber mucosa, make the narrow and small secretions of tube chamber easy
Obstruction tube chamber, causes inadequate drainage and increases to infect；Bronchial obstruction inadequate drainage can induce pulmonary infection.Current Chinese medicine and western medicine group
Closing treatment has ampicillin, amoxicillin or quinolone antibiotic, or erythromycin, Roxithromycin, clarithromycin and Zitromax
The anti-inflammatory agents such as element, but its therapeutic effect is undesirable and side effect is larger.But at present Chinese medicine there is also that treatment course is longer, effect
Not substantially the problems such as.
Content of the invention
It is an object of the invention to provide a kind of Chinese medicine and western medicine combination for treating bronchiectasiss, to solve above-mentioned background skill
The problem proposed in art.
For achieving the above object, the present invention provides following technical scheme：
A kind of Chinese medicine and western medicine combination for treating bronchiectasiss, according to the primary raw material of weight portion be：Beta, beta-dimethyl third
Alkene acyl shikonin 5-11 parts, ethoxychelerythrine 23-28 parts, Herba Gentianae Algidae 6-15 parts, Folium Isatidiss 5-12 parts, Herba Canscorae
17-26 parts, Herba Canscorae 8-12 parts, dalbergin 2-4 parts, 7,8- dihydroxy -4- phenyl coumarin 3-6 parts, -3 β-D- of pungent shellfish A prime
Glucoside 7-8 parts.
As further scheme of the invention：The Chinese medicine and western medicine combination of the treatment bronchiectasiss, according to weight portion
Primary raw material is：Beta, beta-dimethyl acryloyl shikonin 6-9 parts, ethoxychelerythrine 25-26 parts, Herba Gentianae Algidae 6-15
Part, Folium Isatidiss 6-10 parts, Herba Canscorae 19-22 parts, Herba Canscorae 9-11 parts, dalbergin 2-4 parts, 7,8- dihydroxy -4- phenyl tonkabeans
Plain 3-6 parts, -3 β of pungent shellfish A prime-D-Glucose glycosides 7-8 parts.
As further scheme of the invention：The Chinese medicine and western medicine combination of the treatment bronchiectasiss, according to weight portion
Primary raw material is：8 parts of beta, beta-dimethyl acryloyl shikonin, 26 parts of ethoxychelerythrine, 12 parts of Herba Gentianae Algidae, Folium Isatidiss
8 parts, 21 parts of Herba Canscorae, 10 parts of Herba Canscorae, 3 parts of dalbergin, 5 parts of 7,8- dihydroxy -4- phenyl coumarins, -3 β-D- of pungent shellfish A prime
8 parts of glucoside.
A kind of preparation method of the Chinese medicine and western medicine combination for treating bronchiectasiss, concretely comprises the following steps：
First, in pharmaceutical grade clean area, β is weighed by above-mentioned metering ratio, beta-dimethyl acryloyl shikonin, ethyoxyl are white
Chelerythrine chloride, Herba Gentianae Algidae, Folium Isatidiss, Herba Canscorae, Herba Canscorae, dalbergin, 7,8- dihydroxy -4- phenyl coumarins, Xin Beijia
- 3 β of element-D-Glucose glycosides, sieve, and machinery adds ultra-pure water after mixing, and place in pharmacy mixer, mix 4-8min, control
RSD≤5%, tabletting cold drying after mixing, at 4-8 DEG C, packaging obtains final product the Chinese and Western for the treatment of bronchiectasiss to temperature control
Medicine is combined.
As further scheme of the invention：Mix 6min in concrete steps.
Compared with prior art, the invention has the beneficial effects as follows：
Medicine of the present invention is strictly selected to material composition according to the understanding mechanism of bronchiectasiss, complete so as to reach
The purpose of face rehabilitation, with rapid-action, effect stable, carry taking convenience, long-term taking and have no toxic side effect the characteristics of.
Specific embodiment
Below in conjunction with the embodiment of the present invention, to the embodiment of the present invention in technical scheme be clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the invention, rather than whole embodiment.In based on the present invention
Embodiment, the every other embodiment obtained under the premise of creative work is not made by those of ordinary skill in the art, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of Chinese medicine and western medicine combination for treating bronchiectasiss, according to the primary raw material of weight portion be：Beta, beta-dimethyl third
5 parts of alkene acyl shikonin, 23 parts of ethoxychelerythrine, 6 parts of Herba Gentianae Algidae, 5 parts of Folium Isatidiss, 17 parts of Herba Canscorae, Herba Canscorae 8
Part, 2 parts of dalbergin, 3 parts of 7,8- dihydroxy -4- phenyl coumarins, -3 β of pungent shellfish A prime -7 parts of D-Glucose glycosides.
A kind of preparation method of the Chinese medicine and western medicine combination for treating bronchiectasiss, concretely comprises the following steps：
First, in pharmaceutical grade clean area, β is weighed by above-mentioned metering ratio, beta-dimethyl acryloyl shikonin, ethyoxyl are white
Chelerythrine chloride, Herba Gentianae Algidae, Folium Isatidiss, Herba Canscorae, Herba Canscorae, dalbergin, 7,8- dihydroxy -4- phenyl coumarins, Xin Beijia
- 3 β of element-D-Glucose glycosides, sieve, and machinery adds ultra-pure water after mixing, and place in pharmacy mixer, mix 4min, control RSD
≤ 5%, tabletting cold drying after mixing, at 4 DEG C, packaging obtains final product the Chinese medicine and western medicine group for the treatment of bronchiectasiss to temperature control
Close.
Embodiment 2
A kind of Chinese medicine and western medicine combination for treating bronchiectasiss, according to the primary raw material of weight portion be：Beta, beta-dimethyl third
6 parts of alkene acyl shikonin, 25 parts of ethoxychelerythrine, 6 parts of Herba Gentianae Algidae, 6 parts of Folium Isatidiss, 19 parts of Herba Canscorae, Herba Canscorae 9
Part, 2 parts of dalbergin, 3 parts of 7,8- dihydroxy -4- phenyl coumarins, -3 β of pungent shellfish A prime -7 parts of D-Glucose glycosides.
A kind of preparation method of the Chinese medicine and western medicine combination for treating bronchiectasiss, concretely comprises the following steps：
First, in pharmaceutical grade clean area, β is weighed by above-mentioned metering ratio, beta-dimethyl acryloyl shikonin, ethyoxyl are white
Chelerythrine chloride, Herba Gentianae Algidae, Folium Isatidiss, Herba Canscorae, Herba Canscorae, dalbergin, 7,8- dihydroxy -4- phenyl coumarins, Xin Beijia
- 3 β of element-D-Glucose glycosides, sieve, and machinery adds ultra-pure water after mixing, and place in pharmacy mixer, mix 4min, control RSD
≤ 5%, tabletting cold drying after mixing, at 4 DEG C, packaging obtains final product the Chinese medicine and western medicine group for the treatment of bronchiectasiss to temperature control
Close.
Embodiment 3
A kind of Chinese medicine and western medicine combination for treating bronchiectasiss, according to the primary raw material of weight portion be：Beta, beta-dimethyl third
8 parts of alkene acyl shikonin, 26 parts of ethoxychelerythrine, 12 parts of Herba Gentianae Algidae, 8 parts of Folium Isatidiss, 21 parts of Herba Canscorae, Herba Canscorae 10
Part, 3 parts of dalbergin, 5 parts of 7,8- dihydroxy -4- phenyl coumarins, -3 β of pungent shellfish A prime -8 parts of D-Glucose glycosides.
A kind of preparation method of the Chinese medicine and western medicine combination for treating bronchiectasiss, concretely comprises the following steps：
First, in pharmaceutical grade clean area, β is weighed by above-mentioned metering ratio, beta-dimethyl acryloyl shikonin, ethyoxyl are white
Chelerythrine chloride, Herba Gentianae Algidae, Folium Isatidiss, Herba Canscorae, Herba Canscorae, dalbergin, 7,8- dihydroxy -4- phenyl coumarins, Xin Beijia
- 3 β of element-D-Glucose glycosides, sieve, and machinery adds ultra-pure water after mixing, and place in pharmacy mixer, mix 6min, control RSD
≤ 5%, tabletting cold drying after mixing, at 6 DEG C, packaging obtains final product the Chinese medicine and western medicine group for the treatment of bronchiectasiss to temperature control
Close.
Embodiment 4
A kind of Chinese medicine and western medicine combination for treating bronchiectasiss, according to the primary raw material of weight portion be：Beta, beta-dimethyl third
9 parts of alkene acyl shikonin, 26 parts of ethoxychelerythrine, 15 parts of Herba Gentianae Algidae, 10 parts of Folium Isatidiss, 22 parts of Herba Canscorae, Herba Canscorae
11 parts, 4 parts of dalbergin, 6 parts of 7,8- dihydroxy -4- phenyl coumarins, -3 β of pungent shellfish A prime -8 parts of D-Glucose glycosides.
A kind of preparation method of the Chinese medicine and western medicine combination for treating bronchiectasiss, concretely comprises the following steps：
First, in pharmaceutical grade clean area, β is weighed by above-mentioned metering ratio, beta-dimethyl acryloyl shikonin, ethyoxyl are white
Chelerythrine chloride, Herba Gentianae Algidae, Folium Isatidiss, Herba Canscorae, Herba Canscorae, dalbergin, 7,8- dihydroxy -4- phenyl coumarins, Xin Beijia
- 3 β of element-D-Glucose glycosides, sieve, and machinery adds ultra-pure water after mixing, and place in pharmacy mixer, mix 8min, control RSD
≤ 5%, tabletting cold drying after mixing, at 8 DEG C, packaging obtains final product the Chinese medicine and western medicine group for the treatment of bronchiectasiss to temperature control
Close.
Embodiment 5
A kind of Chinese medicine and western medicine combination for treating bronchiectasiss, according to the primary raw material of weight portion be：Beta, beta-dimethyl third
11 parts of alkene acyl shikonin, 28 parts of ethoxychelerythrine, 15 parts of Herba Gentianae Algidae, 12 parts of Folium Isatidiss, 26 parts of Herba Canscorae, Herba Canscorae
12 parts, 4 parts of dalbergin, 6 parts of 7,8- dihydroxy -4- phenyl coumarins, -3 β of pungent shellfish A prime -8 parts of D-Glucose glycosides.
A kind of preparation method of the Chinese medicine and western medicine combination for treating bronchiectasiss, concretely comprises the following steps：
First, in pharmaceutical grade clean area, β is weighed by above-mentioned metering ratio, beta-dimethyl acryloyl shikonin, ethyoxyl are white
Chelerythrine chloride, Herba Gentianae Algidae, Folium Isatidiss, Herba Canscorae, Herba Canscorae, dalbergin, 7,8- dihydroxy -4- phenyl coumarins, Xin Beijia
- 3 β of element-D-Glucose glycosides, sieve, and machinery adds ultra-pure water after mixing, and place in pharmacy mixer, mix 8min, control RSD
≤ 5%, tabletting cold drying after mixing, at 8 DEG C, packaging obtains final product the Chinese medicine and western medicine group for the treatment of bronchiectasiss to temperature control
Close.
Pharmacology test
1st, chronic toxicity test
It is combined as testing with Chinese medicine and western medicine obtained in the embodiment of the present invention 3, using gastric infusion mode, continuously gives in 24h
Medicine 2 times, per minor tick 8h, is administered 200mg/kg doses every time, and daily accumulation medicine total amount reaches 400mg medicines/kg, equivalent to people
100 times of quantity.After administration in 7d, mice activity, feed, excretion are normal, well-grown, hair color light, and which is average
Body weight increases with the prolongation of experimental period.Every mice of post mortem at 8d, the perusal heart, liver, spleen, lung, kidney,
Brain, thymus, stomach, intestinal etc. do not find color and paramophia, fail to measure median lethal dose(LD 50) (LD50).As a result show：This
Bright Chinese medicine and western medicine is combined without chronic toxicity.
2nd, long term toxicity test
It is combined as testing with Chinese medicine and western medicine obtained in the embodiment of the present invention 3, using gastric infusion mode, by Chinese medicine and western medicine of the present invention
Combination is divided into low dosage, middle dosage, three groups of high dose, the drug dose respectively 40,80,120mg medicines/kg/d of each group, phase
When in 10,20,30 times of clinical dosage.After gastric infusion 24 weeks, medicine of the present invention refers to the general status of animal, hematology
Mark, blood parameters without significantly impact, Systematic anatomy, organ coefficient and histopathological examination also no abnormal disease
Reason changes.It is discontinued 2 weeks and also has no substantially change.As a result show：Chinese medicine and western medicine of the present invention is combined in long term toxicity test, is not found
Overt toxicity reaction and delayed toxicity react.It can be seen that, Chinese medicine and western medicine of the present invention combines non-toxic reaction, and long-term prescription is safe and reliable.
3rd, clinical trial
In October, 2015, in Beijing, 165 patients screened in hospital in April, 2016, and all patients meet bronchus
Di diagnostic criteria is (according to the 7th edition《Internal medicine》The diagnostic criteria of bronchiectasiss：According to pyoptysis expectorant repeatedly, spitting of blood
Medical history and the past have the respiratory tract infection medical history of induction primary disease, CT or HRCT to show bronchiectasic abnormal image performance,
Primary disease can be made a definite diagnosis).Wherein male 95, women 70, minimal ages 22 years old, max age 63 years old, 35.2 years old mean age.
All patients take the Chinese medicine and western medicine combination of the preparation of the embodiment of the present invention 3, and instructions of taking is：Daily 4mg/kg, 3 days courses for the treatment of,
Three courses for the treatment of are treated altogether.
Curative effect situation criterion：Cure：Clinical symptoms are wholly absent, and breast CT check is normal；Effective：Clinical symptoms base
This disappearance, breast CT check are clearly better；Effectively：Clinical symptoms improve, and breast CT check has taken a turn for the better；Invalid：Clinical symptoms
Improve not substantially, before breast CT check is with treating.
Therapeutic effect：165 patients have no adverse reaction during treating, and cure 121, effective 22, effective 16, nothing
Effect 6, total effective rate 96.4%.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Contain an independent technical scheme, this narrating mode of description is only that those skilled in the art should for clarity
Using description as an entirety, the technical scheme in each embodiment can also form those skilled in the art through appropriately combined
Understandable other embodiment.
Claims (5)
1. a kind of Chinese medicine and western medicine combination for treating bronchiectasiss, it is characterised in that the primary raw material according to weight portion is：β,β-
Dimethylacrylshikonin 5-11 parts, ethoxychelerythrine 23-28 parts, Herba Gentianae Algidae 6-15 parts, Folium Isatidiss 5-12 parts,
Herba Canscorae 17-26 parts, Herba Canscorae 8-12 parts, dalbergin 2-4 parts, 7,8- dihydroxy -4- phenyl coumarin 3-6 parts, pungent shellfish A prime -
3 β-D-Glucose glycosides 7-8 parts.
2. the Chinese medicine and western medicine combination for the treatment of bronchiectasiss according to claim 1, it is characterised in that the treatment gas
The Chinese medicine and western medicine combination of enlargement of pipe disease, according to the primary raw material of weight portion be：Beta, beta-dimethyl acryloyl shikonin 6-9 parts, ethoxy
Base chelerythrine 25-26 parts, Herba Gentianae Algidae 6-15 parts, Folium Isatidiss 6-10 parts, Herba Canscorae 19-22 parts, Herba Canscorae 9-11 parts, Huang
Wingceltis element 2-4 parts, 7,8- dihydroxy -4- phenyl coumarin 3-6 parts, -3 β of pungent shellfish A prime-D-Glucose glycosides 7-8 parts.
3. the Chinese medicine and western medicine combination for the treatment of bronchiectasiss according to claim 1 and 2, it is characterised in that the treatment
The Chinese medicine and western medicine combination of bronchiectasiss, according to the primary raw material of weight portion be：8 parts of beta, beta-dimethyl acryloyl shikonin, second
26 parts of epoxide chelerythrine, 12 parts of Herba Gentianae Algidae, 8 parts of Folium Isatidiss, 21 parts of Herba Canscorae, 10 parts of Herba Canscorae, 3 parts of dalbergin, 7,
5 parts of 8- dihydroxy -4- phenyl coumarins, -3 β of pungent shellfish A prime -8 parts of D-Glucose glycosides.
4. the preparation method that a kind of Chinese medicine and western medicine of the treatment bronchiectasiss as described in claim 1-3 is arbitrary is combined, which is special
Levy and be, concretely comprise the following steps：
First, in pharmaceutical grade clean area, β, beta-dimethyl acryloyl shikonin, ethyoxyl Herba Chelidonii are weighed by above-mentioned metering ratio
Red alkali, Herba Gentianae Algidae, Folium Isatidiss, Herba Canscorae, Herba Canscorae, dalbergin, 7,8- dihydroxy -4- phenyl coumarins, pungent shellfish A prime -3
β-D-Glucose glycosides, sieves, and machinery adds ultra-pure water after mixing, and places in pharmacy mixer, mixing 4-8min, and control RSD≤
5%, tabletting cold drying after mixing, at 4-8 DEG C, packaging obtains final product the Chinese medicine and western medicine group for the treatment of bronchiectasiss to temperature control
Close.
5. the preparation method that the Chinese medicine and western medicine for the treatment of bronchiectasiss according to claim 4 is combined, it is characterised in that tool
Mix 6min in body step.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205037A (en) * | 2011-05-19 | 2011-10-05 | 吴文波 | Oral medicinal composition for treating infantile bronchitis caused by bacterial infection and preparation method thereof |
| CN105727144A (en) * | 2016-04-03 | 2016-07-06 | 张鸿 | Traditional Chinese medicine composition for treating bronchitis and preparation method thereof |
-
2016
- 2016-12-17 CN CN201611172212.3A patent/CN106491853A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205037A (en) * | 2011-05-19 | 2011-10-05 | 吴文波 | Oral medicinal composition for treating infantile bronchitis caused by bacterial infection and preparation method thereof |
| CN105727144A (en) * | 2016-04-03 | 2016-07-06 | 张鸿 | Traditional Chinese medicine composition for treating bronchitis and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 倪伟: "《内科学 第10版 新世纪第4版》", 31 July 2016, 中国中医药出版社 * |
| 南京中医药大学编著: "《中药大辞典 第2版 下》", 30 June 2014, 上海科学技术出版社 * |
| 张耕，马威，徐宏峰: "《常用中药毒性研究进展及应用》", 30 September 2013, 湖北科学技术出版社 * |
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Application publication date: 20170315 |