CN106491242A - 人工角膜 - Google Patents

人工角膜 Download PDF

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Publication number
CN106491242A
CN106491242A CN201610152494.4A CN201610152494A CN106491242A CN 106491242 A CN106491242 A CN 106491242A CN 201610152494 A CN201610152494 A CN 201610152494A CN 106491242 A CN106491242 A CN 106491242A
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China
Prior art keywords
artificial cornea
cornea
central optical
artificial
hydroxyapatite
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黄飞
黄一飞
王丽强
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明公开了一种人工角膜，它包括中央光学部分和设在周边的固定部分，其特征在于：在所述人工角膜中央光学部分的圆柱侧外表面和固定部分(2)的内表面涂覆有羟基磷灰石涂层(3)。所述的涂层的纳米粒的平均粒径为20nm。本发明的优点在于利用涂层的隔离性和羟基磷灰石具有的抗菌特性，将其涂覆在人工角膜光学部分圆柱形外表面及周边固定物内表面后，对与患者角膜、房水接触的细菌等微生物产生杀灭作用；由于羟基磷灰石可长久性地涂覆在人工角膜光学部分周围，不改变人工角膜材料本身的特征，人工角膜所具有的固有特性仍被保持，使治疗、护理达到最好的效果。

Description

人工角膜
技术领域
本发明涉及医药技术领域，具体是涉及一种带有增加生物整合性的涂层医用人工角膜。
背景技术
人工角膜是无法用角膜手术复明的角膜混浊病人的最终复明手段。为达到理想的光学效果，人工角膜目前多采用贯通式，即人工角膜光学部分贯通角膜全层，通过支架将光学部分固定在角膜中央，因此人工角膜光学部分与周边支架及组织结构间有一定缝隙。在临床上，正因为这些潜在腔隙，增加了微生物进入眼内的机会，可能导致人工角膜术后最严重的并发症-眼内炎的发生，给疾病的治疗、护理工作带来极大不便，给患者带来痛苦和危险。
发明内容
本发明的目的在于提供一种具有抗菌功能的医用人工角膜，用以减少人工角膜的使用过程中的感染发生率。
为实现上述目的，本发明可采取下述技术方案：
本发明提供了一种人工角膜，它包括中央光学部分和设在周边的固定部分，其特征在于：在所述人工角膜中央光学部分的圆柱侧外表面和固定部分(2)的内表面涂覆有羟基磷灰石涂层(3)。
优选地，所述的中央光学部分为中央光学镜柱(1)，所述的固定部分(2)为角膜板层间固定物或角膜后表面固定物。
优选地，所述的中央光学镜柱(1)的材质为医用级聚甲基丙烯酸甲酯和/或甲基丙烯酸羟乙酯。
优选地，所述的角膜板层间固定物或角膜后表面固定物材料选自医用级聚甲基丙烯酸甲酯或医用级别钛金属。
所述的羟基磷灰石涂层(3)的纳米粒的平均粒径为5～50nm，优选10～30nm，更优选20nm。
本发明的优点在于将羟基磷灰石涂覆在人工角膜光学部分圆柱形外表面和周边固定部分内表面后，羟基磷灰石吸引生物分子电荷而炎症反应轻微，减少PMMA引起的异物反应，使涂层后的镜柱和周围组织达到生物整合的目的，从而减少PMMA镜柱和周围组织的间隙，进一步减少细菌等微生物进入眼内的机会。羟基磷灰石涂层具有较好的生物功能性，同时不改变人工角膜材料本身的特征，人工角膜所具有的固有特性仍被保持，使治疗、护理达到最好的效果。
附图说明
下面结合附图对本发明作进一步说明。
图1是本发明人工角膜的中央光学镜柱(1)、周边固定部分(2)及其表面羟基磷石灰涂层(3)的结构示意图。
具体实施方式
以下通过具体实施方式对本发明的技术方案进行进一步的说明和描述。本领域技术人员可以理解的是，以下的具体实施方式仅仅是为了进一步阐述本发明的目的，而非以任何方式限制本发明的保护范围。
如图1所示，本发明描述的羟基磷灰石医用人工角膜包括中央光学镜柱(1)、设在周边的固定部分(2)以及在所述人工角膜中央光学镜柱(1)的圆柱侧外表面和周边固定部分(2)的内表面涂覆有羟基磷灰石涂层(3)。

Claims (6)

1.一种人工角膜，它包括中央光学部分和设在周边的固定部分，其特征在于：在所述人工角膜中央光学部分的圆柱侧外表面和固定部分(2)的内表面涂覆有羟基磷灰石涂层(3)。
2.根据权利要求1所述的人工角膜，其特征在于：所述的中央光学部分为中央光学镜柱(1)，所述的固定部分(2)为角膜板层间固定物或角膜后表面固定物。
3.根据权利要求2所述的人工角膜，其特征在于：所述的中央光学镜柱(1)的材质为医用级聚甲基丙烯酸甲酯和/或甲基丙烯酸羟乙酯。
4.根据权利要求2所述的人工角膜，其特征在于：所述的角膜板层间固定物或角膜后表面固定物材料选自医用级聚甲基丙烯酸甲酯或医用级别钛金属。
5.根据权利要求1～4任一项所述的人工角膜，其特征在于：所述的羟基磷灰石涂层(3)的纳米粒的平均粒径为5～50nm。
6.根据权利要求5所述的人工角膜，其特征在于：所述的羟基磷灰石土层(3)的纳米粒的平均粒径为20nm。
CN201610152494.4A 2016-03-17 2016-03-17 人工角膜 Pending CN106491242A (zh)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109512548A (zh) * 2018-09-11 2019-03-26 翟嘉洁 一种人工角膜
CN109820621A (zh) * 2019-03-01 2019-05-31 广州锐澄医疗技术有限公司 一种复合型人工角膜及其制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4424753A1 (de) * 1994-07-13 1996-01-18 Fraunhofer Ges Forschung Retina-Implantat
CN101001589A (zh) * 2004-06-01 2007-07-18 贝克顿迪肯森公司 眼植入物及其制备和使用方法
CN201160919Y (zh) * 2008-03-05 2008-12-10 黄一飞 新型分体式人工角膜
CN201939532U (zh) * 2010-12-23 2011-08-24 姚晓明 一种人工眼角膜
CN103565557A (zh) * 2013-11-15 2014-02-12 厦门大学 一种人工角膜
CN103830021A (zh) * 2012-11-30 2014-06-04 复旦大学附属眼耳鼻喉科医院 一种人工角膜及其制备方法
CN204562464U (zh) * 2015-04-08 2015-08-19 河南宇宙人工晶状体研制有限公司 带有钛金属膜的人工角膜
CN206183436U (zh) * 2016-03-17 2017-05-24 黄一飞 人工角膜

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4424753A1 (de) * 1994-07-13 1996-01-18 Fraunhofer Ges Forschung Retina-Implantat
CN101001589A (zh) * 2004-06-01 2007-07-18 贝克顿迪肯森公司 眼植入物及其制备和使用方法
CN201160919Y (zh) * 2008-03-05 2008-12-10 黄一飞 新型分体式人工角膜
CN201939532U (zh) * 2010-12-23 2011-08-24 姚晓明 一种人工眼角膜
CN103830021A (zh) * 2012-11-30 2014-06-04 复旦大学附属眼耳鼻喉科医院 一种人工角膜及其制备方法
CN103565557A (zh) * 2013-11-15 2014-02-12 厦门大学 一种人工角膜
CN204562464U (zh) * 2015-04-08 2015-08-19 河南宇宙人工晶状体研制有限公司 带有钛金属膜的人工角膜
CN206183436U (zh) * 2016-03-17 2017-05-24 黄一飞 人工角膜

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109512548A (zh) * 2018-09-11 2019-03-26 翟嘉洁 一种人工角膜
CN109820621A (zh) * 2019-03-01 2019-05-31 广州锐澄医疗技术有限公司 一种复合型人工角膜及其制备方法

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Application publication date: 20170315